Naturally Occurring Missense MRGPRX2 Variants Display Loss of Function Phenotype for Mast Cell Degranulation in Response to Substance P, Hemokinin-1, Human β-Defensin-3, and Icatibant

Pharmacogenomics of GPCR Drug Targets

(2018) Alexander S. Hauser et al.   CELL

Mas-Related G-Protein Coupled Receptors and Cowhage-Induced Itch

(2018) Vemuri B. Reddy et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Substance P activates Mas-related G protein–coupled receptors to induce itch

(2017) Ehsan Azimi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A single amino acid in MRGPRX2 necessary for binding and activation by pruritogens

(2017) Vemuri B. Reddy et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

In silico design of novel probes for the atypical opioid receptor MRGPRX2

(2017) Katherine Lansu et al.   Nature Chemical Biology

Implications of MRGPRX2 in human and experimental cardiometabolic diseases

(2017) Ehsan Azimi et al.   Nature Reviews Cardiology

The dual regulation of substance P-mediated inflammation via human synovial mast cells in rheumatoid arthritis

(2017) Yuki Okamura et al.   ALLERGOLOGY INTERNATIONAL

Functional relevance of naturally occurring mutations in adhesion G protein-coupled receptor ADGRD1 (GPR133)

(2016) Liane Fischer et al.   BMC GENOMICS

Roles of Mas-related G protein–coupled receptor X2 on mast cell–mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases

(2016) Hariharan Subramanian et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

How mast cells make decisions

(2016) Jörn Karhausen et al.   JOURNAL OF CLINICAL INVESTIGATION

Different activation signals induce distinct mast cell degranulation strategies

(2016) Nicolas Gaudenzio et al.   JOURNAL OF CLINICAL INVESTIGATION

Autocrine hemokinin-1 functions as an endogenous adjuvant for IgE-mediated mast cell inflammatory responses

(2015) Tina L. Sumpter et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria

(2014) Daisuke Fujisawa et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions

(2014) Benjamin D. McNeil et al.   NATURE

A general framework for estimating the relative pathogenicity of human genetic variants

(2014) Martin Kircher et al.   NATURE GENETICS

 -Defensins Activate Human Mast Cells via Mas-Related Gene X2

(2013) H. Subramanian et al.   JOURNAL OF IMMUNOLOGY

Naturally occurring HCA1 missense mutations result in loss of function: potential impact on lipid deposition

(2012) Jamie R. Doyle et al.   JOURNAL OF LIPID RESEARCH

Randomized placebo-controlled trial of the bradykinin B2 receptor antagonist icatibant for the treatment of acute attacks of hereditary angioedema: the FAST-3 trial

(2011) William R. Lumry et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Mas-related Gene X2 (MrgX2) Is a Novel G Protein-coupled Receptor for the Antimicrobial Peptide LL-37 in Human Mast Cells

(2011) Hariharan Subramanian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PMX-53 as a Dual CD88 Antagonist and an Agonist for Mas-Related Gene 2 (MrgX2) in Human Mast Cells

(2011) H. Subramanian et al.   MOLECULAR PHARMACOLOGY

An update on innate defense molecules of human gingiva

(2011) Lijian Jin   PERIODONTOLOGY 2000

Diversity and modularity of G protein-coupled receptor structures

(2011) Vsevolod Katritch et al.   TRENDS IN PHARMACOLOGICAL SCIENCES