Article
Automation & Control Systems
Waqar Ahmad, Wenjun Yan, Min Ling, Chengdu Liang
Summary: Designing biomimetic olfactory neuroepithelium (BONe) with subnanosized active domains as artificial olfactory receptors (ORs) is highly desirable to sense various colorless and odorless hazardous odorants. Introduction of DNA-incorporated 3D BONe facilitates optimal tuning of d-band center and in situ anchoring of PdO2 subnanoscale clusters (PdO2-sNCs) on reduced graphene oxide (rGO) to mimic natural ONe morphology. The BONe design shows benchmarked H-2-sensing performance with a short recovery time, low limit of detection, and long-term durability.
ADVANCED INTELLIGENT SYSTEMS
(2023)
Review
Biochemistry & Molecular Biology
Irene Fatuzzo, Giovanni Francesco Niccolini, Federica Zoccali, Luca Cavalcanti, Mario Giuseppe Bellizzi, Gabriele Riccardi, Marco de Vincentiis, Marco Fiore, Carla Petrella, Antonio Minni, Christian Barbato
Summary: Olfactory capacity decline is associated with aging and may indicate the early stages of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Understanding the role of olfaction in these diseases is of great interest to scientists. Olfactory impairment could potentially serve as an early marker for neurodegenerative diseases, but further research is needed to fully understand the underlying mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Marta Barrera-Conde, Karina Ausin, Mercedes Lachen-Montes, Joaquin Fernandez-Irigoyen, Liliana Galindo, Aida Cuenca-Royo, Cristina Fernandez-Aviles, Victor Perez, Rafael de la Torre, Enrique Santamaria, Patricia Robledo
Summary: The study found that cannabis use causes specific alterations in RNA-related proteins in olfactory neuroepithelium cells of schizophrenia patients, which are correlated with cognitive performance and clinical signs.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, Research & Experimental
Yoojin Seo, Ji-Su Ahn, Ye Young Shin, Su-Jeong Oh, Min-Hye Song, Min-Jung Kang, Jung -Min Oh, Dongjun Lee, Yun Hak Kim, Byung-Chul Lee, Tae-Hoon Shin, Hyung-Sik Kim
Summary: This study found that mesenchymal stem cells (MSCs) can improve olfactory dysfunction in old mice through immunomodulation. The results suggest that the growth factor Gal1 produced by MSCs plays a key role in the immunomodulatory action.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Neurosciences
Alejandra Delgado-Sequera, Maria Hidalgo-Figueroa, Marta Barrera-Conde, Ma Carmen Duran-Ruiz, Carmen Castro, Cristina Fernandez-Aviles, Rafael de la Torre, Ismael Sanchez-Gomar, Victor Perez, Noelia Geribaldi-Doldan, Patricia Robledo, Esther Berrocoso
Summary: This study investigated the effects of chronic cannabis use on olfactory neuroepithelium cells, revealing alterations in cell processes and changes in functional proteomic pathways. Cannabis users showed changes in protein expression related to cytoskeleton, cell proliferation, and cell death, as well as implications in cancer, gastrointestinal, and neurodevelopmental pathologies. The findings suggest that cannabis may impact key processes in the developing brain, resembling characteristics seen in mental disorders such as DiGeorge syndrome, schizophrenia, and bipolar disorder.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Cell Biology
Kei Ogawa, Kenichi Asano, Satoshi Yotsumoto, Tsuyoshi Yamane, Makoto Arita, Yoshihiro Hayashi, Hironori Harada, Chieko Makino-Okamura, Hidehiro Fukuyama, Kenji Kondo, Tatsuya Yamasoba, Masato Tanaka
Summary: Recent research has shown that neutrophils can transform into double-positive cells expressing neurosupportive genes in the olfactory neuroepithelium (OE) under inflammatory conditions. These double-positive cells, derived from neutrophils, increase significantly during inflammation or tissue damage. Neutrophils change their surface markers and gene expression over time, expressing neurogenesis-related genes in addition to inflammation related genes.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Cell Biology
Pilar Alvarez, Beatriz Bellosillo, Francesc Colom, Raquel Longaron, Marta Barrera-Conde, Lierni Fernandez-Ibarrondo, Alba Toll, Jose Maria Gines, Rafael de la Torre, Victor Perez-Sola, Patricia Robledo
Summary: This exploratory study reports the presence of fetal microchimerism (FMc) in the olfactory neuroepithelium (ON) of both healthy and depressed women with male offspring, with depressed women having fewer microchimeric cells. These findings open new pathways to study FMc in the ON, female depression, and mother-child bonding.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Geetika Sahni, Shu-Yung Chang, Jeremy Teo Choon Meng, Jerome Zu Yao Tan, Jean Jacques Clement Fatien, Carine Bonnard, Kagistia Hana Utami, Puck Wee Chan, Thong Teck Tan, Umut Altunoglu, Hulya Kayserili, Mahmoud Pouladi, Bruno Reversade, Yi-Chin Toh
Summary: Research has successfully directed the formation of neural embryonic tissues from human pluripotent stem cells, replicating cellular processes relevant to early neurodevelopment. Spatial-temporal patterning of mesoendoderm guides the development of primitive ectoderm, facilitating tissue folding of the prospective neuroepithelium. The model allows for detection of structural dysmorphia in neuroepithelium tissues and differentiation between neural tube defect-inducing drugs.
Article
Cell Biology
Muhammad Ali Shahbaz, Francesca De Bernardi, Arto Alatalo, Magdalini Sachana, Laure-Alix Clerbaux, Amalia Munoz, Surat Parvatam, Brigitte Landesmann, Katja M. Kanninen, Sandra Coecke
Summary: Loss of the sense of smell is a symptom of COVID-19, with most patients recovering within a few weeks, while others experience persistent anosmia. This study aims to evaluate the mechanisms leading to short-term anosmia following SARS-CoV-2 infection. Using an adverse outcome pathway (AOP) framework, the study proposes a sequence of measurable key events that contribute to short-term anosmia, providing insights for further research and therapeutic intervention.
Article
Cell & Tissue Engineering
Noemie M. L. P. Berenger-Currias, Maria Mircea, Esmee Adegeest, Patrick R. van den Berg, Marleen Feliksik, Mazene Hochane, Timon Idema, Sander J. Tans, Stefan Semrau
Summary: The researchers have reported the formation of gastruloids consisting of mouse embryonic stem cells and extraembryonic endoderm cells, which exhibit the formation of neural epithelia. Through single-cell RNA-seq and differentiation experiments, the neural characteristics of the epithelial tissue are demonstrated, along with the mechanism of mESCs inducing XEN cell differentiation.
JOURNAL OF TISSUE ENGINEERING
(2022)
Review
Allergy
Concepcio Marin, Isam Alobid, Mireya Fuentes, Mauricio Lopez-Chacon, Joaquim Mullol
Summary: This review examines the impact of olfactory dysfunction on mental illness. The neurobiology of olfaction is described, as well as the common olfactory alterations in several mental illnesses. The role of olfactory pathways in regulating higher brain functions and its involvement in the pathophysiology of psychiatric disorders are highlighted, along with the effect of inflammation on neurogenesis as a possible mechanism for olfactory dysfunction in psychiatric conditions.
CURRENT ALLERGY AND ASTHMA REPORTS
(2023)
Article
Cell & Tissue Engineering
Jie Ren, Xianli Wang, Chuanming Dong, Guangming Wang, Wenjun Zhang, Chunhui Cai, Minxian Qian, Danjing Yang, Bin Ling, Ke Ning, Zhiyong Mao, Baohua Liu, Tinghua Wang, Liuliu Xiong, Wenyuan Wang, Aibin Liang, Zhengliang Gao, Jun Xu
Summary: In this study, it was found that DNA damage is reduced in aged mice's neural stem cells compared to young mice, and this reduction is achieved through the upregulation of Sirt1 expression and DNA repair processes. This reduced DNA damage and the upregulation of Sirt1 expression may represent a compensatory mechanism to protect stem cells from excessive DNA damage and mitigate memory loss and other stresses during aging.
Review
Pharmacology & Pharmacy
Arianna Di Stadio, Cinzia Severini, Andrea Colizza, Marco De Vincentiis, Ignazio La Mantia
Summary: This review discusses the origin and treatment options for olfactory dysfunction, especially acquired olfactory loss related to COVID-19. Due to the difficulty in identifying the exact cause through clinical investigations, researchers speculate about the mechanisms of olfactory disorder based on the different results obtained from various treatment methods. They believe that these treatments might also be effective for olfactory diseases related to neurodegeneration.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2022)
Review
Cell Biology
Xiuli Dan, Noah Wechter, Samuel Gray, Joy G. Mohanty, Deborah L. Croteau, Vilhelm A. Bohr
Summary: This study explores alterations in olfactory functions as early biomarkers for neurodegeneration, particularly in early-stage Parkinson's and Alzheimer's disease. Implementing early treatment to postpone or avert pathological development is crucial for these diseases.
AGEING RESEARCH REVIEWS
(2021)
Article
Biology
Michael Garratt, Ilkim Erturk, Roxann Alonzo, Frank Zufall, Trese Leinders-Zufall, Scott D. Pletcher, Richard A. Miller
Summary: Previous research has suggested that young mice are particularly sensitive to endocrine or nutritional signals during the first few weeks of life. Olfactory cues can influence early development and lifespan in mice, with female mice showing a significant increase in lifespan when exposed to odors from adult females during early stages.
Article
Neurosciences
Julie H. Coleman, Brian Lin, Jonathan D. Louie, Jesse Peterson, Robert P. Lane, James E. Schwob
JOURNAL OF NEUROSCIENCE
(2019)
Article
Otorhinolaryngology
Eric H. Holbrook, Sidharth V. Puram, Reiner B. See, Aaron G. Tripp, Dinesh G. Nair
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2019)
Article
Otorhinolaryngology
Dawei Wu, Stacey T. Gray, Eric H. Holbrook, Nicolas Y. Busaba, Benjamin S. Bleier
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2019)
Article
Otorhinolaryngology
Brett T. Jensen, Eric H. Holbrook, Philip G. Chen, Amber U. Luong, Michael J. Marino, William C. Yao
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2019)
Article
Otorhinolaryngology
George A. Scangas, Benjamin S. Bleier, Qasim Husain, Eric H. Holbrook, Stacey T. Gray, Ralph Metson
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2019)
Review
Otorhinolaryngology
Alan D. Workman, D. Bradley Welling, Bob S. Carter, William T. Curry, Eric H. Holbrook, Stacey T. Gray, George A. Scangas, Benjamin S. Bleier
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2020)
Review
Otorhinolaryngology
Zachary M. Soler, Zara M. Patel, Justin H. Turner, Eric H. Holbrook
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2020)
Article
Otorhinolaryngology
Ashton E. Lehmann, Aaishah R. Raquib, Shan H. Siddiqi, Josh Meier, Marlene L. Durand, Stacey T. Gray, Eric H. Holbrook
Summary: The study suggests that postoperative placebo is noninferior to prophylactic antibiotics after endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) in terms of postoperative sinonasal-specific quality of life (QOL). There were no significant differences in postoperative endoscopic scores or infection rates between the antibiotic and placebo groups, but the rate of diarrhea was significantly higher in the antibiotic group.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2021)
Editorial Material
Otorhinolaryngology
Annette A. Wang, Vinay K. Rathi, Roy Xiao, Eric H. Holbrook, George A. Scangas, Alan D. Workman, Stacey T. Gray
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2022)
Article
Neurosciences
Vera Gaun, Jeffrey R. Martens, James E. Schwob
Summary: Olfactory sensory neurons have the ability to regenerate and adapt to new odors, protecting the population from environmental insult. The lifespan of these neurons is still uncertain, but a recent study revealed spatial and temporal differences in their survival.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Neurosciences
Mira Fitzek, Parthkumar K. Patel, Peter D. Solomon, Brian Lin, Thomas Hummel, James E. Schwob, Eric H. Holbrook
Summary: Aging is associated with a gradual loss of olfactory sensory neurons, which results in a reduction in synaptic connections within the olfactory bulb. This loss of neurons and synapses occurs in a specific and uneven manner. Decreasing mitotically active olfactory epithelium basal cells may contribute to age-related decline in neurons and loss of smell perception in humans.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Review
Otorhinolaryngology
Zara M. Patel, Eric H. Holbrook, Justin H. Turner, Nithin D. Adappa, Mark W. Albers, Aytug Altundag, Simone Appenzeller, Richard M. Costanzo, Ilona Croy, Greg E. Davis, Puya Dehgani-Mobaraki, Richard L. Doty, Valerie B. Duffy, Bradley J. Goldstein, David A. Gudis, Antje Haehner, Thomas S. Higgins, Claire Hopkins, Caroline Huart, Thomas Hummel, Kawinyarat Jitaroon, Robert C. Kern, Ashoke R. Khanwalkar, Masayoshi Kobayashi, Kenji Kondo, Andrew P. Lane, Matt Lechner, Donald A. Leopold, Joshua M. Levy, Michael J. Marmura, Lisha Mclelland, Takaki Miwa, Paul J. Moberg, Christian A. Mueller, Sagar U. Nigwekar, Erin K. O'Brien, Teodor G. Paunescu, Robert Pellegrino, Carl Philpott, Jayant M. Pinto, Evan R. Reiter, David R. Roalf, Nicholas R. Rowan, Rodney J. Schlosser, James Schwob, Allen M. Seiden, Timothy L. Smith, Zachary M. Soler, Leigh Sowerby, Bruce K. Tan, Andrew Thamboo, Bozena Wrobel, Carol H. Yan
Summary: This article reviews the literature on clinical olfaction, olfactory loss, and olfactory dysfunction over the past two decades and introduces the International Consensus on Allergy and Rhinology: Olfaction (ICAR:O). Nearly 100 topics were thoroughly reviewed, providing important insights and clear guidance for the diagnosis and treatment of patients, while also highlighting gaps in our knowledge and evidence base.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2022)
Article
Multidisciplinary Sciences
Hironobu Nishijima, Matthew J. Zunitch, Masafumi Yoshida, Kenji Kondo, Tatsuya Yamasoba, James E. Schwob, Eric H. Holbrook
Summary: This study identified two fluorescence probes that can rapidly detect and evaluate the entire extent of mice OE. These probes can be used to monitor OE degeneration and the regenerative response to therapeutic interventions.
Article
Developmental Biology
Jonathan D. Louie, Benjamin H. Bromberg, Matthew J. Zunitch, James E. Schwob
Summary: Horizontal basal cells (HBCs) play a crucial role in regenerating the damaged olfactory epithelium (OE) by differentiating into olfactory sensory neurons (OSNs) and other non-neuronal cell types. The Notch signaling pathway has a context-dependent effect on HBC activity following OE injury. This study shows that HBCs depend on an inversion of the Notch pathway to properly mediate OE regeneration.