Article
Immunology
Lauren Van Zeebroeck, Rebeca Arroyo Hornero, Beatriz F. Corte-Real, Ibrahim Hamad, Torsten B. Meissner, Markus Kleinewietfeld
Summary: Tregs are crucial for maintaining immune homeostasis and have potential therapeutic value in various diseases. While current genome editing protocols for Tregs are limited, our rapid and effective method may advance possibilities for Treg-based cellular therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Kathryn A. Knoop, Keely G. McDonald, Chyi-Song Hsieh, Phillip Tarr, Rodney D. Newberry
Summary: Atopic disorders are on the rise in Western societies, characterized by immune responses to environmental triggers. Early life exposure to diet and microbes shapes the intestinal Treg population significantly. Tregs developed early in life play a crucial role in restraining systemic inflammatory responses into adulthood.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Beatriz F. F. Corte-Real, Rebeca Arroyo Hornero, Aleksandra Dyczko, Ibrahim Hamad, Markus Kleinewietfeld
Summary: CSF2RB (CD131) may serve as a potential biomarker for autoimmune diseases in Tregs, with its overexpression potentially being linked to disease development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Christina Seitz, Anne-Laure Joly, Fang Fang, Katie Frith, Paul Gray, John Andersson
Summary: The transcription factor FOXP3 is crucial for the development and function of CD4(+)FOXP3(+) regulatory T (Treg) cells. Alterations in the expression of FOXP3 isoforms are associated with inflammatory disease progression. This study investigates the effects of a specific FOXP3 mutation on Treg cell subsets. The findings suggest that the full-length FOXP3 isoform is important for maintaining Treg cell lineage stability but not essential for Treg cell activation.
CLINICAL IMMUNOLOGY
(2022)
Review
Immunology
Yiran Qiu, Shouyu Ke, Jieqiong Chen, Zhizhen Qin, Wenle Zhang, Yaqin Yuan, Dehua Meng, Gang Zhao, Kejin Wu, Bin Li, Dan Li
Summary: This review summarizes the latest findings on the dynamic connections and reciprocal regulations of non-lymphoid Treg cell subsets in the immune escape of tumour cells in solid tumors, providing new insights for the development of next-generation engineered T cell-based immune treatments for solid tumors.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Biaolong Deng, Weiqi Zhang, Yicheng Zhu, Yangyang Li, Dan Li, Bin Li
Summary: Regulatory T (Treg) cells play a critical role in maintaining immune homeostasis and their dysfunction in aged patients may contribute to age-related diseases. Immune therapies targeting Treg cells show promising results in treating cancers and autoimmune diseases. Understanding Treg cell function better may help in developing new immune therapies against aging.
Article
Immunology
Disha Rao, Johanna A. A. Stunnenberg, Ruben Lacroix, Petros Dimitriadis, Joanna Kaplon, Fabienne Verburg, Paula T. T. van van Royen, Esmee P. Hoefsmit, Kathrin Renner, Christian U. U. Blank, Daniel S. S. Peeper
Summary: Glucose limitation and increased lactic acid levels due to elevated glycolytic activity of tumor cells create a metabolic barrier for tumor infiltrating immune cells. Regulatory T cells (Tregs) are not inhibited in lactic acid-rich environments, and lactic acid enhances the induction of Tregs. Acidicity in the tumor microenvironment can be targeted therapeutically to reduce Treg-mediated immune suppression within tumors.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Immunology
Juyeun Lee, Dongkyun Kim, Booki Min
Summary: Foxp3(+) regulatory T (Treg) cells are crucial for immune regulation and tolerance, and tissue resident Treg cells play a central role in regulating tissue homeostasis, inflammation, and repair.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Vahid Karpisheh, Seyedeh Mahboubeh Mousavi, Parinaz Naghavi Sheykholeslami, Mehrdad Fathi, Mehran Mohammadpour Saray, Leili Aghebati-Maleki, Reza Jafari, Naime Majidi Zolbanin, Farhad Jadidi-Niaragh
Summary: Treg cells play a critical role in the progression of prostate cancer, with higher levels of Tregs associated with an increased risk of cancer recurrence. Suppressing Tregs or depleting Tregs may be an effective strategy for prostate cancer immunotherapy.
Article
Multidisciplinary Sciences
Kazuki Sato, Yumi Yamashita-Kanemaru, Fumie Abe, Rikito Murata, Yuho Nakamura-Shinya, Kazumasa Kanemaru, Masafumi Muratani, Andre Veillette, Motohito Goto, Mamoru Ito, Akira Shibuya, Kazuko Shibuya
Summary: DNAM-1 regulates Treg cell function via TIGIT signaling, and can potentially serve as a molecular target for enhancing Treg function in inflammatory diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Sarah Yull, Shiva Shafiei, Craig B. Park, Parinaz Kazemi, Emily B. Tiemann, Marie-Helene Godin Page, Daniel Dufort
Summary: Pregnancy success relies on the establishment of maternal tolerance during the preimplantation period, which is regulated by the immunosuppressive function of regulatory T cells. Dysregulation of Nodal expression during the preimplantation period may contribute to insufficient maternal immune adaptations, leading to female infertility and recurrent implantation failure.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Dandan Yang, Xueqiang Zhao, Xin Lin
Summary: Bcl10 plays a critical role in the development and function of regulatory T (Treg) cells, deficiency of which leads to impaired development and suppressive function of Treg cells, even causing lethal autoimmunity. Bcl10-deficient Treg cells can undergo conversion into proinflammatory cells and decrease in effector Treg cell populations. The study provides genetic evidence that Bcl10 is essential for Treg cell development and function.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Takashi MaruYama, Shuhei Kobayashi, Hiroko Nakatsukasa, Yuki Moritoki, Daiki Taguchi, Yoichi Sunagawa, Tatsuya Morimoto, Atsuko Asao, Wenwen Jin, Yuji Owada, Naoto Ishii, Yoshiharu Iwabuchi, Akihiko Yoshimura, WanJun Chen, Hiroyuki Shibata
Summary: Regulatory T cells (Tregs) orchestrate antitumor immune responses, with TGF-beta promoting Treg generation through NF-kappa B/p300 and SMAD signaling pathways. GO-Y030 inhibits Treg generation and stability by blocking these pathways, resulting in potent anticancer effects in vivo tumor models.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xinlin Xiong, Zhenhua Luo, Haiyan Zhou, Zonggang Duan, Li Niu, Kai Zhang, Guangwei Huang, Wei Li
Summary: This study investigated the role and alterations of TIGIT+Tregs in acute coronary syndrome (ACS) patients. The results showed that TIGIT+Tregs levels were significantly reduced in ACS patients, accompanied by increased IL-6 expression and decreased TGF-I3 expression. Downregulated TIGIT+Tregs were independent predictors of ACS.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Immunology
Andrey Velichkov, Rumyana Susurkova, Mariya Muhtarova, Margarita Guenova, Benedicte Charmeteau-de Muylder, Remi Cheynier, Gueorgui Nikolov, Emiliana Konova, Velislava Terzieva
Summary: Unexplained infertility is a significant challenge for clinicians and researchers and has a major social impact. This study focuses on the subset of regulatory T cells and their involvement in maternal tolerance towards the fetus. The findings indicate group-specific properties in the CD45RA+ T cell compartment between healthy parous, nulliparous, and women with unexplained infertility.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)