G5G2.5 core-shell tecto-dendrimer specifically targets reactive glia in brain ischemia

Toll-Like Receptor 4 (TLR4) and Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) Activation Balance Astrocyte Polarization into a Proinflammatory Phenotype

(2017) Gerardo Rosciszewski et al.   MOLECULAR NEUROBIOLOGY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Myelin phagocytosis by astrocytes after myelin damage promotes lesion pathology

(2016) Gerald Ponath et al.   BRAIN

New insights on the role of microglia in synaptic pruning in health and disease

(2016) Soyon Hong et al.   CURRENT OPINION IN NEUROBIOLOGY

Microglial migration and interactions with dendrimer nanoparticles are altered in the presence of neuroinflammation

(2016) Fan Zhang et al.   Journal of Neuroinflammation

Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease

(2016) Julien Couturier et al.   Journal of Neuroinflammation

Astroglial heterogeneity: merely a neurobiological question? Or an opportunity for neuroprotection and regeneration after brain injury?

(2016) AlbertoJavier Ramos   Neural Regeneration Research

Isolation and Characterization of Ischemia-Derived Astrocytes (IDAs) with Ability to Transactivate Quiescent Astrocytes

(2016) Alejandro Villarreal et al.   Frontiers in Cellular Neuroscience

Dendrimers Target the Ischemic Lesion in Rodent and Primate Models of Nonarteritic Anterior Ischemic Optic Neuropathy

(2016) Yan Guo et al.   PLoS One

Systemic dendrimer-drug treatment of ischemia-induced neonatal white matter injury

(2015) Elizabeth Nance et al.   JOURNAL OF CONTROLLED RELEASE

Chronic systemic IL-1β exacerbates central neuroinflammation independently of the blood–brain barrier integrity

(2015) Verónica Murta et al.   JOURNAL OF NEUROIMMUNOLOGY

Notch1–STAT3–ETBRsignaling axis controls reactive astrocyte proliferation after brain injury

(2015) Matthew D. LeComte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stroke Neurologist’s Perspective on the New Endovascular Trials

(2015) James C. Grotta et al.   STROKE

Enhanced antimelanoma activity of methotrexate and zoledronic acid within polymeric sandwiches

(2014) Priscila Schilrreff et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Emerging concepts in dendrimer-based nanomedicine: from design principles to clinical applications

(2014) R. M. Kannan et al.   JOURNAL OF INTERNAL MEDICINE

S100B protein activates a RAGE-dependent autocrine loop in astrocytes: implications for its role in the propagation of reactive gliosis

(2014) Alejandro Villarreal et al.   JOURNAL OF NEUROCHEMISTRY

Reactive Gliosis and the Multicellular Response to CNS Damage and Disease

(2014) Joshua E. Burda et al.   NEURON

The Proinflammatory RAGE/NF-κB Pathway Is Involved in Neuronal Damage and Reactive Gliosis in a Model of Sleep Apnea by Intermittent Hypoxia

(2014) Maria Florencia Angelo et al.   PLoS One

Astrocytes refine cortical connectivity at dendritic spines

(2014) W Christopher Risher et al.   eLife

Glial Scar Borders Are Formed by Newly Proliferated, Elongated Astrocytes That Interact to Corral Inflammatory and Fibrotic Cells via STAT3-Dependent Mechanisms after Spinal Cord Injury

(2013) I. B. Wanner et al.   JOURNAL OF NEUROSCIENCE

Role of Scavenger Receptors in Glia-Mediated Neuroinflammatory Response Associated with Alzheimer’s Disease

(2013) Francisca Cornejo et al.   MEDIATORS OF INFLAMMATION

Biodistribution of Fluorescently Labeled PAMAM Dendrimers in Neonatal Rabbits: Effect of Neuroinflammation

(2013) Wojciech G. Lesniak et al.   MOLECULAR PHARMACEUTICS

Heterogeneity of reactive astrocytes

(2013) Mark A. Anderson et al.   NEUROSCIENCE LETTERS

Does Socioeconomic Status or Acculturation Modify the Association Between Ethnicity and Hypertension Treatment Before Stroke?

(2013) Deborah A. Levine et al.   STROKE

The good and bad of microglia/macrophages: new hope in stroke therapeutics

(2012) Ya-chi Huang et al.   ACTA PHARMACOLOGICA SINICA

CNS response to a second pro-inflammatory event depends on whether the primary demyelinating lesion is active or resolved

(2012) Veronica Murta et al.   BRAIN BEHAVIOR AND IMMUNITY

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Multifunctionalized CMCht/PAMAM Dendrimer Nanoparticles Modulate the Cellular Uptake by Astrocytes and Oligodendrocytes in Primary Cultures of Glial Cells

(2012) Susana R. Cerqueira et al.   MACROMOLECULAR BIOSCIENCE

In Vivo Distribution and Toxicity of PAMAM Dendrimers in the Central Nervous System Depend on Their Surface Chemistry

(2012) Lorenzo Albertazzi et al.   MOLECULAR PHARMACEUTICS

Engulfing Astrocytes Protect Neurons from Contact-Induced Apoptosis following Injury

(2012) Camilla Lööv et al.   PLoS One

Dendrimer-Based Postnatal Therapy for Neuroinflammation and Cerebral Palsy in a Rabbit Model

(2012) S. Kannan et al.   Science Translational Medicine

Microglia Response and In Vivo Therapeutic Potential of Methylprednisolone-Loaded Dendrimer Nanoparticles in Spinal Cord Injury

(2012) Susana R. Cerqueira et al.   Small

Computational design principles for bioactive dendrimer based constructs as antagonists of the TLR4-MD-2-LPS complex

(2011) Teresa Barata et al.   BIOMATERIALS

S100B alters neuronal survival and dendrite extension via RAGE-mediated NF-κB signaling

(2011) Alejandro Villarreal et al.   JOURNAL OF NEUROCHEMISTRY

Endocytosis of nanomedicines

(2010) Gaurav Sahay et al.   JOURNAL OF CONTROLLED RELEASE

Carboxymethylchitosan/Poly(amidoamine) Dendrimer Nanoparticles in Central Nervous Systems-Regenerative Medicine: Effects on Neuron/Glial Cell Viability and Internalization Efficiency

(2010) António J. Salgado et al.   MACROMOLECULAR BIOSCIENCE

Dendrimer Internalization and Intracellular Trafficking in Living Cells

(2010) Lorenzo Albertazzi et al.   MOLECULAR PHARMACEUTICS

Intrinsic targeting of inflammatory cells in the brain by polyamidoamine dendrimers upon subarachnoid administration

(2010) Hui Dai et al.   Nanomedicine

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Neuroprotection by biodegradable PAMAM ester (e-PAM-R)-mediated HMGB1 siRNA delivery in primary cortical cultures and in the postischemic brain

(2009) Il-Doo Kim et al.   JOURNAL OF CONTROLLED RELEASE

Intermittent hypoxia during sleep induces reactive gliosis and limited neuronal death in rats: implications for sleep apnea

(2009) Rolando Xavier Aviles-Reyes et al.   JOURNAL OF NEUROCHEMISTRY

A newin vitromodel of the glial scar inhibits axon growth

(2008) Ina B. Wanner et al.   GLIA