Unconjugated bilirubin induces pyroptosis in cultured rat cortical astrocytes

Inflammatory signature of cerebellar neurodegeneration during neonatal hyperbilirubinemia in Ugt1 -/- mouse model

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NLRP3 inflammasome: a promising target in ischemic stroke

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The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease

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The Blockade of NF-κB Activation by a Specific Inhibitory Peptide Has a Strong Neuroprotective Role in a Sprague-Dawley Rat Kernicterus Model

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NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model

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Bilirubin-induced neurologic dysfunction (BIND)

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Bilirubin-induced neural impairment: A special focus on myelination, age-related windows of susceptibility and associated co-morbidities

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Societal impact of bilirubin-induced hearing impairment in resource-limited nations

(2015) Bolajoko O. Olusanya   Seminars in Fetal & Neonatal Medicine

Why is kernicterus still a major cause of death and disability in low-income and middle-income countries?

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Developmental Onset of Bilirubin-induced Neurotoxicity Involves Toll-like Receptor 2-dependent Signaling in HumanizedUDP-glucuronosyltransferase1Mice

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Die another way – non-apoptotic mechanisms of cell death

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Minocycline improves recognition memory and attenuates microglial activation in Gunn rat: A possible hyperbilirubinemia-induced animal model of schizophrenia

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Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer’s disease

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Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

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Bilirubin-Induced Neurologic Damage — Mechanisms and Management Approaches

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NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

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Lipid peroxidation is not the primary mechanism of bilirubin-induced neurologic dysfunction in jaundiced Gunn rat pups

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The Evolving Landscape of Neurotoxicity by Unconjugated Bilirubin: Role of Glial Cells and Inflammation

(2012) Dora Brites   Frontiers in Pharmacology

Caspase-1-induced pyroptotic cell death

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Astrocyte–neuron metabolic relationships: for better and for worse

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Astrocyte reactivity to unconjugated bilirubin requires TNF-α and IL-1β receptor signaling pathways

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The Inflammasome Sensor, NLRP3, Regulates CNS Inflammation and Demyelination via Caspase-1 and Interleukin-18

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Adenovirus Membrane Penetration Activates the NLRP3 Inflammasome

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Features of bilirubin-induced reactive microglia: From phagocytosis to inflammation

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Astrocytes: biology and pathology

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Unbound (Free) Bilirubin: Improving the Paradigm for Evaluating Neonatal Jaundice

(2009) C. E. Ahlfors et al.   CLINICAL CHEMISTRY

Contribution of Inflammatory Processes to Nerve Cell Toxicity by Bilirubin and Efficacy of Potential Therapeutic Agents

(2009) Adelaide Fernandes et al.   CURRENT PHARMACEUTICAL DESIGN

Bilirubin selectively inhibits cytochromecoxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid

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Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Minocycline and neurodegenerative diseases

(2008) Hye-Sun Kim et al.   BEHAVIOURAL BRAIN RESEARCH

Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms

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