Review
Immunology
Cong Chen, Jie Wang, Chao Liu, Jun Hu
Summary: Acute myocardial infarction (MI) is a common and fatal global disease, and heart failure (HF) remains a significant risk despite standard treatment. Cardiac resident macrophages (cMacs) have emerged as key regulators in the pathophysiology of post-MI progression, regulating aspects such as immune cell recruitment, cell clearance, fibrosis, and energy metabolism. Targeting cMacs presents a promising therapeutic strategy, including using nanocarriers to deliver drugs or introducing exogenous protective cMacs through cell therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Amil. M. M. Shah, Brian Claggett, Narayana Prasad, Guichu Li, Mayra Volquez, Karola Jering, Maja Cikes, Attila Kovacs, Wilfried Mullens, Jose C. Nicolau, Lars Kober, Peter Van der Meer, Pardeep. S. S. Jhund, Ghionul Ibram, Martin Lefkowitz, Yinong Zhou, Scott. D. D. Solomon, Marc A. Pfeffer
Summary: This study compared the effects of sacubitril/valsartan and ramipril on left ventricular function and adverse remodeling after acute myocardial infarction (AMI). The results showed that patients randomized to sacubitril/valsartan had better improvements in filling pressure, left ventricular volume changes, and other aspects compared to those randomized to ramipril.
Article
Pharmacology & Pharmacy
Anahita Abdali, Goran Marinkovic
Summary: This review summarizes key cells, processes, and tissue compartments involved in myelopoiesis during steady state, atherosclerosis development, and myocardial infarction.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Masashi Tomimatsu, Kotaro Matsumoto, Moe Ashizuka, Shohei Kumagai, Shota Tanaka, Takafumi Nakae, Kosei Yokota, Shunsuke Kominami, Ryota Kajiura, Daisuke Okuzaki, Daisuke Motooka, Aki Shiraishi, Takaya Abe, Hideo Matsuda, Yoshiaki Okada, Makiko Maeda, Shigeto Seno, Masanori Obana, Yasushi Fujio
Summary: Runx2 plays an important role in cardiac remodeling after myocardial infarction, with its deficiency leading to cardiac dysfunction and exacerbated fibrosis, possibly through regulating endothelial cell function.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Konstantinos D. Rizas, Luisa Freyer, Nikolay Sappler, Lukas von Stuelpnagel, Peter Spielbichler, Aresa Krasniqi, Michael Schreinlechner, Felix N. Wenner, Fabian Theurl, Amira Behroz, Elodie Eiffener, Mathias P. Klemm, Annika Schneidewind, Martin Zens, Theresa Dolejsi, Ulrich Mansmann, Steffen Massberg, Axel Bauer
Summary: The study compared the efficacy of digital smart devices in detecting atrial fibrillation (AF) and found that digital screening technology more than doubled the detection rate of treatment-relevant AF compared to usual care. This technology has the potential for broad applicability and further studies are needed to assess if digital screening for AF leads to better treatment outcomes.
Review
Engineering, Biomedical
Shuyi He, Zaiyuan Zhang, Rifang Luo, Qing Jiang, Li Yang, Yunbing Wang
Summary: Heart failure is a global public health problem that needs urgent solutions. HF due to myocardial infarction is the main cause of morbidity and mortality. Injectable hydrogel therapy has emerged as a minimally invasive tissue engineering approach that can provide mechanical support and improve the cellular microenvironment for myocardial tissue regeneration.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Cardiac & Cardiovascular Systems
Stefan Frantz, Moritz Jens Hundertmark, Jeanette Schulz-Menger, Frank Michael Bengel, Johann Bauersachs
Summary: Most patients survive acute myocardial infarction, but the prevalence of heart failure is increasing, leading to economic strain on healthcare systems. Pathological changes in the heart significantly impact patient outcomes. Risk factors like diabetes, chronic obstructive pulmonary disease, and female sex can distinctively shape the progression towards heart failure.
EUROPEAN HEART JOURNAL
(2022)
Review
Cardiac & Cardiovascular Systems
Matthew Deberge, Rajesh Chaudhary, Samantha Schroth, Edward B. Thorp
Summary: Immune cell function in the myocardium plays a crucial role in regulating cardiac function and pathology. This function is fueled by metabolic shifts and metabolite availability. Insight into immunometabolism has potential therapeutic implications for shifting the balance towards cardioprotection.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Review
Physiology
Sabina Sahanic, Judith Loeffler-Ragg, Piotr Tymoszuk, Richard Hilbe, Egon Demetz, Rebecca K. Masanetz, Markus Theurl, Johannes Holfeld, Can Gollmann-Tepekoeylue, Alexandar Tzankov, Guenter Weiss, Martin Giera, Ivan Tancevski
Summary: This review focuses on the spatiotemporal kinetics and inflammatory signatures of innate immune cells in response to SARS-CoV-2 compared to influenza virus infection, highlighting the mechanisms underlying exaggerated inflammation and death. Insights from investigating a public RNA-seq database of bronchoalveolar lavage cells from COVID-19 patients offer critical information on the regulation of key enzymes involved in lipid mediator synthesis, contributing to the current understanding of the lipidome in severe cases. Additionally, potential approaches to sustain the synthesis of pro-resolving lipid mediators derived from 3-PUFAs are discussed as crucial in preventing acute lung injury and fatality from COVID-19.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Elvira Forte, Bryant Perkins, Amalia Sintou, Harkaran S. Kalkat, Angelos Papanikolaou, Catherine Jenkins, Mashael Alsubaie, Rasheda A. Chowdhury, Theodore M. Duffy, Daniel A. Skelly, Jane Branca, Mohamed Bellahcene, Michael D. Schneider, Sian E. Harding, Milena B. Furtado, Fu Siong Ng, Muneer G. Hasham, Nadia Rosenthal, Susanne Sattler
Summary: After ischemic injury to the heart, cross-priming dendritic cells play a role in activating cytotoxic CD8(+) T cells by presenting self-antigens from necrotic cardiac cells. Research suggests that activation of cytotoxic CD8(+) T cells by cross-priming DC may exacerbate inflammatory damage of the myocardium and corresponding decline in cardiac function.
Article
Cardiac & Cardiovascular Systems
John W. Ostrominski, Muthiah Vaduganathan, Senthil Selvaraj, Brian L. Claggett, Zi Michael Miao, Akshay S. Desai, Pardeep S. Jhund, Mikhail N. Kosiborod, Carolyn S. P. Lam, Silvio E. Inzucchi, Felipe A. Martinez, Rudolf A. de Boer, Adrian F. Hernandez, Sanjiv J. Shah, Magnus Petersson, Anna Maria Langkilde, John J. V. Mcmurray, Scott D. Solomon
Summary: This study analyzed the potential role of dapagliflozin in treating apparent treatment-resistant hypertension (aTRH) in heart failure patients. The results showed that dapagliflozin consistently improved cardiovascular outcomes and was well-tolerated in patients with aTRH.
Article
Nanoscience & Nanotechnology
Syed Baseeruddin Alvi, Divya Sridharan, Shridhar K. Sanghvi, Muhamad Mergaye, Uzair Ahmed, Sarah K. Mikula, Harpreet Singh, Mahmood Khan
Summary: This study demonstrates the potential of polydopamine nanoparticles (PDA-NPs) as a bioactive agent to enhance contractility and beat propagation of cardiomyocytes. PDA-NPs improve mitochondrial bioenergetics and have cardiotonic effects on the heart. In addition, they can modulate the genetic expression of cardiomyocytes.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Cardiac & Cardiovascular Systems
Kieran F. Docherty, Alice M. Jackson, Mark Macartney, Ross T. Campbell, Mark C. Petrie, Marc A. Pfeffer, John J. V. McMurray, Pardeep S. Jhund
Summary: The risk of heart failure hospitalization (HFH) following acute myocardial infarction (AMI) has decreased in Scotland over the past 25 years, likely due to improvements in coronary reperfusion and secondary prevention therapies.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Biochemistry & Molecular Biology
Jidong Rong, Tianmu He, Jianyong Zhang, Zhixun Bai, Bei Shi
Summary: This study aimed to identify early lipid biomarkers for the development of post-MI heart failure. Serum samples from MI and pMIHF patients were analyzed, and several potential biomarkers were found that could be used to predict and diagnose post-MI heart failure.
LIPIDS IN HEALTH AND DISEASE
(2023)
Review
Critical Care Medicine
Yutian Li, Qianqian Li, Guo-Chang Fan
Summary: Macrophages are crucial for cardiac development, homeostasis, and healing, playing a vital role in clearing dying cells and cellular debris through efferocytosis. Understanding macrophage efferocytosis provides valuable insights on cardiac health and offers new therapeutic strategies for patients with heart failure.
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)