Article
Materials Science, Multidisciplinary
Nuno Cruz, Javier Gil, Miquel Punset, Jose Maria Manero, Joao Paulo Tondela, Pablo Verdeguer, Conrado Aparicio, Elisa Ruperez
Summary: This study introduces the use of Piranha solution as a passivating and bactericidal agent for metallic dental meshes and evaluates its effects on the properties of the meshes. The results showed that Piranha solution passivation improved hydrophilicity and exhibited notable antibacterial activity, but it also decreased electrochemical stability and increased ion release.
Article
Materials Science, Multidisciplinary
Ankit Jain, Nisha Kumari, Sheeja Jagadevan, Vivek Bajpai
Summary: This study investigated the variation in surface free energy, adhesion strength, and bacterial attachment during early colonization by fabricating two different sizes of micro dimple textured surfaces on Ti6Al4V. The results showed that the surface roughness of the textured surfaces increased, as did the surface free energy and adhesion strength of water and diiodomethane on the textured surfaces. Bacterial attachment in the form of E. coli cellular chains was observed during the initial colonization process.
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
(2021)
Article
Materials Science, Multidisciplinary
Mirjam Bajt Leban, Tadeja Kosec, Matjaz Finsgar
Summary: In the additively manufactured TiAlV samples, a higher amount of ions was released in artificial saliva compared to wrought alloy samples. The total amount of ions released was 10 times higher in artificial saliva containing NaF, and 100 times higher in artificial saliva containing lactic acid.
Article
Materials Science, Coatings & Films
William DeFlorio, Kelsey Crawford, Shuhao Liu, Yinying Hua, Luis Cisneros-Zevallos, Mustafa Akbulut
Summary: The demand for bacterial antifouling surface treatment technologies for titanium alloy medical devices is increasing. This study reports the development of a durable, fluorine-free superhydrophobic surface treatment, capable of reducing the costs and dangers associated with medical device infections.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Meng Zhang, Yongsheng Wang, Wenru Jia, Dandan Ma, Xiaobo Huang, Shengwang Yu, Yucheng Wu
Summary: Ta2O5-doped TiO2 nanotubes were prepared to improve cytocompatibility to endothelial cells, showing potential for biomedical applications.
Article
Materials Science, Coatings & Films
Zi-Yi Zhang, Tian-Yu Huang, Da-Jun Zhai, Hai-Bo Wang, Ke-Qin Feng, Lin Xiang
Summary: Coatings with different content of Zn element were successfully formed on Ti6Al4V substrates by micro-arc oxidation (MAO) to enhance the bioactivity and antibacterial activity of titanium alloys. The microstructure and composition of the coatings were characterized, and their bioactive and antibacterial activities were evaluated. The results showed that increasing Zn2+ concentration in the electrolyte resulted in changes in the properties and composition of the coatings, including thickness, surface roughness, porosity, and crystalline phases. The Zn-doped coatings improved cell viability and exhibited antibacterial activity.
SURFACE & COATINGS TECHNOLOGY
(2023)
Article
Materials Science, Ceramics
Itishree Ratha, Pradyot Datta, Nimu Chand Reger, Himanka Das, Vamsi Krishna Balla, K. Bavya Devi, Mangal Roy, Samit Kumar Nandi, Biswanath Kundu
Summary: The feasibility of plasma spray-coated metallic implants and the potential of multi-ion doped hydroxyapatite (HAp) coated titanium substrates for orthopaedic applications were investigated. The results showed that multi-ion doping significantly improved the adhesion, hardness, and corrosion resistance of the coating, leading to enhanced osseointegration in vivo. This suggests that multi-ion doped HAp coated titanium substrate can be a promising implant coating material for orthopaedic applications.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Multidisciplinary
Ana Claudia Sene, Michely Glenda Pereira da Silva, Paulo Fabricio Macario, Angela Aparecida Vieira, Priscila Maria Sarmeiro Correa Marciano Leite, Newton Soares da Silva, Francisco Das Chagas Marques, Lucia Vieira
Summary: This study investigates the effectiveness of DLC smoothing coatings on stainless steel and titanium alloy to reduce tribocorrosion and improve cell viability. The results show that the DLC coatings have suitable interaction properties, no cytotoxicity or genotoxicity, and demonstrate low friction and high hardness, making them ideal for use on fixed implants.
Review
Chemistry, Multidisciplinary
Qian Zhou, Zhangyong Si, Kun Wang, Kunpeng Li, Weilin Hong, Yuezhou Zhang, Peng Li
Summary: This article systematically summarizes the recent progress of smart antimicrobial drug delivery systems triggered by bacterial secreted enzymes. These systems can achieve precise and controlled release of antimicrobial agents in the microenvironment of bacterial infections, providing possibilities for slowing the development of antimicrobial resistance.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Nanoscience & Nanotechnology
Kristina Y. Gudz, Liubov Yu Antipina, Elizaveta S. Permyakova, Andrey M. Kovalskii, Anton S. Konopatsky, Svetlana Yu Filippovich, Ivan A. Dyatlov, Pavel Slukin, Sergei G. Ignatov, Dmitry Shtansky
Summary: This study demonstrates that nanoparticles conjugated with antibacterial components are promising carriers for fighting bacterial and fungal infections, showing high bactericidal and fungicidal activities against a variety of pathogens. Extensive biological tests have shown the potential of antibiotic-loaded nanocarriers in providing broad protection against multi-drug resistant bacteria and fungi.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Ceramics
Kong Weicheng, Yu Zhou, Hu Jun
Summary: Carburizing treatment improves the adhesion force and mechanical properties of Cr doped DLC coating on TA, leading to a reduction in friction. The carburizing treatment also promotes the formation of self-repairing carbonyl in the Cr doped DLC coating, which has a unique friction-reducing characteristic with the oil-wet property.
CERAMICS INTERNATIONAL
(2021)
Review
Nanoscience & Nanotechnology
Pranav P. Kalelkar, Milan Riddick, Andres J. Garcia
Summary: This review discusses the use of antibacterial biomaterials and non-antibiotic therapies to improve the ability to combat antibiotic resistance and recurring infections. Utilizing biomaterials allows for targeted delivery of multiple agents while reducing systemic adverse effects, showing great potential for future development.
NATURE REVIEWS MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Ying Huang, Lei Mu, Xin Zhao, Yong Han, Baolin Guo
Summary: Researchers have developed a self-healing hydrogel with good electrical conductivity and antioxidant activity for burn wound repair. The hydrogel can release antibiotics on demand and shows excellent antibacterial properties, in vivo antibacterial activity, and wound inflammation control compared to conventional dressings. This smart release hydrogel is highly advantageous for bacterial-infected burn wound healing.
Article
Materials Science, Multidisciplinary
B. Aksakal, Y. Say, Z. A. Sinirlioglu
Summary: The goal of this study was to enhance the antibacterial activity and cell viability of the Rex-734 alloy in biomedical applications. Different biocomposite coatings, including HAp, HAp/Ag, and HAp/Se/Chit, were applied to the alloy and characterized. The addition of Ag and Se improved the antimicrobial efficiency, while the addition of Se and Chit increased cell viability.
MATERIALS TODAY COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Gad Frankel, Sophia David, Wen Wen Low, Chloe Seddon, Joshua L. C. Wong, Konstantinos Beis
Summary: Bacterial conjugation is a contact-dependent mechanism of plasmid transfer, and recent research has shown that F-like plasmids can select bacterial hosts through the expression of different isoforms of the outer membrane protein TraN. The TraN sensor binds compatible outer membrane proteins in the recipient to select bacterial hosts. This study provides new insights into the function of the TraN sensor in selecting bacterial hosts prior to DNA transfer.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Bianca Dumontel, Veronica Conejo-Rodriguez, Maria Vallet-Regi, Miguel Manzano
Summary: In recent years, the functionalization of mesoporous silica nanoparticles (MSNs) with responsive pore gatekeepers has shown potential for drug delivery systems (DDS) with controlled release. The use of natural biopolymers as smart materials in drug delivery applications has been investigated extensively. This review summarizes the coating procedures with natural polysaccharides and protein-based biopolymers, focusing on their application as responsive materials to endogenous stimuli. Biopolymer-coated MSNs have shown promising therapeutic outcomes and potential for selective treatment of various diseases.
Article
Pharmacology & Pharmacy
Ana Arenas-Vivo, Vanessa Celis Arias, Georgiana Amariei, Roberto Rosal, Isabel Izquierdo-Barba, Tania Hidalgo, Maria Vallet-Regi, Hiram I. Beltran, Sandra Loera-Serna, Patricia Horcajada
Summary: Surface microbial colonization and biofilm formation are major problems causing human infectious diseases, and traditional treatments are often ineffective in eliminating biofilms. This study presents a silver-based metal-organic framework (AgBDC) that has antifouling properties and can prevent bacterial adhesion and surface contamination.
Article
Chemistry, Physical
Marta Martin-Garcia, John Jairo Aguilera-Correa, Maria Angeles Arenas, Ignacio M. Garcia-Diego, Ana Conde, Juan Jose de Damborenea, Jaime Esteban
Summary: Prosthetic joint infection is a rare but costly problem. This study evaluated the adherence of different bacteria to two types of alloys commonly used in joint prostheses. The results showed that the interaction between bacteria and the alloys differed significantly, with the CoCrMo alloy having an aggregating effect on all bacteria and additional anti-adherent activity against Pseudomonas aeruginosa.
Article
Chemistry, Physical
Xabier Sandua, Pedro J. J. Rivero, Ana Conde, Joseba Esparza, Rafael Rodriguez
Summary: This study compares the photocatalytic efficiency of different deposition techniques for dispersing TiO2 nanoparticles onto a polymeric electrospun fiber matrix. The efficiency is evaluated through wettability measurements and organic dye degradation. The results show that although all three techniques induce super hydrophilic behavior, there are notable differences in the photocatalytic efficiency in degrading Rhodamine B.
Article
Pharmacology & Pharmacy
Daniel Lozano, Beatriz Leiva, Ines S. Gomez-Escalonilla, Sergio Portal-Nunez, Arancha R. de Gortazar, Miguel Manzano, Maria Vallet-Regi
Summary: Osteoporosis is commonly treated with antiresorptive drugs and anabolic agents, but these treatments have limitations. Pleiotrophin (PTN), a protein involved in tissue repair, and mesoporous silica nanoparticles (MSNs), a drug-delivery system, have shown potential for improving bone regeneration. In this study, PTN-loaded MSNs significantly enhanced osteogenesis and osteoblast differentiation when tested on MC3T3-E1 cells and human mesenchymal stem cells. This proof of concept suggests that MSNs can effectively deliver PTN and may be a promising treatment for osteoporosis and bone-regeneration scenarios.
Article
Microbiology
Alba Ruedas-Lopez, Marta Tato, Antonio Broncano-Lavado, Jaime Esteban, Maria Jesus Ruiz-Serrano, Maria Sanchez-Cueto, Carlos Toro, Diego Domingo, Juana Cacho, Laura Barrado, Paula Lopez-Roa
Summary: The study aimed to determine the subspecies distribution of Mycobacterium abscessus (MABS) and its correlation with antibiotic profiles. The clinical isolates included 50 (52.1%) MABS subsp. abscessus, 33 (34.4%) MABS subsp. massiliense, and 13 (13.5%) MABS subsp. bolletii. Resistance rates varied among different drugs, with amikacin, cefoxitin, linezolid, and imipenem showing high activity against MABS. The GenoType NTM-DR assay demonstrated a high level of agreement with the traditional drug susceptibility testing.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
J. J. Aguilera-Correa, B. Salinas, M. Gonzalez-Arjona, D. de Pablo, P. Munoz, E. Bouza, M. J. Fernandez Acenero, J. Esteban, M. Desco, L. Cusso
Summary: This study compared structural and molecular imaging techniques to assess disease progression in a mouse model of osteomyelitis. The results showed that FDG-PET imaging was more sensitive than MRI and CT in differentiating between infection and inflammation at early stages.
MICROBIOLOGY SPECTRUM
(2023)
Review
Infectious Diseases
Guillermo Santamaria-Corral, Abrar Senhaji-Kacha, Antonio Broncano-Lavado, Jaime Esteban, Meritxell Garcia-Quintanilla
Summary: Phage therapy is an alternative therapy used as a last resort against multidrug-resistant bacteria infections. Pseudomonas aeruginosa, a pathogen that commonly infects immunocompromised individuals, can be effectively treated using bacteriophages alone or in combination with antibiotics. This review summarizes recent studies highlighting the synergistic effects of phage-antibiotic combinations and successful treatments.
Article
Polymer Science
Jesus L. Pablos, Javier Jimenez-Holguin, Sandra Sanchez Salcedo, Antonio J. Salinas, Teresa Corrales, Maria Vallet-Regi
Summary: The production of customized polymeric hydrogels in the form of 3D scaffolds with application in bone tissue engineering is currently a topic of great interest. Based on gelatin methacryloyl (GelMa) as one of the most popular used biomaterials, GelMa with two different methacryloylation degrees (DM) was obtained, to achieve crosslinked polymer networks by photoinitiated radical polymerization.
Article
Polymer Science
Beatriz Toirac, John Jairo Aguilera-Correa, Aranzazu Mediero, Jaime Esteban, Antonia Jimenez-Morales
Summary: This study evaluated a novel hybrid organic-inorganic sol-gel coating in vitro, which was loaded with different concentrations of linezolid and/or cefoxitin. The coating effectively inhibited biofilm formation of Staphylococcus species without compromising cell viability and proliferation.
Article
Chemistry, Multidisciplinary
Laura Casarrubios, Monica Cicuendez, Maria Vallet-Regi, Maria Teresa Portoles, Daniel Arcos, Maria Jose Feito
Summary: Bioactive mesoporous glass nanospheres (nanoMBGs) loaded with ipriflavone can produce positive immune effects, which have great potential for the treatment of osteoporosis and fracture prevention.
Article
Chemistry, Medicinal
Maider Ugalde-Arbizu, John Jairo Aguilera-Correa, Eider San Sebastian, Paulina L. L. Paez, Estela Nogales, Jaime Esteban, Santiago Gomez-Ruiz
Summary: Antibiotic resistance is a global problem, and this study aimed to synthesize and characterize seven materials based on silica mesoporous nanoparticles functionalized with fluoroquinolones, Cu2+ or Ag+ species. The antibacterial properties of these materials were evaluated against different strains including Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa. The Ag+ materials exhibited a broader spectrum of antibacterial activity, inhibiting even multi-drug resistant strains, and the material with phenytoin sodium showed potential in reducing biofilm development and inhibiting bacterial growth.
Article
Materials Science, Biomaterials
Llanos Salar-Vidal, Alvaro Aunon, Jaime Esteban
Summary: Despite recent advances, microbiological diagnosis of prosthetic joint infections remains challenging. Molecular biology techniques, including multiplex PCR assays and metagenomics, have shown potential but are still experimental. A few studies have evaluated the use of these methods in clinical routine and proposed protocols. However, their interpretation requires a multidisciplinary team with experience.
Article
Microbiology
Maria-Carmen Munoz-Egea, Arij Akir, Jaime Esteban
Summary: The genus Mycobacterium includes deadly pathogens like tuberculosis and leprosy, but it also includes environmental microorganisms. Some of these environmental species can be human pathogens, and the study of their biofilms has increased in recent decades. The importance of glycopeptidolipids and lipidic molecules in the extracellular matrix of mycobacterial biofilms has been well established. Mycobacterial biofilms have clinical importance in chronic diseases, especially lung diseases and implant-related ones. The increasing resistance of mycobacteria in biofilm form has been proven, and new tools or approaches are needed to treat these patients.
