Article
Oncology
Catherine T. Haring, Lulia A. Kana, Sarah M. Dermody, Collin Brummel, Jonathan B. McHugh, Keith A. Casper, Steven B. Chinn, Kelly M. Malloy, Michelle Mierzwa, Mark E. P. Prince, Andrew J. Rosko, Jennifer Shah, Chaz L. Stucken, Andrew G. Shuman, J. Chad Brenner, Matthew E. Spector, Francis P. Worden, Paul L. Swiecicki
Summary: A retrospective analysis of 447 patients with HNSCC revealed that HPV negativity, high neutrophil/lymphocyte ratio, disease-free interval ≤6 months, and poor performance status were predictors of worse survival. Furthermore, the majority of recurrences and metastases occurred within 6 months to 2 years after treatment completion.
Article
Oncology
Christian Doll, Friedrich Mrosk, Lea Freund, Felix Neumann, Kilian Kreutzer, Jan Voss, Jan-Dirk Raguse, Marcus Beck, Dirk Boehmer, Kerstin Rubarth, Max Heiland, Steffen Koerdt
Summary: The necessity of contralateral elective neck dissection in patients with lateralized oral squamous cell carcinoma and ipsilateral cervical lymph node metastasis is still controversial. This retrospective analysis conducted at a high-volume tumor center in Germany over a 10-year period suggests that occult contralateral neck metastases are rare in this cohort, and routine contralateral elective neck dissection may not be necessary.
Article
Biochemistry & Molecular Biology
Alexander Michael Grandits, Sophie Bromberger, Gerwin Heller, Barbara Andrea Reinoehl, Erwin Tomasich, Klaudia Schossleitner, Anna Sophie Berghoff, Thorsten Fuereder, Rotraud Wieser
Summary: Head and neck squamous cell carcinoma (HNSCC) is a frequent malignancy with a poor prognosis. EVI1, a novel oncogene, promotes cellular proliferation and invasiveness in HNSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Wan Duan, Zhangxia Wu, Xueying Mei, Jingyuan Li, Huanzi Lu, Yujie Liang, Xiaomei Lao, Guiqing Liao
Summary: This study examined the role of platelets in the tumor microenvironment of oral squamous cell carcinoma (OSCC) and found that intratumoral platelet microthrombi (PLT-MT) were associated with clinicopathological characteristics and predictive value. PLT-MT was also correlated with lymph node metastasis and prognosis prediction.
Article
Otorhinolaryngology
Alberto Grammatica, Michele Tomasoni, Milena Fior, Emanuela Ulaj, Tommaso Gualtieri, Paolo Bossi, Simonetta Battocchio, Davide Lombardi, Alberto Deganello, Davide Mattavelli, Piero Nicolai, Fabio Girardi, Cesare Piazza
Summary: The study confirmed that factors like primary tumor diameter and depth of infiltration, as well as the pattern of nodal recurrence, were significant prognostic indicators for overall survival in patients with cSCC of the head and neck. Patients with cervical nodal metastasis were found to have a worse prognosis compared to those with intraparotid metastasis.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Wenqian Xie, Peiliang Lin, Zhijuan Li, Huan Wan, Faya Liang, Jianming Fan, Lanlan Deng, Xiaoming Huang
Summary: This study aimed to evaluate the prognostic value of lymphatic metastatic size in HNSCC, and the results showed that lymphatic metastatic size is an independent prognostic factor in HNSCC, which can assist in postoperative adjuvant treatment decisions.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Oncology
Nicholas R. Lenze, Douglas R. Farquhar, Siddharth Sheth, Jose P. Zevallos, Catherine Lumley, Jeffrey Blumberg, Samip Patel, Trevor Hackman, Mark C. Weissler, Wendell G. Yarbrough, Andrew F. Olshan, Adam M. Zanation
Summary: In this study, it was found that socioeconomic status (SES) may have a prognostic ability similar to overall stage for HPV-negative head and neck squamous cell carcinoma (HNSCC) patients. Low SES was associated with significantly increased risk of mortality and this association persisted even after adjusting for other factors.
Review
Oncology
Michael J. L. Hurrell, Tsu-Hui (Hubert) Low, Ardalan Ebrahimi, Michael Veness, Bruce Ashford, Sandro Porceddu, Jonathan R. Clark
Summary: Australia has the highest incidence of cutaneous squamous cell carcinoma of the head and neck (HNcSCC) in the world, but finding an effective staging system is still ongoing. Despite significant contributions in prognostication and nodal staging by Australian institutions, challenges remain.
Article
Oncology
Elham Mohebbi, Maryam Hadji, Hamideh Rashidian, Abass Rezaianzadeh, Maryam Marzban, Ali Akbar Haghdoost, Ahmad Naghibzadeh Tahami, Abdolvahab Moradi, Mahin Gholipour, Farid Najafi, Roya Safari-Faramani, Reza Alizadeh-Navaei, Alireza Ansari-Moghaddam, Mahdieh Bakhshi, Azim Nejatizadeh, Masumeh Mahmoudi, Soodabeh Shahidsales, Saeideh Ahmadi-Simab, Ali Asghar Arabi Mianroodi, Monireh Sadat Seyyedsalehi, Bayan Hosseini, Vahideh Peyghambari, Mohammad Shirkhoda, Reza Shirkoohi, Elmira Ebrahimi, Soheila Manifar, Mohammad Ali Mohagheghi, Laura Rozek, Paul Brennan, Hossein Poustchi, Arash Etemadi, Eero Pukkala, Joachim Schuz, Reza Malekzadeh, Elisabete Weiderpass, Afarin Rahimi-Movaghar, Paolo Boffetta, Farin Kamanagar, Kazem Zendehdel
Summary: The study revealed an association between opium use and increased risk of multiple anatomical subsites of head and neck cancer, with this risk being influenced by smoking.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Otorhinolaryngology
Craig P. Mooney, Jonathan R. Clark, Kerwin Shannon, Carsten E. Palme, Ardalan Ebrahimi, Kan Gao, Sydney Ch'ng, Michael Elliott, Ruta Gupta, Tsu-Hui (Hubert) Low
Summary: This study found that regional metastasis of head and neck cutaneous squamous cell carcinoma to the neck confers worse outcomes compared to metastasis to the parotid alone.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Shao Wenhua, Takaaki Tsunematsu, Masaaki Umeda, Hiroaki Tawara, Natsumi Fujiwara, Yasuhiro Mouri, Rieko Arakaki, Naozumi Ishimaru, Yasusei Kudo
Summary: Recently, it has been reported that the partial-epithelial-mesenchymal transition (p-EMT) program is associated with metastasis in head and neck squamous cell carcinoma (HNSCC). The study focused on the role of a novel cancer-specific POSTN isoform, Iso5, in HNSCC and found that Iso5 promoted invasion together with another isoform, Iso3. The researchers suggest that Iso5 can be a useful marker for detecting cancer cells undergoing p-EMT and a potential target for diagnosis and therapy in HNSCC.
Article
Oncology
Linda Hofmann, Malgorzata Harasymczuk, Diana Huber, Miroslaw J. Szczepanski, Grzegorz Dworacki, Theresa L. Whiteside, Marie-Nicole Theodoraki
Summary: Arginase-1 plays an important role in the clinicopathology and prognosis of head and neck cancer. High tumor Arginase-1 levels are associated with favorable clinicopathology and prognosis, while high plasma Arginase-1 levels are associated with unfavorable clinicopathology. The presence of Arginase-1 in exosomes explains this discrepancy. High levels of exosomal Arginase-1 are associated with lymph node metastasis and shorter recurrence-free survival.
Article
Oncology
Alvin K. Liu, Jonn Wu, Eric Berthelet, Nafisha Lalani, Nicole Chau, Eric Tran, Sarah Nicole Hamilton
Summary: Brain metastases from head and neck cancer are rare and carry a poor prognosis, with treatment involving intracranial radiotherapy associated with improved survival.
Article
Multidisciplinary Sciences
Qingyun Liao, Jing Yang, Zhaoyi Lu, Qingshan Jiang, Yongqian Gong, Lijun Liu, Hong Peng, Qin Wang, Xin Zhang, Zhifeng Liu
Summary: FTH1 plays a critical role in the progression and metastasis of head and neck squamous cell carcinoma and can serve as a promising prognostic factor and therapeutic target.
Review
Oncology
Leandro Luongo Matos, Yasmin Laryssa Moura Guimaraes, Ana Kober Leite, Claudio Roberto Cernea
Summary: Oral squamous cell carcinoma (OSCC) patients with larger depth of invasion (DOI) and/or width are included in stage III, which is a heterogeneous group. Features such as extranodal extension, positive or close margins, specific tumor and nodal characteristics are associated with adverse prognosis and warrant adjuvant treatment. However, for stage III OSCC without adverse features, there is no strong evidence to recommend or exclude adjuvant treatment. Further studies are needed to determine the appropriate management for these patients.
CURRENT ONCOLOGY REPORTS
(2023)
Article
Genetics & Heredity
Yingying Jiang, Kun Wu, Wei Cao, Qin Xu, Xu Wang, Xing Qin, Xiaoning Wang, Yan Li, Jianjun Zhang, Wantao Chen
Article
Dentistry, Oral Surgery & Medicine
Yu Zhang, Canbang Peng, Zhen Tian, Wei Cao, Xi Yang, Tong Ji
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2020)
Article
Oncology
Zhongjing Lv, Kun Wu, Xing Qin, Jian Yuan, Ming Yan, Jianjun Zhang, Lizhen Wang, Tong Ji, Wei Cao, Wantao Chen
CANCER MANAGEMENT AND RESEARCH
(2020)
Article
Medicine, Research & Experimental
Xueqin Zhu, Xing Qin, Xiaoning Wang, Yingnan Wang, Wei Cao, Jianjun Zhang, Wantao Chen
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2020)
Article
Multidisciplinary Sciences
Chengyao Zhang, Wei Cao, Jiawu Wang, Jiannan Liu, Jialiang Liu, Hao Wu, Siyi Li, Chenping Zhang
Article
Otorhinolaryngology
Wenkai Zhou, Canbang Peng, Zheqi Liu, Wei Cao
Summary: This study analyzed the risk factors for survival in elderly patients with oral squamous cell carcinoma and developed a novel clinical signature for prognosis. Results indicated that high N stage, low hemoglobin level, low BMI, and high NLR were associated with poor survival outcomes. The constructed nomogram showed a good predictive ability.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Oncology
Xuejie Li, Zheqi Liu, Wenkai Zhou, Xiaofang Liu, Wei Cao
Summary: The study revealed that high expression of CCL22 in T/MF SCC may promote the recruitment of Th2 cells and help predict a better survival. Additionally, mutations in NOTCH1 inhibit the differentiation of Th2 cells, facilitating tumor progression.
Editorial Material
Oncology
Wei Cao, Qiang Shen, Ming Yann Lim
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Lei Wang, Wenjing Pang, Kun Zhou, Lei Li, Feng Wang, Wei Cao, Xiangjun Meng
Summary: This study provides further insights into the risk factors for esophageal squamous cell carcinoma (ESCC) in patients with a history of head and neck squamous cell carcinoma (HNSCC). The study found that HNSCC patients, especially drinkers with an alcohol flushing response and those with high Ki67 labeling index (Ki67 LI) in HNSCC tissue, were more likely to develop ESCC.
JOURNAL OF ONCOLOGY
(2022)
Article
Cell Biology
Yu Zhang, Chengzhong Lin, Zheqi Liu, Yiting Sun, Mingtao Chen, Yibo Guo, Wei Liu, Chenping Zhang, Wantao Chen, Jian Sun, Ronghui Xia, Yuhua Hu, Xi Yang, Jiang Li, Zhiyuan Zhang, Wei Cao, Shuyang Sun, Xu Wang, Tong Ji
Summary: This study reveals that cancer cells can utilize nociceptive nerves to survive in nutrient-poor environments. Cancer cells secrete NGF through ROS-triggered activation of c-Jun, which stimulates nerves to produce CGRP. The neurogenic CGRP induces cytoprotective autophagy in cancer cells through Rap1-mediated disruption of the mTOR-Raptor interaction. Blocking CGRP can inhibit the vicious cycle between cancer cells and nerves and therapeutically benefit nutrient-starvation therapies.
Article
Biochemistry & Molecular Biology
Zhenlin Dai, Zheqi Liu, Rong Yang, Wei Cao, Tong Ji
Summary: Osteosarcoma (OS), the most common malignant bone tumor, lacks updated treatment strategies. This study identified EVI2B as a significantly upregulated gene in OS tumor samples and demonstrated its association with chemokine signaling, cytokine-cytokine receptor interaction, and Human T-cell leukemia virus 1 infection. The prognostic prediction model including EVI2B, DOCK2, and CD33 indicated EVI2B as an independent protective prognostic marker in OS. The study also revealed the close relationship between EVI2B expression, monocyte and macrophage infiltration in OS, providing clear evidence for its prognostic value.
Article
Chemistry, Multidisciplinary
Wenkai Zhou, Yisheng Feng, Chengzhong Lin, Chi Kuan Chao, Ziqi He, Shiyao Zhao, Jieyuan Xue, Xu-Yun Zhao, Wei Cao
Summary: A highly expressed lncRNA DUXAP9, found in oral squamous cell carcinoma (OSCC), is positively associated with poor prognosis. DUXAP9 promotes OSCC cell proliferation, migration, invasion, and tumor growth through the upregulation of N-cadherin, Vimentin, Ki67, PCNA, and EZH2 and downregulation of E-cadherin. Yin Yang 1 (YY1) activates the transcription of DUXAP9 in OSCC. Moreover, DUXAP9 interacts with EZH2 and inhibits its degradation, thereby blocking its translocation from the nucleus to the cytoplasm. DUXAP9 may serve as a promising therapeutic target for OSCC.
Article
Cell Biology
Zheqi Liu, Wenkai Zhou, Chengzhong Lin, Xiaoning Wang, Xu Zhang, Yu Zhang, Rong Yang, Wantao Chen, Wei Cao
Summary: FOXD2-AS1 is closely associated with clinical characteristics in oral squamous cell carcinoma, and its high expression predicts poor prognosis in patients. It functions by promoting cell proliferation and migration, suppressing adaptive immunity, and participating in the development of oral squamous cell carcinoma.
Article
Medicine, Research & Experimental
Xiaohao Liu, Dongsheng Mao, Guoli Deng, Yuchen Song, Fan Zhang, Shiqi Yang, Genxi Li, Feng Liu, Wei Cao, Xiaoli Zhu
Article
Oncology
Lei Wang, Wenjing Pang, Kun Zhou, Lei Li, Feng Wang, Wei Cao, Xiangjun Meng
Summary: This study investigated the clinicopathological features of esophageal cancer in patients with a history of head and neck squamous cell carcinoma (HNSCC). Most cases were male patients aged 50-69 years, with higher proportion of early esophageal cancer and successful surgical treatment in the synchronous carcinoma group compared to the metachronous carcinoma group. Detection of esophageal cancer should be prioritized in HNSCC patients.
TRANSLATIONAL CANCER RESEARCH
(2021)
