Redox cofactor engineering in industrial microorganisms: strategies, recent applications and future directions

Coupling xylitol dehydrogenase with NADH oxidase improves l -xylulose production in Escherichia coli culture

(2017) Qi Han et al.   ENZYME AND MICROBIAL TECHNOLOGY

Engineering Escherichia coli for poly-(3-hydroxybutyrate) production guided by genome-scale metabolic network analysis

(2017) Yangyang Zheng et al.   ENZYME AND MICROBIAL TECHNOLOGY

Enhanced xylose fermentation by engineered yeast expressing NADH oxidase through high cell density inoculums

(2017) Guo-Chang Zhang et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Effects of Increased NADPH Concentration by Metabolic Engineering of the Pentose Phosphate Pathway on Antibiotic Production and Sporulation in Streptomyces lividans TK24

(2017) Xue-Mei Jin et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Enhanced solvent production by metabolic engineering of a twin-clostridial consortium

(2017) Zhiqiang Wen et al.   METABOLIC ENGINEERING

Harnessing the respiration machinery for high-yield production of chemicals in metabolically engineered Lactococcus lactis

(2017) Jianming Liu et al.   METABOLIC ENGINEERING

Cofactor self-sufficient whole-cell biocatalysts for the production of 2-phenylethanol

(2017) Pengchao Wang et al.   METABOLIC ENGINEERING

A modular metabolic engineering approach for the production of 1,2-propanediol from glycerol by Saccharomyces cerevisiae

(2017) Zia-ul Islam et al.   METABOLIC ENGINEERING

Cofactor engineering to regulate NAD+/NADH ratio with its application to phytosterols biotransformation

(2017) Liqiu Su et al.   Microbial Cell Factories

Engineering redox homeostasis to develop efficient alcohol-producing microbial cell factories

(2017) Chunhua Zhao et al.   Microbial Cell Factories

Cofactor engineering improved CALB production in Pichia pastoris through heterologous expression of NADH oxidase and adenylate kinase

(2017) Charumathi Jayachandran et al.   PLoS One

In Vitro Reconstitution and Optimization of the Entire Pathway to Convert Glucose into Fatty Acid

(2017) Zheng Liu et al.   ACS Synthetic Biology

Enhanced NADPH production in the pentose phosphate pathway accelerates lipid accumulation in the oleaginous diatom Fistulifera solaris

(2017) Kyoko Osada et al.   Algal Research-Biomass Biofuels and Bioproducts

Cofactor Engineering for Enhanced Production of Diols by Klebsiella pneumoniae From Co-Substrate

(2017) Meng Wang et al.   Biotechnology Journal

Cofactor engineering in cyanobacteria to overcome imbalance between NADPH and NADH: A mini review

(2017) Jongmoon Park et al.   Frontiers of Chemical Science and Engineering

A novel approach to improve poly-γ-glutamic acid production by NADPH Regeneration in Bacillus licheniformis WX-02

(2017) Dongbo Cai et al.   Scientific Reports

The transcriptional regulator NtrC controls glucose-6-phosphate dehydrogenase expression and polyhydroxybutyrate synthesis through NADPH availability in Herbaspirillum seropedicae

(2017) Euclides Nenga Manuel Sacomboio et al.   Scientific Reports

Metabolic Engineering of Mortierella alpina for Enhanced Arachidonic Acid Production through the NADPH-Supplying Strategy

(2016) Guangfei Hao et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Alternative Biotransformation of Retinal to Retinoic Acid or Retinol by an Aldehyde Dehydrogenase from Bacillus cereus

(2016) Seung-Hye Hong et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Multi-modular engineering of 1,3-propanediol biosynthesis system in Klebsiella pneumoniae from co-substrate

(2016) Meng Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Enhancing biomass and ethanol production by increasing NADPH production in Synechocystis sp. PCC 6803

(2016) Yun-Nam Choi et al.   BIORESOURCE TECHNOLOGY

New artificial fluoro-cofactor of hydride transfer with novel fluorescence assay for redox biocatalysis

(2016) Lei Zhang et al.   CHEMICAL COMMUNICATIONS

Better than Nature: Nicotinamide Biomimetics That Outperform Natural Coenzymes

(2016) Tanja Knaus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Towards the exploitation of glycerol's high reducing power in Saccharomyces cerevisiae -based bioprocesses

(2016) Mathias Klein et al.   METABOLIC ENGINEERING

Combining metabolic engineering and biocompatible chemistry for high-yield production of homo-diacetyl and homo-( S , S )-2,3-butanediol

(2016) Jianming Liu et al.   METABOLIC ENGINEERING

Stress Physiology of Lactic Acid Bacteria

(2016) Konstantinos Papadimitriou et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage

(2016) Ling Liu et al.   Nature Chemical Biology

Nonenzymatic and Metal-Free Organocatalysis for in Situ Regeneration of Oxidized Cofactors by Activation and Reduction of Molecular Oxygen

(2016) Chenjie Zhu et al.   ACS Catalysis

Synthesis of (3R)-acetoin and 2,3-butanediol isomers by metabolically engineered Lactococcus lactis

(2016) Vijayalakshmi Kandasamy et al.   Scientific Reports

Engineering an NADPH/NADP+ Redox Biosensor in Yeast

(2016) Jie Zhang et al.   ACS Synthetic Biology

A General Tool for Engineering the NAD/NADP Cofactor Preference of Oxidoreductases

(2016) Jackson K. B. Cahn et al.   ACS Synthetic Biology

Engineering a d-lactate dehydrogenase that can super-efficiently utilize NADPH and NADH as cofactors

(2016) Hengkai Meng et al.   Scientific Reports

Elucidating the contributions of multiple aldehyde/alcohol dehydrogenases to butanol and ethanol production in Clostridium acetobutylicum

(2016) Zongjie Dai et al.   Scientific Reports

Systems pathway engineering of Corynebacterium crenatum for improved L-arginine production

(2016) Zaiwei Man et al.   Scientific Reports

Enhanced H2 Production and Redirected Metabolic Flux via Overexpression of fhlA and pncB in Klebsiella HQ-3 Strain

(2015) Muhammad Jawed et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Expression of Lactococcus lactis NADH oxidase increases 2,3-butanediol production in Pdc-deficient Saccharomyces cerevisiae

(2015) Jin-Woo Kim et al.   BIORESOURCE TECHNOLOGY

Metabolic engineering of Bacillus subtilis for redistributing the carbon flux to 2,3-butanediol by manipulating NADH levels

(2015) Taowei Yang et al.   Biotechnology for Biofuels

Enhanced production of poly-3-hydroxybutyrate by Escherichia coli over-expressing multiple copies of NAD kinase integrated in the host genome

(2015) Jie Zhang et al.   BIOTECHNOLOGY LETTERS

Enhanced 1-Butanol Production in Engineered Klebsiella pneumoniae by NADH Regeneration

(2015) Miaomiao Wang et al.   ENERGY & FUELS

A computational strategy for altering an enzyme in its cofactor preference to NAD(H) and/or NADP(H)

(2015) Dongbing Cui et al.   FEBS Journal

Loss of NADH Oxidase Activity in Streptococcus mutans Leads to Rex-Mediated Overcompensation in NAD+Regeneration by Lactate Dehydrogenase

(2015) J. L. Baker et al.   JOURNAL OF BACTERIOLOGY

Elucidating central metabolic redox obstacles hindering ethanol production in Clostridium thermocellum

(2015) R. Adam Thompson et al.   METABOLIC ENGINEERING

Efficient production of 2,3-butanediol in Saccharomyces cerevisiae by eliminating ethanol and glycerol production and redox rebalancing

(2015) Sujin Kim et al.   METABOLIC ENGINEERING

Potential production platform of n-butanol in Escherichia coli

(2015) Mukesh Saini et al.   METABOLIC ENGINEERING

Rational design of a synthetic Entner–Doudoroff pathway for improved and controllable NADPH regeneration

(2015) Chiam Yu Ng et al.   METABOLIC ENGINEERING

Improvement of exopolysaccharide production in Lactobacillus casei LC2W by overexpression of NADH oxidase gene

(2015) Nan Li et al.   MICROBIOLOGICAL RESEARCH

Systems strategies for developing industrial microbial strains

(2015) Sang Yup Lee et al.   NATURE BIOTECHNOLOGY

Substitutions at the cofactor phosphate-binding site of a clostridial alcohol dehydrogenase lead to unexpected changes in substrate specificity

(2015) Danielle J. Maddock et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Manipulating multi-system of NADPH regulation in Escherichia coli for enhanced S-adenosylmethionine production

(2015) Yawei Chen et al.   RSC Advances

NADPH-generating systems in bacteria and archaea

(2015) Sebastiaan K. Spaans et al.   Frontiers in Microbiology

Role of Malic Enzyme during Fatty Acid Synthesis in the Oleaginous Fungus Mortierella alpina

(2014) G. Hao et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Insights into electron flux through manipulation of fermentation conditions and assessment of protein expression profiles in Clostridium thermocellum

(2014) Thomas Rydzak et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Increased fatty acid unsaturation and production of arachidonic acid by homologous over-expression of the mitochondrial malic enzyme in Mortierella alpina

(2014) Guangfei Hao et al.   BIOTECHNOLOGY LETTERS

Fine-tuning of NADH oxidase decreases byproduct accumulation in respiration deficient xylose metabolic Saccharomyces cerevisiae

(2014) Jin Hou et al.   BMC BIOTECHNOLOGY

Redox-Responsive Repressor Rex Modulates Alcohol Production and Oxidative Stress Tolerance in Clostridium acetobutylicum

(2014) L. Zhang et al.   JOURNAL OF BACTERIOLOGY

Structure-based Conversion of the Coenzyme Requirement of a Short-chain Dehydrogenase/Reductase Involved in Bacterial Alginate Metabolism

(2014) Ryuichi Takase et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improving the NADH-cofactor specificity of the highly active AdhZ3 and AdhZ2 from Escherichia coli K-12

(2014) André Pick et al.   JOURNAL OF BIOTECHNOLOGY

Enhanced acetic acid and succinic acid production under microaerobic conditions by Corynebacterium glutamicum harboring Escherichia coli transhydrogenase gene pntAB

(2014) Yuto Yamauchi et al.   JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY

A de novo NADPH generation pathway for improving lysine production of Corynebacterium glutamicum by rational design of the coenzyme specificity of glyceraldehyde 3-phosphate dehydrogenase

(2014) Rajesh Reddy Bommareddy et al.   METABOLIC ENGINEERING

Efficient Whole-Cell Biocatalyst for Acetoin Production with NAD+ Regeneration System through Homologous Co-Expression of 2,3-Butanediol Dehydrogenase and NADH Oxidase in Engineered Bacillus subtilis

(2014) Teng Bao et al.   PLoS One

Efficient bioethanol production by overexpression of endogenous Saccharomyces cerevisiae xylulokinase and NADPH-dependent aldose reductase with mutated strictly NADP+-dependent Pichia stipitis xylitol dehydrogenase

(2014) Sadat Mohammad Rezq Khattab et al.   PROCESS BIOCHEMISTRY

Engineering redox balance through cofactor systems

(2014) Xiulai Chen et al.   TRENDS IN BIOTECHNOLOGY

Metabolic engineering of Corynebacterium glutamicum for L-arginine production

(2014) Seok Hyun Park et al.   Nature Communications

COFACTOR SPECIFICITY ENGINEERING OF STREPTOCOCCUS MUTANS NADH OXIDASE 2 FOR NAD(P) + REGENERATION IN BIOCATALYTIC OXIDATIONS

(2014) Barbara Petschacher et al.   Computational and Structural Biotechnology Journal

Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water

(2013) Svenja Staudt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enhancement of succinate production by metabolically engineered Escherichia coli with co-expression of nicotinic acid phosphoribosyltransferase and pyruvate carboxylase

(2013) Jiangfeng Ma et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Metabolic engineering and transhydrogenase effects on NADPH availability inescherichia coli

(2013) Joanna Jan et al.   BIOTECHNOLOGY PROGRESS

Cofactor engineering for advancing chemical biotechnology

(2013) Yipeng Wang et al.   CURRENT OPINION IN BIOTECHNOLOGY

A self-sufficient Baeyer–Villiger biocatalysis system for the synthesis of ɛ-caprolactone from cyclohexanol

(2013) H. Mallin et al.   ENZYME AND MICROBIAL TECHNOLOGY

Unraveling the function of paralogs of the aldehyde dehydrogenase super family from Sulfolobus solfataricus

(2013) D. Esser et al.   EXTREMOPHILES

Boost in bioethanol production using recombinant Saccharomyces cerevisiae with mutated strictly NADPH-dependent xylose reductase and NADP+-dependent xylitol dehydrogenase

(2013) Sadat Mohammad Rezq Khattab et al.   JOURNAL OF BIOTECHNOLOGY

Improvement of NADPH bioavailability in Escherichia coli by replacing NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase GapA with NADP+-dependent GapB from Bacillus subtilis and addition of NAD kinase

(2013) Yipeng Wang et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Metabolic engineering of Corynebacterium glutamicum for increasing the production of l-ornithine by increasing NADPH availability

(2013) Ling-Yan Jiang et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Model-driven rebalancing of the intracellular redox state for optimization of a heterologous n-butanol pathway in Escherichia coli

(2013) Jae Hyung Lim et al.   METABOLIC ENGINEERING

Metabolic engineering of Escherichia coli to minimize byproduct formate and improving succinate productivity through increasing NADH availability by heterologous expression of NAD+-dependent formate dehydrogenase

(2013) Grant J. Balzer et al.   METABOLIC ENGINEERING

Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid-derived biofuels and chemicals

(2013) Weerawat Runguphan et al.   METABOLIC ENGINEERING

General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH

(2013) S. Brinkmann-Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced biofuel production through coupled acetic acid and xylose consumption by engineered yeast

(2013) Na Wei et al.   Nature Communications

Engineering of cofactor regeneration enhances (2S,3S)-2,3-butanediol production from diacetyl

(2013) Yu Wang et al.   Scientific Reports

Engineering of Corynebacterium glutamicum for High-Yield l-Valine Production under Oxygen Deprivation Conditions

(2012) Satoshi Hasegawa et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Effects of NADH kinase on NADPH-dependent biotransformation processes in Escherichia coli

(2012) Won-Heong Lee et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Engineering of formate dehydrogenase: synergistic effect of mutations affecting cofactor specificity and chemical stability

(2012) Kathrin Hoelsch et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Crystal Structures of Phosphite Dehydrogenase Provide Insights into Nicotinamide Cofactor Regeneration

(2012) Yaozhong Zou et al.   BIOCHEMISTRY

Energy conservation via electron bifurcating ferredoxin reduction and proton/Na+ translocating ferredoxin oxidation

(2012) Wolfgang Buckel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Characterization of H2O-forming NADH oxidase from Streptococcus pyogenes and its application in l-rare sugar production

(2012) Hui Gao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Enhanced acetoin production by Serratia marcescens H32 with expression of a water-forming NADH oxidase

(2012) Jian-An Sun et al.   BIORESOURCE TECHNOLOGY

Electron Bifurcation Involved in the Energy Metabolism of the Acetogenic Bacterium Moorella thermoacetica Growing on Glucose or H2 plus CO2

(2012) H. Huang et al.   JOURNAL OF BACTERIOLOGY

Dihydrophenanthridine: A New and Easily Regenerable NAD(P)H Model for Biomimetic Asymmetric Hydrogenation

(2012) Qing-An Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activating transhydrogenase and NAD kinase in combination for improving isobutanol production

(2012) Aiqin Shi et al.   METABOLIC ENGINEERING

Anr, the anaerobic global regulator, modulates the redox state and oxidative stress resistance in Pseudomonas extremaustralis

(2012) P. M. Tribelli et al.   MICROBIOLOGY-SGM

Systems metabolic engineering of microorganisms for natural and non-natural chemicals

(2012) Jeong Wook Lee et al.   Nature Chemical Biology

Mimicking Nature: Synthetic Nicotinamide Cofactors for C═C Bioreduction Using Enoate Reductases

(2012) Caroline E. Paul et al.   ORGANIC LETTERS

Fine Tuning of the Lactate and Diacetyl Production through Promoter Engineering in Lactococcus lactis

(2012) Tingting Guo et al.   PLoS One

Decreased Xylitol Formation during Xylose Fermentation in Saccharomyces cerevisiae Due to Overexpression of Water-Forming NADH Oxidase

(2011) Guo-Chang Zhang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Enhanced production of GDP-l-fucose by overexpression of NADPH regenerator in recombinant Escherichia coli

(2011) Won-Heong Lee et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Engineering of microorganisms for the production of biofuels and perspectives based on systems metabolic engineering approaches

(2011) Yu-Sin Jang et al.   BIOTECHNOLOGY ADVANCES

Production of 3-hydroxypropionic acid via malonyl-CoA pathway using recombinant Escherichia coli strains

(2011) Chelladurai Rathnasingh et al.   JOURNAL OF BIOTECHNOLOGY

Creation of Bioorthogonal Redox Systems Depending on Nicotinamide Flucytosine Dinucleotide

(2011) Debin Ji et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biomimetic Asymmetric Hydrogenation: In Situ Regenerable Hantzsch Esters for Asymmetric Hydrogenation of Benzoxazinones

(2011) Qing-An Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineered ketol-acid reductoisomerase and alcohol dehydrogenase enable anaerobic 2-methylpropan-1-ol production at theoretical yield in Escherichia coli

(2011) Sabine Bastian et al.   METABOLIC ENGINEERING

Simultaneous production of 1,3-dihydroxyacetone and xylitol from glycerol and xylose using a nanoparticle-supported multi-enzyme system with in situ cofactor regeneration

(2010) Ying Zhang et al.   BIORESOURCE TECHNOLOGY

Ethanol production from xylose in engineered Saccharomyces cerevisiae strains: current state and perspectives

(2009) Akinori Matsushika et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Xylose reductase from Pichia stipitis with altered coenzyme preference improves ethanolic xylose fermentation by recombinant Saccharomyces cerevisiae

(2009) Oskar Bengtsson et al.   Biotechnology for Biofuels

Expression of protein engineered NADP+-dependent xylitol dehydrogenase increases ethanol production from xylose in recombinant Saccharomyces cerevisiae

(2008) Akinori Matsushika et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Bioethanol production from xylose by recombinant Saccharomyces cerevisiae expressing xylose reductase, NADP+-dependent xylitol dehydrogenase, and xylulokinase

(2008) Akinori Matsushika et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Replacing Escherichia coli NAD-dependent glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with a NADP-dependent enzyme from Clostridium acetobutylicum facilitates NADPH dependent pathways

(2008) Irene Martínez et al.   METABOLIC ENGINEERING

Introduction of an NADH regeneration system into Klebsiella oxytoca leads to an enhanced oxidative and reductive metabolism of glycerol

(2008) Yanping Zhang et al.   METABOLIC ENGINEERING

Structure and functional properties of theBacillus subtilistranscriptional repressor Rex

(2008) Ellen Wang et al.   MOLECULAR MICROBIOLOGY