JNK-mediated microglial DICER degradation potentiates inflammatory responses to induce dopaminergic neuron loss

Downregulation of miR-7116-5p in microglia by MPP+ sensitizes TNF-α production to induce dopaminergic neuron damage

(2017) Qian He et al.   GLIA

Dicer Deficiency Differentially Impacts Microglia of the Developing and Adult Brain

(2017) Diana Varol et al.   IMMUNITY

Dicer Cleavage by Calpain Determines Platelet microRNA Levels and Function in DiabetesNovelty and Significance

(2015) Amro Elgheznawy et al.   CIRCULATION RESEARCH

MicroRNA-223 regulates inflammation and brain injury via feedback to NLRP3 inflammasome after intracerebral hemorrhage

(2015) Zhao Yang et al.   MOLECULAR IMMUNOLOGY

Neuroprotective and anti-inflammatory properties of a novel non-thiazolidinedione PPARγ agonist in vitro and in MPTP-treated mice

(2015) D. Lecca et al.   NEUROSCIENCE

TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production

(2015) Junfeng Wang et al.   Nature Communications

A Requirement for ERK-Dependent Dicer Phosphorylation in Coordinating Oocyte-to-Embryo Transition in C. elegans

(2014) Melanie Drake et al.   DEVELOPMENTAL CELL

A MicroRNA Processing Defect in Smokers' Macrophages Is Linked to SUMOylation of the Endonuclease DICER

(2014) Thomas J. Gross et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dicer in immune cell development and function

(2013) Anand S. Devasthanam et al.   IMMUNOLOGICAL INVESTIGATIONS

Neuroprotective and Anti-inflammatory Properties of a Coffee Component in the MPTP Model of Parkinson’s Disease

(2013) Kang-Woo Lee et al.   Neurotherapeutics

Valproic Acid Causes Proteasomal Degradation of DICER and Influences miRNA Expression

(2013) Zhaiyi Zhang et al.   PLoS One

Proteome-wide profiling of activated transcription factors with a concatenated tandem array of transcription factor response elements

(2013) C. Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection

(2013) Laurieann Casey Klockow et al.   VIROLOGY

Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation

(2013) C Parisi et al.   Cell Death & Disease

DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88

(2012) Valeria Tarallo et al.   CELL

A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model mice

(2012) Varsha Shukla et al.   FASEB JOURNAL

Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin

(2012) Wei Shao et al.   NATURE

Regulation of human Dicer by the resident ER membrane protein CLIMP-63

(2012) Geneviève Pépin et al.   NUCLEIC ACIDS RESEARCH

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

(2011) Hiroki Kaneko et al.   NATURE

Use of ibuprofen and risk of Parkinson disease

(2011) X. Gao et al.   NEUROLOGY

Neuroinflammation in Parkinson's disease

(2011) Etienne C. Hirsch et al.   PARKINSONISM & RELATED DISORDERS

Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration

(2010) Sébastien S. Hébert et al.   HUMAN MOLECULAR GENETICS

Neuroinflammation is a key player in Parkinson’s disease and a prime target for therapy

(2010) Li Qian et al.   JOURNAL OF NEURAL TRANSMISSION

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway

(2010) Eugene D Ponomarev et al.   NATURE MEDICINE

Caspase-Dependent Conversion of Dicer Ribonuclease into a Death-Promoting Deoxyribonuclease

(2010) A. Nakagawa et al.   SCIENCE

Dicerablation in oligodendrocytes provokes neuronal impairment in mice

(2009) Daesung Shin et al.   ANNALS OF NEUROLOGY

The influence of microglia on the pathogenesis of Parkinson's disease

(2009) Caitríona M. Long-Smith et al.   PROGRESS IN NEUROBIOLOGY

The lipopolysaccharide Parkinson’s disease animal model: mechanistic studies and drug discovery

(2008) Garima Dutta et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway

(2008) Y. Tai et al.   JOURNAL OF CELL SCIENCE

GPS 2.0, a Tool to Predict Kinase-specific Phosphorylation Sites in Hierarchy

(2008) Yu Xue et al.   MOLECULAR & CELLULAR PROTEOMICS

Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration

(2008) T. L. Cuellar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA