The oncogenic neurotrophin receptor tropomyosin-related kinase variant, TrkAIII

Spontaneous regression of neuroblastoma

(2018) Garrett M. Brodeur   CELL AND TISSUE RESEARCH

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

Targeting the PI3K pathway in cancer: are we making headway?

(2018) Filip Janku et al.   Nature Reviews Clinical Oncology

Efficacy of Larotrectinib in TRK Fusion–Positive Cancers in Adults and Children

(2018) Alexander Drilon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibiting TRK Proteins in Clinical Cancer Therapy

(2018) Allison Lange et al.   Cancers

Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 – Part II

(2017) Justin J. Bailey et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Oncogene-Induced Replication Stress Drives Genome Instability and Tumorigenesis

(2017) Dan Sarni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TrkA is a binding partner of NPM-ALK that promotes the survival of ALK+ T-cell lymphoma

(2017) Wenyu Shi et al.   Molecular Oncology

Cytosolic proteostasis through importing of misfolded proteins into mitochondria

(2017) Linhao Ruan et al.   NATURE

Identification of a DNA Damage–Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers

(2017) Jing Chen et al.   Cancer Discovery

TrkAIII signals endoplasmic reticulum stress to the mitochondria in neuroblastoma cells, resulting in glycolytic metabolic adaptation

(2017) Antonietta Rosella Farina et al.   Oncotarget

Endoplasmic Reticulum Stress, Unfolded Protein Response, and Cancer Cell Fate

(2017) Marco Corazzari et al.   Frontiers in Oncology

Nerve growth factor: role in growth, differentiation and controlling cancer cell development

(2016) Luigi Aloe et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cancer Metabolism: Fueling More than Just Growth

(2016) Namgyu Lee et al.   MOLECULES AND CELLS

Inhibition of nonsense-mediated RNA decay by ER stress

(2016) Zhelin Li et al.   RNA

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

TRAIL induces pro-apoptotic crosstalk between the TRAIL-receptor signaling pathway and TrkAIII in SH-SY5Y cells, unveiling a potential therapeutic “Achilles heel” for the TrkAIII oncoprotein in neuroblastoma

(2016) Luciana Gneo et al.   Oncotarget

TrkA is amplified in malignant melanoma patients and induces an anti-proliferative response in cell lines

(2015) Luigi Pasini et al.   BMC CANCER

TFG clusters COPII-coated transport carriers and promotes early secretory pathway organization

(2015) A. Johnson et al.   EMBO JOURNAL

Evaluation of a Congenital Infantile Fibrosarcoma by Comprehensive Genomic Profiling Reveals an LMNA-NTRK1 Gene Fusion Responsive to Crizotinib

(2015) Victor Wong et al.   JNCI-Journal of the National Cancer Institute

Sensitivity to Entrectinib Associated With a Novel LMNA-NTRK1 Gene Fusion in Metastatic Colorectal Cancer

(2015) Andrea Sartore-Bianchi et al.   JNCI-Journal of the National Cancer Institute

Retrograde TrkAIII transport from ERGIC to ER: a re-localisation mechanism for oncogenic activity

(2015) Antonietta Rosella Farina et al.   Oncotarget

Evaluation of a Congenital Infantile Fibrosarcoma by Comprehensive Genomic Profiling Reveals an LMNA-NTRK1 Gene Fusion Responsive to Crizotinib

(2015) Victor Wong et al.   JNCI-Journal of the National Cancer Institute

Sensitivity to Entrectinib Associated With a Novel LMNA-NTRK1 Gene Fusion in Metastatic Colorectal Cancer

(2015) Andrea Sartore-Bianchi et al.   JNCI-Journal of the National Cancer Institute

New insights into the roles of CHOP-induced apoptosis in ER stress

(2014) Yiming Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

The TrkAIII Oncoprotein Inhibits Mitochondrial Free Radical ROS-Induced Death of SH-SY5Y Neuroblastoma Cells by Augmenting SOD2 Expression and Activity at the Mitochondria, within the Context of a Tumour Stem Cell-like Phenotype

(2014) Pierdomenico Ruggeri et al.   PLoS One

Kinase fusions are frequent in Spitz tumours and spitzoid melanomas

(2014) Thomas Wiesner et al.   Nature Communications

TRKing Down an Old Oncogene in a New Era of Targeted Therapy

(2014) Aria Vaishnavi et al.   Cancer Discovery

The Warburg effect version 2.0: Metabolic reprogramming of cancer stem cells

(2013) JAVIER MENENDEZ et al.   CELL CYCLE

Control of ALK (wild type and mutated forms) phosphorylation: Specific role of the phosphatase PTP1B

(2013) M.C. Boutterin et al.   CELLULAR SIGNALLING

The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered

(2013) Hui K. Gan et al.   FEBS Journal

Ordered Recruitment of Dynactin to the Microtubule Plus-End is Required for Efficient Initiation of Retrograde Axonal Transport

(2013) A. J. Moughamian et al.   JOURNAL OF NEUROSCIENCE

TrkAIII Promotes Microtubule Nucleation and Assembly at the Centrosome in SH-SY5Y Neuroblastoma Cells, Contributing to an Undifferentiated Anaplastic Phenotype

(2013) Antonietta R. Farina et al.   Biomed Research International

Manganese Superoxide Dismutase (Sod2) and Redox-Control of Signaling Events That Drive Metastasis

(2012) Nadine Hempel et al.   Anti-Cancer Agents in Medicinal Chemistry

Exon-level expression analyses identify MYCN and NTRK1 as major determinants of alternative exon usage and robustly predict primary neuroblastoma outcome

(2012) A Schramm et al.   BRITISH JOURNAL OF CANCER

Immortalized cells and one oncogene in malignant transformation: old insights on new explanation

(2011) Vadym M Kavsan et al.   BMC CELL BIOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Targeting Mcl-1 for the therapy of cancer

(2011) Bridget A Quinn et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Ras trafficking, localization and compartmentalized signalling

(2011) Ian A. Prior et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Inhibiting NF-κB activation by small molecules as a therapeutic strategy

(2010) Subash C. Gupta et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Trk activation in the secretory pathway promotes Golgi fragmentation

(2010) Leslayann C. Schecterson et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The Alternative TrkAIII Splice Variant Targets the Centrosome and Promotes Genetic Instability

(2009) A. R. Farina et al.   MOLECULAR AND CELLULAR BIOLOGY

The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells

(2009) A R Farina et al.   ONCOGENE

Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins

(2008) Noriko Gotoh   CANCER SCIENCE

Identification of ALK as a major familial neuroblastoma predisposition gene

(2008) Yaël P. Mossé et al.   NATURE

DNA amplification is a ubiquitous mechanism of oncogene activation in lung and other cancers

(2008) W W Lockwood et al.   ONCOGENE

Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis

(2008) C. Hetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA