Orexin Receptor Antagonists Differ from Standard Sleep Drugs by Promoting Sleep at Doses That Do Not Disrupt Cognition

Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties

(2012) Paul J. Coleman et al.   ChemMedChem

Differential Effects of a Dual Orexin Receptor Antagonist (SB-649868) and Zolpidem on Sleep Initiation and Consolidation, SWS, REM Sleep and EEG Power Spectra in a Model of Situational Insomnia

(2012) Paolo Bettica et al.   NEUROPSYCHOPHARMACOLOGY

Orexin Receptors: Pharmacology and Therapeutic Opportunities

(2011) Thomas E. Scammell et al.   Annual Review of Pharmacology and Toxicology

Promotion of Sleep by Suvorexant—A Novel Dual Orexin Receptor Antagonist

(2011) Christopher J. Winrow et al.   JOURNAL OF NEUROGENETICS

Phase I studies on the safety, tolerability, pharmacokinetics and pharmacodynamics of SB-649868, a novel dual orexin receptor antagonist

(2011) Paolo Bettica et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Sleep Neurobiology from a Clinical Perspective

(2011)   SLEEP

Orexin Receptor Antagonism, a New Sleep-Promoting Paradigm: An Ascending Single-Dose Study With Almorexant

(2010) P Hoever et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant

(2010) Hendrik Dietrich et al.   PSYCHOPHARMACOLOGY

Discovery of a Potent, CNS-Penetrant Orexin Receptor Antagonist Based on anN,N-Disubstituted-1,4-diazepane Scaffold that Promotes Sleep in Rats

(2009) David B. Whitman et al.   ChemMedChem

Highway driving performance and cognitive functioning the morning after bedtime and middle-of-the-night use of gaboxadol, zopiclone and zolpidem

(2009) TIM R. M. LEUFKENS et al.   JOURNAL OF SLEEP RESEARCH

Systemic and intrabasalis administration of the orexin-1 receptor antagonist, SB-334867, disrupts attentional performance in rats

(2009) Karen E. Boschen et al.   PSYCHOPHARMACOLOGY

The α1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala

(2009) Brian Wiltgen   Frontiers in Behavioral Neuroscience

Effects of prolonged-release melatonin, zolpidem, and their combination on psychomotor functions, memory recall, and driving skills in healthy middle aged and elderly volunteers

(2008) S. Otmani et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

International Union of Pharmacology. LXX. Subtypes of  -Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update

(2008) R. W. Olsen et al.   PHARMACOLOGICAL REVIEWS

The effect of antagonization of orexin 1 receptors in CA1 and dentate gyrus regions on memory processing in passive avoidance task

(2007) Esmaeil Akbari et al.   BEHAVIOURAL BRAIN RESEARCH