IFN-γ orchestrates tumor elimination, tumor dormancy, tumor escape, and progression

The Role of Tissue Macrophage-Mediated Inflammation on NAFLD Pathogenesis and Its Clinical Implications

(2017) Anna Alisi et al.   MEDIATORS OF INFLAMMATION

IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting

(2017) Kazuyoshi Takeda et al.   Nature Communications

Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

(2016) Joseph L. Benci et al.   CELL

Tumor-reactive immune cells protect against metastatic tumor and induce immunoediting of indolent but not quiescent tumor cells

(2016) Kyle K. Payne et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IFN-γ from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer

(2015) K Abiko et al.   BRITISH JOURNAL OF CANCER

IRF-1 inhibits NF-κB activity, suppresses TRAF2 and cIAP1 and induces breast cancer cell specific growth inhibition

(2015) Michaele J Armstrong et al.   CANCER BIOLOGY & THERAPY

Biological and Therapeutic Impact of Intratumor Heterogeneity in Cancer Evolution

(2015) Nicholas McGranahan et al.   CANCER CELL

Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis Is Marked by a Higher Frequency of Th17 Cells in the Liver and an Increased Th17/Resting Regulatory T Cell Ratio in Peripheral Blood and in the Liver

(2015) Monika Rau et al.   JOURNAL OF IMMUNOLOGY

Interferon-γ-induced activation of JAK1 and JAK2 suppresses tumor cell susceptibility to NK cells through upregulation of PD-L1 expression

(2015) Roberto Bellucci et al.   OncoImmunology

Interferon-gamma induced cell death: Regulation and contributions of nitric oxide, cJun N-terminal kinase, reactive oxygen species and peroxynitrite

(2014) Srabanti Rakshit et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

High STAT1 mRNA levels but not its tyrosine phosphorylation are associated with macrophage infiltration and bad prognosis in breast cancer

(2014) Piotr Tymoszuk et al.   BMC CANCER

Real-Time Detection of CTL Function Reveals Distinct Patterns of Caspase Activation Mediated by Fas versus Granzyme B

(2014) Jinzhu Li et al.   JOURNAL OF IMMUNOLOGY

Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the U.S.

(2013) Robert J. Wong et al.   HEPATOLOGY

The adaptation model of immunity

(2013) Masoud H Manjili   Immunotherapy

Doxorubicin sensitizes human tumor cells to NK cell- and T-cell-mediated killing by augmented TRAIL receptor signaling

(2013) Erik Wennerberg et al.   INTERNATIONAL JOURNAL OF CANCER

Tumor STAT1 Transcription Factor Activity Enhances Breast Tumor Growth and Immune Suppression Mediated by Myeloid-derived Suppressor Cells

(2013) Laura M. Hix et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Radiation-Induced Equilibrium Is a Balance between Tumor Cell Proliferation and T Cell-Mediated Killing

(2013) H. Liang et al.   JOURNAL OF IMMUNOLOGY

IFN-γ Rα Is a Key Determinant of CD8+ T Cell-Mediated Tumor Elimination or Tumor Escape and Relapse in FVB Mouse

(2013) Maciej Kmieciak et al.   PLoS One

HER-2 pulsed dendritic cell vaccine can eliminate HER-2 expression and impact ductal carcinoma in situ

(2012) Anupama Sharma et al.   CANCER

Interferon-γ-induced activation of Signal Transducer and Activator of Transcription 1 (STAT1) up-regulates the tumor suppressing microRNA-29 family in melanoma cells

(2012) Martina J Schmitt et al.   Cell Communication and Signaling

NF-κB1 deficiency stimulates the progression of non-alcoholic steatohepatitis (NASH) in mice by promoting NKT-cell-mediated responses

(2012) Irene Locatelli et al.   CLINICAL SCIENCE

Role of Obesity and Lipotoxicity in the Development of Nonalcoholic Steatohepatitis: Pathophysiology and Clinical Implications

(2012) Kenneth Cusi   GASTROENTEROLOGY

Interferon-gamma induces autophagy with growth inhibition and cell death in human hepatocellular carcinoma (HCC) cells through interferon-regulatory factor-1 (IRF-1)

(2011) Peiyuan Li et al.   CANCER LETTERS

Interferon-γ links ultraviolet radiation to melanomagenesis in mice

(2011) M. Raza Zaidi et al.   NATURE

Early-stage formation of an epigenetic field defect in a mouse colitis model and non-essential roles of T- and B-cells in DNA methylation induction

(2011) M Katsurano et al.   ONCOGENE

STAT1 interacts directly with cyclin D1/Cdk4 and mediates cell cycle arrest

(2010) Gloria Dimco et al.   CELL CYCLE

Population-based risk factors and resource utilization for HCC: US perspective

(2010) A. Sanyal et al.   CURRENT MEDICAL RESEARCH AND OPINION

IFN  Promotes Papilloma Development by Up-regulating Th17-Associated Inflammation

(2009) M. Xiao et al.   CANCER RESEARCH

Immune-Induced Epithelial to Mesenchymal Transition In vivo Generates Breast Cancer Stem Cells

(2009) M. Santisteban et al.   CANCER RESEARCH

Molecular Mechanisms of IFN-γ to Up-Regulate MHC Class I Antigen Processing and Presentation

(2009) Fang Zhou   INTERNATIONAL REVIEWS OF IMMUNOLOGY

TNFR1 Signaling and IFN-γ Signaling Determine whether T Cells Induce Tumor Dormancy or Promote Multistage Carcinogenesis

(2008) Nele Müller-Hermelink et al.   CANCER CELL

IFN-γ Induces Apoptosis in HL-60 Cells Through Decreased Bcl-2 and Increased Bak Expression

(2008) Yan Zhou et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH