Frontline Science: Rapid adipose tissue expansion triggers unique proliferation and lipid accumulation profiles in adipose tissue macrophages

IL-6 Regulates M2 Polarization and Local Proliferation of Adipose Tissue Macrophages in Obesity

(2017) Julia Braune et al.   JOURNAL OF IMMUNOLOGY

CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors

(2017) Allah Nawaz et al.   Nature Communications

Adipose Tissue Dendritic Cells Are Independent Contributors to Obesity-Induced Inflammation and Insulin Resistance

(2016) Kae Won Cho et al.   JOURNAL OF IMMUNOLOGY

Osteopontin is a key player for local adipose tissue macrophage proliferation in obesity

(2016) Matteo Tardelli et al.   Molecular Metabolism

Surgical removal of inflamed epididymal white adipose tissue attenuates the development of non-alcoholic steatohepatitis in obesity

(2015) P Mulder et al.   INTERNATIONAL JOURNAL OF OBESITY

Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue Expansion

(2015) Nathalie Pamir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid-Overloaded Enlarged Adipocytes Provoke Insulin Resistance Independent of Inflammation

(2015) Jong In Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

(2015) Felix M Wensveen et al.   NATURE IMMUNOLOGY

Activation of NF-κB drives the enhanced survival of adipose tissue macrophages in an obesogenic environment

(2015) Andrea A. Hill et al.   Molecular Metabolism

Lipid storage by adipose tissue macrophages regulates systemic glucose tolerance

(2014) Myriam Aouadi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Naringenin suppresses macrophage infiltration into adipose tissue in an early phase of high-fat diet-induced obesity

(2014) Hiroki Yoshida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

(2014) Shinya U. Amano et al.   Cell Metabolism

An MHC II-Dependent Activation Loop between Adipose Tissue Macrophages and CD4+ T Cells Controls Obesity-Induced Inflammation

(2014) Kae Won Cho et al.   Cell Reports

Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells

(2014) Kanakadurga Singer et al.   Molecular Metabolism

Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation

(2013) Xiaoyuan Xu et al.   Cell Metabolism

Identification of an Adipogenic Niche for Adipose Tissue Remodeling and Restoration

(2013) Yun-Hee Lee et al.   Cell Metabolism

Local proliferation of macrophages in adipose tissue during obesity-induced inflammation

(2013) Julia Haase et al.   DIABETOLOGIA

Adipose Tissue Foam Cells Are Present in Human Obesity

(2013) Hagit Shapiro et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1

(2013) Stephen J. Jenkins et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tracking adipogenesis during white adipose tissue development, expansion and regeneration

(2013) Qiong A Wang et al.   NATURE MEDICINE

Short Term High Fat Diet Challenge Promotes Alternative Macrophage Polarization in Adipose Tissue via Natural Killer T Cells and Interleukin-4

(2012) Yewei Ji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CX3CR1 Deficiency Does Not Influence Trafficking of Adipose Tissue Macrophages in Mice With Diet-Induced Obesity

(2012) David L. Morris et al.   Obesity

Adipose tissue macrophages: phenotypic plasticity and diversity in lean and obese states

(2011) David L Morris et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice

(2011) Xavier Prieur et al.   DIABETES

Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet-Induced Insulin Resistance

(2011) Y. S. Lee et al.   DIABETES

Aberrant Accumulation of Undifferentiated Myeloid Cells in the Adipose Tissue of CCR2-Deficient Mice Delays Improvements in Insulin Sensitivity

(2011) Dario A. Gutierrez et al.   DIABETES

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation

(2010) Michael Spencer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Dynamic, M2-Like Remodeling Phenotypes of CD11c+ Adipose Tissue Macrophages During High-Fat Diet-Induced Obesity in Mice

(2010) M. E. Shaul et al.   DIABETES

Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity

(2010) J. M. Wentworth et al.   DIABETES

Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue

(2010) Aliki Kosteli et al.   JOURNAL OF CLINICAL INVESTIGATION

Osteopontin Is Required for the Early Onset of High Fat Diet-Induced Insulin Resistance in Mice

(2010) Justin Chapman et al.   PLoS One

Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity

(2010) Roger H. Unger et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Visceral Adipose Tissue and Atherosclerosis

(2009) Miina Ohman et al.   Current Vascular Pharmacology

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

(2008) Kihwa Kang et al.   Cell Metabolism

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

(2008) David Patsouris et al.   Cell Metabolism

Remodeling Phenotype of Human Subcutaneous Adipose Tissue Macrophages

(2008) V. Bourlier et al.   CIRCULATION