Sphingolipid changes do not underlie fatty acid-evoked GLUT4 insulin resistance nor inflammation signals in muscle cells

Could Ceramides Become the New Cholesterol?

(2018) Scott A. Summers   Cell Metabolism

Sphingolipids and Lipoproteins in Health and Metabolic Disorders

(2017) Jahangir Iqbal et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Distinct Akt phosphorylation states are required for insulin regulated Glut4 and Glut1-mediated glucose uptake

(2017) Muheeb Beg et al.   eLife

LA and ALA prevent glucose intolerance in obese male rats without reducing reactive lipid content, but cause tissue-specific changes in fatty acid composition

(2016) Sarthak Matravadia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Diminished anabolic signaling response to insulin induced by intramuscular lipid accumulation is associated with inflammation in aging but not obesity

(2016) Donato A. Rivas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Oleate dose-dependently regulates palmitate metabolism and insulin signaling in C2C12 myotubes

(2016) Frédéric Capel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Characterization of the role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice

(2016) Masayuki Sugimoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism

(2016) Bhagirath Chaurasia et al.   Cell Metabolism

The Crucial Role of C18-Cer in Fat-Induced Skeletal Muscle Insulin Resistance

(2016) Agnieszka U. Blachnio-Zabielska et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

A Role for Ceramides, but Not Sphingomyelins, as Antagonists of Insulin Signaling and Mitochondrial Metabolism in C2C12 Myotubes

(2016) Min Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitic acid feeding increases ceramide supply in association with increased milk yield, circulating nonesterified fatty acids, and adipose tissue responsiveness to a glucose challenge

(2016) J.E. Rico et al.   JOURNAL OF DAIRY SCIENCE

CrossTalk opposing view: Intramyocellular ceramide accumulation does not modulate insulin resistance

(2016) Max C. Petersen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Evaluation of treadmill exercise effect on muscular lipid profiles of diabetic fatty rats by nanoflow liquid chromatography–tandem mass spectrometry

(2016) Jong Cheol Lee et al.   Scientific Reports

Selective Insulin Resistance in Adipocytes

(2015) Shi-Xiong Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of sphingolipid metabolism with calorie restriction enhances insulin action in skeletal muscle

(2015) Diana N. Obanda et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Impaired mitochondrial fat oxidation induces adaptive remodeling of muscle metabolism

(2015) Shawna E. Wicks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of CeramideDe NovoSynthesis Ameliorates Diet Induced Skeletal Muscles Insulin Resistance

(2015) Krzysztof Kurek et al.   Journal of Diabetes Research

Muscle ectopic fat deposition contributes to anabolic resistance in obese sarcopenic old rats through eIF2α activation

(2014) Nicolas Tardif et al.   AGING CELL

Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation

(2014) Amira Klip et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Training status diverges muscle diacylglycerol accumulation during free fatty acid elevation

(2014) Lisa S. Chow et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance

(2014) Sarah M. Turpin et al.   Cell Metabolism

Insulin-Sensitizing Effect of LXR Agonist T0901317 in High-Fat Fed Rats is Associated with Restored Muscle GLUT4 Expression and Insulin-Stimulated AS160 Phosphorylation

(2014) Marcin Baranowski et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Nucleotides Released From Palmitate-Challenged Muscle Cells Through Pannexin-3 Attract Monocytes

(2014) Nicolas J. Pillon et al.   DIABETES

Chronic muscle stimulation improves insulin sensitivity while increasing subcellular lipid droplets and reducing selected diacylglycerol and ceramide species in obese Zucker rats

(2014) Graham P. Holloway et al.   DIABETOLOGIA

Skeletal muscle ceramide species in men with abdominal obesity

(2014) Maria Pia de la Maza et al.   Journal of Nutrition Health & Aging

Inhibition of neutral sphingomyelinases in skeletal muscle attenuates fatty-acid induced defects in metabolism and stress

(2014) Mahesh Verma et al.   SpringerPlus

Mechanisms Underlying the Onset of Oral Lipid-Induced Skeletal Muscle Insulin Resistance in Humans

(2013) B. Nowotny et al.   DIABETES

Ceramide accumulation in L6 skeletal muscle cells due to increased activity of ceramide synthase isoforms has opposing effects on insulin action to those caused by palmitate treatment

(2013) Georgia Frangioudakis et al.   DIABETOLOGIA

A sustained increase in plasma NEFA upregulates the Toll-like receptor network in human muscle

(2013) Sophie E. Hussey et al.   DIABETOLOGIA

PI3 kinase directly phosphorylates Akt1/2 at Ser473/474 in the insulin signal transduction pathway

(2013) A Tsuchiya et al.   JOURNAL OF ENDOCRINOLOGY

Effect of a sustained reduction in plasma free fatty acid concentration on insulin signalling and inflammation in skeletal muscle from human subjects

(2013) Hanyu Liang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pro-Inflammatory macrophages increase in skeletal muscle of high fat-Fed mice and correlate with metabolic risk markers in humans

(2013) Lisbeth N. Fink et al.   Obesity

Effects of Inhibition of Serine Palmitoyltransferase (SPT) and Sphingosine Kinase 1 (SphK1) on Palmitate Induced Insulin Resistance in L6 Myotubes

(2013) Agnieszka Mikłosz et al.   PLoS One

Ceramides Contained in LDL Are Elevated in Type 2 Diabetes and Promote Inflammation and Skeletal Muscle Insulin Resistance

(2012) J. Boon et al.   DIABETES

The Sphingosine-1-Phosphate Analog FTY720 Reduces Muscle Ceramide Content and Improves Glucose Tolerance in High Fat-Fed Male Mice

(2012) Clinton R. Bruce et al.   ENDOCRINOLOGY

Plasma sphingolipids are biomarkers of metabolic syndrome in non-human primates maintained on a Western-style diet

(2012) J T Brozinick et al.   INTERNATIONAL JOURNAL OF OBESITY

Fenretinide Prevents Lipid-induced Insulin Resistance by Blocking Ceramide Biosynthesis

(2012) Benjamin T. Bikman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complete failure of insulin-transmitted signaling, but not obesity-induced insulin resistance, impairs respiratory chain function in muscle

(2012) A. Franko et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Role of intramyocelluar lipids in human health

(2012) Paul M. Coen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Insulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: The effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids

(2011) Y.Y. Lam et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance: Another Paradox in Endurance-Trained Athletes?

(2011) F. Amati et al.   DIABETES

Plasma deoxysphingolipids: a novel class of biomarkers for the metabolic syndrome?

(2011) A. Othman et al.   DIABETOLOGIA

Amplification and Demultiplexing in Insulin-regulated Akt Protein Kinase Pathway in Adipocytes

(2011) Shi-Xiong Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

Contraction-related stimuli regulate GLUT4 traffic in C2C12-GLUT4myc skeletal muscle cells

(2010) Wenyan Niu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Oral administration of a PPAR-δ agonist to rodents worsens, not improves, maximal insulin-stimulated glucose transport in skeletal muscle of different fibers

(2010) Justin Cresser et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Saturated- and n-6 Polyunsaturated-Fat Diets Each Induce Ceramide Accumulation in Mouse Skeletal Muscle: Reversal and Improvement of Glucose Tolerance by Lipid Metabolism Inhibitors

(2010) G. Frangioudakis et al.   ENDOCRINOLOGY

Influence of Gender, Obesity, and Muscle Lipase Activity on Intramyocellular Lipids in Sedentary Individuals

(2009) Cedric Moro et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Direct and macrophage-mediated actions of fatty acids causing insulin resistance in muscle cells

(2009) Phillip J. Bilan et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells

(2008) Maria L. Watson et al.   BIOCHEMICAL JOURNAL

Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity

(2008) M. Skovbro et al.   DIABETOLOGIA