Immunoregulatory functions and the therapeutic implications of GARP-TGF-β in inflammation and cancer
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Immunoregulatory functions and the therapeutic implications of GARP-TGF-β in inflammation and cancer
Authors
Keywords
TGF-β, GARP, Treg, Immune tolerance, Cancer, Platelets
Journal
Journal of Hematology & Oncology
Volume 11, Issue 1, Pages -
Publisher
Springer Nature
Online
2018-02-20
DOI
10.1186/s13045-018-0570-z
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Glycoprotein A repetitions predominant (GARP) positively regulates transforming growth factor (TGF) β3 and is essential for mouse palatogenesis
- (2017) Bill X. Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PD-1, PD-L1 (B7-H1) and Tumor-Site Immune Modulation Therapy: The Historical Perspective
- (2017) Jun Wang et al. Journal of Hematology & Oncology
- Tumor-associated macrophages: from basic research to clinical application
- (2017) Li Yang et al. Journal of Hematology & Oncology
- Cutting Edge: Active TGF-β1 Released from GARP/TGF-β1 Complexes on the Surface of Stimulated Human B Lymphocytes Increases Class-Switch Recombination and Production of IgA
- (2017) Olivier Dedobbeleer et al. JOURNAL OF IMMUNOLOGY
- Role of GARP in the activation of latent TGF-β1
- (2017) Julie Stockis et al. Molecular BioSystems
- Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8
- (2017) Julie Stockis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Non-resolving inflammation and cancer
- (2017) Hong-Yang Wang Science China-Life Sciences
- Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells
- (2017) Stephanie Downs-Canner et al. Nature Communications
- The role of platelet and endothelial GARP in thrombosis and hemostasis
- (2017) Elien Vermeersch et al. PLoS One
- GARP inhibits allergic airway inflammation in a humanized mouse model
- (2016) H. Meyer-Martin et al. ALLERGY
- Methylation of an intragenic alternative promoter regulates transcription of GARP
- (2016) Sonja Haupt et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Surface Expression of TGFβ Docking Receptor GARP Promotes Oncogenesis and Immune Tolerance in Breast Cancer
- (2016) Alessandra Metelli et al. CANCER RESEARCH
- Molecular Pathways: The Balance between Cancer and the Immune System Challenges the Therapeutic Specificity of Targeting Nuclear Factor- B Signaling for Cancer Treatment
- (2016) K. P. Zeligs et al. CLINICAL CANCER RESEARCH
- Deletion of interleukin-6 in monocytes/macrophages suppresses the initiation of hepatocellular carcinoma in mice
- (2016) Lingxiang Kong et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- IL-6 Inhibits Upregulation of Membrane-Bound TGF-β 1 on CD4+T Cells and Blocking IL-6 Enhances Oral Tolerance
- (2016) Chantal Kuhn et al. JOURNAL OF IMMUNOLOGY
- Targeted Resequencing and Functional Testing Identifies Low-Frequency Missense Variants in the Gene Encoding GARP as Significant Contributors to Atopic Dermatitis Risk
- (2016) Judith Manz et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- TGF-β: the master regulator of fibrosis
- (2016) Xiao-ming Meng et al. Nature Reviews Nephrology
- How Soluble GARP Enhances TGFβ Activation
- (2016) Sven Fridrich et al. PLoS One
- Activated glycoprotein A repetitions predominant (GARP)–expressing regulatory T cells inhibit allergen-induced intestinal inflammation in humanized mice
- (2015) Melanie Eschborn et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- GP96 is a GARP chaperone and controls regulatory T cell functions
- (2015) Yongliang Zhang et al. JOURNAL OF CLINICAL INVESTIGATION
- Hepatic Stellate Cells Inhibit T Cells through Active TGF-β1 from a Cell Surface–Bound Latent TGF-β1/GARP Complex
- (2015) Yan Li et al. JOURNAL OF IMMUNOLOGY
- Transforming Growth Factor Beta Family: Insight into the Role of Growth Factors in Regulation of Fracture Healing Biology and Potential Clinical Applications
- (2015) Łukasz A. Poniatowski et al. MEDIATORS OF INFLAMMATION
- Targeting the TGFβ pathway for cancer therapy
- (2015) Cindy Neuzillet et al. PHARMACOLOGY & THERAPEUTICS
- Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo
- (2015) Julia Cuende et al. Science Translational Medicine
- Identification and characterization of latency-associated peptide-expressing γδ T cells
- (2015) Rafael M. Rezende et al. Nature Communications
- Helios, and not FoxP3, is the marker of activated Tregs expressing GARP/LAP
- (2015) Eyad Elkord et al. Oncotarget
- Tyrosine phosphorylation in Toll-like receptor signaling
- (2014) Saurabh Chattopadhyay et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Lower circulating platelet counts and antiplatelet therapy independently predict better outcomes in patients with head and neck squamous cell carcinoma
- (2014) Saleh Rachidi et al. Journal of Hematology & Oncology
- Release of Active TGF-β1 from the Latent TGF-β1/GARP Complex on T Regulatory Cells Is Mediated by Integrin β8
- (2014) Justin P. Edwards et al. JOURNAL OF IMMUNOLOGY
- A draft map of the human proteome
- (2014) Min-Sik Kim et al. NATURE
- Mass-spectrometry-based draft of the human proteome
- (2014) Mathias Wilhelm et al. NATURE
- Platelets Effects on Tumor Growth
- (2014) Hadi A. Goubran et al. SEMINARS IN ONCOLOGY
- Platelet–Cancer Interactions
- (2014) Julie Stakiw et al. SEMINARS IN THROMBOSIS AND HEMOSTASIS
- Mesenchymal Stromal Cells Express GARP/LRRC32 on Their Surface: Effects on Their Biology and Immunomodulatory Capacity
- (2014) Ana Belén Carrillo-Galvez et al. STEM CELLS
- Soluble GARP has potent antiinflammatory and immunomodulatory impact on human CD4+ T cells
- (2013) S. A. Hahn et al. BLOOD
- Higher Frequencies of GARP+CTLA-4+Foxp3+ T Regulatory Cells and Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Are Associated with Impaired T-Cell Functionality
- (2013) S. Kalathil et al. CANCER RESEARCH
- Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients
- (2013) Mercedes Herrera et al. CANCER SCIENCE
- TLR2 enhances ovarian cancer stem cell self-renewal and promotes tumor repair and recurrence
- (2013) Ilana Chefetz et al. CELL CYCLE
- Unchaining the beast; insights from structural and evolutionary studies on TGFβ secretion, sequestration, and activation
- (2013) Ian B. Robertson et al. CYTOKINE & GROWTH FACTOR REVIEWS
- The platelet–cancer loop
- (2013) Hadi A. Goubran et al. European Journal of Internal Medicine
- α7 Helix Region of αI Domain Is Crucial for Integrin Binding to Endoplasmic Reticulum Chaperone gp96
- (2013) Feng Hong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of the Expression of GARP/Latent TGF- 1 Complexes on Mouse T Cells and Their Role in Regulatory T Cell and Th17 Differentiation
- (2013) J. P. Edwards et al. JOURNAL OF IMMUNOLOGY
- miR-142-3p Is Involved in CD25+ CD4 T Cell Proliferation by Targeting the Expression of Glycoprotein A Repetitions Predominant
- (2013) Q. Zhou et al. JOURNAL OF IMMUNOLOGY
- Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization
- (2013) Klaus Bønnelykke et al. NATURE GENETICS
- GARP Is Regulated by miRNAs and Controls Latent TGF-β1 Production by Human Regulatory T Cells
- (2013) Emilie Gauthy et al. PLoS One
- Complexities of TGF-β Targeted Cancer Therapy
- (2012) Erin C. Connolly et al. International Journal of Biological Sciences
- The Molecular Chaperone gp96/GRP94 Interacts with Toll-like Receptors and Integrins via Its C-terminal Hydrophobic Domain
- (2012) Shuang Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Deletion of TGF- signaling in myeloid cells enhances their anti-tumorigenic properties
- (2012) S. V. Novitskiy et al. JOURNAL OF LEUKOCYTE BIOLOGY
- GARP regulates the bioavailability and activation of TGFβ
- (2012) Rui Wang et al. MOLECULAR BIOLOGY OF THE CELL
- Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
- (2012) Sergei I. Grivennikov et al. NATURE
- Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
- (2012) Luke Jostins et al. NATURE
- TGF-β is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy
- (2012) Jeffrey P Marcoe et al. NATURE IMMUNOLOGY
- Targeting Regulatory T Cells in Cancer
- (2011) W. L. Byrne et al. CANCER RESEARCH
- The NF-κB pathway mediates lysophosphatidic acid (LPA)-induced VEGF signaling and cell invasion in epithelial ovarian cancer (EOC)
- (2011) Sonia Dutta et al. GYNECOLOGIC ONCOLOGY
- Latent TGF-β structure and activation
- (2011) Minlong Shi et al. NATURE
- Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer
- (2011) R. Navab et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Normal ranges of angiogenesis regulatory proteins in human platelets
- (2010) Jon E. Peterson et al. AMERICAN JOURNAL OF HEMATOLOGY
- Transient Tumor-Fibroblast Interactions Increase Tumor Cell Malignancy by a TGF-β Mediated Mechanism in a Mouse Xenograft Model of Breast Cancer
- (2010) Christina H. Stuelten et al. PLoS One
- Foxp3 Regulates Megakaryopoiesis and Platelet Function
- (2009) Jamie J. Bernard et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis
- (2009) M. Staron et al. BLOOD
- Anti-inflammatory and pro-inflammatory roles of TGF-β, IL-10, and IL-22 in immunity and autoimmunity
- (2009) Shomyseh Sanjabi et al. CURRENT OPINION IN PHARMACOLOGY
- Membrane protein GARP is a receptor for latent TGF-β on the surface of activated human Treg
- (2009) Julie Stockis et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression
- (2009) Ethan M. Shevach IMMUNITY
- GARP: a key receptor controlling FOXP3 in human regulatory T cells
- (2009) M. Probst-Kepper et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Anti-CD25 Antibody-Mediated Depletion of Effector T Cell Populations Enhances Susceptibility of Mice to Acute but Not Chronic Toxoplasma gondii Infection
- (2009) K. N. Couper et al. JOURNAL OF IMMUNOLOGY
- GARP (LRRC32) is essential for the surface expression of latent TGF- on platelets and activated FOXP3+ regulatory T cells
- (2009) D. Q. Tran et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells
- (2009) R. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Role of transforming growth factor-β superfamily signaling pathways in human disease
- (2008) Kelly J. Gordon et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins
- (2008) Marie N. O'Connor et al. BLOOD
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started