Journal
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Volume 33, Issue 8, Pages 1485-1491Publisher
WILEY
DOI: 10.1111/jgh.14116
Keywords
elderly patients; leukocytapheresis; safety; ulcerative colitis
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Funding
- Health and Sciences Research Grants for Research on Intractable Diseases from the Ministry of Health, Labour and Welfare of Japan
- National Defense Medical College
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Background and AimThe number of elderly patients with ulcerative colitis (UC) is increasing. Several new therapies for UC have improved patient outcomes. Leukocytapheresis (LCAP) is an extracorporeal therapy for UC. However, its efficacy and safety for elderly UC patients has not been reported. MethodsWe conducted a post hoc analysis of data from a large, prospective, observational study of LCAP, conducted at 116 medical facilities in Japan between May 2010 and December 2012. Of 847 patients included in this analysis, LCAP was used in 75 (8.9%) elderly patients (65years) and 772 (91.1%) non-elderly patients. ResultsThere were no serious adverse events in the elderly, and the rate of adverse events between the non-elderly and elderly was not different. Overall rate of remission was also not different between the two groups. In patients who were not on concomitant treatment with corticosteroids, the rate of remission was significantly higher in the elderly group than in the non-elderly group (90.9% [20/22] vs 64.6% [135/209], P=0.02). ConclusionsReal-world data demonstrate that the safety and tolerability of LCAP were comparable in the elderly and non-elderly groups, indicating that it is well tolerated by elderly UC patients.
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