Trpc6 inactivation confers protection in a model of severe nephrosis in rats

Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho

(2017) Yueh-Lin Wu et al.   KIDNEY INTERNATIONAL

NMDA Receptors as Potential Therapeutic Targets in Diabetic Nephropathy: Increased Renal NMDA Receptor Subunit Expression in Akita Mice and Reduced Nephropathy Following Sustained Treatment With Memantine or MK-801

(2016) Hila Roshanravan et al.   DIABETES

Mechanical challenges to the glomerular filtration barrier: adaptations and pathway to sclerosis

(2016) Wilhelm Kriz et al.   PEDIATRIC NEPHROLOGY

Random Splicing of Several Exons Caused by a Single Base Change in the Target Exon of CRISPR/Cas9 Mediated Gene Knockout

(2016) Marcel Kapahnke et al.   Cells

Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels

(2015) T Maier et al.   BRITISH JOURNAL OF PHARMACOLOGY

Gq signaling causes glomerular injury by activating TRPC6

(2015) Liming Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

TRPC6 is the endothelial calcium channel that regulates leukocyte transendothelial migration during the inflammatory response

(2015) Evan W. Weber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The glomerular permeability factors in idiopathic nephrotic syndrome

(2015) Jean-Claude Davin   PEDIATRIC NEPHROLOGY

TRPC6 channel translocation into phagosomal membrane augments phagosomal function

(2015) Vladimir Riazanski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence of a Role for Fibroblast Transient Receptor Potential Canonical 3 Ca2+ Channel in Renal Fibrosis

(2014) Y. Saliba et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Single-Gene Cause in 29.5% of Cases of Steroid-Resistant Nephrotic Syndrome

(2014) C. E. Sadowski et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol

(2013) Marc Anderson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Inhibition of the TRPC5 ion channel protects the kidney filter

(2013) Thomas Schaldecker et al.   JOURNAL OF CLINICAL INVESTIGATION

TRPC6 Regulates CXCR2-Mediated Chemotaxis of Murine Neutrophils

(2013) O. Lindemann et al.   JOURNAL OF IMMUNOLOGY

Diacylglycerol-containing oleic acid induces increases in [Ca2+]i via TRPC3/6 channels in human T-cells

(2012) Celia Carrillo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation

(2012) Mohammad Tauseef et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart

(2012) Jian Xie et al.   Nature Communications

Angiotensin II Contributes to Podocyte Injury by Increasing TRPC6 Expression via an NFAT-Mediated Positive Feedback Signaling Pathway

(2011) Tom Nijenhuis et al.   AMERICAN JOURNAL OF PATHOLOGY

The Proteoglycan Syndecan 4 Regulates Transient Receptor Potential Canonical 6 Channels via RhoA/Rho-associated Protein Kinase Signaling

(2011) Ying Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

cAMP Activates TRPC6 Channels via the Phosphatidylinositol 3-Kinase (PI3K)-Protein Kinase B (PKB)-Mitogen-activated Protein Kinase Kinase (MEK)-ERK1/2 Signaling Pathway

(2011) Bing Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPC6 Enhances Angiotensin II-induced Albuminuria

(2011) J. Eckel et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Circulating Permeability Factors in Idiopathic Nephrotic Syndrome and Focal Segmental Glomerulosclerosis

(2010) E. T. McCarthy et al.   Clinical Journal of the American Society of Nephrology

Podocyte-Specific Overexpression of Wild Type or Mutant Trpc6 in Mice Is Sufficient to Cause Glomerular Disease

(2010) Paola Krall et al.   PLoS One

Antagonistic Regulation of Actin Dynamics and Cell Motility by TRPC5 and TRPC6 Channels

(2010) D. Tian et al.   Science Signaling

Simple 2,4-Diacylphloroglucinols as Classic Transient Receptor Potential-6 Activators--Identification of a Novel Pharmacophore

(2009) K. Leuner et al.   MOLECULAR PHARMACOLOGY

A Novel TRPC6 Mutation That Causes Childhood FSGS

(2009) Saskia F. Heeringa et al.   PLoS One

The self-association of two N-terminal interaction domains plays an important role in the tetramerization of TRPC4

(2008) Pascale K. Lepage et al.   CELL CALCIUM

Loss of classical transient receptor potential 6 channel reduces allergic airway response

(2008) S. Sel et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Animal models of renal disease

(2008) K. Susztak et al.   KIDNEY INTERNATIONAL

The first ankyrin-like repeat is the minimum indispensable key structure for functional assembly of homo- and heteromeric TRPC4/TRPC5 channels

(2007) Rainer Schindl et al.   CELL CALCIUM