Heat-shock protein-90 prolongs septic neutrophil survival by protecting c-Src kinase and caspase-8 from proteasomal degradation

Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations

(2016) Carolin Fleischmann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Resveratrol Protects against Sepsis-Associated Encephalopathy and Inhibits the NLRP3/IL-1βAxis in Microglia

(2016) Da-ming Sui et al.   MEDIATORS OF INFLAMMATION

Histone deacetylase inhibitors prevent pulmonary endothelial hyperpermeability and acute lung injury by regulating heat shock protein 90 function

(2015) Atul D. Joshi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A randomized phase II study of ganetespib, a heat shock protein 90 inhibitor, in combination with docetaxel in second-line therapy of advanced non-small cell lung cancer (GALAXY-1)

(2015) S. Ramalingam et al.   ANNALS OF ONCOLOGY

Current challenges in understanding immune cell functions during septic syndromes

(2015) Zechariah Franks et al.   BMC IMMUNOLOGY

Novel Hsp90 inhibitor FW-04-806 displays potent antitumor effects in HER2-positive breast cancer cells as a single agent or in combination with lapatinib

(2015) Wei Huang et al.   CANCER LETTERS

Intracellular signalling during neutrophil recruitment

(2015) Attila Mócsai et al.   CARDIOVASCULAR RESEARCH

The uncovering of ESE-1 in human neutrophils: implication of its role in neutrophil function and survival

(2015) C M Lee et al.   GENES AND IMMUNITY

The HSP90 inhibitor ganetespib: A potential effective agent for Acute Myeloid Leukemia in combination with cytarabine

(2015) M. Lazenby et al.   LEUKEMIA RESEARCH

Heat shock protein 90 inhibition abrogates TLR4-mediated NF-κB activity and reduces renal ischemia-reperfusion injury

(2015) Stephen O’Neill et al.   Scientific Reports

HSP90 Inhibition Suppresses Lipopolysaccharide-Induced Lung Inflammation In Vivo

(2015) Andrew Lilja et al.   PLoS One

Inhibitory effects of heat shock protein 90 blockade on proinflammatory human Th1 and Th17 cell subpopulations

(2014) Stefan Tukaj et al.   Journal of Inflammation-London

Why have clinical trials in sepsis failed?

(2014) John C. Marshall   TRENDS IN MOLECULAR MEDICINE

The -144C/A Polymorphism in the Promoter of HSP90beta Is Associated with Multiple Organ Dysfunction Scores

(2013) Yan Zhao et al.   PLoS One

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

The role of neutrophils during intestinal inflammation

(2012) B M Fournier et al.   Mucosal Immunology

Spotlight on the microbes that produce heat shock protein 90-targeting antibiotics

(2012) P. W. Piper et al.   Open Biology

Evolution and function of diverse Hsp90 homologs and cochaperone proteins

(2011) Jill L. Johnson   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

17-DMAG targets the nuclear factor- B family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition

(2010) E. Hertlein et al.   BLOOD

In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days

(2010) J. Pillay et al.   BLOOD

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TLR4/MyD88/PI3K interactions regulate TLR4 signaling

(2009) Michelle H. W. Laird et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Src kinase participates in LPS-induced activation of NADPH oxidase

(2009) Jennifer Check et al.   MOLECULAR IMMUNOLOGY

Heat Shock Protein 90 Inhibitors Protect and Restore Pulmonary Endothelial Barrier Function

(2008) Alexander Antonov et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Innate immunity meets with cellular stress at the IKK complex: Regulation of the IKK complex by HSP70 and HSP90

(2008) Antero Salminen et al.   IMMUNOLOGY LETTERS