The potential mechanism of mitochondrial dysfunction in septic cardiomyopathy

Human trypsin inhibitor reduces the apoptosis of lipopolysaccharide-induced human kidney-2 cells by promoting mitochondrial fusion

(2017) Ning Liu et al.   Molecular Medicine Reports

Resistance exercise improves cardiac function and mitochondrial efficiency in diabetic rat hearts

(2017) Tae Hee Ko et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

miRNA-133a-UCP2 pathway regulates inflammatory bowel disease progress by influencing inflammation, oxidative stress and energy metabolism

(2017) Xi Jin et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Endotoxemia Engages the RhoA Kinase Pathway to Impair Cardiac Function By Altering Cytoskeleton, Mitochondrial Fission, and Autophagy

(2016) Sebastien Preau et al.   ANTIOXIDANTS & REDOX SIGNALING

Cardiac-specific overexpression of thioredoxin 1 attenuates mitochondrial and myocardial dysfunction in septic mice

(2016) Juana P. Sánchez-Villamil et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Metabolic regulation of mitochondrial dynamics

(2016) Prashant Mishra et al.   JOURNAL OF CELL BIOLOGY

By Regulating Mitochondrial Ca2+-Uptake UCP2 Modulates Intracellular Ca2+

(2016) Lukas Jaroslaw Motloch et al.   PLoS One

Mitochondrial Function in Sepsis

(2016) Nishkantha Arulkumaran et al.   SHOCK

A PGC-1α-Mediated Transcriptional Network Maintains Mitochondrial Redox and Bioenergetic Homeostasis against Doxorubicin-Induced Toxicity in Human Cardiomyocytes: Implementation of TT21C

(2016) Haitao Yuan et al.   TOXICOLOGICAL SCIENCES

Mitochondrial Dynamics and Metabolic Regulation

(2016) Timothy Wai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Ischemic postconditioning protects the heart against ischemia–reperfusion injury via neuronal nitric oxide synthase in the sarcoplasmic reticulum and mitochondria

(2016) L Hu et al.   Cell Death & Disease

Measurement of Mitochondrial Respiration and Motility in Acute Care

(2016) David H. Jang et al.   JOURNAL OF INTENSIVE CARE MEDICINE

Omega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsis

(2016) Cassiano Felippe Gonçalves-de-Albuquerque et al.   PLoS One

Overexpression of Hypo-Phosphorylated IκBβ at Ser313 Protects the Heart against Sepsis

(2016) Guang-Qing Wang et al.   PLoS One

Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing Mitochondrial Biogenesis through the AMPK/PGC-1α Pathway in Rats

(2016) Lingyu Li et al.   Scientific Reports

The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases

(2015) Kiichi Nakahira et al.   ANTIOXIDANTS & REDOX SIGNALING

Glucocorticoids enhance prolonged clearance of apoptotic cells by upregulating liver X receptor, peroxisome proliferator-activated receptor-δ and UCP2

(2015) Éva Garabuczi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Silencing of uncoupling protein 2 by small interfering RNA aggravates mitochondrial dysfunction in cardiomyocytes under septic conditions

(2015) GUILANG ZHENG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Mitochondrial Mechanisms in Septic Cardiomyopathy

(2015) María Cimolai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The mitochondrial permeability transition pore: Molecular nature and role as a target in cardioprotection

(2015) Paolo Bernardi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Incidence and risk factors of sepsis mortality in labor, delivery and after birth: Population-based study in the USA

(2015) Ghassan Al-Ostad et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

The Role of Uncoupling Protein 2 During Myocardial Dysfunction in a Canine Model of Endotoxin Shock

(2015) Xiaoting Wang et al.   SHOCK

Comparison of the Proinflammatory and Procoagulant Properties of Nuclear, Mitochondrial, and Bacterial DNA

(2015) Vinai C. Bhagirath et al.   SHOCK

Protection against renal ischemia–reperfusion injury in vivo by the mitochondria targeted antioxidant MitoQ

(2015) Anna J. Dare et al.   Redox Biology

Mitochondrial ROS Induces Cardiac Inflammation via a Pathway through mtDNA Damage in a Pneumonia-Related Sepsis Model

(2015) Xiao Yao et al.   PLoS One

Multiple blocks in the engagement of oxidative phosphorylation in putative ovarian cancer stem cells: implication for maintenance therapy with glycolysis inhibitors

(2015) Ayesha B. Alvero et al.   Oncotarget

The RNA binding protein hnRNP-K mediates post-transcriptional regulation of uncoupling protein-2 by angiopoietin-1

(2014) Tariq A. Tahir et al.   CELLULAR SIGNALLING

Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function

(2014) Yingmei Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart

(2014) Alexander T. Akhmedov et al.   HEART FAILURE REVIEWS

Dynamics of Mitochondrial DNA Nucleoids Regulated by Mitochondrial Fission Is Essential for Maintenance of Homogeneously Active Mitochondria during Neonatal Heart Development

(2014) Takaya Ishihara et al.   MOLECULAR AND CELLULAR BIOLOGY

Hydrogen Sulfide and Endothelium-Dependent Vasorelaxation

(2014) Jerzy Bełtowski et al.   MOLECULES

Epidemiology and Outcome of Severe Sepsis and Septic Shock in Intensive Care Units in Mainland China

(2014) Jianfang Zhou et al.   PLoS One

Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation

(2014) Kiichi Nakahira et al.   PLOS MEDICINE

Mechanisms of Cardiac and Renal Dysfunction in Patients Dying of Sepsis

(2013) Osamu Takasu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Protective role of PARK2/Parkin in sepsis-induced cardiac contractile and mitochondrial dysfunction

(2013) Jérôme Piquereau et al.   Autophagy

Forkhead box protein A1 inhibits the expression of uncoupling protein 2 in hydrogen peroxide-induced A549 cell line

(2013) Lan Song et al.   CELL STRESS & CHAPERONES

UCP2, a mitochondrial protein regulated at multiple levels

(2013) Massimo Donadelli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Peroxisome Proliferator–Activated Receptor-γ Activation Prevents Sepsis-Related Cardiac Dysfunction and Mortality In Mice

(2013) Konstantinos Drosatos et al.   Circulation-Heart Failure

A Circadian Clock Gene, Rev-erb , Modulates the Inflammatory Function of Macrophages through the Negative Regulation of Ccl2 Expression

(2013) S. Sato et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology

(2013) Ming Zhan et al.   KIDNEY INTERNATIONAL

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cobalt Protoporphyrin Accelerates TFEB Activation and Lysosome Reformation during LPS-Induced Septic Insults in the Rat Heart

(2013) Kana Unuma et al.   PLoS One

UCP2 inhibition triggers ROS-dependent nuclear translocation of GAPDH and autophagic cell death in pancreatic adenocarcinoma cells

(2012) Ilaria Dando et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Mitochondrial Control of Cellular Life, Stress, and Death

(2012) Lorenzo Galluzzi et al.   CIRCULATION RESEARCH

Cardiac-specific overexpression of catalase attenuates lipopolysaccharide-induced myocardial contractile dysfunction: Role of autophagy

(2012) Subat Turdi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cardioprotection by acetylcholine: A novel mechanism via mitochondrial biogenesis and function involving the PGC-1α pathway

(2012) Lei Sun et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Effect of conjugated linoleic acid on inhibition of prolyl hydroxylase 1 in hearts of mice

(2012) Jize Zhang et al.   Lipids in Health and Disease

Sepsis-Induced Cardiac Mitochondrial Dysfunction Involves Altered Mitochondrial-Localization of Tyrosine Kinase Src and Tyrosine Phosphatase SHP2

(2012) Qun S. Zang et al.   PLoS One

Human neuronal uncoupling proteins 4 and 5 (UCP4 and UCP5): structural properties, regulation, and physiological role in protection against oxidative stress and mitochondrial dysfunction

(2012) David B. Ramsden et al.   Brain and Behavior

The presence of the −866A/55Val/Ins haplotype in the uncoupling protein 2 (UCP2) gene is associated with decreased UCP2 gene expression in human retina

(2011) Bianca M. de Souza et al.   EXPERIMENTAL EYE RESEARCH

Roles of Oxidative Stress, Apoptosis, PGC-1α and Mitochondrial Biogenesis in Cerebral Ischemia

(2011) Shang-Der Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

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(2011) Bixi Jian et al.   MOLECULAR MEDICINE

Status epilepticus stimulates peroxisome proliferator-activated receptor γ coactivator 1-α/mitochondrial antioxidant system pathway by a nitric oxide-dependent mechanism

(2011) Y.X. Han et al.   NEUROSCIENCE

Survival in Critical Illness Is Associated with Early Activation of Mitochondrial Biogenesis

(2010) Jane E. Carré et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Uncoupling protein 2 G(-866)A polymorphism: a new gene polymorphism associated with C-reactive protein in type 2 diabetic patients C-reactive protein in type 2 diabetic patients

(2010) Emanuela Lapice et al.   Cardiovascular Diabetology

Mitochondria in the diabetic heart

(2010) H. Bugger et al.   CARDIOVASCULAR RESEARCH

TNF-α and IL-1β increase Ca2+ leak from the sarcoplasmic reticulum and susceptibility to arrhythmia in rat ventricular myocytes

(2010) David J. Duncan et al.   CELL CALCIUM

Mitochondrial fission and fusion

(2010) Iain Scott et al.   Essays in Biochemistry

Mutation of mitochondrial ATP8 gene improves hepatic energy status in a murine model of acute endotoxemic liver failure

(2010) Christian Eipel et al.   LIFE SCIENCES

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Negative regulation of UCP2 by TGFβ signaling characterizes low and intermediate-grade primary breast cancer

(2010) A Sayeed et al.   Cell Death & Disease

Carbon Monoxide Rescues Mice from Lethal Sepsis by Supporting Mitochondrial Energetic Metabolism and Activating Mitochondrial Biogenesis

(2009) S. Lancel et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Prevention of endotoxin-induced sarcoplasmic reticulum calcium leak improves mitochondrial and myocardial dysfunction*

(2008) Sidi Mohammed Hassoun et al.   CRITICAL CARE MEDICINE

Nitric oxide synthase-2 induction optimizes cardiac mitochondrial biogenesis after endotoxemia

(2008) Crystal M. Reynolds et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of endothelial barrier function by reactive oxygen and nitrogen species

(2008) Adel Boueiz et al.   MICROVASCULAR RESEARCH