Article
Biochemistry & Molecular Biology
Ying Yu, Yingjie Shen, Siyi Zhang, Nan Wang, Lan Luo, Xinyi Zhu, Xiejun Xu, Weitao Cong, Litai Jin, Zhongxin Zhu
Summary: The study demonstrates that FGF21 can suppress inflammation induced by C. acnes through counteracting activation of TLR2, NF-κB, and MAPK signaling pathways and reducing the expression of inflammatory cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Xu Chen, Manli Miao, Meng Zhou, Jie Chen, Dapeng Li, Ling Zhang, Anjiang Sun, Minglong Guan, Zixi Wang, Ping Liu, Shengquan Zhang, Xiaojun Zha, Xiaoyun Fan
Summary: In asthma, PLA activates the mTORC1-STAT3-FGFBP1 signaling pathway, leading to increased FGFBP1 expression in airway epithelial cells and promoting angiogenesis, impacting the development and treatment of asthma.
CELL DEATH & DISEASE
(2021)
Article
Chemistry, Medicinal
Krzysztof K. Bojarski, Sergey A. Samsonov
Summary: This study analyzed the impact of GAG chain polarity on interactions with Fibroblast Growth Factors-1 and -2, finding that while they can be bound by the proteins at the same binding sites, they may orient differently, with the orientation present in the experimental structure being more favorable.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2021)
Review
Neurosciences
Qingxiang Zhang, Zhiguo Chen, Kaili Zhang, Jie Zhu, Tao Jin
Summary: This article reviews the role of fibroblast growth factor (FGF) signaling pathway in progressive multiple sclerosis and its potential as a therapeutic target. FGF signaling is involved in oligodendrocyte lineage, neural stem cell proliferation and differentiation, central nervous system myelination, and neuroinflammation control. Recent interventions targeting FGF and its receptor (FGFR) have shown moderate improvement in autoimmune encephalomyelitis symptoms in multiple sclerosis animal models.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Endocrinology & Metabolism
Giovanni Vitale, Alessia Cozzolino, Pasqualino Malandrino, Roberto Minotta, Giulia Puliani, Davide Saronni, Antongiulio Faggiano, Annamaria Colao
Summary: Neuroendocrine neoplasms are tumors originating from neuroendocrine cells in different organs, with dysregulation of receptor tyrosine kinases playing a crucial role in their development and progression. Research on the role of the fibroblast growth factor receptor system in NENs and the potential of FGFR selective inhibitors shows promising anti-tumor activity in advanced NEN patients, with further studies needed for confirmation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Physical
Jana Mikesova, Daria Miliaieva, Pavla Stenclova, Marek Kindermann, Tereza Vuckova, Marcela Madlikova, Milan Fabry, Vaclav Veverka, Jiri Schimer, Pavel Krejci, Stepan Stehlik, Petr Cigler
Summary: Fibroblast growth factors (FGFs) play a crucial role in regulating mammalian development, metabolism, and homeostasis. Recent research has identified detonation nanodiamonds (NDs) with positive zeta-potential as effective binders of FGF molecules, preventing their interaction with receptors. In this study, the researchers investigated the influence of ND origin, surface modification, size, and purification steps on the binding affinity of FGF2, a representative member of the FGF family.
Review
Medicine, Research & Experimental
Hao Chen, Jiazhou Li, Demao Zhang, Xuedong Zhou, Jing Xie
Summary: The fibroblast growth factor family (FGFs) are cytokines that play crucial roles in growth, development, metabolism, and diseases, with FGF19 showing spatial-temporal gene expression specificity in the skeletal system and influencing bone-related diseases.
Article
Biochemistry & Molecular Biology
Nuo-qi Wang, Wei-hua Jia, Lin Yin, Na Li, Mei-dai Liang, Jia-min Shang, Bi-yu Hou, Li Zhang, Gui-fen Qiang, Guan-hua Du, Xiu-ying Yang
Summary: This study investigates the influence of diabetes and sex on the expression patterns of FGFs in normal and diabetic wound healing in mice. The expression patterns of Fgfs were affected by sex in both normal and diabetic mice during wound healing. In addition, sex differentially influenced the expression patterns of Fgfrs in non-wound skin and wounds in both normal and diabetic mice. Female mice had larger wound areas in the early stage of wound healing.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Kento Takaya, Noriko Aramaki-Hattori, Shigeki Sakai, Keisuke Okabe, Toru Asou, Kazuo Kishi
Summary: Skin wounds in developing mouse fetuses can heal without scar formation, unlike adult mammalian wounds. It has been found that the fibroblast growth factor (FGF) family plays a crucial role in fetal wound healing, with FGF7 potentially being associated with scar formation. Administration of FGF7 can inhibit fibrosis and promote epithelialization, providing a potential therapeutic option for scarless wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Savalan Babapoor-Farrokhran, Deanna Gill, Jafar Alzubi, Sumeet K. Mainigi
Summary: Atrial fibrillation (AF) is a common arrhythmia associated with hypoxia and the HIF pathway. Certain cytokines may serve as biomarkers for AF, aiding in diagnosis and treatment. Targeting these cytokines shows promise for the management of AF.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Review
Virology
Giulia Lottini, Erika Plicanti, Michele Lai, Paola Quaranta, Mauro Pistello, Giulia Freer
Summary: Fibroblast growth factors (FGFs) are important proteins in the development and maintenance of various tissues in the body. In addition to their role in cancer development, recent studies suggest that FGFs also play a virus-specific role in the regulation of the immune response during viral infections. Further research is needed to fully understand the effects and mechanisms of FGFs during viral infection and determine their potential as a therapeutic approach.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marlena Typiak, Tomasz Kulesza, Patrycja Rachubik, Dorota Rogacka, Irena Audzeyenka, Stefan Angielski, Moin A. Saleem, Agnieszka Piwkowska
Summary: Studies have shown that Klotho protein has a positive impact on renal function under hyperglycemic conditions, increasing FGFR levels and improving glycolytic rates and albumin permeability of podocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lucas M. O'Neill, Yar Xin Phang, Zhaojin Liu, Sarah A. Lewis, Ahmed Aljohani, Ayren McGahee, Gina Wade, Mugagga Kalyesubula, Judith Simcox, James M. Ntambi
Summary: SCD1 deficiency enhances insulin signaling and whole-body glucose uptake, and protects against high-carbohydrate diet-induced obesity. IGFBP1 is significantly elevated in GKO and LKO mice, regulated by oleic acid (18:1n9).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Alessio Ardizzone, Valentina Bova, Giovanna Casili, Alberto Repici, Marika Lanza, Raffaella Giuffrida, Cristina Colarossi, Marzia Mare, Salvatore Cuzzocrea, Emanuela Esposito, Irene Paterniti
Summary: Cancer, the leading cause of death worldwide, requires successful strategies for treatment. Growth factors like VEGF, bFGF, and TGF-beta play significant roles in tumor growth, activating essential signaling pathways and promoting cell proliferation, angiogenesis, and metastasis. Specifically, bFGF is secreted by tumor cells and interacts with its receptors (FGFRs), leading to tumor cell proliferation, invasion, and upregulation of pro-inflammatory and anti-apoptotic proteins. Studies have focused on developing therapeutic strategies targeting the bFGF/FGFR axis, considering its involvement in oncogenesis. This review comprehensively examines the biological mechanisms of bFGF in the tumor microenvironment, available anticancer therapies targeting FGFRs, and the prognostic value of bFGF.
Article
Biochemistry & Molecular Biology
Beatrice Richter, Tamar Kapanadze, Nina Weingaertner, Stefanie Walter, Isabel Vogt, Andrea Grund, Jessica Schmitz, Jan Hinrich Braesen, Florian P. Limbourg, Dieter Haffner, Maren Leifheit-Nestler
Summary: High phosphate intake may lead to progressive kidney injury and represents an underestimated health problem for kidney health.
Article
Allergy
Stephanie Musiol, Carla P. Harris, Ruth Karlina, Johanna M. Gostner, Birgit Rathkolb, Benjamin Schnautz, Evelyn Schneider, Lisa Mair, Ernesto Elorduy Vergara, Claudia Flexeder, Sibylle Koletzko, Carl-Peter Bauer, Tamara Schikowski, Dietrich Berdel, Andrea von Berg, Gunda Herberth, Jan Rozman, Martin Hrabe de Angelis, Marie Standl, Carsten B. Schmidt-Weber, Siegfried Ussar, Francesca Alessandrini
Summary: This study investigated the association between starch, sucrose, and fat in relation to allergic sensitization and asthma prevalence in humans, as well as their underlying mechanisms using mouse models. The findings suggest that high consumption of digestible carbohydrates is associated with an increased prevalence of asthma in humans and aggravated lung allergic inflammation in mice, involving oxidative stress-related mechanisms.
Article
Biochemistry & Molecular Biology
Lillian Garrett, Dietrich Truembach, Nadine Spielmann, Wolfgang Wurst, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe De Angelis, Sabine M. Hoelter
Summary: Neuropsychiatric diseases represent a significant global disease burden and require innovative approaches for pathogenic understanding, biomarker identification, and therapeutic strategies. The malfunction of the heart/brain axis, particularly through the autonomic nervous system and brain central autonomic network interaction, plays a crucial role in the etiology of these diseases. This inter-relationship offers potential avenues for novel diagnosis and treatment approaches.
Article
Immunology
Debolina Ganguly, Marcel O. Schmidt, Morgan Coleman, Tuong-Vi Cindy Ngo, Noah Sorrelle, Adrian T. A. Dominguez, Gilbert Z. Murimwa, Jason E. Toombs, Cheryl Lewis, Yisheng V. Fang, Fatima Valdes-Mora, David Gallego-Ortega, Anton Wellstein, Rolf A. Brekken
Summary: Metastatic cancer cells adapt to secondary organs by producing PTN and activating the NF-kappa B pathway, leading to increased cytokine production, neutrophil recruitment, and T cell dysfunction. Targeting PTN presents a promising addition to the current regimen for treating metastatic TNBC.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Manuela A. Oestereicher, Janine M. Wotton, Shinya Ayabe, Ghina Bou About, Tsz Kwan Cheng, Jae-Hoon Choi, Dave Clary, Emily M. Dew, Lahcen Elfertak, Alain Guimond, Hamed Haseli Mashhadi, Jason D. Heaney, Lois Kelsey, Piia Keskivali-Bond, Federico Lopez Gomez, Susan Marschall, Michael McFarland, Hamid Meziane, Violeta Munoz Fuentes, Ki-Hoan Nam, Zuzana Nichtova, Dale Pimm, Lynette Bower, Jan Prochazka, Jan Rozman, Luis Santos, Michelle Stewart, Nobuhiko Tanaka, Christopher S. Ward, Amelia M. E. Willett, Robert Wilson, Robert E. Braun, Mary E. Dickinson, Ann M. Flenniken, Yann Herault, K. C. Kent Lloyd, Ann-Marie Mallon, Colin McKerlie, Stephen A. Murray, Lauryl M. J. Nutter, Radislav Sedlacek, Je Kyung Seong, Tania Sorg, Masaru Tamura, Sara Wells, Elida Schneltzer, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Jacqueline K. White, Nadine Spielmann
Summary: This study provides the first reference ranges for electrocardiography in laboratory mice, which are important for diagnostic decision-making and pre-clinical scientific research.
Review
Biochemistry & Molecular Biology
Jiri Lindovsky, Zuzana Nichtova, Nathalia R. V. Dragano, David Pajuelo Reguera, Jan Prochazka, Helmut Fuchs, Susan Marschall, Valerie Gailus-Durner, Radislav Sedlacek, Martin Hrabe de Angelis, Jan Rozman, Nadine Spielmann
Summary: Cardiovascular diseases have a high mortality rate globally and pose a significant burden on health care systems. The International Mouse Phenotyping Consortium (IMPC) utilizes mouse models to study cardiovascular diseases and aims to target each protein-coding gene to examine multiple organ systems. This review discusses the recent advances of the IMPC in cardiac research, focusing on the diagnostic requirements for high-throughput electrocardiography and transthoracic echocardiography in mice. Additionally, it explores the relationship between metabolism and the heart, highlighting the phenotypes that emerge in knockout mice for certain genes and identifying novel loss-of-function genes affecting both metabolism and the cardiovascular system.
Article
Biochemistry & Molecular Biology
Christina Bukas, Isabella Galter, Patricia da Silva-Buttkus, Helmut Fuchs, Holger Maier, Valerie Gailus-Durner, Christian L. Mueller, Martin Hrabe de Angelis, Marie Piraud, Nadine Spielmann
Summary: Echo2Pheno is an automatic statistical learning workflow specifically designed for analyzing and interpreting high-throughput non-anesthetized transthoracic murine echocardiographic images. It accurately confirms known cardiovascular genotype-phenotype relationships and discovers novel genes causing altered cardiovascular phenotypes. This provides an important step toward automatic end-to-end learning for linking echocardiographic readouts to cardiovascular phenotypes in conscious mice.
Article
Biochemistry & Molecular Biology
Patricia da Silva-Buttkus, Nadine Spielmann, Tanja Klein-Rodewald, Christine Schuett, Antonio Aguilar-Pimentel, Oana V. Amarie, Lore Becker, Julia Calzada-Wack, Lillian Garrett, Raffaele Gerlini, Markus Kraiger, Stefanie Leuchtenberger, Manuela A. Oestereicher, Birgit Rathkolb, Adrian Sanz-Moreno, Claudia Stoeger, Sabine M. Hoelter, Claudia Seisenberger, Susan Marschall, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis
Summary: Rare diseases pose challenges in medicine due to their diverse clinical manifestations and low prevalence. The lack of specific treatments for the majority of rare diseases highlights the need for research. Genome sequencing technology allows for the identification of potential disease-causing genes, but further confirmation is required. Mouse knockout models are crucial for studying the genetics of rare diseases and the German Mouse Clinic is a pioneer in this field. Collaboration between research institutions, clinicians, and patient groups is necessary to advance the understanding and treatment of rare diseases.
Article
Oncology
Gregory T. T. Gallanis, Ghada M. M. Sharif, Marcel O. O. Schmidt, Benjamin N. N. Friedland, Rohith Battina, Raneen Rahhal, John E. E. Davis Jr, Irfan S. S. Khan, Anton Wellstein, Anna T. T. Riegel
Summary: CDK4/6 inhibitors (CDKis) are effective in treating hormone-receptor-positive breast cancer, but resistance is common. This study found that pretreatment with palbociclib can promote metastasis of CDKi-resistant cancer cells in the lungs by inducing cellular senescence in host tissues. Palbociclib-induced gene expression changes and altered immune populations were observed in the lungs, and senescent endothelial cells were identified in lung metastases. In vitro, palbociclib-treated endothelial cells exhibited senescent features and increased tumor cell migration and invasion. These findings highlight the impact of CDKi-induced cellular senescence on metastasis and provide insights into the tumor microenvironment.
Article
Medicine, Research & Experimental
Megan E. McNamara, Netanel Loyfer, Amber J. Kiliti, Marcel O. Schmidt, Sapir Shabi-Porat, Sidharth S. Jain, Sarah Martinez Roth, A. Patrick McDeed, Nesreen Shahrour, Elizabeth Ballew, Yun-Tien Lin, Heng-Hong Li, Anne Deslattes Mays, Sonali Rudra, Anna T. Riegel, Keith Unger, Tommy Kaplan, Anton Wellstein
Summary: We analyzed cell-free, methylated DNA released from dying cells into the circulation to evaluate radiation-induced cellular damage in different tissues. By mapping the circulating DNA fragments to human and mouse tissues, we found that cell-type-specific DNA blocks were mainly hypomethylated and located within signature genes of cellular identity. In a mouse model and in patients with breast cancer undergoing radiation treatment, changes in cell-free methylated DNA reflected tissue-specific responses to radiation.
Article
Biochemistry & Molecular Biology
Howard T. Jacobs, Marten Szibor, Birgit Rathkolb, Patricia da Silva-Buttkus, Juan Antonio Aguilar-Pimentel, Oana V. Amarie, Lore Becker, Julia Calzada-Wack, Nathalia Dragano, Lillian Garrett, Raffaele Gerlini, Sabine M. Hoelter, Tanja Klein-Rodewald, Markus Kraiger, Stefanie Leuchtenberger, Susan Marschall, Manuela A. Oestereicher, Kristina Pfannes, Adrian Sanz-Moreno, Claudia Seisenberger, Nadine Spielmann, Claudia Stoeger, Wolfgang Wurst, Helmut Fuchs, Martin Hrabe de Angelis, Valerie Gailus-Durner
Summary: The alternative oxidase (AOX) can delay the onset and progression of respiratory-chain diseases, but it does not provide long-term benefit.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Meng Yuan, Megan E. E. Barefoot, Kendell Peterson, Moray J. J. Campbell, Jan K. K. Blancato, Manjing Chen, Marcel O. O. Schmidt, Amber J. J. Kiliti, Hong-Bin Fang, Anton Wellstein, Anna T. T. Riegel, Ghada M. M. Sharif
Summary: Mutations in the ANKRD11/ANCO1 gene are implicated in neurodegenerative disorders and show loss of heterozygosity and low expression in certain cancers. This study demonstrates that low ANCO1 mRNA and protein expression levels are prognostic markers for poor clinical outcomes in breast cancer, particularly in the triple-negative subtype. Knockdown of ANCO1 in early-stage triple-negative breast cancer cells promotes aneuploidy, cellular senescence, and enhanced invasion. Loss of ANCO1 expression activates breast-cancer-specific enhancers and oncogenic pathways, accelerating the early-stage progression of breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Immunology
Henning Jacobsen, Kerstin Walendy-Gnirss, Nilgun Tekin-Bubenheim, Nancy Mounogou Kouassi, Isabel Ben-Batalla, Nikolaus Berenbrok, Martin Wolff, Vinicius Pinho dos Reis, Martin Zickler, Lucas Scholl, Annette Gries, Hanna Jania, Arne Duesedau, Gundula Pilnitz-Stolze, Aicha Jeridi, Ali O. Yildirim, Helmut Fuchs, Valerie Gailus-Durner, Claudia Stoeger, Martin Hrabe de Angelis, Tatjana Manuylova, Karin Klingel, Fiona J. Culley, Jochen Behrends, Sonja Loges, Bianca Schneider, Susanne Krauss-Etschmann, Peter Openshaw, Guelsah Gabriel
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Asrar Ali Khan, Gema Valera Vazquez, Montse Gustems, Rafaele Matteoni, Fei Song, Philipp Gormanns, Sabine Fessele, Michael Raess, Martin de Angelis, INFRAFRONTIER Consortium
Summary: INFRAFRONTIER has become a prominent research infrastructure in Europe for mouse model generation, phenotyping, archiving, and distribution. With a network of 22 partners from 15 countries, INFRAFRONTIER continuously expands its resources and services for the research community. By combining European rodent model expertise, INFRAFRONTIER aims to enhance accessibility of cutting-edge disease modelling technologies in Europe. The article provides an overview of INFRAFRONTIER's latest developments, its widely utilized services, resources, and technical advancements, including its database, Curated Disease Models, Cancer and Rare Disease resources, and state-of-the-art services.
Article
Endocrinology & Metabolism
Leona Kovac, Thomas Goj, Meriem Ouni, Martin Irmler, Markus Jaehnert, Johannes Beckers, Martin Hrabe De Angelis, Andreas Peter, Anja Moller, Andreas L. Birkenfeld, Cora Weigert, Annette Schuermann
Summary: Exercise training can improve glucose tolerance in obese individuals, but some may not respond positively. This study analyzed gene expression and DNA methylation in skeletal muscle of low and high responders to endurance training, identifying differences in gene expression and potential novel markers for intervention success.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)