Cilengitide downmodulates invasiveness and vasculogenic mimicry of neuropilin 1 expressing melanoma cells through the inhibition of αvβ5 integrin

Cilengitide Inhibits Attachment and Invasion of Malignant Pleural Mesothelioma Cells through Antagonism of Integrins αvβ3 and αvβ5

(2014) Ngan Ching Cheng et al.   PLoS One

Targeting Placental Growth Factor/Neuropilin 1 Pathway Inhibits Growth and Spread of Medulloblastoma

(2013) Matija Snuderl et al.   CELL

αv-Integrin isoform expression in primary human tumors and brain metastases

(2013) Alexander Vogetseder et al.   INTERNATIONAL JOURNAL OF CANCER

KLF8 and FAK cooperatively enrich the active MMP14 on the cell surface required for the metastatic progression of breast cancer

(2013) H Lu et al.   ONCOGENE

Challenging resistance mechanisms to therapies for metastatic melanoma

(2013) Lucio Tentori et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Highly Invasive Melanoma Cells Activate the Vascular Endothelium via an MMP-2/Integrin αvβ5–Induced Secretion of VEGF-A

(2012) Anna Desch et al.   AMERICAN JOURNAL OF PATHOLOGY

Tumor Cell Vasculogenic Mimicry

(2012) Richard E.B. Seftor et al.   AMERICAN JOURNAL OF PATHOLOGY

A randomized phase II study of cilengitide (EMD 121974) in patients with metastatic melanoma

(2012) Kevin B. Kim et al.   MELANOMA RESEARCH

Vasculogenic Mimicry of HT1080 Tumour Cells In Vivo: Critical Role of HIF-1α-Neuropilin-1 Axis

(2012) Roli M. Misra et al.   PLoS One

Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation

(2011) Carlos Mas-Moruno et al.   Anti-Cancer Agents in Medicinal Chemistry

Cilengitide: an RGD pentapeptide ανβ3 and ανβ5 integrin inhibitor in development for glioblastoma and other malignancies

(2011) David A Reardon et al.   Future Oncology

Interdependency of cell adhesion, force generation and extracellular proteolysis in matrix remodeling

(2011) R. Kirmse et al.   JOURNAL OF CELL SCIENCE

VEGFR1 and PKCα signaling control melanoma vasculogenic mimicry in a VEGFR2 kinase-independent manner

(2011) Amalia Vartanian et al.   MELANOMA RESEARCH

Melanoma Vasculogenic Mimicry Capillary-Like Structure Formation Depends on Integrin and Calcium Signaling

(2011) AMALIA VARTANIAN et al.   MICROCIRCULATION

Expression of the soluble vascular endothelial growth factor receptor-1 in cutaneous melanoma: role in tumour progression

(2010) F. Ruffini et al.   BRITISH JOURNAL OF DERMATOLOGY

Integrins: versatile receptors controlling melanocyte adhesion, migration and proliferation

(2010) Perrine Pinon et al.   Pigment Cell & Melanoma Research

Cooperation between integrin ανβ3 and VEGFR2 in angiogenesis

(2009) Payaningal R. Somanath et al.   ANGIOGENESIS

Specific Cross-talk between Epidermal Growth Factor Receptor and Integrin αvβ5 Promotes Carcinoma Cell Invasion and Metastasis

(2009) Jill M. Ricono et al.   CANCER RESEARCH

αvβ3 Integrin Limits the Contribution of Neuropilin-1 to Vascular Endothelial Growth Factor-induced Angiogenesis

(2009) Stephen D. Robinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin signalling at a glance

(2009) D. S. Harburger et al.   JOURNAL OF CELL SCIENCE

Regulation of cell signalling by uPAR

(2009) Harvey W. Smith et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neuropilins: structure, function and role in disease

(2008) Caroline Pellet-Many et al.   BIOCHEMICAL JOURNAL

Inhibition of endothelial cell migration and angiogenesis by a vascular endothelial growth factor receptor-1 derived peptide

(2008) Pedro M. Lacal et al.   EUROPEAN JOURNAL OF CANCER

Cilengitide induces cellular detachment and apoptosis in endothelial and glioma cells mediated by inhibition of FAK/src/AKT pathway

(2008) Leticia Oliveira-Ferrer et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH