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Suvorexant in Patients With Insomnia: Results From Two 3-Month Randomized Controlled Clinical Trials

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Assessment of the Abuse Potential of the Orexin Receptor Antagonist, Suvorexant, Compared With Zolpidem in a Randomized Crossover Study

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Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements

(2015) Anthony J. Roecker et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Statistical refocusing in the design of Phase II trials offers promise of increased R&D productivity

(2014) Stacy R. Lindborg et al.   NATURE REVIEWS DRUG DISCOVERY

Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism

(2014) Christine Dugovic et al.   Frontiers in Neuroscience

Orexin (Hypocretin) Receptor Agonists and Antagonists for Treatment of Sleep Disorders

(2013) Michihiro Mieda et al.   CNS DRUGS

Orexin Receptor Antagonists Differ from Standard Sleep Drugs by Promoting Sleep at Doses That Do Not Disrupt Cognition

(2013) J. M. Uslaner et al.   Science Translational Medicine

Orexin receptor antagonism for treatment of insomnia: A randomized clinical trial of suvorexant

(2012) W. J. Herring et al.   NEUROLOGY

Orexin Receptors: Pharmacology and Therapeutic Opportunities

(2011) Thomas E. Scammell et al.   Annual Review of Pharmacology and Toxicology

Computer-Assisted Sleep Classification according to the Standard of the American Academy of Sleep Medicine: Validation Study of the AASM Version of the Somnolyzer 24 × 7

(2010) Peter Anderer et al.   NEUROPSYCHOBIOLOGY

Blockade of Orexin-1 Receptors Attenuates Orexin-2 Receptor Antagonism-Induced Sleep Promotion in the Rat

(2009) C. Dugovic et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Orexin Receptor Antagonism: A New Principle in Neuroscience

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Orexin neuronal circuitry: Role in the regulation of sleep and wakefulness

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