A degradatory fate for CCR4 suggests a primary role in Th2 inflammation

Pretransplantation Anti-CCR4 Antibody Mogamulizumab Against Adult T-Cell Leukemia/Lymphoma Is Associated With Significantly Increased Risks of Severe and Corticosteroid-Refractory Graft-Versus-Host Disease, Nonrelapse Mortality, and Overall Mortality

(2016) Shigeo Fuji et al.   JOURNAL OF CLINICAL ONCOLOGY

Distinct CCR7 glycosylation pattern shapes receptor signaling and endocytosis to modulate chemotactic responses

(2016) Mark A. Hauser et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Targeting chemokine receptors in disease – a case study of CCR4

(2015) Roberto Solari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Maraviroc – A CCR5 Antagonist for the Treatment of HIV-1 Infection

(2015) Elna Van Der Ryst   Frontiers in Immunology

Internalization of the chemokine receptor CCR4 can be evoked by orthosteric and allosteric receptor antagonists

(2014) Laura Ajram et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Gain-of-functionCCR4mutations in adult T cell leukemia/lymphoma

(2014) Masao Nakagawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Chemokine Receptor CXCR3 Is Degraded following Internalization and Is Replenished at the Cell Surface by De Novo Synthesis of Receptor

(2014) A. Meiser et al.   JOURNAL OF IMMUNOLOGY

Distinct Conformations of the Chemokine Receptor CCR4 with Implications for Its Targeting in Allergy

(2014) J. M. Viney et al.   JOURNAL OF IMMUNOLOGY

Biased and G Protein-Independent Signaling of Chemokine Receptors

(2014) Anne Steen et al.   Frontiers in Immunology

Stevens-Johnson Syndrome associated with mogamulizumab treatment of adult T-cell leukemia / lymphoma

(2013) Takashi Ishida et al.   CANCER SCIENCE

CCL17/thymus and activation-regulated chemokine induces calcitonin gene–related peptide in human airway epithelial cells through CCR4

(2013) Kandace Bonner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Safety, tolerability, pharmacokinetics and pharmacodynamics of GSK2239633, a CC-chemokine receptor 4 antagonist, in healthy male subjects: results from an open-label and from a randomised study

(2013) Anthony Cahn et al.   BMC Pharmacology & Toxicology

Chemokine Receptor Antagonists

(2012) James Pease et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemokine Receptor 4 Plays a Key Role in T Cell Recruitment into the Airways of Asthmatic Patients

(2010) P. Vijayanand et al.   JOURNAL OF IMMUNOLOGY

Impaired Recruitment of Grk6 and β-Arrestin2 Causes Delayed Internalization and Desensitization of a WHIM Syndrome-Associated CXCR4 Mutant Receptor

(2009) Peter J. McCormick et al.   PLoS One

Plerixafor, a CXCR4 antagonist for the mobilization of hematopoietic stem cells

(2008) Geoffrey L Uy et al.   EXPERT OPINION ON BIOLOGICAL THERAPY