Article
Biochemistry & Molecular Biology
Mia J. Coleman, Luis M. Espino, Hernan Lebensohn, Marija Zimkute, Negar Yaghooti, Christina L. Ling, Jessica M. Gross, Natalia Listwan, Sandra Cano, Vanessa Garcia, Debbie M. Lovato, Susan L. Tigert, Drew R. Jones, Rama R. Gullapalli, Neal E. Rakov, Euriko G. Torrazza Perez, Eliseo F. Castillo
Summary: This study evaluated intestinal health in human subjects with metabolic syndrome (MetS) and found significant alterations in fecal lipid profiles in MetS patients, potentially occurring before the onset of gut inflammation or increased intestinal permeability. Additionally, fecal metabolomics was identified as a non-invasive, accurate screening method for both MetS and non-alcoholic fatty liver disease (NAFLD).
Article
Genetics & Heredity
Jeany Delafiori, Rinaldo Focaccia Siciliano, Arthur Noin de Oliveira, Jose Carlos Nicolau, Geovana Manzan Sales, Talia Falcao Dalcoquio, Estela Natacha Brandt Busanello, Adriana Eguti, Diogo Noin de Oliveira, Adriadne Justi Bertolin, Luiz Augusto dos Santos, Rocio Salsoso, Fabiana G. Marcondes-Braga, Nelson Duran, Mauricio Wesley Perroud Jr, Ester Cerdeira Sabino, Leonardo Oliveira Reis, Wagner Jose Favaro, Rodrigo Ramos Catharino
Summary: In this study, skin imprints and plasma samples were analyzed to study the metabolomics of COVID-19. The results showed that plasma samples outperformed skin imprints in diagnosing COVID-19, while skin imprints were excellent for assessing disease severity. Specific lipid molecules were identified as discriminative biomarkers for identifying hospitalized patients through skin imprinting. This research confirms the potential utility of skin imprinting as a non-invasive sampling method for COVID-19 screening.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Food Science & Technology
Pedro Castillo, Mariona Palou, David Otero, Paula Nunez, Andreu Palou, Catalina Pico
Summary: This study demonstrates that supplementation with myo-inositol during lactation can improve metabolic health in male rats and reverse metabolic alterations caused by gestational calorie restriction. Myo-inositol supplementation lowered triglyceride and insulin levels, and improved insulin resistance in male rats. Further investigation is needed to determine the effects in females.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Chemistry, Applied
Xinhua Hou, Run Zhang, Man Yang, Naiqi Niu, Junchao Wu, Ze Shu, Pengfei Zhang, Lijun Shi, Fuping Zhao, Ligang Wang, Lixian Wang, Longchao Zhang
Summary: Chinese indigenous pig breeds have higher intramuscular fat content and better meat quality. This study investigated the differential metabolites and lipids in the skeletal muscle of Laiwu and Yorkshire pigs, revealing their association with intramuscular fat content and meat flavor. The results showed that the Laiwu pig had a faster lipid droplet formation and contained more triglyceride, reflecting its higher intramuscular fat content.
Article
Genetics & Heredity
Arturo Vega-Beyhart, Marta Iruarrizaga, Adriana Pane, Guillermo Garcia-Eguren, Oriol Giro, Laura Boswell, Gloria Aranda, Vanesa Flores, Gregori Casals, Cristina Alonso, Mireia Mora, Irene Halperin, Francesc Carmona, Joaquim Ensenat, Oscar Vidal, Ting Hu, Gemma Rojo, Ramon Gomis, Felicia A. Hanzu
Summary: Chronic cortisol excess leads to metabolic alterations that go beyond conventional biomarkers, particularly in patients with Cushing syndrome (CS). The extent of hypercortisolism determines lipid and amino acid concentrations, resulting in a unique metabolic signature of 20 metabolites. Cortisol excess profoundly affects the Kennedy and Lands cycle pathways.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Food Science & Technology
Rosario Pardo, Marc Velilla, Laura Herrero, Luis Cervela, Marcelo L. Ribeiro, Rafael Simo, Josep A. Villena
Summary: Calorie restriction (CR) and SIRT1 have distinct yet converging effects on white adipose tissue (WAT) gene expression, with CR enhancing mitochondrial biogenesis and reducing WAT inflammation, while SIRT1 downregulates extracellular matrix-related gene networks. These findings suggest that while SIRT1 may not mediate most of CR's effects on WAT gene expression, the two pathways work together to ameliorate WAT inflammation.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Plant Sciences
Yun Wang, Jiawei Wu, Jiaying Zhu, Chujie Ding, Wanfeng Xu, Haiping Hao, Jun Zhang, Guangji Wang, Lijuan Cao
Summary: The traditional Chinese medicine preparation Shengmai Yin and its components, especially red ginseng saponin extracts, showed significant effects in reducing serum cholesterol levels and aortic root plaque areas in mouse models of hypercholesteremia and atherosclerosis. The ginsenosides from Shengmai Yin were found to exert therapeutic effects by maintaining lipid homeostasis, particularly cholesterol and lysophosphatidylcholines.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Nutrition & Dietetics
Jingyi Zhang, Sujuan Li, Xiaoping Luo, Cai Zhang
Summary: Maternal obesity has a significant impact on the metabolism of offspring, both in childhood and adulthood, through intrauterine metabolic programming. The hypothalamus plays a crucial role in regulating energy metabolism in offspring exposed to maternal obesity. This article reviews the development of the hypothalamus, its role in energy homeostasis, potential mechanisms underlying the developmental programming of energy metabolism, and possible therapeutic approaches for preventing metabolic diseases in later life. Challenges and future directions of hypothalamic regulation in children born to obese mothers are also discussed.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Pedro Castillo, Catalina Amadora Pomar, Andreu Palou, Mariona Palou, Catalina Pico
Summary: The study aimed to analyze the long-term metabolic effects of leptin supplementation during suckling in the offspring of diet-induced obese rats and the potential benefits of improving maternal diet during lactation. The results showed that leptin treatment significantly improved metabolic profile and body fat accumulation under standard diet conditions, with stronger effects in male offspring. However, under high-fat diet conditions, the offspring of dams fed as high-fat diet showed metabolic alterations that were not observed in the offspring of dams switched to standard diet during lactation. Leptin supplementation improved glucose homeostasis in male offspring but impaired insulin sensitivity in female offspring born to high-fat diet-fed dams. These findings highlight the importance of balanced maternal diet during the perinatal period, especially lactation, for the metabolic health of offspring, and the beneficial effects of leptin supplementation during suckling, particularly in male offspring.
Article
Environmental Sciences
Fangda Peng, Jing Dai, Qingjun Qian, Xiangfu Cao, Lifang Wang, Min Zhu, Shujin Han, Wubin Liu, Yan Li, Teng Xue, Xianyang Chen, Xiaoli Yang, Jiaolei Wang, Huanqiang Wang, Tao Li, Chunguang Ding
Summary: This study found that coal dust exposure leads to changes in serum metabolites across multiple metabolic pathways. A diagnostic model composed of three differential metabolites showed strong discriminatory ability between coal worker's pneumoconiosis patients and exposed individuals.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Medicine, General & Internal
Blandine Comte, Stephanie Monnerie, Marion Brandolini-Bunlon, Cecile Canlet, Florence Castelli, Emeline Chu-Van, Benoit Colsch, Francois Fenaille, Charlotte Joly, Fabien Jourdan, Natacha Lenuzza, Bernard Lyan, Jean-Francois Martin, Carole Migne, Jose A. Morais, Melanie Petera, Nathalie Poupin, Florence Vinson, Etienne Thevenot, Christophe Junot, Pierrette Gaudreau, Estelle Pujos-Guillot
Summary: The study used a multiplatform metabolomics and lipidomics untargeted strategy to characterize metabolic perturbations in MetS, identifying significant changes and defining a comprehensive MetS signature for future clinical applications. This approach provides insights into the systemic alterations of metabolism in MetS, contributing to better diagnostic methods for the syndrome.
Article
Fisheries
Yanni Zhao, Jiamin Ren, Heyang Jiang, Xuefeng Chen, Mudan Xu, Yue Li, Jieyu Zhao, Dan Chen, Kun Zhang, Hua Li, Huan Liu
Summary: Vibrio alginolyticus is a significant aquaculture pathogen, with Hfq deletion leading to increased de novo synthesis of fatty acids and nucleotides, altered lipid metabolism affecting cell division and growth, suppression of branched amino acid and aromatic amino acid synthesis, and enhanced TCA cycle to impact cell stress defenses and energy metabolism.
Article
Cell Biology
Qingqing Wang, Yexiong Tan, Tianyi Jiang, Xiaolin Wang, Qi Li, Yanli Li, Liwei Dong, Xinyu Liu, Guowang Xu
Summary: This study comprehensively analyzed the metabolic reprogramming in hepatocellular carcinoma (HCC) using metabolomics and lipidomics. The findings revealed enhanced aerobic glycolysis and de novo lipogenesis in HCC tissue, as well as repression of the urea cycle. Additionally, a differential correlation network was constructed, identifying key molecules related to the disease, and a panel of biomarkers was generated for prognostic risk stratification of HCC patients.
Review
Biochemistry & Molecular Biology
Caitlyn E. Bowman, Zoltan Arany, Michael J. Wolfgang
Summary: Pregnancy is a nutritionally sensitive stage, and communication between mother and fetus through metabolites is crucial. Studies on humans and animals provide insights into the metabolic adaptations of the fetus, placenta, and mother during pregnancy. Understanding the dynamic nature of maternal-fetal metabolic communication may lead to the discovery of new biomarkers and therapeutic targets for metabolic disorders in pregnancy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Chemistry, Applied
Genghua Chen, Lin Qi, Shuai Zhang, Haoqi Peng, Zetong Lin, Xiquan Zhang, Qinghua Nie, Wen Luo
Summary: A comprehensive comparison of metabolomic, lipidomic, and proteomic profiles between Shitou goose and Wuzhong goose revealed significant differences in meat quality, with energy metabolism and fatty acid metabolism pathways playing a major role in distinguishing breast and leg muscles.
Article
Automation & Control Systems
Veronique Cariou, Marie-Cecile Alexandre-Gouabau, Tom F. Wilderjans
Summary: The establishment of comprehensive studies in life sciences, such as time-scale metabolomics, necessitates the use of dimension reduction techniques for three-way data structures. A new approach called CLV3W is proposed to partition variables into nonoverlapping clusters and estimate rank-one Parafac model within each cluster. Two constrained CLV3W models, including a nonnegativity constraint and a constraint on the weighting system, aim to provide more parsimonious and interpretable models. These constraints are evaluated in simulation and applied to case studies in sensory evaluation and metabolomics data analysis.
JOURNAL OF CHEMOMETRICS
(2021)
Article
Chemistry, Inorganic & Nuclear
Arnaud De Luca, Alice Kuster, Illa Tea, Dominique Darmaun, Jean-Christophe Roze, Richard Robins, Regis Hankard
Summary: The study indicates a decrease in N-15 natural isotope abundance for plasma amino acid pools in the fetal-placental unit.
ISOTOPES IN ENVIRONMENTAL AND HEALTH STUDIES
(2021)
Article
Gastroenterology & Hepatology
Alexandre Lapillonne, Alain Bocquet, Andre Briend, Jean-Pierre Chouraqui, Dominique Darmaun, Francois Feillet, Marie-Laure Frelut, Dominique Guimber, Regis Hankard, Noel Peretti, Jean-Christophe Roze, Umberto Simeoni, Dominique Turck, Christophe Dupont
Summary: Pregnant and lactating women are frequently exposed to environmental pollutants, but current evidence does not conclusively show any significant health consequences for infants exposed through breastfeeding. Despite this, the benefits of breastfeeding are believed to outweigh any potential harm from pollutant exposure in human milk. Public health measures to reduce contamination levels and support further research in this area are recommended to ensure continued promotion of breastfeeding.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Public, Environmental & Occupational Health
Jean-Pierre Chouraqui, Dominique Turck, Andre Briend, Dominique Darmaun, Alain Bocquet, Francois Feillet, Marie-Laure Frelut, Jean-Philippe Girardet, Dominique Guimber, Regis Hankard, Alexandre Lapillonne, Noel Peretti, Jean-Christophe Roze, Umberto Simeoni, Christophe Dupont
Summary: Most religious dietary rules, when followed according to traditions, are not harmful to health. However, strict adherence to some rules may result in nutritional deficiencies, particularly in populations facing unfavorable socio-economic or environmental conditions.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Editorial Material
Pediatrics
A. Bocquet, R. Barouki, A. Briend, J. -P. Chouraqui, D. Darmaun, F. Feillet, M. -L. Frelut, D. Guimber, A. Lapillonne, N. Peretti, J. -C. Roze, U. Simeoni, D. Turck, C. Dupont
ARCHIVES DE PEDIATRIE
(2021)
Article
Nutrition & Dietetics
Clair-Yves Boquien, Helene Billard, Laure Simon, Cecile Boscher, Arnaud Legrand, Evelyne Joram, Thomas Moyon, Marie-Cecile Alexandre-Gouabau, Dominique Darmaun, Jean-Christophe Roze
Summary: This study aimed to investigate the relationship between protein content in native breast milk and the 2-year neurodevelopment outcome in preterm infants. The results showed that the protein content in breast milk was not associated with neurodevelopmental outcomes in preterm infants at 2 years of age.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Editorial Material
Medicine, Research & Experimental
Dominique Darmaun
Summary: The study suggests that repeated fasting, mimicking the fasting experienced by observant Muslim pregnant women during Ramadan, may alter placental amino acid transport and increase the incidence of low birth weight. However, there is currently no clear-cut evidence to prove whether fasting during Ramadan does indeed affect fetal growth, highlighting the need for further large-scale studies to validate the findings.
Article
Nutrition & Dietetics
Thomas Sevrin, Charlene Sirvins, Agnes David, Audrey Aguesse, Alexis Gandon, Blandine Castellano, Dominique Darmaun, Clair-Yves Boquien, Marie-Cecile Alexandre-Gouabau
Summary: The study found that supplementation of arginine during gestation and lactation can enhance milk flow and mammary lipogenesis in rat dams nursing large litters.
JOURNAL OF NUTRITION
(2021)
Review
Pediatrics
Mark J. Johnson, Alexandre Lapillonne, Jiri Bronsky, Magnus Domellof, Nicholas Embleton, Silvia Iacobelli, Frank Jochum, Koen Joosten, Sanja Kolacek, Walter A. Mihatsch, Sissel J. Moltu, John W. L. Puntis, Arieh Riskin, Raanan Shamir, Merit M. Tabbers, Johannes B. Van Goudoever, Miguel Saenz de Pipaon
Summary: The paper summarizes the key research priorities in pediatric parenteral nutrition, ranking them in order of importance according to expert opinion. The highest ranked priority is the need to understand the relationship between total energy intake, rapid catch-up growth, and later metabolic and neurocognitive outcomes. Research into the optimal intakes of macronutrients is also highlighted as a key area of focus.
PEDIATRIC RESEARCH
(2022)
Article
Nutrition & Dietetics
Jean-Pierre Chouraqui, Dominique Darmaun, Auree Salmon-Legagneur, Raanan Shamir
Summary: This study aimed to assess protein intake in infants and children and examine its sources and consumption patterns. The results showed that protein intake was generally higher than the recommended intake and increased with age. Overall, protein intake has decreased over the past few decades but still remains higher than the recommended intake. Animal sources of food were the main contributors to protein intake, and the potential long-term health consequences of such high intake deserve consideration.
CLINICAL NUTRITION
(2022)
Article
Mathematical & Computational Biology
Rayan Eid, Claudine Landes, Alix Pernet, Emmanuel Benoit, Pierre Santagostini, Angelina El Ghaziri, Julie Bourbeillon
Summary: In this research, a new method was introduced to handle mixed datasets, and a sparse visualization interface was built using semantic distance and archetype concept. This method can be applied to various mixed datasets and has significant implications for studying organisms and species.
Article
Nutrition & Dietetics
Jean-Christophe Roze, Mickael Hartweg, Laure Simon, Helene Billard, Yipu Chen, Sean Austin, Cecile Boscher, Thomas Moyon, Dominique Darmaun, Clara L. Garcia Rodenas, Clair-Yves Boquien
Summary: This study explored the impact of HMOs on growth and neurodevelopment in preterm infants. The findings showed that HMO concentrations decreased with advancing postnatal age. Total HMOs were positively correlated with neonatal length growth. Among Secretor(+) Lewis(+) mothers, LNFP-III was significantly associated with neurodevelopmental scores at 2 years.
CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Matthew Benson, Jobayer Hossain, Dominique Darmaun
Summary: Previous studies have shown that adolescents with type 1 diabetes mellitus (T1DM) have decreased levels of glutathione (GSH), and that GSH is inversely related to glycemic control. This study aimed to determine if improved glycemic control and dietary antioxidants could restore blood GSH levels in adolescents with poorly controlled T1DM.
NUTRITION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)