Mechanisms linking T-wave alternans to spontaneous initiation of ventricular arrhythmias in rabbit models of long QT syndrome

Memory-Induced Chaos in Cardiac Excitation

(2017) Julian Landaw et al.   PHYSICAL REVIEW LETTERS

Spontaneous initiation of premature ventricular complexes and arrhythmias in type 2 long QT syndrome

(2016) Xiaodong Huang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Perpetuation of torsade de pointes in heterogeneous hearts: competing foci or re-entry?

(2016) Nele Vandersickel et al.   JOURNAL OF PHYSIOLOGY-LONDON

Stochastic pacing reveals the propensity to cardiac action potential alternans and uncovers its underlying dynamics

(2016) Yann Prudat et al.   JOURNAL OF PHYSIOLOGY-LONDON

Early afterdepolarizations promote transmural reentry in ischemic human ventricles with reduced repolarization reserve

(2016) Sara Dutta et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

The link between abnormal calcium handling and electrical instability in acquired long QT syndrome – Does calcium precipitate arrhythmic storms?

(2016) Jan Němec et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Mechanisms of Ventricular Arrhythmias: From Molecular Fluctuations to Electrical Turbulence

(2015) Zhilin Qu et al.   Annual Review of Physiology

In Vivo and In Silico Investigation Into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular CardiomyocytesNovelty and Significance

(2015) Xin Zhou et al.   CIRCULATION RESEARCH

Complex excitation dynamics underlie polymorphic ventricular tachycardia in a transgenic rabbit model of long QT syndrome type 1

(2015) Tae Yun Kim et al.   HEART RHYTHM

Spatially Discordant Alternans and Arrhythmias in Tachypacing-Induced Cardiac Myopathy in Transgenic LQT1 Rabbits: The Importance of IKs and Ca2+ Cycling

(2015) Emily Lau et al.   PLoS One

Hyperphosphorylation of RyRs Underlies Triggered Activity in Transgenic Rabbit Model of LQT2 Syndrome

(2014) Dmitry Terentyev et al.   CIRCULATION RESEARCH

Two Types of T Wave Alternans in Long-QT Syndrome

(2014) Juan Shu et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2

(2014) Arash Sadrieh et al.   Nature Communications

β-adrenergic stimulation activates early afterdepolarizations transiently via kinetic mismatch of PKA targets

(2013) Yuanfang Xie et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Determinants of Beat-to-Beat Variability of Repolarization Duration in the Canine Ventricular Myocyte: A Computational Analysis

(2013) Jordi Heijman et al.   PLoS Computational Biology

Revisiting the ionic mechanisms of early afterdepolarizations in cardiomyocytes: predominant by Ca waves or Ca currents?

(2012) Zhenghang Zhao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Estradiol promotes sudden cardiac death in transgenic long QT type 2 rabbits while progesterone is protective

(2012) Katja E. Odening et al.   HEART RHYTHM

Mechanisms and Determinants of Ultralong Action Potential Duration and Slow Rate-Dependence in Cardiac Myocytes

(2012) Zhilin Qu et al.   PLoS One

Differential conditions for early after-depolarizations and triggered activity in cardiomyocytes derived from transgenic LQT1 and LQT2 rabbits

(2011) Gong-Xin Liu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Irregularly Appearing Early Afterdepolarizations in Cardiac Myocytes: Random Fluctuations or Dynamical Chaos?

(2010) Daisuke Sato et al.   BIOPHYSICAL JOURNAL

Prevention of Torsade de Pointes in Hospital Settings

(2010) Barbara J. Drew et al.   CIRCULATION

Calcium oscillations and T-wave lability precede ventricular arrhythmias in acquired long QT type 2

(2010) Jan Němec et al.   HEART RHYTHM

T-wave alternans and arrhythmogenesis in cardiac diseases

(2010) Zhilin Qu   Frontiers in Physiology

Macrovolt T-Wave Alternans and Polymorphic Ventricular Tachycardia

(2009) Christopher L. Holley et al.   CIRCULATION

Targeted SERCA2a Gene Expression Identifies Molecular Mechanism and Therapeutic Target for Arrhythmogenic Cardiac Alternans

(2009) Michael J. Cutler et al.   Circulation-Arrhythmia and Electrophysiology

Origin of complex behaviour of spatially discordant alternans in a transgenic rabbit model of type 2 long QT syndrome

(2009) Ohad Ziv et al.   JOURNAL OF PHYSIOLOGY-LONDON

Synchronization of chaotic early afterdepolarizations in the genesis of cardiac arrhythmias

(2009) D. Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternans of cardiac calcium cycling in a cluster of ryanodine receptors: a simulation study

(2008) T. Tao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Calcium-activated chloride current contributes to action potential alternations in left ventricular hypertrophy rabbit

(2008) Donglin Guo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Role of Conduction Velocity Restitution and Short-Term Memory in the Development of Action Potential Duration Alternans in Isolated Rabbit Hearts

(2008) Sergey Mironov et al.   CIRCULATION

Heart failure enhances susceptibility to arrhythmogenic cardiac alternans

(2008) Lance D. Wilson et al.   HEART RHYTHM

A Rabbit Ventricular Action Potential Model Replicating Cardiac Dynamics at Rapid Heart Rates

(2007) Aman Mahajan et al.   BIOPHYSICAL JOURNAL