Myeloid-specific TAK1 deletion results in reduced brain monocyte infiltration and improved outcomes after stroke

Splenectomy protects aged mice from injury after experimental stroke

(2018) Anjali Chauhan et al.   NEUROBIOLOGY OF AGING

Myeloid C/EBPβ deficiency reshapes microglial gene expression and is protective in experimental autoimmune encephalomyelitis

(2017) Marta Pulido-Salgado et al.   Journal of Neuroinflammation

TAK1 regulates resident macrophages by protecting lysosomal integrity

(2017) Yosuke Sakamachi et al.   Cell Death & Disease

TAK1 inhibition attenuates both inflammation and fibrosis in experimental pneumoconiosis

(2017) Jie Li et al.   Cell Discovery

Dynamics of T cell responses after stroke

(2016) Dipender Gill et al.   CURRENT OPINION IN PHARMACOLOGY

Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke

(2014) Jens Neumann et al.   ACTA NEUROPATHOLOGICA

VCAM-1/α4β1 Integrin Interaction Is Crucial for Prompt Recruitment of Immune T Cells into the Brain during the Early Stage of Reactivation of Chronic Infection with Toxoplasma gondii To Prevent Toxoplasmic Encephalitis

(2014) Qila Sa et al.   INFECTION AND IMMUNITY

The Role of the Spleen in Ischemic Stroke

(2014) Keith R Pennypacker et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Enterocyte-Derived TAK1 Signaling Prevents Epithelium Apoptosis and the Development of Ileitis and Colitis

(2014) R. Kajino-Sakamoto et al.   JOURNAL OF IMMUNOLOGY

α4 Integrin Is a Regulator of Leukocyte Recruitment After Experimental Intracerebral Hemorrhage

(2014) Matthew D. Hammond et al.   STROKE

Transforming Growth Factor–β Signaling in Hepatocytes Promotes Hepatic Fibrosis and Carcinogenesis in Mice With Hepatocyte-Specific Deletion of TAK1

(2013) Ling Yang et al.   GASTROENTEROLOGY

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

(2013) Tobias Goldmann et al.   NATURE NEUROSCIENCE

Deletion of macrophage migration inhibitory factor worsens stroke outcome in female mice

(2013) L. Christine Turtzo et al.   NEUROBIOLOGY OF DISEASE

Inhibition of Calcium/Calmodulin-Dependent Protein Kinase Kinase β and Calcium/Calmodulin-Dependent Protein Kinase IV Is Detrimental in Cerebral Ischemia

(2013) Louise D. McCullough et al.   STROKE

Perfusion of Ischemic Brain in Young and Aged Animals

(2013) Bharti Manwani et al.   STROKE

Cell type-specific function of TAK1 in innate immune signaling

(2013) Adebusola A. Ajibade et al.   TRENDS IN IMMUNOLOGY

NF-κB contributes to the detrimental effects of social isolation after experimental stroke

(2012) Venugopal Reddy Venna et al.   ACTA NEUROPATHOLOGICA

Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain

(2012) Angela M. Kaindl et al.   ANNALS OF NEUROLOGY

Licensing of myeloid cells promotes central nervous system autoimmunity and is controlled by peroxisome proliferator-activated receptor γ

(2012) Stephanie Hucke et al.   BRAIN

Protection from cerebral ischemia by inhibition of TGFβ-activated kinase

(2012) Benjamin J. White et al.   EXPERIMENTAL NEUROLOGY

TAK1 inhibition for treatment of cerebral ischemia

(2012) Dirk A. Ridder et al.   EXPERIMENTAL NEUROLOGY

TAK1 Negatively Regulates NF-κB and p38 MAP Kinase Activation in Gr-1+CD11b+ Neutrophils

(2012) Adebusola Alagbala Ajibade et al.   IMMUNITY

Inflammatory cell trafficking across the blood-brain barrier: chemokine regulation and in vitro models

(2012) Yukio Takeshita et al.   IMMUNOLOGICAL REVIEWS

A Transient Decrease in Spleen Size Following Stroke Corresponds to Splenocyte Release into Systemic Circulation

(2012) Hilary A. Seifert et al.   Journal of Neuroimmune Pharmacology

TAK1 Is Essential for Osteoclast Differentiation and Is an Important Modulator of Cell Death by Apoptosis and Necroptosis

(2012) Betty Lamothe et al.   MOLECULAR AND CELLULAR BIOLOGY

Wild-type microglia arrest pathology in a mouse model of Rett syndrome

(2012) Noël C. Derecki et al.   NATURE

Myeloid Takl Acts as a Negative Regulator of the LPS Response and Mediates Resistance to Endotoxemia

(2012) Christina Eftychi et al.   PLoS One

Deletion of TAK1 in the Myeloid Lineage Results in the Spontaneous Development of Myelomonocytic Leukemia in Mice

(2012) Betty Lamothe et al.   PLoS One

Targeting of TAK1 in inflammatory disorders and cancer

(2012) Hiroaki Sakurai   TRENDS IN PHARMACOLOGICAL SCIENCES

Acute inhibition of TAK1 protects against neuronal death in cerebral ischemia

(2011) M Neubert et al.   CELL DEATH AND DIFFERENTIATION

Effects of Gender on Gene Expression in the Blood of Ischemic Stroke Patients

(2011) Yingfang Tian et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

CD8+ T Cells Primed in the Periphery Provide Time-Bound Immune-Surveillance to the Central Nervous System

(2011) K. G. Young et al.   JOURNAL OF IMMUNOLOGY

TAK1 Suppresses a NEMO-Dependent but NF-κB-Independent Pathway to Liver Cancer

(2010) Kira Bettermann et al.   CANCER CELL

Leucocyte apoptosis in patients with acute ischaemic stroke

(2010) Nai-Wen Tsai et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Autoactivation of Transforming Growth Factor β-activated Kinase 1 Is a Sequential Bimolecular Process

(2010) Roland Scholz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A critical role of TAK1 in B-cell receptor–mediated nuclear factor κB activation

(2009) James Schuman et al.   BLOOD

TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes

(2009) Michael Karin et al.   IMMUNOLOGICAL REVIEWS

Resistin Up-Regulates COX-2 Expression via TAK1-IKK-NF-κB Signaling Pathway

(2009) Jian Zhang et al.   INFLAMMATION

TNF-Like Weak Inducer of Apoptosis (TWEAK) Activates Proinflammatory Signaling Pathways and Gene Expression through the Activation of TGF- -Activated Kinase 1

(2009) M. Kumar et al.   JOURNAL OF IMMUNOLOGY

The value of leukocyte adhesion molecules in patients after ischemic stroke

(2009) Nai-Wen Tsai et al.   JOURNAL OF NEUROLOGY

Alternate Pathways Preserve Tumor Necrosis Factor-α Production After Nuclear Factor-κB Inhibition in Neonatal Cerebral Hypoxia–Ischemia

(2009) Cora H. Nijboer et al.   STROKE

Role of microglial IKKβ in kainic acid-induced hippocampal neuronal cell death

(2008) Ik-Hyun Cho et al.   BRAIN

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN

NF-κB signaling in cerebral ischemia

(2008) D.A. Ridder et al.   NEUROSCIENCE