Editorial Material
Immunology
Xinxin Wang, Yuping Lai
Summary: In this study, the authors investigate the mechanism by which pattern recognition receptors NOD1 and NOD2 sense bacterial muropeptides to induce inflammation in keratinocytes. They demonstrate that solute carrier 46A2 (SLC46A2) transports DAP-muropeptides into the cytosol, leading to NOD1 activation and subsequent skin inflammation during psoriasis.
Article
Oncology
Wenyong Huang, Dongmei Ye, Wenjing He, Xiaoshun He, Xiaomin Shi, Yifang Gao
Summary: The study found that MAIT cells in patients with HCC had lower levels in both peripheral blood and liver compared to healthy controls, with reduced IFN-γ production. While peripheral MAIT cells showed upregulation of HLA-DR and PD-1, intrasinusoidal MAIT cells did not exhibit significant differences. Additionally, MAIT cells were significantly enriched in the livers of HCC patients, showing high levels of activation and exhaustion markers.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Microbiology
Madeline S. S. Akbari, Rebecca A. A. Keogh, Jana N. N. Radin, Yamil Sanchez-Rosario, Michael D. L. Johnson, Alexander R. R. Horswill, Thomas E. E. Kehl-Fie, Lindsey R. R. Burcham, Kelly S. S. Doran
Summary: The presence of metal ions such as zinc and nickel in diabetic wound infections plays a crucial role in the survival and spread of pathogenic bacteria GBS. Therefore, characterizing host immunity is of great significance in enhancing defense against GBS infection.
Article
Oncology
Bin-Jin Hwang, Li-Chung Tsao, Chaitanya R. Acharya, Timothy Trotter, Pankaj Agarwal, Junping Wei, Tao Wang, Xiao-Yi Yang, Gangjun Lei, Takuya Osada, Herbert Kim Lyerly, Michael A. Morse, Zachary Conrad Hartman
Summary: This study demonstrates that the suppression of innate immune gene expression in tumor cells is a major factor contributing to the insensitivity of colorectal cancer to immune checkpoint inhibitor treatment. By reintroducing the suppressed gene MAVS, the study found that it can stimulate both local and systemic immune responses against the tumor and enhance the efficacy of anti-tumor immunotherapy when combined with PD-L1 inhibitors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Chemistry, Multidisciplinary
DaeYong Lee, Kristin Huntoon, Yifan Wang, Wen Jiang, Betty Y. S. Kim
Summary: The discovery of immune checkpoint blockade has revolutionized cancer treatment, but current immunotherapies are only effective for a small subset of patients. Future advancements in cancer immunotherapy will focus on developing novel therapeutic molecules or immunoengineered cells. Biomaterials can efficiently reprogram and recruit immune cells in tumors to activate T cell immunity against advanced cancers.
ADVANCED MATERIALS
(2021)
Article
Medicine, Research & Experimental
George Hindy, Daniel J. Tyrrell, Alexi Vasbinder, Changli Wei, Feriel Presswalla, Hui Wang, Pennelope K. Blakely, Ayse Bilge Ozel, Sarah E. Graham, Grace H. Holton, Joseph Dowsett, Akl C. Fahed, Kingsley-Michael Amadi, Grace K. Erne, Annika Tekumulla, Anis Ismail, Christopher Launius, Nona Sotoodehnia, James S. Pankow, Lise Wegner Thorner, Christian Erikstrup, Ole Birger Pedersen, Karina Banasik, Soren Brunak, Henrik Ullum, Jesper Eugen-Olsen, Sisse Rye Ostrowski, Mary E. Haas, Jonas B. Nielsen, Luca A. Lotta, Gunnar Engstrom, Olle Melander, Marju Orho-Melander, Lili Zhao, Venkatesh L. Murthy, David J. Pinsky, Cristen J. Willer, Susan R. Heckbert, Jochen Reiser, Daniel R. Goldstein, Karl C. Desch, Salim S. Hayek
Summary: The study using epidemiologic, genetic, and experimental approaches found that suPAR is a pathogenic factor for atherosclerosis, with its levels strongly associated with cardiovascular outcomes and predictive of coronary artery calcification. The missense variant rs4760 in the PLAUR gene leads to higher suPAR levels, and Mendelian randomization analysis confirms a causal relationship between genetically predicted suPAR levels and atherosclerotic phenotypes. In experimental models, increased suPAR levels modulate monocyte function to promote atherosclerosis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Immunology
Karla Ruiz-Cortes, Daniel N. Villageliu, Derrick R. Samuelson
Summary: Alcohol use can impact the function of both innate and adaptive immune cells, leading to immune dysfunction and organ damage. The role of innate lymphocytes, particularly liver-resident natural killer cells, in alcohol-induced pathogenesis is of increasing interest. However, the specific role of innate lymphocytes in alcohol-induced end-organ damage remains unclear.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Louise M. E. Muller, Gemma Migneco, Gina B. Scott, Jenny Down, Sancha King, Basem Askar, Victoria Jennings, Babatunde Oyajobi, Karen Scott, Emma West, Christy Ralph, Adel Samson, Elizabeth J. Ilett, Munitta Muthana, Matt Coffey, Alan Melcher, Christopher Parrish, Gordon Cook, Michelle Lawson, Fiona Errington-Mais
Summary: The study demonstrates that reovirus can reduce MM tumor burden and myeloma-induced bone disease, increase NK cell and CD8(+) T cell numbers, activate these cells, and upregulate effector-memory CD8(+) T cells. Reovirus is able to kill MM cells by activating NK cells and MM-specific CD8(+) T cells, suggesting that reovirus-induced immunotherapy should be combined with agents that enhance antitumor immune responses.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Microbiology
Eva Burger
Summary: Protective immunity against Paracoccidioides involves a stepwise activation of various cellular and soluble components, starting with non-specific innate immunity, followed by the role of specific antibodies and the mechanisms of cellular immunity.
Review
Microbiology
Ayush Kumar, Georgia Stavrakis, Andrew H. Karaba
Summary: Herpesviruses are common DNA viruses that cause lifelong infections and are associated with various diseases. While they can evade the immune system, they are recognized by the innate immune system, leading to inflammation. Recent studies have found that inflammasome signaling plays a role in herpesvirus innate immune activation and impacts disease outcomes.
Article
Biochemistry & Molecular Biology
Anuradha Ray, Sagar L. Kale, Richard P. Ramonell
Summary: Despite advancements in pulmonary immunology, there is still much work to be done in understanding coordinated immune responses in the lung. The SARS-CoV-2 pandemic has shown the inadequacy of current models of host-pathogen interactions and emphasized the importance of unraveling complex biological questions for immunologists. The 64th Annual Thomas L. Petty Aspen Lung Conference focused on bridging the gap between innate and adaptive immunity in the lung, discussing disease pathogenesis, immune responses, autoimmune lung diseases, immunologic cancer treatments, and new paradigms for lung disease prevention and treatment.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Review
Microbiology
Ayush Kumar, Georgia Stavrakis, Andrew H. Karaba
Summary: Herpesviruses are common DNA viruses that cause lifelong infections and are associated with various diseases. They activate the innate immune system by inflammasome signaling, leading to inflammation and potential disease outcomes.
Review
Immunology
Lucas Leite Cunha, Victor Alexandre dos Santos Valsecchi, Laura Sterian Ward
Summary: The immune response is remodeled with aging, which is called immunosenescence. Some scientists believe immunosenescence is an adaptation of the immune system to the aging environment, while others think aging leads to chronic inflammation. Studying immunosenescence can bring practical innovations to medicine and the health system.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
P. Spencer Gill, Tammy R. Ozment, Nicole H. Lewis, Edward R. Sherwood, David L. Williams
Summary: Aging and infection severity are closely related, with age as an independent predictor of mortality in sepsis. Trained immunity can improve immune function in aging and/or sepsis patients, but there is limited data on trained immunity in the aging immune system or in the presence of sepsis. This study found that trained immunity can be induced in aging monocytes and monocytes from sepsis patients, resulting in enhanced metabolic capacity and cytokine production.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Zhineng Wang, Ying Sun, Wenbo Yao, Qian Ba, Hui Wang
Summary: Cadmium, a biologically non-essential heavy metal, widely present in the environment and foods, is mainly known for its immunotoxicity, which includes modulation of immune cell activity, induction of immune responses, and alteration of antibody production.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zelia Gouveia, Ana R. Carlos, Xiaojing Yuan, Frederico Aires-da-Silva, Roland Stocker, Ghassan J. Maghzal, Sonia S. Leal, Claudio M. Gomes, Smilja Todorovic, Olga Iranzo, Susana Ramos, Ana C. Santos, Iqbal Hamza, Joao Goncalves, Miguel P. Soares
Article
Immunology
Vineel P. Reddy, Krishna C. Chinta, Vikram Saini, Joel N. Glasgow, Travis D. Hull, Amie Traylor, Fernanda Rey-Stolle, Miguel P. Soares, Rajhmun Madansein, Md Aejazur Rahman, Coral Barbas, Kievershen Nargan, Threnesan Naidoo, Pratistadevi K. Ramdial, James F. George, Anupam Agarwal, Adrie J. C. Steyn
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Monika Bambouskova, Laurent Gorvel, Vicky Lampropoulou, Alexey Sergushichev, Ekaterina Loginicheva, Kendall Johnson, Daniel Korenfeld, Mary Elizabeth Mathyer, Hyeryun Kim, Li-Hao Huang, Dustin Duncan, Howard Bregman, Abdurrahman Keskin, Andrea Santeford, Rajendra S. Apte, Raghav Sehgal, Britney Johnson, Gaya K. Amarasinghe, Miguel P. Soares, Takashi Satoh, Shizuo Akira, Tsonwin Hai, Cristina de Guzman Strong, Karine Auclair, Thomas P. Roddy, Scott A. Biller, Marko Jovanovic, Eynav Klechevsky, Kelly M. Stewart, Gwendalyn J. Randolph, Maxim N. Artyomov
Review
Immunology
Ana Rita Carlos, Sebastian Weis, Miguel P. Soares
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Susana Ramos, Ana Rita Carlos, Balamurugan Sundaram, Viktoria Jeney, Ana Ribeiro, Raffaella Gozzelino, Claudia Bank, Erida Gjini, Faouzi Braza, Rui Martins, Temitope Wilson Ademolue, Birte Blankenhaus, Zelia Gouveia, Pedro Faisca, Damian Trujillo, Silvia Cardoso, Sofia Rebelo, Laura del Barrio, Abolfazl Zarjou, Subhashini Bolisetty, Anupam Agarwal, Miguel P. Soares
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Endocrinology & Metabolism
Birte Blankenhaus, Faouzi Braza, Rui Martins, Patricia Bastos-Amador, Ismael Gonzalez-Garcia, Ana Rita Carlos, Ines Mahu, Pedro Faisca, Jose Moura Nunes, Pedro Ventura, Verena Hoerr, Sebastian Weis, Joel Guerra, Silvia Cardoso, Ana Domingos, Miguel Lopez, Miguel P. Soares
MOLECULAR METABOLISM
(2019)
Article
Biochemistry & Molecular Biology
Franziska A. Englert, Raphael A. Seidel, Kerstin Galler, Zelia Gouveia, Miguel P. Soares, Ute Neugebauer, Mark G. Clemens, Christoph Sponholz, Stefan H. Heinemann, Georg Pohnert, Michael Bauer, Sebastian Weis
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2019)
Article
Clinical Neurology
Judith Hauptmann, Lisa Johann, Federico Marini, Maja Kitic, Elisa Colombo, Ilgiz A. Mufazalov, Martin Krueger, Khalad Karram, Sonja Moos, Florian Wanke, Florian C. Kurschus, Matthias Klein, Silvia Cardoso, Judith Strauss, Subhashini Bolisetty, Fred Luehder, Markus Schwaninger, Harald Binder, Ingo Bechman, Tobias Bopp, Anupam Agarwal, Miguel P. Soares, Tommy Regen, Ari Waisman
ACTA NEUROPATHOLOGICA
(2020)
Article
Medicine, Research & Experimental
Emmanuelle Alaluf, Benoit Vokaer, Aurelie Detavernier, Abdulkader Azouz, Marion Splittgerber, Alice Carrette, Louis Boon, Frederick Libert, Miguel Soares, Alain Le Moine, Stanislas Goriely
Article
Biology
Sumnima Singh, Patricia Bastos-Amador, Jessica Ann Thompson, Mauro Truglio, Bahtiyar Yilmaz, Silvia Cardoso, Daniel Sobral, Miguel P. Soares
Summary: This study shows that deletion of the Ggta1 gene can shape the composition of gut microbiota via an Ig-dependent mechanism, where antibodies play a role in reducing microbiota pathogenicity. This suggests that loss of GGTA1 function in ancestral primates might have been influenced by microbiota interactions.
Article
Multidisciplinary Sciences
Elisa Jentho, Cristian Ruiz-Moreno, Boris Novakovic, Ioannis Kourtzelis, Wout L. Megchelenbrink, Rui Martins, Triantafyllos Chavakis, Miguel P. Soares, Lydia Kalafati, Joel Guerra, Franziska Roestel, Peter Bohm, Maren Godmann, Tatyana Grinenko, Anne Eugster, Martina Beretta, Leo A. B. Joosten, Mihai G. Netea, Michael Bauer, Hendrik G. Stunnenberg, Sebastian Weis
Summary: Trained immunity refers to long-lasting adaptations of innate immunity, and labile heme has been identified as a previously unrecognized inducer of trained immunity. Unlike other inducers that rely on pathogen-associated molecular patterns, heme training activates a unique signaling pathway and is associated with the expansion of self-renewing hematopoetic stem cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Sebastian Weis, Ana Rita Carlos, Maria Raquel Moita, Sumnima Singh, Birte Blankenhaus, Silvia Cardoso, Rasmus Larsen, Sofia Rebelo, Sascha Schaeuble, Laura Del Barrio, Gilles Mithieux, Fabienne Rajas, Sandro Lindig, Michael Bauer, Miguel P. Soares
Review
Immunology
Miguel P. Soares, Luis Teixeira, Luis F. Moita
NATURE REVIEWS IMMUNOLOGY
(2017)
Article
Immunology
Kei Sakamoto, Yun-Gi Kim, Hideki Hara, Nobuhiko Kamada, Gustavo Caballero-Flores, Emanuela Tolosano, Miguel P. Soares, Jose L. Puente, Naohiro Inohara, Gabriel Nunez
SCIENCE IMMUNOLOGY
(2017)
