Article
Pharmacology & Pharmacy
Wen-wen Zhao, Meng Xiao, Xia Wu, Xiu-wei Li, Xiao-xi Li, Ting Zhao, Lan Yu, Xiao-qing Chen
Summary: Treatment with IsA can prevent HFD-induced NAFLD and reduce cholesterol levels by regulating gut microbiota and BA metabolism, through mechanisms including enhanced BA synthesis and excretion, as well as altered expression of key hepatic transporters.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Mengjie Kong, Yan Peng, Liyan Qiu
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease worldwide, but there is no FDA-approved drug for its treatment. This study designed oligochitosan-derivated nanovesicles to deliver an FXR agonist and miR-34a antagomir for NAFLD treatment. The nanovesicles effectively reduced lipid deposition in cells and showed promising results in NAFLD mice models. The study also demonstrated the activation of SIRT1 through the FXR/miR-34a/SIRT1 regulatory loop.
ACTA BIOMATERIALIA
(2023)
Review
Chemistry, Multidisciplinary
Ting-ying Jiao, Yuan-di Ma, Xiao-zhen Guo, Yun-fei Ye, Cen Xie
Summary: Nonalcoholic fatty liver disease (NAFLD), characterized by lipid accumulation in liver cells, has become the primary cause of chronic liver diseases worldwide. The progression of NAFLD to nonalcoholic steatohepatitis (NASH) is strongly related to multiple metabolic disorders and diseases. Disturbances in bile acid metabolism play a significant role in NASH pathogenesis, and bile acid receptors are considered attractive targets for NASH treatment.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Shuai Xu, Lina Kong, Lin Li, Changyuan Wang, Jiangning Gu, Haifeng Luo, Qiang Meng
Summary: This study found that FXR is significantly reduced in the livers of NAFLD patients. Overexpression of FXR can improve NAFLD and inhibit oxidative stress and AIM2 inflammasome activation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Gastroenterology & Hepatology
Xinzhu Liu, Jiaxuan Wang, Maogang Li, Jiannan Qiu, Xingying Li, Li Qi, Jia Liu, Ping Liu, Guoxiang Xie, Xiaoning Wang
Summary: FXR plays a key role in both BA and FA metabolism in NAFLD combined with cholestasis, suggesting it may be a potential target for the treatment of disorders in BA and FA metabolism in this condition.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Plant Sciences
Chuangpeng Shen, Zhisen Pan, Shuangcheng Wu, Mingxuan Zheng, Chong Zhong, Xiaoyi Xin, Shaoyang Lan, Zhangzhi Zhu, Min Liu, Haoxiang Wu, Qingyin Huang, Junmei Zhang, Zhangzhou Liu, Yuqi Si, Haitao Tu, Zhijun Deng, Yuanyuan Yu, Hong Liu, Yanhua Zhong, Jiewen Guo, Jiazhong Cai, Shaoxiang Xian
Summary: Emodin, a major bioactive constituent of Cassia mimosoides Linn, has protective effects against high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) by activating farnesoid X receptor (FXR) signaling. Emodin improves lipid accumulation, insulin resistance, inflammation, and oxidative stress through FXR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Varsha D. D. Shiragannavar, Nirmala G. G. Sannappa Gowda, Lakshana D. D. Puttahanumantharayappa, Shreyas H. H. Karunakara, Smitha Bhat, Shashanka K. K. Prasad, Divya P. P. Kumar, Prasanna K. K. Santhekadur
Summary: The incidence of non-alcoholic fatty liver disease (NAFLD) is rapidly increasing and has become a major disease in the modern world. Withaferin A, a natural dietary compound, shows potential as a therapeutic agent for the treatment of NAFLD due to its anti-inflammatory properties and its ability to regulate metabolism-associated gene expressions.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Junxiao Li, Chuhe Liu, Zhenyu Zhou, Baokai Dou, Jinwen Huang, Leilei Huang, Peiyong Zheng, Shengjie Fan, Cheng Huang
Summary: ITG has shown promising therapeutic effects in improving hepatic steatosis, inflammation, fibrosis, and cholestatic liver injury in different mouse models, suggesting its potential as a novel therapy for NASH, hepatic fibrosis, or primary biliary cholangitis.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Xian-Chun Zhong, Ya-Meng Liu, Xiao-Xia Gao, Kristopher W. Krausz, Bing Niu, Frank J. Gonzalez, Cen Xie
Summary: The study found that caffeic acid phenethyl ester (CAPE) can improve obesity-related fatty liver disease (NAFLD) by inhibiting bacterial bile salt hydrolase (BSH) activity in the gut, suggesting that propolis enriched with CAPE may serve as a promising therapeutic agent for the treatment of NAFLD.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Pharmacology & Pharmacy
Suwen Chen, Shangwen Sun, Yanan Feng, Xiu Li, Guoliang Yin, Pengpeng Liang, Wenfei Yu, Decheng Meng, Xin Zhang, Hongshuai Liu, Fengxia Zhang
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common liver disease without approved treatment. Hepatic farnesoid X receptor (FXR) is a potential therapeutic target for NAFLD. Diosgenin (DG), a natural compound from Chinese herbal medicine, effectively prevents metabolic diseases. Our research reveals that DG can alleviate NAFLD by regulating the hepatic FXR-SHP-SREBP1C/PPARa/CD36 pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hao Sun, Jongsook Kim Kemper
Summary: This review discusses the role of aberrantly expressed microRNAs in reducing AMPK activity in NAFLD and NASH, as well as the underlying mechanisms and therapeutic potential of targeting the miR-AMPK pathway for these liver diseases.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Ines L. Paraiso, Thai Q. Tran, Armando Alcazar Magana, Payel Kundu, Jaewoo Choi, Claudia S. Maier, Gerd Bobe, Jacob Raber, Chrissa Kioussi, Jan F. Stevens
Summary: This study demonstrated that XN supplementation in a high-fat diet can alleviate hepatic steatosis and reduce BA concentrations in FXR-deficient mice, with a stronger effect in males. XN also induced the expression of CAR, PXR, and GR genes in the livers of FXR-deficient mice, suggesting activation of BA detoxification pathways as the predominant mechanism. These findings indicate a sex-dependent relationship between FXR, lipids, and BAs, and suggest that XN improves HFD-induced liver dysfunction through both FXR-dependent and independent signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Aoxiang Zhuge, Shengjie Li, Yin Yuan, Shengyi Han, Jiafeng Xia, Qiangqiang Wang, Shuting Wang, Pengcheng Lou, Bo Li, Lanjuan Li
Summary: Research has found that Obeticholic acid (OCA) has unsatisfactory antifibrotic effect and deficient responsive rate in treating non-alcoholic steatohepatitis (NASH). This is due to the gut microbiota shaped by OCA, which induces lipid peroxidation and impairs its antifibrotic effect. Additionally, OCA leads to liver ROS accumulation, causing hepatocyte ferroptosis and activation of hepatic stellate cells (HSCs). However, inhibiting lipid peroxidation can rescue the antifibrotic effect of OCA.
Review
Pharmacology & Pharmacy
Jianglian She, Tanwei Gu, Xiaoyan Pang, Yonghong Liu, Lan Tang, Xuefeng Zhou
Summary: This review provides an overview of natural products that can influence LXRs and FXR, serving as a reference for future research on novel LXRs and FXR agonists and antagonists, and attracting more professional scholars for in-depth discussions.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Stefano Fiorucci, Michele Biagioli, Monia Baldoni, Patrizia Ricci, Valentina Sepe, Angela Zampella, Eleonora Distrutti
Summary: FXR agonists show potential in treating nonalcoholic fatty liver disease, but side effects such as elevated cholesterol levels and pruritus are common. Studies are underway to evaluate the benefits and safety of combination therapies.
EXPERT OPINION ON DRUG DISCOVERY
(2021)
Article
Cell Biology
Yilin Wang, Jin Wen, Marwan Almoiliqy, Yaojia Wang, Zhihao Liu, Xiaobo Yang, Xiaolong Lu, Qiang Meng, Jinyong Peng, Yuan Lin, Pengyuan Sun
Summary: Sesamin protects against and ameliorates intestinal ischemia-reperfusion (I/R) injuries and hypoxia/reoxygenation (H/R) injuries by activating the Nrf2 signaling pathway, showing anti-inflammatory, antioxidative, and antiapoptotic effects in both in vivo and in vitro models. Activation of the Nrf2/HO-1/NQO1 signaling pathway is crucial in mediating these effects.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Pharmacology & Pharmacy
Zhihao Liu, Xiaozhou Wen, Guangji Wang, Ying Zhou
Summary: 23-HBA significantly enhances the efficacy of anti-tumor agents in MDR cells, related to P-gp inhibition. Experimental results demonstrate that 23-HBA can improve cytotoxicity of ADR and VCR in MDR cells and affect the transport of P-gp substrates.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rui Liu, Kate Marshall, Rui Ma, Kim Lien Thi Pham, Gauri Shetye, Zhihao Liu, Sanghyun Cho, Hyunyoung Jeong, Scott G. Franzblau, Garrett C. Moraski, Marvin J. Miller
Summary: This article describes the research on the design and synthesis of potent deuterated IAPs and investigates the effect of deuteration on metabolism through microsomal stability studies.
BIOORGANIC CHEMISTRY
(2022)
Correction
Pharmacology & Pharmacy
Xue Sun, Xingping Duan, Changyuan Wang, Zhihao Liu, Pengyuan Sun, Xiaokui Huo, Xiaodong Ma, Huijun Sun, Kexin Liu, Qiang Meng
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Yanfang Li, Zhihao Liu, Gillian Manka Tamia, Xiaohua He, Jianghao Sun, Pei Chen, Seong-Ho Lee, Thomas T. Y. Wang, Boyan Gao, Zhuohong Xie, Liangli Lucy Yu
Summary: Different types of phenolic compounds in tomato seeds were analyzed, with the insoluble bound fraction showing stronger antioxidant activity and anti-cancer cell proliferation effects. The soluble free and insoluble bound fractions significantly inhibited colorectal cancer cell proliferation, providing a basis for the future use of tomato seeds as nutraceuticals in dietary supplements and functional foods.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Yanfang Li, Zhihao Liu, Melody Zeng, Alem El Kadiri, Jhongyan Huang, Ashley Kim, Xiaohua He, Jianghao Sun, Pei Chen, Thomas T. Y. Wang, Yaqiong Zhang, Boyan Gao, Zhuohong Xie, Liangli Lucy Yu
Summary: In this study, clove water and ethanol extracts were found to have potential in reducing the risk of SARS-CoV-2 infection by suppressing the binding between spike protein and ACE2, reducing ACE2 availability, and scavenging free radicals. Clove water extract showed stronger inhibitory effects and free radical scavenging activities than ethanol extract.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Agriculture, Multidisciplinary
Zhihao Liu, Mengliang Zhang, Pei Chen, James M. Harnly, Jianghao Sun
Summary: This review discusses the applications of mass spectrometry (MS) techniques in food and agricultural research, including targeted and nontargeted analysis. It summarizes recent publications in the field, such as flow injection MS fingerprinting, chromatography-tandem MS metabolomics, and ambient mass spectrometry. The review also highlights the development of MS data deconvolution software packages and databases for metabolomic studies.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Zhihao Liu, Roderick Moore, Ying Gao, Pei Chen, Liangli Yu, Mengliang Zhang, Jianghao Sun
Summary: This study used UHPLC-HRMS-based metabolomic approach to analyze the secondary metabolites of wild and cultivated American ginsengs, and found significant differences in ginsenoside profiles between the two. Wild American ginsengs had more abundant and diverse octillol-type ginsenosides, while cultivated American ginsengs had a wider distribution of protopanaxadiol and oleanolic acid-type ginsenosides. The results suggested that the in-house metabolite library and UHPLC-HRMS were effective for identifying characteristic components for distinguishing wild and cultivated American ginseng.
Article
Agriculture, Multidisciplinary
Zhuohong Xie, Yanfang Li, Zhihao Liu, Melody Zeng, Jeffrey C. Moore, Boyan Gao, Xianli Wu, Jianghao Sun, Thomas T. Y. Wang, Pamela Pehrsson, Xiaohua He, Liangli Lucy Yu
Summary: In this study, the bioactives in cinnamon water and ethanol extracts were identified, and it was found that they can suppress the binding of SARS-CoV-2 spike protein to ACE2, reduce ACE2 availability, and scavenge free radicals. Furthermore, new compounds were discovered in cinnamon.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Boyan Gao, Lin Zhu, Zhihao Liu, Yanfang Li, Xiaohua He, Xianli Wu, Pamela Pehrsson, Jianghao Sun, Zhuohong Xie, Margaret Slavin, Liangli Lucy Yu
Summary: This study examined the chemical compositions of water and ethanol extracts of honeysuckle, as well as their potential in inhibiting SARS-CoV-2 spike protein binding to ACE2, suppressing ACE2 activity, and scavenging reactive free radicals. The results showed that both extracts inhibited the binding of SARS-CoV-2 spike protein to ACE2 and ACE2 activity. The water extract had stronger inhibitory effects on ACE2 activity and higher scavenging activities against free radicals compared to the ethanol extract. These findings suggest that honeysuckle may reduce the risk of SARS-CoV-2 infection and severe COVID-19 symptoms.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Uyory Choe, Yanfang Li, Zhihao Liu, Yuanhang Yao, Xiaohua He, Jianghao Sun, Xianli Wu, Pamela Pehrsson, Yaqiong Zhang, Boyan Gao, Thomas T. Y. Wang, Liangli Lucy Yu
Summary: This study evaluates dill's potential in preventing SARS-CoV-2 infiltration and alleviating COVID-19 symptoms. The results show that dill extracts have the ability to inhibit the interaction between SARS-CoV-2 spike protein and ACE2 receptor, as well as ACE2 enzyme activity. Additionally, dill exhibits high total phenolic content and free radical scavenging capacity.
ACS FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Yuanhang Yao, Monica Whent, Yanfang Li, Zhihao Liu, Pamela Pehrsson, Jianghao Sun, Pei Chen, Dejian Huang, Thomas T. Y. Wang, Xianli Wu, Liangli Yu
Summary: In this study, water and ethanol extracts of dried thyme were analyzed for their chemical composition and their effects on the SARS-CoV-2 spike protein-ACE2 interaction, ACE2 activity, and free radical scavenging capacity. The results showed that thyme extracts inhibited the spike protein-ACE2 interaction, inhibited ACE2 activity, and exhibited free radical scavenging capacity. The findings suggest that thyme extract could potentially be used to prevent SARS-CoV-2 infection and mitigate the complications from the infection.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Zhihao Liu, Jenna Shi, Jiawei Wan, Quynchi Pham, Zhi Zhang, Jianghao Sun, Liangli Yu, Yaguang Luo, Thomas T. Y. Wang, Pei Chen
Summary: This study provides the first report on the polyphenol and glucosinolate composition of kale and broccoli microgreens grown in different environments. The results showed a clear variation in secondary metabolites between growth chamber and windowsill conditions, suggesting that the growing environment affects the composition of health-beneficial components in vegetables.
ACS FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Food Science & Technology
Yanfang Li, Katherine Wu, Zhihao Liu, Xiaohua He, Jianghao Sun, Melody Zeng, Seong-Ho Lee, Thomas T. Y. Wang, Boyan Gao, Zhuohong Xie, Cheng- Wei, Liangli Lucy Yu
Summary: This study investigated the effects of different thermal treatments (steaming and baking) on the chemical compositions, antioxidant components, and antioxidant properties of tomato seeds. The results showed that thermal treatments can alter the phenolic compositions of tomato seeds and steaming can effectively enhance their antioxidant activities.
ACS FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Food Science & Technology
Zhihao Liu, Zi Teng, Daniel J. Pearlstein, Pei Chen, Liangli Yu, Bin Zhou, Yaguang Luo, Jianghao Sun
Summary: This research investigated the effect of LED light wavelengths on the phytochemical profiles of Ruby Streaks mustard microgreens, and found that red and magenta light promoted the accumulation of anthocyanins and aliphatic GLs, while blue light was dominant in the accumulation of non-anthocyanin phenolics.
ACS FOOD SCIENCE & TECHNOLOGY
(2022)