Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation

PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier

(2016) Slava Rom et al.   Journal of Neuroinflammation

Flaxseed lignans enriched in secoisolariciresinol diglucoside prevent acute asbestos-induced peritoneal inflammation in mice

(2015) Ralph A. Pietrofesa et al.   CARCINOGENESIS

The Flaxseed-Derived Lignan Phenolic Secoisolariciresinol Diglucoside (SDG) Protects Non-Malignant Lung Cells from Radiation Damage

(2015) Anastasia Velalopoulou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

miR-98 and let-7g* Protect the Blood-Brain Barrier Under Neuroinflammatory Conditions

(2015) Slava Rom et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Potential protective properties of flax lignan secoisolariciresinol diglucoside

(2015) Muhammad Imran et al.   Nutrition Journal

Poly(ADP-ribose) Polymerase-1 Inhibition in Brain Endothelium Protects the Blood—Brain Barrier under Physiologic and Neuroinflammatory Conditions

(2014) Slava Rom et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Activation of Peroxisome Proliferator-Activated Receptor   (PPAR ) Suppresses Rho GTPases in Human Brain Microvascular Endothelial Cells and Inhibits Adhesion and Transendothelial Migration of HIV-1 Infected Monocytes

(2014) S. H. Ramirez et al.   JOURNAL OF IMMUNOLOGY

Isolation, characterization and antihyperlipidemic activity of secoisolariciresinol diglucoside in poloxamer-407-induced experimental hyperlipidemia

(2014) Anand A. Zanwar et al.   PHARMACEUTICAL BIOLOGY

Novel Synthetic (S,S) and (R,R)-Secoisolariciresinol Diglucosides (SDGs) Protect Naked Plasmid and Genomic DNA From Gamma Radiation Damage

(2014) Om P. Mishra et al.   RADIATION RESEARCH

Cannabinoid Receptor 2 Activation

(2013) Shilpa J. Buch   AMERICAN JOURNAL OF PATHOLOGY

Selective Activation of Cannabinoid Receptor 2 in Leukocytes Suppresses Their Engagement of the Brain Endothelium and Protects the Blood-Brain Barrier

(2013) Slava Rom et al.   AMERICAN JOURNAL OF PATHOLOGY

Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs)

(2013) Om P. Mishra et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Radiation mitigating properties of the lignan component in flaxseed

(2013) Ralph Pietrofesa et al.   BMC CANCER

Glycogen Synthase Kinase 3β Inhibition Prevents Monocyte Migration across Brain Endothelial Cells via Rac1-GTPase Suppression and Down-Regulation of Active Integrin Conformation

(2012) Slava Rom et al.   AMERICAN JOURNAL OF PATHOLOGY

Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease

(2012) Jesse D. Sengillo et al.   BRAIN PATHOLOGY

Radioprotective Role in Lung of the Flaxseed Lignan Complex Enriched in the Phenolic Secoisolariciresinol Diglucoside (SDG)

(2012) Melpo Christofidou-Solomidou et al.   RADIATION RESEARCH

Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier

(2010) Michael J Bernas et al.   Nature Protocols

Age exaggerates proinflammatory cytokine signaling and truncates signal transducers and activators of transcription 3 signaling following ischemic stroke in the rat

(2010) V.A. DiNapoli et al.   NEUROSCIENCE

Flaxseed lignan lowers blood cholesterol and decreases liver disease risk factors in moderately hypercholesterolemic men

(2010) Satoshi Fukumitsu et al.   NUTRITION RESEARCH

A randomized controlled trial of the effects of flaxseed lignan complex on metabolic syndrome composite score and bone mineral in older adults

(2009) Stephen M. Cornish et al.   Applied Physiology Nutrition and Metabolism

Real-time Analysis of Conformation-sensitive Antibody Binding Provides New Insights into Integrin Conformational Regulation

(2009) Alexandre Chigaev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flaxseed and Cardiovascular Health

(2009) Kailash Prasad   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Mechanism of Ceftriaxone Induction of Excitatory Amino Acid Transporter-2 Expression and Glutamate Uptake in Primary Human Astrocytes

(2008) Seok-Geun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Strategies to advance translational research into brain barriers

(2008) Edward Neuwelt et al.   LANCET NEUROLOGY

The role of cytoskeleton in the regulation of vascular endothelial barrier function

(2008) Natalia V. Bogatcheva et al.   MICROVASCULAR RESEARCH

Regression of hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed

(2007) Kailash Prasad   ATHEROSCLEROSIS

Secoisolariciresinol diglucoside induces neovascularization-mediated cardioprotection against ischemia–reperfusion injury in hypercholesterolemic myocardium

(2007) Suresh Varma Penumathsa et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY