Deregulation of the protein phosphatase 2A, PP2A in cancer: complexity and therapeutic options

Inhibition of protein methylesterase 1 decreased cancerous phenotypes in endometrial adenocarcinoma cell lines and xenograft tumor models

(2016) Michelle Pusey et al.   TUMOR BIOLOGY

LB100, a small molecule inhibitor of PP2A with potent chemo- and radio-sensitizing potential

(2015) Christopher S Hong et al.   CANCER BIOLOGY & THERAPY

Circumventing Cellular Control of PP2A by Methylation Promotes Transformation in an Akt-Dependent Manner

(2015) Jennifer B. Jackson et al.   NEOPLASIA

Effect of FTY720 on the SET–PP2A complex in acute myeloid leukemia; SET binding drugs have antagonistic activity

(2014) R Pippa et al.   LEUKEMIA

PP2A Inhibition Is a Common Event in Colorectal Cancer and Its Restoration Using FTY720 Shows Promising Therapeutic Potential

(2014) I. Cristobal et al.   MOLECULAR CANCER THERAPEUTICS

PP2A-Mediated Regulation of Ras Signaling in G2 Is Essential for Stable Quiescence and Normal G1 Length

(2014) Nana Naetar et al.   MOLECULAR CELL

Deregulation of the phosphatase, PP2A is a common event in breast cancer, predicting sensitivity to FTY720

(2014) Shawn Baldacchino et al.   EPMA Journal

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer

(2013) Parthasarathy Seshacharyulu et al.   CANCER LETTERS

Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer

(2013) Zi Liu et al.   CARCINOGENESIS

Identification of the general transcription factor Yin Yang 1 as a novel and specific binding partner for S6 Kinase 2

(2013) Heba M.S. Ismail et al.   CELLULAR SIGNALLING

Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells

(2013) Zi Liu et al.   ACS Medicinal Chemistry Letters

Carnosic acid modulates Akt/IKK/NF-κB signaling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells

(2012) Susanta Kar et al.   APOPTOSIS

The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity

(2012) Ward Sents et al.   FEBS Journal

CIP2A Is a Predictor of Poor Prognosis in Colon Cancer

(2012) Hao-Wei Teng et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Genenames.org: the HGNC resources in 2013

(2012) Kristian A. Gray et al.   NUCLEIC ACIDS RESEARCH

CIP2A signature reveals the MYC dependency of CIP2A-regulated phenotypes and its clinical association with breast cancer subtypes

(2012) M Niemelä et al.   ONCOGENE

Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression

(2011) C. M. Lucas et al.   BLOOD

Prognostic role of CIP2A expression in serous ovarian cancer

(2011) C Böckelman et al.   BRITISH JOURNAL OF CANCER

Essential Requirement for PP2A Inhibition by the Oncogenic Receptor c-KIT Suggests PP2A Reactivation as a Strategy to Treat c-KIT+ Cancers -- Letter

(2011) A. G. Dumont et al.   CANCER RESEARCH

Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse

(2011) Pengyu Gu et al.   GENESIS

Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma

(2011) Hany A. Omar et al.   HEPATOLOGY

CIP2A is over-expressed in acute myeloid leukaemia and associated with HL60 cells proliferation and differentiation

(2011) J. WANG et al.   International Journal of Laboratory Hematology

Identification and Characterization of an Alternatively Spliced Isoform of the Human Protein Phosphatase 2Aα Catalytic Subunit

(2011) Deivid L. S. Migueleti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Phosphatase 2A (B55α) Prevents Premature Activation of Forkhead Transcription Factor FoxM1 by Antagonizing Cyclin A/Cyclin-dependent Kinase-mediated Phosphorylation

(2011) Mónica Alvarez-Fernández et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein E and Peptide Mimetics Modulate Inflammation by Binding the SET Protein and Activating Protein Phosphatase 2A

(2011) D. J. Christensen et al.   JOURNAL OF IMMUNOLOGY

Discovery and Optimization of Sulfonyl Acrylonitriles as Selective, Covalent Inhibitors of Protein Phosphatase Methylesterase-1

(2011) Daniel A. Bachovchin et al.   JOURNAL OF MEDICINAL CHEMISTRY

PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect

(2011) I Cristóbal et al.   LEUKEMIA

Human Cancer-Associated Mutations in the A  Subunit of Protein Phosphatase 2A Increase Lung Cancer Incidence in A  Knock-In and Knockout Mice

(2011) R. Ruediger et al.   MOLECULAR AND CELLULAR BIOLOGY

The Structural Basis for Tight Control of PP2A Methylation and Function by LCMT-1

(2011) Vitali Stanevich et al.   MOLECULAR CELL

Loss of PINK1 function decreases PP2A activity and promotes autophagy in dopaminergic cells and a murine model

(2011) Zhifeng Qi et al.   NEUROCHEMISTRY INTERNATIONAL

Targeting SET/I2PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy

(2011) C H Switzer et al.   ONCOGENE

PP2A-B56α controls oncogene-induced senescence in normal and tumor human melanocytic cells

(2011) S Mannava et al.   ONCOGENE

Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors

(2011) D. A. Bachovchin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer

(2011) Christopher H. Switzer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Evaluation of PPP2R2A as a prostate cancer susceptibility gene: a comprehensive germline and somatic study

(2011) Yu Cheng et al.   Cancer Genetics

FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: A protective role of autophagy

(2010) Ning Zhang et al.   Autophagy

Identification of PP2A Complexes and Pathways Involved in Cell Transformation

(2010) A. A. Sablina et al.   CANCER RESEARCH

PP2A Regulatory Subunit PP2A-B′ Counteracts S6K Phosphorylation

(2010) Katrin Hahn et al.   Cell Metabolism

Targeting the BCR-ABL Signaling Pathway in Therapy-Resistant Philadelphia Chromosome-Positive Leukemia

(2010) T. O'Hare et al.   CLINICAL CANCER RESEARCH

PP2A:B56ϵ, a Substrate ofCaspase-3, Regulatesp53-dependent andp53-independent Apoptosis during Development

(2010) Zhigang Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PTEN- and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice

(2010) Tongsen Zheng et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

CIP2A expression is increased in prostate cancer

(2010) Markku H Vaarala et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Regulation of protein phosphatase 2A methylation by LCMT1 and PME-1 plays a critical role in differentiation of neuroblastoma cells

(2010) Jean-Marie Sontag et al.   JOURNAL OF NEUROCHEMISTRY

PME-1 Protects Extracellular Signal-Regulated Kinase Pathway Activity from Protein Phosphatase 2A-Mediated Inactivation in Human Malignant Glioma

(2009) P. Puustinen et al.   CANCER RESEARCH

CIP2A Is Associated with Human Breast Cancer Aggressivity

(2009) C. Come et al.   CLINICAL CANCER RESEARCH

Novel pathway in Bcr-Abl signal transduction involves Akt-independent, PLC-γ1-driven activation of mTOR/p70S6-kinase pathway

(2009) B Markova et al.   ONCOGENE

Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity

(2009) C H Switzer et al.   ONCOGENE

Igbp1 is part of a positive feedback loop in stem cell factor-dependent, selective mRNA translation initiation inhibiting erythroid differentiation

(2008) G. Grech et al.   BLOOD

Protein phosphatase 2A (PP2A), a drugable tumor suppressor in Ph1(+) leukemias

(2008) Danilo Perrotti et al.   CANCER AND METASTASIS REVIEWS

Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling

(2008) Archana Mukhopadhyay et al.   FASEB JOURNAL