Blocking IL-2 Signal In Vivo with an IL-2 Antagonist Reduces Tumor Growth through the Control of Regulatory T Cells
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Blocking IL-2 Signal In Vivo with an IL-2 Antagonist Reduces Tumor Growth through the Control of Regulatory T Cells
Authors
Keywords
-
Journal
JOURNAL OF IMMUNOLOGY
Volume 200, Issue 10, Pages 3475-3484
Publisher
The American Association of Immunologists
Online
2018-04-04
DOI
10.4049/jimmunol.1700433
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Cytokine Signaling in the Development and Homeostasis of Regulatory T cells
- (2017) Kevin H. Toomer et al. Cold Spring Harbor Perspectives in Biology
- An essential role for the IL-2 receptor in Treg cell function
- (2016) Takatoshi Chinen et al. NATURE IMMUNOLOGY
- Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps
- (2015) Suman Mitra et al. IMMUNITY
- PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells
- (2013) Erin E. West et al. JOURNAL OF CLINICAL INVESTIGATION
- Human IL-2 Mutein with Higher Antitumor Efficacy Than Wild Type IL-2
- (2013) T. Carmenate et al. JOURNAL OF IMMUNOLOGY
- Fine epitope specificity of antibodies against interleukin-2 explains their paradoxical immunomodulatory effects
- (2013) Gertrudis Rojas et al. mAbs
- Mathematical Models of the Impact of IL2 Modulation Therapies on T Cell Dynamics
- (2013) Kalet León et al. Frontiers in Immunology
- The Prognostic Value of FoxP3+ Tumor-Infiltrating Lymphocytes in Cancer: A Critical Review of the Literature
- (2012) R. J. deLeeuw et al. CLINICAL CANCER RESEARCH
- Deciphering the molecular bases of the biological effects of antibodies against Interleukin-2: A versatile platform for fine epitope mapping
- (2012) Gertrudis Rojas et al. IMMUNOBIOLOGY
- Modeling the role of IL2 in the interplay between CD4+ helper and regulatory T cells: studying the impact of IL2 modulation therapies
- (2012) K. Garcia-Martinez et al. INTERNATIONAL IMMUNOLOGY
- Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’
- (2012) Aron M. Levin et al. NATURE
- Targeting regulatory T cells
- (2012) Christine Ménétrier-Caux et al. Targeted Oncology
- Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages
- (2011) Wei Liao et al. NATURE IMMUNOLOGY
- Dendritic Cell Vaccination in Combination with Anti-CD25 Monoclonal Antibody Treatment: A Phase I/II Study in Metastatic Melanoma Patients
- (2010) J. F. M. Jacobs et al. CLINICAL CANCER RESEARCH
- Efficient Treg depletion induces T-cell infiltration and rejection of large tumors
- (2010) Xingrui Li et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity
- (2010) Thomas R. Malek et al. IMMUNITY
- In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression
- (2009) Kylie E. Webster et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Engineered Interleukin-2 Antagonists for the Inhibition of Regulatory T Cells
- (2009) David V. Liu et al. JOURNAL OF IMMUNOTHERAPY
- Modeling the role of IL-2 in the interplay between CD4+ helper and regulatory T cells: Assessing general dynamical properties
- (2009) Karina García-Martínez et al. JOURNAL OF THEORETICAL BIOLOGY
- Regulatory T cells exert checks and balances on self tolerance and autoimmunity
- (2009) Kajsa Wing et al. NATURE IMMUNOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More