Article
Orthopedics
Ruoyi Ding, Chuan Lu, Jieyun Zhao, Dongmei He
Summary: HO after alloplastic TJR with fat graft was generally not severe except for type IV, which was associated with ankylosis. Preserving sufficient TJR space was important for ankylosis prevention.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Veterinary Sciences
J. C. Almansa Ruiz, R. M. Kirberger, G. Steenkamp
Summary: This study described and evaluated the clinical application of temporomandibular joint injections using betamethasone and ropivacaine in German Shepherd dogs suffering from non-odontogenic orofacial pain. The results showed that this treatment technique was feasible with a decent outcome, and there were differences in the clinical signs free period between dogs injected on one side versus both sides. Further randomized studies are recommended for validation.
JOURNAL OF SMALL ANIMAL PRACTICE
(2021)
Article
Medicine, General & Internal
Christopher Schmidt, Taila Ertel, Martin Arbogast, Boris Huegle, Thekla von Kalle, Andreas Neff
Summary: Involvement of the temporomandibular joint is common in patients with rheumatoid arthritis and juvenile idiopathic arthritis, with many cases being asymptomatic. Early diagnosis and treatment are essential, but there is still a lack of consensus in management. Regular clinical evaluation is recommended, particularly for patients with juvenile idiopathic arthritis.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2022)
Review
Medicine, General & Internal
Maciej Checinski, Kamila Checinska, Natalia Turosz, Anita Brzozowska, Dariusz Chlubek, Maciej Sikora
Summary: This mapping review aims to discuss the current research directions on intracavitary temporomandibular joints (TMJs) injections for patients with temporomandibular joint disorders (TMDs). A total of 152 qualified reports were identified from 2712 records, and the results showed that viscosupplementation with hyaluronic acid (HA) was the best-documented injectable administered into TMJ cavities, but there is a growing trend in the use of centrifuged blood preparations for injections.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This article provides updated guidelines for the pharmacologic management of juvenile idiopathic arthritis (JIA), focusing on different forms of JIA and providing recommendations for treatment and tapering of medications. The evidence for these recommendations is generally low quality, but the inclusion of patients and caregivers in the decision-making process strengthens the relevance and applicability of the guideline.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Kristin Sweeney, Shruti Handa, Meredith August, David A. Keith
Summary: This study identified several risk factors associated with TMJ HO, which can help improve diagnostic and treatment strategies.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Zhen Ma, Yiming Wang, Yang Xue, Wuyang Zhang, Dengke Li, Yuan Li, Guowei Li, Hongzhi Zhou, Xiangxiang Hu, Tiange Deng, Kaijin Hu
Summary: This study aimed to explore the pathogenesis of traumatic temporomandibular joint (TMJ) bony ankylosis in a rat model. The results showed that MMP13 and RUNX2 genes were significantly downregulated in endochondral ossification of TMJ bony ankylosis. The main pathways related to endochondral ossification were Parathyroid hormone synthesis, secretion and action, Relaxin signaling pathway, and IL-17 signaling pathway.
Article
Orthopedics
Roland E. Willburger, Friederike Brinkhoff, Jan Nottenkamper, Jan Krapp, Stella Oberberg
Summary: The formation of HO is completed three years after THA, and after this point, HO will not further increase. If HO occurs or increases after more than three years postoperatively, other triggering causes should be considered.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This study provides updated guidelines for pharmacologic management of juvenile idiopathic arthritis (JIA), focusing on specific types of JIA and treatment options. The recommendations are based on low-quality evidence and are conditional in nature.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Orthopedics
Duncan S. Van Nest, Samuel Clarkson, Emanuele Chisari, Matthew B. Sherman, Javad Parvizi
Summary: The study aimed to examine the influence of aspirin as venous thromboembolism prophylaxis on heterotopic ossification formation following total joint arthroplasty. Results showed that patients receiving aspirin had lower rates of HO after both THA and TKA, suggesting a potential protective effect of aspirin against HO formation.
JOURNAL OF ARTHROPLASTY
(2021)
Review
Cell Biology
Robert J. Pignolo, Maurizio Pacifici
Summary: Metabolic derivatives of vitamin A, known as retinoids, regulate tissue and organ functions prenatally and postnatally. Studies showed that chondrogenic cell differentiation and cartilage maturation require the absence of retinoid signaling and repression function by unliganded RARs. Synthetic retinoid agonists could be potential pharmacological agents to inhibit heterotopic ossification.
Review
Cell & Tissue Engineering
Lukasz Pulik, Bartosz Mierzejewski, Aleksandra Sibilska, Iwona Grabowska, Maria Anna Ciemerych, Pawel Legosz, Edyta Brzoska
Summary: Heterotopic ossification is the formation of bone in non-osseous tissues, and it can be caused by genetic or non-genetic factors. TGF beta 1, BMPs, activin A, and other factors are known to induce HO. Dysregulation of noncoding RNAs may also play a role in the development of HO.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
George A. E. Pickering, Favour Felix-Ilemhenbhio, Matthew J. Clark, Klaudia Kocsy, Jonathan Simpson, Ilaria Bellantuono, Alison Gartland, Jeremy Mark Wilkinson, Konstantinos Hatzikotoulas, Endre Kiss-Toth
Summary: This study aimed to identify new therapeutic molecular targets for severe HO. Through a genome-wide scan and association analysis, the KIF26B gene was found to be associated with HO severity. The expression of KIF26B in bone and its role in osteogenic differentiation were confirmed through experiments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Hui Ben, Erica Kholinne, Chu Hui Zeng, Hood Alsaqri, Jun-Bum Lee, Sang-Pil So, Kyoung-Hwan Koh, In-Ho Jeon
Summary: This study retrospectively reviewed data from 205 patients who underwent elbow arthroscopy and found that HO was a minor complication with a prevalence rate of 6.3%. It was usually located in the medial compartment of the elbow. Younger age, longer tourniquet time, and longer surgical time were identified as risk factors for HO formation after elbow arthroscopy.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Review
Cell Biology
Yili Xu, Mei Huang, Wenzhen He, Chen He, Kaixuan Chen, Jing Hou, Min Huang, Yurui Jiao, Ran Liu, Nanyu Zou, Ling Liu, Changjun Li
Summary: In this article, the primary characteristics of heterotopic ossification are reviewed from both clinical and basic research perspectives, with a special highlight on the influence of mechanics on heterotopic ossification, which serves an important role in the prophylaxis and treatment of HO.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Rheumatology
Mirkamal Tolend, Thitiporn Junhasavasdikul, Randy Q. Cron, Emilio J. Inarejos Clemente, Thekla von Kalle, Christian J. Kellenberger, Bernd Koos, Elka Miller, Marion A. van Rossum, Rotraud K. Saurenmann, Lynn Spiegel, Jennifer Stimec, Marinka Twilt, Nikolay Tzaribachev, Shelly Abramowicz, Simone Appenzeller, Linda Z. Arvidsson, Saurabh Guleria, Jacob L. Jaremko, Eva Kirkhus, Tore A. Larheim, Arthur B. Meyers, Jyoti Panwar, Cory M. Resnick, Susan C. Shelmerdine, Brian M. Feldman, Andrea S. Doria
Summary: A DCE survey was used to determine the relative importance weights of items and grades of the JAMRIS-TMJ, showing high convergent validity with an unrestricted, holistic vignette ranking method.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Daniel D. Reiff, Randy Q. Cron
Summary: This review provides an in-depth analysis of multisystem inflammatory disease in children (MIS-C) following COVID-19. It discusses the clinical findings, pathophysiology, imaging and laboratory studies, treatment algorithms, and disease outcomes. MIS-C can be challenging to diagnose due to its non-specific presentation, but accurate diagnosis can be achieved through common laboratory features, imaging findings, and historical clues, enabling appropriate treatment with therapies such as IVIG. Aggressive treatment leads to good outcomes, and longitudinal studies shed light on long-term cardiac sequelae and recovery.
CURRENT RHEUMATOLOGY REPORTS
(2022)
Article
Biology
Daniel D. Reiff, Mingce Zhang, Emily A. Smitherman, Melissa L. Mannion, Matthew L. Stoll, Peter Weiser, Randy Q. Cron
Summary: This study found decreased NK cell function and features of sHLH in a severe COVID-19 patient, and identified a mutation in the patient's genetic makeup. The mutation resulted in significantly decreased NK cell degranulation and cytolysis. These findings are important for understanding the pathophysiology, diagnosis, and treatment of severe COVID-19 cases.
Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This study provides recommendations for the management of juvenile idiopathic arthritis, focusing on nonpharmacologic therapies, medication monitoring, immunizations, and imaging. The guideline emphasizes the importance of improving patient quality of life and involving patients and caregivers in decision-making. However, the evidence quality for all recommendations is low.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This study provides updated guidelines for pharmacologic management of juvenile idiopathic arthritis (JIA), focusing on specific types of JIA and treatment options. The recommendations are based on low-quality evidence and are conditional in nature.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This guideline provides recommendations for the management of juvenile idiopathic arthritis, focusing on nonpharmacologic therapies, medication monitoring, immunizations, and imaging. Recommendations include physical therapy and occupational therapy interventions, a healthy diet, medication monitoring, immunizations, and shared decision-making with patients/caregivers.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This article provides updated guidelines for the pharmacologic management of juvenile idiopathic arthritis (JIA), focusing on different forms of JIA and providing recommendations for treatment and tapering of medications. The evidence for these recommendations is generally low quality, but the inclusion of patients and caregivers in the decision-making process strengthens the relevance and applicability of the guideline.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Matthew Gibson, Randy Q. Cron, Matthew L. Stoll, Brian E. Kinard, Tessa Patterson, Chung How Kau
Summary: This study found significant differences in airway dimensions, particularly in the nasopharyngeal airway volume and the most constricted cross-sectional area, between juvenile idiopathic arthritis (JIA) patients and healthy controls. Additionally, there may be an impact on posterior facial dimensions in JIA patients.
APPLIED SCIENCES-BASEL
(2022)
Article
Biology
Anshul Vagrecha, Mingce Zhang, Suchitra Acharya, Shannon Lozinsky, Aaron Singer, Chana Levine, Maha Al-Ghafry, Carolyn Fein Levy, Randy Q. Cron
Summary: Children with COVID-19 have the potential to develop a novel syndrome known as MIS-C, characterized by high levels of inflammation. This study discovered that a small number of children with MIS-C carried genetic mutations, including a variant called DOCK8, which may be a risk factor for the development of this syndrome. These findings contribute to a better understanding of the mechanisms underlying MIS-C.
Editorial Material
Rheumatology
Melissa L. Mannion, Randy Q. Cron
ARTHRITIS CARE & RESEARCH
(2023)
Editorial Material
Immunology
Randy Q. Cron
Summary: In addition to the acute phase, a significant percentage of SARS-CoV-2 patients experience prolonged illness with varying symptoms. Longitudinal data collection on immunologic, inflammatory, and metabolic factors has allowed the development of a composite signature that can predict recovery.
Article
Biology
Daniel D. Reiff, Mingce Zhang, Randy Q. Cron
Summary: Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by uncontrolled inflammation and immune system activation. Primary HLH (pHLH) is caused by genetic mutations that lead to organ failure and can be fatal. Secondary HLH (sHLH) can be triggered by genetic mutations in certain genes. This study focused on the significance of a DOCK2 mutation in the pathogenesis of sHLH and its implications for diagnosis and treatment.
Review
Immunology
Pui Y. Lee, Randy Q. Cron
Summary: Cytokine storm syndromes (CSSs) are potentially fatal hyperinflammatory states characterized by persistent immune cell activation and excessive cytokine production. CSSs can be caused by genetic errors of immunity, infections, chronic inflammatory diseases, or malignancies. This review explores the biology of different types of CSSs, the involvement of immune pathways, the contribution of host genetics, and discusses treatment approaches.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Pediatrics
Daniel D. Reiff, Randy Q. Cron
Summary: Cytokine storm syndrome (CSS) is a serious condition caused by severe systemic inflammation and immune activation. The use of cytokine-directed therapies, such as interleukin-1 receptor antagonist, has shown promising results in treating CSS in ECMO patients.
Editorial Material
Rheumatology
Daniel D. Reiff, Randy Q. Cron