Protein phosphatase 2A activation mechanism contributes to JS-K induced caspase-dependent apoptosis in human hepatocellular carcinoma cells

Targeting cancer cell mitochondria as a therapeutic approach: recent updates

(2017) Qingbin Cui et al.   Future Medicinal Chemistry

PP2A as a master regulator of the cell cycle

(2016) Nathan Wlodarchak et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Potential anti-tumor effects of FTY720 associated with PP2A activation: a brief review

(2016) Ion Cristóbal et al.   CURRENT MEDICAL RESEARCH AND OPINION

Pharmacological Activation of Protein Phosphatase 2 A (PP2A): A Novel Strategy to Fight Against Human Malignancies?

(2016) Maria Rosaria Carratù et al.   CURRENT MEDICINAL CHEMISTRY

Physiological and Pharmacological Control of BAK, BAX, and Beyond

(2016) Mark P.A. Luna-Vargas et al.   TRENDS IN CELL BIOLOGY

Deregulation of the protein phosphatase 2A, PP2A in cancer: complexity and therapeutic options

(2016) Godfrey Grech et al.   TUMOR BIOLOGY

All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase

(2015) Jaya Sangodkar et al.   FEBS Journal

Combination treatment with triptolide and hydroxycamptothecin synergistically enhances apoptosis in A549 lung adenocarcinoma cells through PP2A-regulated ERK, p38 MAPKs and Akt signaling pathways

(2015) GUANMIN MENG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The Nitric Oxide Prodrug JS-K Induces Ca2+-Mediated Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells

(2015) Ling Liu et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Inhibition of oleandrin on the proliferation and invasion of osteosarcoma cells in vitro by suppressing Wnt/β-catenin signaling pathway

(2015) Yunlong Ma et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The Role of Nitric Oxide Synthase Uncoupling in Tumor Progression

(2015) C. S. Rabender et al.   MOLECULAR CANCER RESEARCH

Regulation of PP2A by Sphingolipid Metabolism and Signaling

(2015) Joshua Oaks et al.   Frontiers in Oncology

Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56  stabilizes its antiapoptotic activity

(2014) I. C. C. Low et al.   BLOOD

FTY720 Induces Apoptosis of M2 Subtype Acute Myeloid Leukemia Cells by Targeting Sphingolipid Metabolism and Increasing Endogenous Ceramide Levels

(2014) Limin Chen et al.   PLoS One

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer

(2013) Parthasarathy Seshacharyulu et al.   CANCER LETTERS

Cancerous Inhibitor of Protein Phosphatase 2A, an Emerging Human Oncoprotein and a Potential Cancer Therapy Target

(2013) A. Khanna et al.   CANCER RESEARCH

Mechanism of action for the cytotoxic effects of the nitric oxide prodrug JS-K in murine erythroleukemia cells

(2013) Monika Z. Kaczmarek et al.   LEUKEMIA RESEARCH

JS-K, a glutathione/glutathione S-transferase-activated nitric oxide releasing prodrug inhibits androgen receptor and WNT-signaling in prostate cancer cells

(2012) Martin Laschak et al.   BMC CANCER

JS-K; a nitric oxide-releasing prodrug, modulates β-catenin/TCF signaling in leukemic Jurkat cells: Evidence of an S-nitrosylated mechanism

(2010) Niharika Nath et al.   BIOCHEMICAL PHARMACOLOGY

Ceramide Produces Apoptosis Through Induction of p27kip1by Protein Phosphatase 2A-dependent Akt Dephosphorylation in PC-3 Prostate Cancer Cells

(2010) Sang Woo Kim et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Nitric oxide and sphingolipids: mechanisms of interaction and role in cellular pathophysiology

(2008) Cristiana Perrotta et al.   BIOLOGICAL CHEMISTRY