p53 Disruption Increases Uracil Accumulation in DNA of Murine Embryonic Fibroblasts and Leads to Folic Acid–Nonresponsive Neural Tube Defects in Mice

Genetic backgrounds and modifier genes of NTD mouse models: An opportunity for greater understanding of the multifactorial etiology of neural tube defects

(2017) Renee Y.M. Leduc et al.   Birth Defects Research

A hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesis

(2017) Karla Misselbeck et al.   Scientific Reports

SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation

(2014) A Paone et al.   Cell Death & Disease

E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression

(2012) L. A. Carvajal et al.   GENES & DEVELOPMENT

Serine Hydroxymethyltransferase Anchorsde NovoThymidylate Synthesis Pathway to Nuclear Lamina for DNA Synthesis

(2012) Donald D. Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice

(2011) Anna E Beaudin et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Shmt1 Heterozygosity Impairs Folate-Dependent Thymidylate Synthesis Capacity and Modifies Risk of Apcmin-Mediated Intestinal Cancer Risk

(2011) A. J. MacFarlane et al.   CANCER RESEARCH

Live imaging of apoptosis in a novel transgenic mouse highlights its role in neural tube closure

(2011) Yoshifumi Yamaguchi et al.   JOURNAL OF CELL BIOLOGY

Insights into metabolic mechanisms underlying folate-responsive neural tube defects: A minireview

(2009) Anna E. Beaudin et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

The involvement of cell death and survival in neural tube defects: a distinct role for apoptosis and autophagy?

(2008) F Cecconi et al.   CELL DEATH AND DIFFERENTIATION

Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function

(2008) K. A. Burren et al.   HUMAN MOLECULAR GENETICS

Cytoplasmic Serine Hydroxymethyltransferase Regulates the Metabolic Partitioning of Methylenetetrahydrofolate but Is Not Essential in Mice

(2008) Amanda J. MacFarlane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mthfd1Is an Essential Gene in Mice and Alters Biomarkers of Impaired One-carbon Metabolism

(2008) Amanda J. MacFarlane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY