PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier

Insights into End-Organ Injury in HIV Infection

(2015) Yuri Persidsky   AMERICAN JOURNAL OF PATHOLOGY

The Role of Neuroinflammation in Dementias

(2015) Giuseppe Pasqualetti et al.   Current Neurology and Neuroscience Reports

Poly(ADP-ribose) polymerase inhibitor therapeutic effect: are we just scratching the surface?

(2015) Michael O Hottiger   EXPERT OPINION ON THERAPEUTIC TARGETS

miR-98 and let-7g* Protect the Blood-Brain Barrier Under Neuroinflammatory Conditions

(2015) Slava Rom et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

NF-κB transcriptional activation by TNFα requires phospholipase C, extracellular signal-regulated kinase 2 and poly(ADP-ribose) polymerase-1

(2015) Billy Vuong et al.   Journal of Neuroinflammation

PARP-1 involvement in neurodegeneration: A focus on Alzheimer’s and Parkinson’s diseases

(2015) Sara Martire et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The role of poly(ADP-ribose) polymerase-1 inhibitor in carrageenan-induced lung inflammation in mice

(2015) Sheikh Fayaz Ahmad et al.   MOLECULAR IMMUNOLOGY

Immune interventions in stroke

(2015) Ying Fu et al.   Nature Reviews Neurology

Inflammation, Iron, Energy Failure, and Oxidative Stress in the Pathogenesis of Multiple Sclerosis

(2015) Lukas Haider   Oxidative Medicine and Cellular Longevity

Poly(ADP-ribose) polymerases as modulators of mitochondrial activity

(2015) Peter Bai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

NF-kB signaling mediates acquired resistance after PARP inhibition

(2015) Yuko Nakagawa et al.   Oncotarget

Poly(ADP-ribose) polymerase-1 inhibitor modulates T regulatory and IL-17 cells in the prevention of adjuvant induced arthritis in mice model

(2014) Sheikh Fayaz Ahmad et al.   CYTOKINE

p38α deficiency and oxidative stress cause cytokinesis failure in hepatocytes

(2014) M. Tormos Ana et al.   FREE RADICAL BIOLOGY AND MEDICINE

Poly(ADP-ribose) Polymerase-1 Inhibition in Brain Endothelium Protects the Blood—Brain Barrier under Physiologic and Neuroinflammatory Conditions

(2014) Slava Rom et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neurogenesis and Inflammation after Ischemic Stroke: What is Known and Where We Go from Here

(2014) Matthew K Tobin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Activation of Peroxisome Proliferator-Activated Receptor   (PPAR ) Suppresses Rho GTPases in Human Brain Microvascular Endothelial Cells and Inhibits Adhesion and Transendothelial Migration of HIV-1 Infected Monocytes

(2014) S. H. Ramirez et al.   JOURNAL OF IMMUNOLOGY

Removable cranial windows for long-term imaging in awake mice

(2014) Glenn J Goldey et al.   Nature Protocols

Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

(2014) Daniel Knowland et al.   NEURON

Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2

(2014) Wei Qiu et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PARP1 enhances inflammatory cytokine expression by alteration of promoter chromatin structure in microglia

(2014) Ricardo Iván Martínez-Zamudio et al.   Brain and Behavior

Structural basis for the inhibition of poly(ADP-ribose) polymerases 1 and 2 by BMN 673, a potent inhibitor derived from dihydropyridophthalazinone

(2014) Mika Aoyagi-Scharber et al.   Acta Crystallographica Section F-Structural Biology Communications

Selective Activation of Cannabinoid Receptor 2 in Leukocytes Suppresses Their Engagement of the Brain Endothelium and Protects the Blood-Brain Barrier

(2013) Slava Rom et al.   AMERICAN JOURNAL OF PATHOLOGY

Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis

(2013) Partha Mukhopadhyay et al.   HEPATOLOGY

 2 Integrin-Mediated Crawling on Endothelial ICAM-1 and ICAM-2 Is a Prerequisite for Transcellular Neutrophil Diapedesis across the Inflamed Blood-Brain Barrier

(2013) R. Gorina et al.   JOURNAL OF IMMUNOLOGY

Glycogen Synthase Kinase 3β Inhibition Prevents Monocyte Migration across Brain Endothelial Cells via Rac1-GTPase Suppression and Down-Regulation of Active Integrin Conformation

(2012) Slava Rom et al.   AMERICAN JOURNAL OF PATHOLOGY

Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation

(2012) Kensaku Mizuno   CELLULAR SIGNALLING

Lipopolysaccharide activates ERK–PARP-1–RelA pathway and promotes nuclear factor–κB transcription in murine macrophages

(2012) Linlin Liu et al.   HUMAN IMMUNOLOGY

Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor

(2012) Joana C d’Avila et al.   Journal of Neuroinflammation

Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

(2012) Elisabet Wahlberg et al.   NATURE BIOTECHNOLOGY

Aspects of VLA-4 and LFA-1 regulation that may contribute to rolling and firm adhesion

(2012) Alexandre Chigaev et al.   Frontiers in Immunology

Signaling Mechanism of Poly(ADP-Ribose) Polymerase-1 (PARP-1) in Inflammatory Diseases

(2011) Xueqing Ba et al.   AMERICAN JOURNAL OF PATHOLOGY

The integrin LFA-1 signals through ZAP-70 to regulate expression of high-affinity LFA-1 on T lymphocytes

(2011) R. Evans et al.   BLOOD

A new cannabinoid CB2 receptor agonist HU-910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury

(2011) Bėla Horváth et al.   BRITISH JOURNAL OF PHARMACOLOGY

How do immune cells overcome the blood-brain barrier in multiple sclerosis?

(2011) Catherine Larochelle et al.   FEBS LETTERS

PARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity

(2011) Leonardo Cavone et al.   Multiple Sclerosis Journal

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Effect of Acute Poly(ADP-Ribose) Polymerase Inhibition by 3-AB on Blood–Brain Barrier Permeability and Edema Formation after Focal Traumatic Brain Injury in Rats

(2010) Thomas Lescot et al.   JOURNAL OF NEUROTRAUMA

Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier

(2010) Michael J Bernas et al.   Nature Protocols

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

(2009) Bayani Uttara et al.   Current Neuropharmacology

Real-time Analysis of Conformation-sensitive Antibody Binding Provides New Insights into Integrin Conformational Regulation

(2009) Alexandre Chigaev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of conformer-specific activation of the integrin LFA-1 by a chemokine-triggered Rho signaling module

(2009) Matteo Bolomini-Vittori et al.   NATURE IMMUNOLOGY

Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE

(2009) Mauricio F Farez et al.   NATURE IMMUNOLOGY

Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

(2009) Mathias Gelderblom et al.   STROKE

PARP-1 Inhibition Prevents Oxidative and Nitrosative Stress–Induced Endothelial Cell Death via Transactivation of the VEGF Receptor 2

(2008) Marlene T. Mathews et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammation and the neurovascular unit in the setting of focal cerebral ischemia

(2008) G.J. del Zoppo   NEUROSCIENCE

Poly(ADP-ribose)polymerase 1 (PARP-1) and postischemic brain damage

(2007) F MORONI   CURRENT OPINION IN PHARMACOLOGY