Article
Biochemistry & Molecular Biology
Xin Hou, Mengjun Huang, Xixi Zeng, Yanhong Zhang, Anbang Sun, Qifang Wu, Lin Zhu, Hu Zhao, Yanhong Liao
Summary: This study found that TRPC6 knockout can significantly improve renal damage induced by I/R, enhance autophagy levels, alleviate MMP depolarization and apoptotic changes caused by I/R, and down-regulate PI3K/AKT and ERK signaling, providing a new avenue for future AKI therapies.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Charith U. B. Wijerathne, Kathy K. W. Au-Yeung, Yaw L. Siow, O. Karmin
Summary: Oxidative stress is a major factor in adverse outcomes of acute kidney injury, and deficiency in micronutrients is common in this condition. This study found that 5-MTHF can improve kidney function by activating Nrf2 and restoring antioxidant defense, thereby reducing oxidative stress.
Article
Biochemistry & Molecular Biology
Giovanna Casili, Alessio Ardizzone, Rossella Basilotta, Marika Lanza, Alessia Filippone, Irene Paterniti, Emanuela Esposito, Michela Campolo
Summary: Ischemia/reperfusion injury (IRI) is a complex pathophysiological process characterized by blood circulation disorder. Effective therapies for renal IRI are still lacking, but a selective inhibitor of prolyl oligopeptidase (POP), KYP2047, has shown promising results in reducing renal injury and inflammation, as well as modulating angiogenesis, offering a novel therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Masahito Sawahata, Yasuhiko Izumi, Akinori Akaike, Toshiaki Kume
Summary: In this study, a novel ischemia-reperfusion model was developed using zebrafish induced by hypoxic treatment. The H/R treatment led to increased brain cell death, reduced fluorescence intensity of kaede in neuronal cells, and significantly increased glial fibrillary acidic protein immunoreactivity in zebrafish larvae, indicating a potential new model for ischemia-reperfusion.
BRAIN RESEARCH BULLETIN
(2021)
Article
Biotechnology & Applied Microbiology
Mao Yang, Ningning Xi, Meng Gao, Yanwei Yu
Summary: Sitagliptin has a protective effect against I/R injury in cardiomyocytes, potentially by regulating SIRT3 and autophagy.
Article
Medical Laboratory Technology
Shunv Cai, Yixing Liu, Yun Cheng, Junbo Yuan, Jun Fang
Summary: The study demonstrated that Dex has protective effects on H9c2 cardiomyocytes exposed to H/R treatment, leading to increased cell viability, inhibited inflammatory response, suppressed apoptosis, and alleviated ER stress and oxidative stress. Dex inhibited the intrinsic pathway of apoptosis and enhanced the activation of the JAK2/STAT3 signaling pathway in H/R-treated H9c2 cells. Overall, Dex shows promise as a therapeutic agent for myocardial I/R.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Kannaporn Intachai, Siriporn C. Chattipakorn, Nipon Chattipakorn, Krekwit Shinlapawittayatorn
Summary: Acetylcholine exerts cardioprotection against H/R-induced apoptosis, autophagy, and mitochondrial impairment through the activation of both muscarinic and nicotinic receptors.
Article
Biochemistry & Molecular Biology
Marlize Ferreira-Cravo, Daniel C. Moreira, Marcelo Hermes-Lima
Summary: The upregulation of endogenous antioxidants is a common response in animals that tolerate hypoxia/anoxia for extended periods. This study investigated the role of glutathione (GSH) in controlling redox homeostasis under the stress of anoxia and reoxygenation in Helix aspersa. The depletion of total GSH (tGSH) using BSO revealed that GSH is required to withstand the oxidative challenge induced by hypoxia and reoxygenation in land snails.
Review
Biochemistry & Molecular Biology
Maurits Roorda, Jan Lj Miljkovic, Harry van Goor, Robert H. Henning, Hjalmar R. Bouma
Summary: Hydrogen sulfide (H2S), previously known as a putrid, toxic gas, is now recognized as the third gasotransmitter alongside nitric oxide (NO) and carbon monoxide (CO) in mammalian systems. H2S plays a critical role in regulating vascular and cellular function in the kidneys, impacting blood flow, glomerular filtration rate, and the renin-angiotensin axis. Furthermore, H2S offers protection against acute kidney injury (AKI) by enhancing ATP production and preventing damage due to free radicals during hypoxia or ischemia-reperfusion injury. Understanding the (sub)cellular signaling mechanisms of H2S can lead to novel therapeutic targets for preventing kidney injury.
Article
Immunology
Yun Wang, Zhe Chen, Jing Luo, Jing Zhang, A-ming Sang, Zhen-shun Cheng, Xin-yi Li
Summary: This study demonstrates that salidroside postconditioning attenuates ferroptosis-mediated lung ischemia-reperfusion injury by activating the Nrf2/SLC7A11 signaling axis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Fuyuan Li, Qianqian Mao, Jinyu Wang, Xiaoying Zhang, Xinyan Lv, Bo Wu, Tingxu Yan, Ying Jia
Summary: This study investigates the protective mechanism of Salidroside (SAL) on cerebral ischemia reperfusion injury (CIRI) through regulating the Nrf2/Trx1 axis. Results showed that SAL effectively alleviates infarction rate, improves histopathological changes, and reduces apoptosis and oxidative stress in CIRI rats and PC12 cells. It also inhibits ASK1/MAPK and activates Nrf2/Trx1 signaling pathway.
METABOLIC BRAIN DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Kun-Ling Tsai, Pei-Ling Hsieh, Wan-Ching Chou, Hui-Ching Cheng, Yu-Ting Huang, Shih-Hung Chan
Summary: The study suggests that DAPA may alleviate oxidative stress and cardiac apoptosis induced by ischemia/reperfusion injury through modulation of AMPK, improving cardiac function. Additionally, DAPA may protect cardiac cells by influencing mitochondrial function.
CELL AND BIOSCIENCE
(2021)
Article
Medicine, Research & Experimental
Yungang Shan, Deqing Chen, Bo Hu, Guangtao Xu, Wanlu Li, Ye Jin, Xiuhui Jin, Xin Jin, Limin Jin
Summary: The study demonstrated that allicin exerts a protective effect against renal ischemia/reperfusion injury in rats by regulating apoptosis, oxidative stress, and inflammatory response.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Ken-Ichiro Tanaka, Mikako Shimoda, Maho Kubota, Ayaka Takafuji, Masahiro Kawahara, Tohru Mizushima
Summary: Lecithinized superoxide dismutase (PCSOD) effectively ameliorates renal ischemia/reperfusion (I/R) injury by inhibiting ROS production, reducing markers of renal damage and fibrosis, and preventing the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). This suggests that PCSOD could be a promising therapeutic agent for I/R-induced renal injury.
Article
Biochemistry & Molecular Biology
Theodoros Eleftheriadis, Georgios Pissas, Spyridon Golfinopoulos, Maria Efthymiadi, Vassilios Liakopoulos, Ioannis Stefanidis
Summary: Inhibition of malate dehydrogenase-2 (MDH-2) protects renal cells from death or senescence caused by ischemia-reperfusion injury. MDH-2 inhibition reduces oxidative stress and inflammation, and maintains cell proliferation capacity.