Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This article provides updated guidelines for the pharmacologic management of juvenile idiopathic arthritis (JIA), focusing on different forms of JIA and providing recommendations for treatment and tapering of medications. The evidence for these recommendations is generally low quality, but the inclusion of patients and caregivers in the decision-making process strengthens the relevance and applicability of the guideline.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Biology
Artem K. Artamonov, Maria A. Kaneva, Natalia A. Gordeeva, Lubov S. Sorokina, Mikhail M. Kostik
Summary: Our study aimed to evaluate the clinical and laboratory features of juvenile idiopathic arthritis (JIA) children with temporomandibular joint (TMJ) arthritis. TMJ arthritis was detected in 43 (5.7%) of our patients and associated with a longer course of the disease, polyarticular JIA category, treatment with systemic corticosteroids, and longer achievement of remission and involvement of cervical spine, hip, and shoulder. Patients with TMJ arthritis require more biologics and have decreased probability of remission achievement.
Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This guideline provides recommendations for the management of juvenile idiopathic arthritis, focusing on nonpharmacologic therapies, medication monitoring, immunizations, and imaging. Recommendations include physical therapy and occupational therapy interventions, a healthy diet, medication monitoring, immunizations, and shared decision-making with patients/caregivers.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Medicine, General & Internal
Christopher Schmidt, Rudolf Reich, Bernd Koos, Taila Ertel, Marcus Oliver Ahlers, Martin Arbogast, Ima Feurer, Mario Habermann-Krebs, Tim Hilgenfeld, Christian Hirsch, Boris Huegle, Thekla von Kalle, Johannes Kleinheinz, Andreas Kolk, Peter Ottl, Christoph Pautke, Merle Riechmann, Andreas Schoen, Linda Skroch, Marcus Teschke, Wolfgang Wuest, Andreas Neff
Summary: This study emphasizes the importance of early diagnosis and timely treatment of chronic rheumatic arthritis of the temporomandibular joint (TMJ) to avoid severe sequelae. The study aims to identify and discuss controversial topics in guideline development to encourage further research. The results suggest that contrast-enhanced MRI is the preferred diagnostic method for TMJ arthritis, and corticosteroid injection should be limited to therapy-refractory cases and single injection.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pediatrics
Achille Marino, Orazio De Lucia, Roberto Caporali
Summary: This systematic literature review assessed the current role of TMJ US in JIA, showing that US has lower capability in detecting signs of active synovitis of TMJ compared to contrast enhancement MRI. Despite being secondary to MRI, US may help interpret images and intercept significant changes over time in TMJ involvement in JIA.
Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This study provides recommendations for the management of juvenile idiopathic arthritis, focusing on nonpharmacologic therapies, medication monitoring, immunizations, and imaging. The guideline emphasizes the importance of improving patient quality of life and involving patients and caregivers in decision-making. However, the evidence quality for all recommendations is low.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Liana Fraenkel, Joan M. Bathon, Bryant R. England, E. William St Clair, Thurayya Arayssi, Kristine Carandang, Kevin D. Deane, Mark Genovese, Kent Kwas Huston, Gail Kerr, Joel Kremer, Mary C. Nakamura, Linda A. Russell, Jasvinder A. Singh, Benjamin J. Smith, Jeffrey A. Sparks, Shilpa Venkatachalam, Michael E. Weinblatt, Mounir Al-Gibbawi, Joshua F. Baker, Kamil E. Barbour, Jennifer L. Barton, Laura Cappelli, Fatimah Chamseddine, Michael George, Sindhu R. Johnson, Lara Kahale, Basil S. Karam, Assem M. Khamis, Iris Navarro-Millan, Reza Mirza, Pascale Schwab, Namrata Singh, Marat Turgunbaev, Amy S. Turner, Sally Yaacoub, Elie A. Akl
Summary: This guideline provides updated recommendations for the pharmacologic management of rheumatoid arthritis, including the use of disease-modifying antirheumatic drugs (DMARDs), glucocorticoids, and considerations for high-risk populations. The recommendations are not prescriptive and should be made through a shared decision-making process based on individual values, goals, preferences, and comorbidities.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Pediatrics
Emilio J. Inarejos Clemente, Mirkamal Tolend, Maria Navallas, Andrea S. Doria, Arthur B. Meyers
Summary: Contrast-enhanced magnetic resonance imaging (MRI) is the preferred technique for diagnosing and monitoring TMJ disorders in pediatric patients with JIA. TMJ involvement in JIA can lead to significant facial growth impairment if left untreated. Early signs of TMJ involvement are difficult to detect clinically, making MRI a crucial tool for diagnosis and treatment monitoring. This pictorial essay describes a consensus MRI protocol for studying the TMJ in JIA and explores currently available MRI scoring systems.
PEDIATRIC RADIOLOGY
(2023)
Article
Rheumatology
Sascha L. Heckert, Petra C. E. Hissink-Muller, J. Merlijn van den Berg, Dieneke Schonenberg-Meinema, Lisette W. A. van Suijlekom-Smit, Marion A. J. van Rossum, Yvonne Koopman, Rebecca ten Cate, Danielle M. C. Brinkman, Tom W. J. Huizinga, Cornelia F. Allaart, Sytske Anne Bergstra
Summary: We studied the patterns of joint inflammation in JIA and found that joints with inflammation at disease onset tend to have recurrent episodes of inflammation during follow-up. This suggests that local factors may contribute to the occurrence of JIA flares.
Article
Dentistry, Oral Surgery & Medicine
Ingrid Tonni, Andrea Borghesi, Silvia Tonesi, Giulia Fossati, Francesca Ricci, Luca Visconti
Summary: Ultrasound can serve as an alternative tool to detect acute signs of TMJ involvement in JIA patients, showing differences in TMJ features between JIA patients and healthy subjects. LPAS values were significantly higher in the JIA group compared to the control group, with a positive correlation between ultrasound and MR images.
DENTOMAXILLOFACIAL RADIOLOGY
(2021)
Article
Rheumatology
Anandhi Rajendiran, Patricia Klemm, Anastasia Schippers, Anja Scheufen, Tobias Schwarz, Joachim Peitz, Lars-Ove Brandenburg, Norbert Wagner, Alessandro Consolaro, Federica Raggi, Maria Carla Bosco, Tom Luedde, Dirk Foell, Bernd Denecke, Gerd Horneff, Kim Ohl, Klaus Tenbrock
Summary: This study aimed to determine the roles of specific miRNAs in the pathogenesis of JIA. The results showed a different composition of miRNA expression at the site of inflammation compared with peripheral blood. Bioinformatic analysis suggested an overrepresentation of genes involved in metabolic and oxidative stress pathways in the inflamed joint. Despite enhanced ROS levels in the inflammatory environment, JIA T cells exhibited hyperproliferation and overexpression of miR-23a.
Review
Dentistry, Oral Surgery & Medicine
K. Patel, B. Gerber, K. Bailey, N. R. Saeed
Summary: Juvenile idiopathic arthritis (JIA) of the temporomandibular joint (TMJ) is common in children, and early diagnosis is essential. Comprehensive treatment includes pharmacological management, surgical interventions, orthodontics, and psychological support. Total alloplastic TMJ replacement plays an important role in treating end stage deformity.
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2022)
Article
Pediatrics
Andrea Abate, Davide Cavagnetto, Francesca Maria Emilia Rusconi, Paolo Cressoni, Luca Esposito
Summary: This study showed that rapid maxillary expansion (RME) in growing patients with JIA who had not shown TMJ symptoms for at least a year was safe and effective, with improvements in nasal cavity width, maxillary width, and intermolar width. Both JIA patients and healthy controls benefitted similarly from RME treatment, indicating potential benefits for orthodontic care in these patients.
Article
Dentistry, Oral Surgery & Medicine
Malin Collin, Stefan Hagelberg, Malin Ernberg, Britt Hedenberg-Magnusson, Nikolaos Christidis
Summary: This study aimed to investigate the diagnosis of temporomandibular joint (TMJ) involvement in children with juvenile idiopathic arthritis (JIA) through patient history and clinical examination. The results suggest that self-reported TMJ symptoms and smaller MUO with pain may indicate TMJ involvement, although radiographic examinations are necessary for confirmation. The study indicates that the RDC/TMD protocol may be a blunt tool for targeting TMJ involvement in JIA.
JOURNAL OF ORAL REHABILITATION
(2022)
Article
Medicine, General & Internal
Jubran T. Alqanatish, Banan S. Alrewaithi, Wafaa M. Alsewairi, Altaf H. Khan, Mohammed J. Alsalman, Abdulrhman A. Alrasheed
Summary: This study described the clinical and laboratory characteristics of patients with juvenile idiopathic arthritis (JIA) and found that 16% of the patients had temporomandibular joint (TMJ) involvement, with 45% of them having polyarticular disease. The research also showed that a positive antinuclear antibody (ANA) could be a risk factor for TMJ involvement, while a positive HLAB27 might have some protective effects on patients. Early treatment for TMJ arthritis is essential to avoid possible complications.
SAUDI MEDICAL JOURNAL
(2021)
Article
Rheumatology
Kiem Oen, Karine Toupin-April, Brian M. Feldman, Roberta A. Berard, Cia'ran M. Duffy, Lori B. Tucker, Jiahao Tian, Dax G. Rumsey, Jaime Guzman
Summary: This study validates the JIA parent global assessment as a valid measure of health-related quality of life. Comparisons with other HRQoL measures show good construct validity. However, reliability estimates and measurement errors were unsatisfactory, likely due to the time interval between assessments. Causal pathway analysis confirms previous findings.
Editorial Material
Rheumatology
Melissa L. Mannion, Randy Q. Cron
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Sarah Ringold, Anne C. Dennos, Yukiko Kimura, Timothy Beukelman, Peter Shrader, Thomas A. Phillips, Melanie Kohlheim, Laura E. Schanberg, Rae S. M. Yeung, Daniel B. Horton
Summary: The outcomes of disease recapture in children with well-controlled JIA after medication discontinuation were characterized in this study. The study found that approximately half of the patients experienced a flare within 6 months. The use of biologic drugs and a history of flares were associated with increased odds of successful recapture, while limited range of motion in the joints was associated with decreased odds.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Jonathan Park, Michelle Batthish, Roberta A. Berard, Gaelle Chedeville, Jean-Philippe Proulx-Gauthier, Dax G. Rumsey, Lori B. Tucker, Stephanie Wong, Jaime Guzman
Summary: Canadian pediatric rheumatology practices were generally in line with the 2019 JIA guideline recommendations, except for the frequent use of oral MTX and infrequent direct escalation from NSAIDs to bDMARDs in sacroiliitis and enthesitis.
Article
Behavioral Sciences
Myriam Casseus, Wun Jung Kim, Daniel B. B. Horton
Summary: This study examines the co-occurrence of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) in children and their associated mental, behavioral, and developmental disorders (MBDDs). The results show that children with ASD + ADHD have a higher prevalence of various MBDDs compared to children with ASD without ADHD or children with ADHD without ASD. Additionally, children with ASD + ADHD are more likely to receive psychotropic medication. A multidisciplinary approach is needed to address the complex needs of these children.
Editorial Material
Rheumatology
Sheila T. Angeles-Han, Sunil K. Srivastava
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Vijay R. R. Varma, Rishi J. J. Desai, Sheeja Navakkode, Lik-Wei Wong, Carlos Anerillas, Tina Loeffler, Irene Schilcher, Mufaddal Mahesri, Kristyn Chin, Daniel B. B. Horton, Seoyoung C. C. Kim, Tobias Gerhard, Jodi B. B. Segal, Sebastian Schneeweiss, Myriam Gorospe, Sreedharan Sajikumar, Madhav Thambisetty
Summary: This study suggests that hydroxychloroquine (HCQ) initiation may reduce the risk of incident AD and improve synaptic plasticity. It also demonstrates that HCQ can enhance microglial clearance of amyloid plaques, reduce neuroinflammation, and decrease tau phosphorylation. These findings support the idea that HCQ could be a promising candidate for disease-modifying AD treatment.
MOLECULAR PSYCHIATRY
(2023)
Article
Rheumatology
Alejandra Londono Jimenez, Ana Valle, Mohammad Hashim Mustehsan, Shudan Wang, Jammie Law, Maria Salgado Guerrero, Wenzhu B. Mowrey, Daniel B. Horton, David Briceno, Anna Broder
Summary: This study aimed to determine the association between hydroxychloroquine (HCQ) dose and adverse cardiac outcomes in patients with systemic lupus erythematosus (SLE). The results showed that higher doses of HCQ were not associated with an increased risk of heart failure with reduced ejection fraction (HFrEF), life-threatening arrhythmia, or cardiac death among SLE patients. In fact, higher baseline HCQ doses may decrease the risk of these adverse cardiac outcomes among nonsmokers.
ARTHRITIS CARE & RESEARCH
(2023)
Review
Immunology
Ilaria Maccora, Edoardo Marrani, Ilaria Pagnini, Maria Vincenza Mastrolia, Cinzia de Libero, Roberto Caputo, Gabriele Simonini
Summary: Childhood uveitis is a serious condition that can lead to blindness if not properly recognized and treated. This review discusses the main causes, diagnostic approach, risk factors, and difficulties in eye examination for childhood uveitis. The treatment options for childhood uveitis are also discussed in terms of choice, timing, and withdrawal.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Editorial Material
Immunology
Ilaria Maccora, Preston Land, Virginia Miraldi Utz, Sheila T. Angeles-Han
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Review
Immunology
Pui Y. Lee, Randy Q. Cron
Summary: Cytokine storm syndromes (CSSs) are potentially fatal hyperinflammatory states characterized by persistent immune cell activation and excessive cytokine production. CSSs can be caused by genetic errors of immunity, infections, chronic inflammatory diseases, or malignancies. This review explores the biology of different types of CSSs, the involvement of immune pathways, the contribution of host genetics, and discusses treatment approaches.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Pediatrics
Tara McGrath, Jaime Guzman, Lori Tucker, Natalie J. Shiff, Maryna Yaskina, Susan Tupper, Dax G. Rumsey
Summary: Among newly diagnosed children with moderate pain in Juvenile Idiopathic Arthritis (JIA), female sex, lower overall quality of life, and higher enthesitis counts at baseline are predictors of the development of persisting pain.
PEDIATRIC RHEUMATOLOGY
(2023)
Editorial Material
Rheumatology
Daniel D. Reiff, Randy Q. Cron
Article
Medicine, General & Internal
Abigail J. S. Armstrong, Daniel B. Horton, Tracy Andrews, Patricia Greenberg, Jason Roy, Maria Laura Gennaro, Jeffrey L. Carson, Reynold A. Panettieri, Emily S. Barrett, Martin J. Blaser
Summary: This study aimed to assess the variation in the upper respiratory tract microbiome using saliva specimens in a cohort of individuals with primarily mild to moderate disease. The results showed that the salivary microbiome remained stable in unexposed individuals over the study period, and participants with mild to moderate SARS-CoV-2 infection showed microbiome stability throughout and after their infection. However, severe SARS-CoV-2 infection was associated with temporary reductions in microbiome diversity, indicating the limits of microbiome resilience in the face of severe infection.
Letter
Respiratory System
Daniel B. Horton, Amanda L. Neikirk, Yiling Yang, Cecilia Huang, Reynold A. Panettieri Jr, Stephen Crystal, Brian L. Strom, Lauren E. Parlett
Summary: Prior studies have shown a decrease in pediatric asthma exacerbations and asthma-related healthcare utilization during the COVID-19 pandemic, but there is limited information on the incidence of asthma during this period. This retrospective cohort study examined children under 18 without prior asthma diagnosis in a large US commercial claims database. New diagnoses of childhood asthma in the US declined by 52% during the first year of the pandemic compared to the previous 3 years. These findings raise questions about whether pandemic-related changes in triggers affected the incidence of childhood asthma independent of disruptions in healthcare access.
RESPIRATORY RESEARCH
(2023)