Review
Veterinary Sciences
Virginie Gaillard, Sylvie Chastant, Gary England, Oliver Forman, Alexander J. German, Jan S. Suchodolski, Cecilia Villaverde, Pascale Chavatte-Palmer, Franck Peron
Summary: This article reviews the early-life risk factors for obesity, chronic enteropathy, and chronic behavioral problems in dogs and cats. It discusses the importance of understanding these risk factors in order to improve preventive veterinary care and husbandry practices. The article also explores the challenges of studying developmental origins of health and disease (DOHaD) in these species and proposes strategies to increase knowledge in this area.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Carl R. Dahlen, Pawel P. Borowicz, Alison K. Ward, Joel S. Caton, Marta Czernik, Luca Palazzese, Pasqualino Loi, Lawrence P. Reynolds
Summary: Assisted reproductive techniques (ART) and parental nutritional status have significant impacts on embryonic and fetal development, potentially mediated through programming of gene expression. Epigenetic changes may lead to long-term alterations in organ structure and function in offspring after birth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Tomoki Sato, Paolo Sassone-Corsi
Summary: Food intake has a profound impact on systemic physiology, and there is a close link between food intake and circadian rhythms. The biological clock controls circadian rhythms through the cyclic expression of genes, and metabolic states also provide feedback to the molecular clock. Nutritional challenges can reprogram the circadian clock, and various factors are involved in the remodeling process.
Review
Food Science & Technology
Mara Lauriola, Ricard Farre, Pieter Evenepoel, Saskia Adriana Overbeek, Bjorn Meijers
Summary: Patients with CKD have a higher cardiovascular risk than the general population due to the accumulation of uremic toxins. Protein-bound uremic toxins originate from various sources and are difficult to remove with conventional therapies. Diet plays an important role in uremic toxicity, with most toxins derived from the gut. This review summarizes the sources of uremic toxins in foods and discusses their metabolism and potential dietary strategies for reducing their plasma levels.
Article
Neurosciences
M. H. Vickers
Summary: Changes in early life nutrition can have significant effects on the risk of obesity and metabolic disorders in later life, which can be passed on to future generations. This process, known as developmental programming, plays a role in the origins of health and disease. Early nutritional compromise can lead to adverse health outcomes in offspring, with the potential for exacerbation by a poor postnatal nutrition environment. The mechanisms underlying programming are not yet fully understood, but altered neuroendocrine circuits that regulate satiety and energy balance have been identified as a common feature in preclinical models.
Article
Multidisciplinary Sciences
Kay Boulton, Peter W. Wilson, Valerie R. Bishop, Jonathan H. Perez, Toby Wilkinson, Kris Hogan, Natalie Z. M. Homer, Christelle Robert, Jacqueline Smith, Simone L. Meddle, Ian C. Dunn, Kellie Watson
Summary: The study found that the diet and egg treatment of Japanese quail parents significantly affect the growth, reproductive capacity, and stress response of the first generation. Additionally, while maternal stress may have an impact on offspring, enhanced methyl diets appear to have positive effects on bird reproduction, growth, and stress function.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Xiaoli Zhang, Ahmed A. Hasan, Hongwei Wu, Mohamed M. S. Gaballa, Suimin Zeng, Liping Liu, Li Xie, Tobias Jung, Tilman Grune, Bernhard K. Kramer, Burkhard Kleuser, Jian Li, Berthold Hocher
Summary: The effects of feeding male rats a high-fat, high-sucrose and high-salt diet during spermatogenesis on renal outcomes in two generations (F0 and F1) are unclear. This study found that female offspring of F0HD+F1HD rats showed increased urinary albumin excretion and developed glomerulosclerosis and renal interstitial fibrosis. RNA sequencing revealed differential regulation of four genes in the kidneys of female F2 offspring. Epigenetic alterations, such as decreased expression of lncRNA XR-146683.1 and increased methylation of the Cd300lf promoter region, were found in the F0HD+F1HD female F2 offspring. These alterations were associated with decreased Cd300lf mRNA expression and increased urinary albumin excretion in F2 female offspring. The findings suggest that an unhealthy diet in paternal pre-conception may predispose female offspring to chronic kidney disease through epigenetic changes in renal gene expression.
Review
Biochemistry & Molecular Biology
Yajie Tong, Shuqing Zhang, Suzette Riddle, Lubo Zhang, Rui Song, Dongmei Yue
Summary: Intrauterine hypoxia can affect lung cell epigenome, leading to developmental issues and increased risk of diseases in the lungs.
Article
Reproductive Biology
Shuai Zhu, Qiang Wang
Summary: Well balanced and timed metabolism is crucial for oocyte development. While the effects of extrinsic nutrients on oocyte maturation have been well studied, the intrinsic control of oogenesis by intracellular metabolites and metabolic enzymes has been overlooked. Understanding the comprehensive metabolic patterns could provide insights into the regulatory mechanisms of oocyte development.
BIOLOGY OF REPRODUCTION
(2022)
Article
Food Science & Technology
Marlou Klein Hazebroek, Annemarie Baars, Mona Mischke, Annemarie Oosting, Evert M. van Schothorst, Lidewij Schipper
Summary: Early-life feeding with an infant formula containing lipid droplets mimicking those in human milk (HM, Nuturis) reduces adiposity and adipocyte size in adulthood, regardless of adult diet. After a western-style diet (WSD) in adulthood, Nuturis programme reduced macrophage-related gene expression and potentially lowers macrophage content, suggesting protective effects against adipose tissue inflammation in later life.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Genetics & Heredity
Shila Barati, Carlo Fabrizio, Claudia Strafella, Raffaella Cascella, Valerio Caputo, Domenica Megalizzi, Cristina Peconi, Julia Mela, Luca Colantoni, Carlo Caltagirone, Andrea Termine, Emiliano Giardina
Summary: This review discusses the main features of susceptibility and progression in neurodegenerative disorders (NDDs), focusing on Alzheimer's disease (AD) and Parkinson's disease (PD). Metabolism, dietary habits, physical exercise, and microbiota are essential for brain function and preservation. Genetic, epigenetic, and environmental factors can disrupt this balance, leading to neuroinflammation and neurodegeneration. Diet and exercise can directly impact epigenetic modifications and alter the expression of specific genes involved in NDDs. Nutrigenomics provides insights into precision medicine strategies for the treatment and management of these diseases.
Review
Nutrition & Dietetics
Shuang Cai, Shuang Quan, Guangxin Yang, Meixia Chen, Qianhong Ye, Gang Wang, Haitao Yu, Yuming Wang, Shiyan Qiao, Xiangfang Zeng
Summary: Epigenetic modifications play a crucial role in embryonic development, and disruptions caused by nutritional imbalance can impact both embryonic development and adult health. Understanding the regulation of epigenetic modifications in early embryo development is essential for improving reproductive health in mammals through reproductive technologies and nutrition regulation.
ADVANCES IN NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Emanuela Di Gregorio, Gianmaria Miolo, Asia Saorin, Agostino Steffan, Giuseppe Corona
Summary: Cancer metabolism research has regained prominence, challenging the role of genetics in understanding cancer development; the discovery of oncometabolites has brought about a new paradigm of viewing cancer as a metabolic disease; the study of oncometabolites is pivotal in the development of new targeted cancer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Marta Gomez de Cedron, Rocio Moreno Palomares, Ana Ramirez de Molina
Summary: Epigenetic modifications are chemical modifications that can affect gene expression without changing DNA sequences. They occur on histone proteins, DNA, and RNA molecules. These modifications play important roles in developmental programs and functional plasticity, but imbalances can lead to diseases such as metabolic diseases, cancer, and aging.
FRONTIERS IN ONCOLOGY
(2023)
Article
Nutrition & Dietetics
Alba Serrano, Andreu Palou, M. Luisa Bonet, Joan Ribot
Summary: This study found that mild NR supplementation during early postnatal life has beneficial effects on lipid and energy metabolism in skeletal muscle and liver in adulthood, with potential preventive strategies against obesity-related disorders.
Review
Nutrition & Dietetics
Julia L. Finkelstein, Alexander J. Layden, Patrick J. Stover
ADVANCES IN NUTRITION
(2015)
Review
Medicine, Research & Experimental
Xu Lan, Martha S. Field, Patrick J. Stover
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE
(2018)
Article
Nutrition & Dietetics
Erica R. Lachenauer, Sally P. Stabler, Martha S. Field, Patrick J. Stover
JOURNAL OF NUTRITION
(2020)
Article
Nutrition & Dietetics
Padma Maruvada, Patrick J. Stover, Joel B. Mason, Regan L. Bailey, Cindy D. Davis, Martha S. Field, Richard H. Finnell, Cutberto Garza, Ralph Green, Jean-Louis Gueant, Paul F. Jacques, David M. Klurfeld, Yvonne Lamers, Amanda J. MacFarlane, Joshua W. Miller, Anne M. Molloy, Deborah L. O'Connor, Christine M. Pfeiffer, Nancy A. Potischman, Joseph Rodricks, Irwin H. Rosenberg, Sharon A. Ross, Barry Shane, Jacob Selhub, Sally P. Stabler, Jacquetta Trasler, Sedigheh Yamini, Giovanna Zappal
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2020)
Review
Medicine, General & Internal
P. J. Stover, M. S. Field, H. N. Brawley, B. Angelin, P. O. Iverson, G. Fruhbeck
Summary: Adult stem cells play a crucial role in maintaining organ and physiological system renewal, and their nutritional needs are also essential for overall human health and reducing chronic diseases. Understanding the dynamics of stem cell nutritional needs throughout the lifespan is crucial for establishing food and nutrient guidance.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Patrick J. Stover, Cutberto Garza, Jane Durga, Martha S. Field
JOURNAL OF NUTRITION
(2020)