Article
Materials Science, Ceramics
Lynnora O. Grant, C. Fred Higgs III, Zachary C. Cordero
Summary: Reactive binders are effective in mitigating distortion during sintering of binder jet 3D printed components by reinforcing interparticle contacts. The use of aqueous titanium bis-ammonium lactato dihydroxide (TALH) as a reactive binder in sintering binder jet printed TiO2 has been investigated through experiments and micromechanical modeling. TALH treatment results in the formation of a nanocrystalline TiO2 overlayer on the particle surface, which is consumed during sintering. Creep rates are slower in TALH-treated material compared to as-printed TiO2, but faster when compared at equivalent relative density. The dominant effect of TALH on sintering mechanics is increasing the interparticle contact size.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2023)
Article
Construction & Building Technology
Ibrahim Pinarci, Yilmaz Kocak
Summary: This paper reports on the hydration production, micro structuring, and compressive strength results of Portland cement-pumice systems. The study shows that pumice has lower pozzolanic activity in the early period, but the compressive strength increases with time and the cement continues to hydrate. SEM images reveal that the usage of pumice leads to a denser microstructure as the hydration age increases.
CONSTRUCTION AND BUILDING MATERIALS
(2022)
Article
Construction & Building Technology
Jean Noel Yankwa Djobo, Dietmar Stephan
Summary: This study reports the role of calcium in the acidic aluminum phosphate-activation of metakaolin and the characteristics of the resulting binder. It was found that a replacement rate higher than 6 wt% hinders the subsequent dissolution of metakaolin, and highly soluble calcium hydroxide improves the compressive strength while sparsely soluble calcium silicate decreases it.
CEMENT AND CONCRETE RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Dorien Van Hede, Bingbing Liang, Sandy Anania, Mojtaba Barzegari, Bruno Verlee, Gregory Nolens, Justine Pirson, Liesbet Geris, France Lambert
Summary: Utilizing a simulation approach to optimize the internal design of calcium phosphate-based scaffolds for bone regeneration showed promising results. The gyroid experimental internal architecture demonstrated high potential for intra-oral bone regeneration applications.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Construction & Building Technology
Baoying Yu, Jianwei Zhou, Baojun Cheng, Wen Yang
Summary: The study found that the hardened MPC stone is a ceramic-like structure, which will be disrupted when aggregate is added, resulting in a weak interface transition zone, but still maintaining a high compressive strength.
CONSTRUCTION AND BUILDING MATERIALS
(2021)
Article
Materials Science, Ceramics
Chong Chen, Yongzhuang Dong, Can Hu, Yong Du, Shizhong Wei, Jianzhan Long, Changji Wang, Liqiang Xiao, Feng Mao
Summary: This study investigates the possibility of using Ni3Al phase as an alternative binder in WC/TiC/Ti(C,N)-based cermets and successfully fabricates gradient cemented carbide with Ni3Al binder. The gradient carbide exhibits excellent stability, high temperature performance, and oxidation resistance, showing great potential for various applications.
CERAMICS INTERNATIONAL
(2022)
Article
Polymer Science
Zhao Kai, Imjoo Jung, Sunhee Lee
Summary: The purpose of this study was to develop conductivity 3D printed fingertips and confirm their potential for use in a pressure sensor. Index fingertips were 3D printed using thermoplastic polyurethane filament with three types of infill patterns and densities. The coated 3DP index fingertips were analyzed for appearance property, weight changes, compressive property, and electrical property.
Article
Biophysics
Fupo He, Jin Rao, Jielin Zhou, Wenhao Fu, Yao Wang, Yihang Zhang, Fei Zuo, Haishan Shi
Summary: Magnesium calcium phosphate composite bioceramic scaffolds were fabricated using 3D printing technology with Mg3(PO4)2 and β-Ca3(PO4)2 as starting materials. The porosity and compressive strength of the scaffolds could be adjusted by altering the sintering temperature and the formula of starting materials. The Ca3Mg3(PO4)4-based bioceramic scaffolds, prepared from 60 wt% Mg3(PO4)2 and 40 wt% β-Ca3(PO4)2, showed the highest compressive strength and stimulated cellular growth and osteoblastic differentiation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Materials Science, Ceramics
Hanxu Zhang, Chen Jiao, Zhijing He, Mengxing Ge, Zongjun Tian, Changjiang Wang, Zhen Wei, Lida Shen, Huixin Liang
Summary: In this study, porous zirconia scaffolds were coated with calcium silicate and hydroxyapatite using 3D printing technology to improve biological activity and mechanical properties. The coating material effectively filled the pores and increased compressive strength. Higher calcium silicate content in the coating increased degradation rate and showed good cytocompatibility with cell proliferation and differentiation. Coated scaffolds have potential applications in bone repair.
CERAMICS INTERNATIONAL
(2021)
Article
Engineering, Biomedical
Peifang Dee, Sharlene Tan, Hortense Le Ferrand
Summary: This study utilized a direct material extrusion approach to 3D print water-based inks containing CaP microplatelets, resulting in microstructured scaffolds with various designs. The versatile CaP microstructured objects demonstrated good shape retention and print fidelity. The extruded filaments featured a core-shell microstructure with graded microplatelet orientations, providing potential for use in hard tissue engineering applications.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2022)
Article
Engineering, Biomedical
Jiawei Liu, Wen Hou, Wenying Wei, Jian Peng, Xiaopei Wu, Chenxi Lian, Yanan Zhao, Rong Tu, Takashi Goto, Honglian Dai
Summary: This study proposes a strategy to develop high-performance bone cement and establishes a trimagnesium phosphate cement (TMPC) system. The TMPC exhibits high early strength, low curing temperature, neutral pH, and excellent injectability, overcoming the critical limitations of recently studied magnesium phosphate cement. By adjusting the pH of the system, the magnesium-to-phosphate ratio can manipulate the components of hydration products and their transformation, as well as influence the hydration speed and regulate the properties of TMPC. Moreover, TMPC shows outstanding biocompatibility and bone-filling capacity, making it a potential alternative to current bone cements.
BIOACTIVE MATERIALS
(2023)
Article
Agricultural Engineering
Yinglian Zheng, Xiaoli Sun, Xinping Liu, Xinshu Xia, Liren Xiao, Changlin Cao, Qingrong Qian, Qinghua Chen
Summary: This study proposes a strategy to improve the adsorption efficiency of methylene blue on a 3D-printed camellia seed powder scaffold. The scaffold with enhanced porosity through water erosion shows significantly higher removal efficiency and faster adsorption speed. The scaffold with water erosion demonstrates good reusability, suggesting potential for high-efficiency dye molecule removal.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Materials Science, Multidisciplinary
Bocheng Lei, Xiaobo Gao, Ran Zhang, Xin Yi, Qing Zhou
Summary: The PCL#20MgP scaffold prepared by 3D printing technology has strong ability to promote osteogenic differentiation and bone formation, which is suitable for the repair of maxillofacial bone defects.
MATERIALS & DESIGN
(2022)
Article
Materials Science, Ceramics
Farzin Shadianlou, Abolfazl Foorginejad, Yadollah Yaghoubinezhad
Summary: This study evaluated the effect of reduced graphene oxide (RGO) alongside hydroxyapatite (HA) in the mechanical and biological properties of fabricated scaffolds. The results showed that the addition of 2%wt.RGO in the ZrO2/HA matrix exhibited desirable behavior, with increased compressive strength after heat treatment and further enhancement in simulated body fluid. The MTT assay demonstrated no negative cellular interaction and favorable impact on cell adhesion.
CERAMICS INTERNATIONAL
(2022)
Article
Thermodynamics
Zhaoshu Chen, Yong Li, Jiu Yu, Liqiang Deng, Hanyin Chen, Xinkai Tang
Summary: A new method for manufacturing large-area and complex-shaped UTVCs using a screen-printed copper powder wick has been proposed in this study. The heat transfer performance of UTVCs under different liquid-filling ratios and test states has been investigated to optimize their thermal resistance and heat-transfer capability. This proposed manufacturing process provides a new solution for the research of thinner VC and patterned wick structures.
APPLIED THERMAL ENGINEERING
(2022)
Article
Materials Science, Biomaterials
Duy Quang Pham, Christopher C. Berndt, Jan Cizek, Uwe Gbureck, Hala Zreiqat, Zufu Lu, Andrew Siao Ming Ang
Summary: This study investigated the mechanical and biological properties of Baghdadite (BAG) coatings compared to Hydroxyapatite (HAp) coatings on Ti6Al4V substrates. Results showed that the BAG coating exhibited higher hardness, elastic modulus, better scratch and wear resistance, as well as improved human osteoblast attachment and proliferation compared to HAp. Additionally, gene expression analysis indicated higher levels of osteogenic genes on the BAG coating surface.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Anne Bernhardt, Jana Bacova, Uwe Gbureck, Michael Gelinsky
Summary: The study found that the effects of Cu2+ on osteoclasts varied depending on their differentiating or mature state. High TRAP activity does not necessarily correlate with high resorption capacity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Philipp Heilig, Phoebe Sandner, Martin Cornelius Jordan, Rafael Gregor Jakubietz, Rainer Heribert Meffert, Uwe Gbureck, Stefanie Hoelscher-Doht
Summary: Two new compositions of magnesium phosphate cements have been developed to meet clinical demands for high strength, injectability, and drillability. These cements exhibited a setting time of 5 min 30 s, compressive strength comparable to 12-13 MPa, and displacement of the reduced fracture <2 mm. The combination of these cements with screws also showed a higher maximum load until failure compared to using the cements alone.
Article
Chemistry, Physical
Lisa-Marie Gotz, Katharina Holeczek, Jurgen Groll, Tomasz Jungst, Uwe Gbureck
Summary: This study developed printable calcium magnesium phosphate pastes that can harden by immersion in ammonium phosphate solution. The pastes showed good dimensional stability and mechanical performance, making them promising materials for biomedical applications.
Article
Biotechnology & Applied Microbiology
Esther Reina-Romo, Sourav Mandal, Paulo Amorim, Veerle Bloemen, Eleonora Ferraris, Liesbet Geris
Summary: Research aims to quantify the mechanical environment experienced by bioink during 3D printing through in silico modeling, identifying factors influencing cell survival such as nozzle geometry and hydrogel material properties. Simulation results highlight the importance of nozzle radius, nozzle length, and material properties in affecting shear stress and cell viability during the printing process.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Andreas Fuchs, Dorothea Kreczy, Theresa Bruckner, Uwe Gbureck, Philipp Stahlhut, Melanie Bengel, Andreas Hoess, Berthold Nies, Julia Bator, Uwe Klammert, Christian Linz, Andrea Ewald
Summary: The study demonstrates that CaMgP granules exhibit excellent biocompatibility, fast and continuous degradation, and enable proper bone healing without the interposition of connective tissue. These characteristics make CaMgP granules a promising bone substitute material for bone augmentation procedures, especially in sensitive areas.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Engineering, Biomedical
Friederike Kaiser, Lena Schroeter, Svenja Stein, Benjamin Krueger, Jan Weichhold, Philipp Stahlhut, Anita Ignatius, Uwe Gbureck
Summary: Results of several studies have shown that magnesium phosphate cements (MPCs) have excellent biocompatibility, osteoconductivity, and higher solubility compared to calcium phosphates, making them promising alternatives to slowly degrading calcium phosphate cements. Decreasing the powder-liquid ratio (PLR) of the cement can further improve the degradation speed, with the potential for fast bone ingrowth within a few months. However, further modifications may be needed, especially for the K-struvite cement, to achieve a slower resorption and reduced inflammatory response in vivo.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Annika Seifert, Tina Tylek, Carina Blum, Naomi Hemmelmann, Bettina Boettcher, Uwe Gbureck, Juergen Groll
Summary: This study investigated the response of human macrophages to different CaPs and pore structures. The study found that macrophages are capable of releasing ETs in biomaterials, and METs associated with calcium deficient hydroxyapatite were significantly weaker or absent.
Article
Engineering, Biomedical
Michaela Roedel, Joerg Tessmar, Juergen Groll, Uwe Gbureck
Summary: A novel dual setting brushite-gelatin cement with genip-initiated cross-linking of gelatin was developed. The addition of gelatin hydrogel with a concentration of 10.0 w/v% improved the elastic properties, although it resulted in a decrease in compressive strength. The composites with a powder-to-liquid ratio of 2.5 g*mL(-1) exhibited pseudo-ductile fracture behavior during compression testing.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2022)
Article
Engineering, Biomedical
Philipp Heilig, Martin Cornelius Jordan, Mila Marie Paul, Eva Kupczyk, Rainer Heribert Meffert, Uwe Gbureck, Stefanie Hoelscher-Doht
Summary: The study shows that the pullout strength and stiffness of suture anchors can be significantly increased in bone by filling it with magnesium phosphate cement. SwiveLock C anchors perform better when reinforced with additional FibreWire.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Lena Scheller, Stephanie Bachmann, Theresa Zorn, Simon Hanio, Uwe Gbureck, Dimitrios Fatouros, Ann-Christin Poppler, Lorenz Meinel
Summary: In this study, the solidification of drug-loaded microemulsion preconcentrates with the acid-sensitive metal-organic framework ZIF-8 was detailed using various analytical techniques. Nile Red, Vitamin K1, and Lumefantrine were used as model compounds to analyze the adsorption and desorption dynamics. The loaded preconcentrates and drugs were successfully preserved in the crystal structure of ZIF-8, which could be pressed into tablets or 3D-printed into oral dosage forms. The stimuli-responsive metal organic frameworks have the potential to form colloidal microemulsions in solid dosage forms for oral delivery of lipid-based formulations.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Engineering, Biomedical
Yassine Ouhaddi, Baptiste Charbonnier, Juliette Porge, Yu-Ling Zhang, Isadora Garcia, Uwe Gbureck, Liam Grover, Mirko Gilardino, Edward Harvey, Nicholas Makhoul, Jake Barralet
Summary: In this study, we investigated the response of blood vessels to surgical injury or placement of an inorganic construct, and found that only calcium phosphate induced a significant angiogenic response. We also identified changes in macrophage and smooth muscle cell populations, as well as the activation of NLRP3 inflammasome and sustained expression of IL-1 beta. These findings suggest a potential role of sterile inflammation in biomaterial-induced angiogenesis, and provide a new strategy for creating better pro-regenerative biomaterials.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Andreas Fuchs, Michael Bartolf-Kopp, Hartmut Boehm, Anton Straub, Alexander C. C. Kuebler, Christian Linz, Uwe Gbureck
Summary: Composite grafts made of self-setting and oil-based calcium phosphate cement (CPC) pastes, reinforced with 3D-printed polycaprolactone (PCL) fiber mats, can be adapted to various bony defects in oral and maxillofacial surgery. The PCL-reinforced CPC samples have good processability and a high precision of fit, with increased clinical handling properties.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Engineering, Biomedical
Tobias Renner, Paul Otto, Alexander C. Kuebler, Stefanie Hoelscher-Doht, Uwe Gbureck
Summary: A bone adhesive for use in surgeries is currently not available. Phosphoserine modified cements (PMC) based on mixtures of OPLS and calcium phosphates, as well as chelate setting magnesium phosphate cements, have gained popularity. New mineral-organic bone cements based on phosphoserine and magnesium phosphates or oxides were investigated for their adhesive properties. The novel adhesives demonstrated excellent bond strength to bone and outperformed currently available adhesives.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2023)
Meeting Abstract
Cell & Tissue Engineering
Sourav Mandal, Esther Reina-Romo, Nina Van Steenvoort, Paulo Amorim, Veerle Bloemen, Eleonora Ferraris, Liesbet Geris
TISSUE ENGINEERING PART A
(2022)