Antitumor-specific T-cell responses induced by oncolytic adenovirus ONCOS-102 (AdV5/3-D24-GM-CSF) in peritoneal mesothelioma mouse model

Oncolytic Viruses—Interaction of Virus and Tumor Cells in the Battle to Eliminate Cancer

(2017) Anwen Howells et al.   Frontiers in Oncology

Toxicological and bio-distribution profile of a GM-CSF-expressing, double-targeted, chimeric oncolytic adenovirus ONCOS-102 – Support for clinical studies on advanced cancer treatment

(2017) Lukasz Kuryk et al.   PLoS One

Synergistic anti-tumor efficacy of immunogenic adenovirus ONCOS-102 (Ad5/3-D24-GM-CSF) and standard of care chemotherapy in preclinical mesothelioma model

(2016) Lukasz Kuryk et al.   INTERNATIONAL JOURNAL OF CANCER

Oncolytic Adenovirus Loaded with L-carnosine as Novel Strategy to Enhance the Antitumor Activity

(2016) M. Garofalo et al.   MOLECULAR CANCER THERAPEUTICS

Phase I study with ONCOS-102 for the treatment of solid tumors – an evaluation of clinical response and exploratory analyses of immune markers

(2016) Tuuli Ranki et al.   Journal for ImmunoTherapy of Cancer

Oncolytic viruses: a new class of immunotherapy drugs

(2015) Howard L. Kaufman et al.   NATURE REVIEWS DRUG DISCOVERY

Oncolytic adenoviruses coated with MHC-I tumor epitopes increase the antitumor immunity and efficacy against melanoma

(2015) Cristian Capasso et al.   OncoImmunology

Repeated intratumoral administration of ONCOS-102 leads to systemic antitumor CD8+T-cell response and robust cellular and transcriptional immune activation at tumor site in a patient with ovarian cancer

(2015) L Vassilev et al.   OncoImmunology

Innate Immunity to Adenovirus

(2014) Rodinde Hendrickx et al.   HUMAN GENE THERAPY

Oncolytic adenovirus and doxorubicin-based chemotherapy results in synergistic antitumor activity against soft-tissue sarcoma

(2014) Mikko Siurala et al.   INTERNATIONAL JOURNAL OF CANCER

Local treatment of a pleural mesothelioma tumor with ONCOS-102 induces a systemic antitumor CD8+T-cell response, prominent infiltration of CD8+lymphocytes and Th1 type polarization

(2014) Tuuli Ranki et al.   OncoImmunology

Characteristics of neutralizing antibodies to adenovirus capsid proteins in human and animal sera

(2013) Bin Yu et al.   VIROLOGY

Oncolytic Immunotherapy of Advanced Solid Tumors with a CD40L-Expressing Replicating Adenovirus: Assessment of Safety and Immunologic Responses in Patients

(2012) S. Pesonen et al.   CANCER RESEARCH

Oncolytic adenoviruses

(2012) Vincenzo Cerullo et al.   OncoImmunology

Selectivity of Oncolytic Viral Replication Prevents Antiviral Immune Response and Toxicity, but Does Not Improve Antitumoral Immunity

(2010) Engin Gürlevik et al.   MOLECULAR THERAPY

Treatment of Cancer Patients With a Serotype 5/3 Chimeric Oncolytic Adenovirus Expressing GMCSF

(2010) Anniina Koski et al.   MOLECULAR THERAPY

Malignant mesothelioma

(2008) Alastair J Moore et al.   Orphanet Journal of Rare Diseases

Mesothelin targeted cancer immunotherapy

(2007) Raffit Hassan et al.   EUROPEAN JOURNAL OF CANCER