Review
Multidisciplinary Sciences
Lucrece Y. J. Ahovegbe, Patrick E. Ogwang, Emanuel L. Peter, Andrew G. Mtewa, Felicien M. Kasali, Casim U. Tolo, Judith Gbenoudon, Anke Weisheit, Kamba F. Pakoyo
Summary: Research suggests that Vachellia nilotica (V. nilotica) may have potential therapeutic effects against Hepatitis C Virus (HCV) infection, primarily by directly inactivating HCV and modulating immune responses. Further studies are needed to explore its applicability in clinical settings.
SCIENTIFIC AFRICAN
(2021)
Article
Plant Sciences
Khululwa Ndabankulu, Zivanai Tsvuura, Anathi Magadlela
Summary: Soils in grasslands and savannas of southern Africa are acidic and nutrient-poor, which affects the growth of legume plants. The invasive species Leucaena leucocephala disrupts the native vegetation by successfully adapting to low-resource soils. The study investigated the effects of phosphorus deficiency and soil acidity on legume-microbe symbiosis, nitrogen nutrition, and carbon growth costs.
Article
Pharmacology & Pharmacy
Moussa Bamba, Simon Bordage, Marie-Emmanuelle Sahuc, Sophie Moureu, Jennifer Samaillie, Vincent Roumy, Peggy Vauchel, Krasimir Dimitrov, Yves Rouille, Jean Dubuisson, Fezan Honora Tra Bi, Karin Seron, Sevser Sahpaz
Summary: The Carapa procera DC. and Pericopsis laxiflora (Benth.ex Baker) Meeuwen species from Cote d'Ivoire were found to have high antiviral activity against HCV, with low toxicity for hepatic cells. The crude extracts from these plants were rich in polyphenols, including active tannins. Removing the tannins from the extracts resulted in a loss of anti-HCV activity. Using a hydro-ethanolic solvent instead of methanol produced tannin-rich extracts with similar antiviral activity.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Safaet Alam, Md. Moklesur Rahman Sarker, Sadia Afrin, Fahmida Tasnim Richi, Chao Zhao, Jin-Rong Zhou, Isa Naina Mohamed
Summary: The COVID-19 pandemic has greatly affected global public health and posed serious threats to human life. Researchers and pharmaceutical companies are actively seeking plant-based drug treatments for this virus and conducting multiple clinical trials to find effective solutions.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yingying Peng, Zhe Chen, Huanmin Li, Yaowei Han, Dan Sun, Yanjiao Li, Xiaoxia Wu, Hongxiang Chen, Xinmin Li
Summary: This study compared the efficacy and safety of traditional Chinese medicine injections (TCMIs) combined with oseltamivir (TCMIs + oseltamivir) versus oseltamivir alone in the treatment of influenza. The results showed that some TCMIs + oseltamivir combinations were more effective than oseltamivir alone in reducing fever and cough duration. However, the overall therapeutic efficacy and safety remained inconclusive.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nannan Chen, Dongjun Jiang, Baihui Shao, Tongtong Bai, Jinwei Chen, Yu Liu, Zecai Zhang, Yulong Zhou, Xue Wang, Zhanbo Zhu
Summary: Natural products have been recognized as valuable resources for the treatment of viral diseases and the development of effective therapeutic agents. This study focused on screening Chinese herbal monomers for their anti-BVDV viral activity using a molecular docking technique. The results showed that daidzein, curcumin, artemisinine, and apigenin were the most promising herbal monomers for interacting with the nonstructural protein NS5B of BVDV-NADL strain. In vivo and in vitro tests further demonstrated the effectiveness of daidzein and artemisinine in preventing and treating BVDV infection, providing a foundation for developing targeted Chinese pharmaceutical formulations against this virus.
Review
Integrative & Complementary Medicine
Feilin Ge, Yan Yang, Zhaofang Bai, Lanlan Si, Xuemei Wang, Jia Yu, Xiaohe Xiao, Yan Liu, Zhigang Ren
Summary: Chronic hepatitis B (CHB) is a serious public health issue worldwide. While nucleos(t)ide analogues (NAs) have remarkable effects in treating hepatitis B virus (HBV), there are limitations. Traditional Chinese medicine (TCM) has become increasingly important as a complementary therapy for CHB, as it can directly and indirectly target HBV and provide strong antigen inhibition compared to NAs.
Article
Ecology
Jennah Green, Pippa Hankinson, Louise de Waal, Emma Coulthard, John Norrey, David Megson, Neil D'Cruze
Summary: This study aims to characterize the social and economic value of wild animal species used in traditional medicine in South Africa, as well as explore plant-based alternatives. The study found a wide range of animal species were used for medicinal and magico-religious purposes, including threatened species. Lions were particularly valued in the traditional medicine market, but their availability has decreased in recent years. The study provides valuable insights into the socio-economic drivers of traditional healing practices and suggests further research is needed to inform approaches to managing pressures on South Africa's wildlife populations.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2022)
Review
Plant Sciences
Godwin Anywar, Patience Tugume, Esezah K. Kakudidi
Summary: Various Aloe species are widely used in traditional medicine in East Africa for treating a variety of ailments. However, most of the local Aloe species have not been scientifically investigated for their biological activity and toxicity.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Fisheries
Jing-Zhuang Zhao, Lin-Fang Li, Li-Ming Xu, Yi-Zhi Shao, Guang-Ming Ren, Qi Liu, Tong-Yan Lu
Summary: Infectious pancreatic necrosis virus (IPNV) is a major pathogen causing high mortality and economic losses in salmon and trout aquaculture. Traditional Chinese medicine (TCM) has been shown to be effective against viral infections and bufalin, a compound found in TCM, was found to inhibit IPNV infections by targeting viral internalization and RNA replication. Mechanistic research revealed that bufalin's antiviral effects occurred via Na+/K+-ATPase.
Article
Plant Sciences
Lindiwe Sibeko, Timothy Johns, Bi-sek Hsiao
Summary: This article aims to collect reported medicinal plant use during pregnancy and postpartum, analyze the most important taxa in relation to key functional purposes, and test the hypothesis that perinatal plant use is non-random. Data from 410 publications showed that 53% of reports were published from 2005 to 2020, indicating a continuous increase in overall data availability. The most frequently reported categories of plant use were uterotonic, prenatal, lactation and post-partum recovery, and newborn and infant health. Non-random use was observed in the preference for certain plant families during different stages of perinatal care.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Public, Environmental & Occupational Health
Stanislas Zanvo, Chabi A. M. S. Djagoun, Akomian F. Azihou, Brice Sinsin, Philippe Gaubert
Summary: The traditional preservation techniques for animal body parts in traditional medicine markets in Benin are being replaced by modern techniques involving hazardous chemicals, potentially posing serious health risks to practitioners and consumers. The lack of regulation of traditional medicine market activities represents a critical risk to both biodiversity conservation and human health in western Africa.
Article
Plant Sciences
Donisha Shani Niharika Keembiya Liyanagamage, Susanthi Jayasinghe, Anoja Priyadarshani Attanayake, Veranja Karunaratne
Summary: The study found that the traditional polyherbal mixture mentioned above has potent anti-hyperglycemic and antihyperlipidemic effects, with significant restoration of pancreatic beta-cells and improvement in lipoprotein levels in diabetic rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Zijing Hu
Summary: This study aimed to explore South African patients' views of and experiences with traditional Chinese medicine (TCM) for treating COVID-19 infections. The results showed that TCM was effective and inexpensive for COVID-19 treatment. However, there were challenges for the adoption of TCM in South Africa, including patients' lack of TCM knowledge and the inaccessibility of TCM services.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Ling Ye, Shicheng Fan, Pengfei Zhao, Chenghua Wu, Menghua Liu, Shuang Hu, Peng Wang, Hongyu Wang, Huichang Bi
Summary: COVID-19, caused by SARS-CoV-2, has led to a high demand for effective treatments. Antiviral drugs and traditional Chinese medicine formulas have been widely used. However, the potential interactions between these drugs and formulas are currently lacking information. This study aims to summarize and highlight the potential interactions between them, providing useful information for clinical medication.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biochemistry & Molecular Biology
Gourav Rakshit, Pankaj Dagur, Swaha Satpathy, Arjun Patra, Alok Jain, Manik Ghosh
Summary: This study used computational techniques to identify potential anti-viral flavonoids, with luteolin showing promise as an effective compound with good pharmacological properties. The approach highlights the importance of potential natural product sources in combating viral infections.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Environmental Sciences
Stefano Porru, Maria Grazia Lourdes Monaco, Angela Carta, Gianluca Spiteri, Marco Parpaiola, Andrea Battaggia, Giulia Galligioni, Beatrice Ferrazzi, Giuliana Lo Cascio, Davide Gibellini, Angelo Peretti, Martina Brutti, Stefano Tardivo, Giovanna Ghirlanda, Giuseppe Verlato, Stefania Gaino, Denise Peserico, Antonella Bassi, Giuseppe Lippi
Summary: The baseline phase of the SIEROEPID study in Italy examined SARS-CoV-2 seroprevalence among health workers, with an overall seroprevalence of 6% for IgG and IgM, and 4.8% for IgG only. Working in COVID-19 units did not significantly increase infection rates. Performance of laboratory tests for antibody detection varied, with good agreement for IgG but lower agreement for IgM. The study highlighted the importance of large sample sizes, high participation rates, and longitudinal design for risk assessment and management of SARS-CoV-2 infection in healthcare settings.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Immunology
Annarita Mazzariol, Anna Benini, Ilaria Unali, Riccardo Nocini, Marcello Smania, Anna Bertoncelli, Francesco De Sanctis, Stefano Ugel, Katia Donadello, Enrico Polati, Davide Gibellini
Summary: The study found bacterial and fungal superinfection in severe COVID-19 patients, with some bacteria showing strong resistance to carbapenems, suggesting that bacteria may play an important role in the progression of COVID-19.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ehsan Mohammadifar, Matteo Gasbarri, Valeria Cagno, Katharina Achazi, Caroline Tapparel, Rainer Haag, Francesco Stellacci
Summary: Heparin, known for its anticoagulant properties for almost 90 years, has also been recognized as a broad-spectrum antiviral for almost 70 years. However, its anticoagulant effects limit its use as an antiviral drug. Recent research has shown that the addition of hydrophobic linkers to heparin-like compounds can create irreversible interactions with viruses while maintaining low toxicity and broad-spectrum activity. These new compounds, when tested against herpes simplex virus 2 and respiratory syncytial virus, exhibited nanomolar activity, providing a foundation for the design of new nontoxic, broad-spectrum antivirals.
Article
Clinical Neurology
Maria Paola Cecchini, Lorenzo Brozzetti, Nicolo Cardobi, Luca Sacchetto, Davide Gibellini, Stefania Montemezzi, Marta Cheli, Paolo Manganotti, Salvatore Monaco, Gianluigi Zanusso
Summary: A 17-year-old female patient experienced long-lasting anosmia after a mild infection, with partial recovery 15 months later. Neuroimaging did not show microvascular injury in olfactory bulbs and brain, and the patient exhibited symptoms of anosmia with parosmia phenomena and gustatory impairment. Immunocytochemistry of olfactory mucosa swabs revealed high expression of ACE2 in sustentacular cells and lower expression in neuronal-shaped cells. Further longitudinal studies are needed to investigate the persistence of chemosensory impairment.
NEUROLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Antima Chaudhary, Rajiv Tonk, Pankaj Dagur, Suddhasattya Dey, Manik Ghosh
Summary: An authentic and reliable reverse phase-high performance liquid chromatography (RP-HPLC) method was developed and validated for the estimation of olaparib. The optimized method separated olaparib accurately without interference from excipients used in the drug formulations. The developed method was statistically validated according to International Conference on Harmonization guidelines.
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Oncology
Pankaj Dagur, Manik Ghosh
Summary: The methanol fraction of lac dye exhibited promising in vitro anticancer activity, indicating its potential for the development of new anticancer drugs.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Pankaj Dagur, Gourav Rakshit, Murtuja Sheikh, Abanish Biswas, Parineeta Jha, Khattab Al-Khafaji, Manik Ghosh
Summary: The study aims to identify potential phyto-active antiviral compounds from Justicia adhatoda as powerful inhibitors of the Mpro of SARSCOV-2. Through in-silico investigations, molecular docking, ADME, and toxicity prediction, several compounds were found to exhibit excellent solubility and pharmacodynamic characteristics. Network-based pharmacology suggested that these compounds have various modes of action against SARS-CoV-2.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Multidisciplinary
Alice Boarino, Heyun Wang, Francesca Olgiati, Flora Artusio, Melis Ozkan, Stefania Bertella, Nicolo Razza, Valeria Cagno, Jeremy S. Luterbacher, Harm-Anton Klok, Francesco Stellacci
Summary: Transmission of viruses through contact with contaminated surfaces is an important pathway for the spread of infections. This study developed a low-cost and environmentally sustainable antiviral surface coating using spin-coated lignin, which effectively inactivated herpes simplex virus type 2 (>99% after 30 min). The antiviral mechanism is attributed to reactive oxygen species generated upon oxidation of lignin phenols.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Biology
Chiara Medaglia, Ilya Kolpakov, Yong Zhu, Samuel Constant, Song Huang, Arnaud Charles-Antoine Zwygart, Valeria Cagno, Emmanouil T. Dermitzakis, Francesco Stellacci, Ioannis Xenarios, Caroline Tapparel
Summary: This study investigated the effectiveness of an antiviral therapy against influenza virus using single cell transcriptomic studies. It was found that the combination of virucidal sialylated cyclodextrins and interferon lambda can more efficiently inhibit the replication of the H1N1 strain when administered together, and the response to the treatment varies among different types of epithelial cells.
COMMUNICATIONS BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Carmine Varricchio, Gregory Mathez, Trestan Pillonel, Claire Bertelli, Laurent Kaiser, Caroline Tapparel, Andrea Brancale, Valeria Cagno
Summary: Aminoglycoside antibiotic gentamicin has been found to effectively combat various variants of SARS-CoV-2 in different cell lines and respiratory tissue models. It inhibits viral RNA replication and protein expression at an early stage by targeting the ribosomal frameshift signal of SARS-CoV-2.
ANTIVIRAL RESEARCH
(2022)
Article
Virology
Gregory Mathez, Trestan Pillonel, Claire Bertelli, Valeria Cagno
Summary: SARS-CoV-2, the virus responsible for the COVID-19 pandemic, continues to evolve and undergo selective pressure. In an ex vivo cell model, the Alpha and Omicron BA.1 variants showed no adaptation in the spike protein, suggesting the role of adaptive immune response or other anatomical sites in the evolution of the virus.
Article
Biochemistry & Molecular Biology
Rojalini Samanta, Kishanta Kumar Pradhan, Debanjan Sen, Supratik Kar, Manik Ghosh
Summary: Cancer is a life-threatening disease and the second leading cause of death globally. The estrogen receptor is a significant drug target for cancer treatment. Extracts from Datura sp. have been found to greatly inhibit estrogen receptors associated with human cancer.
MOLECULAR DIVERSITY
(2023)
Article
Chemistry, Medicinal
Rojalini Samanta, Manik Ghosh
Summary: This study aimed to develop an optimized, green, and efficient alternative method for extracting flavonoid and phenolic compounds from Oroxylum indicum leaves. Microwave-assisted extraction (MAE) showed a 70% higher yield in a shorter time compared to conventional methods, along with increased flavonoid and phenolic content. This extraction technique is an ideal tool for preserving thermolabile plant constituents and is more environmentally friendly.
PHARMACOGNOSY MAGAZINE
(2023)
Article
Chemistry, Multidisciplinary
Suddhasatya Dey, Sudip Kumar Mandal, Mithun Bhowmick, Manik Ghosh, Pankaj Dagur, Shreya Shah, Biplab Kumar Dey, Ewies F. Ewies
Summary: A quick, simple and reproducible dual column high performance liquid chromatography (HPLC) method was developed to determine albendazole and its metabolites in rat plasma. This method involves two different mobile phases, two different columns and different wavelengths, allowing accurate quantification of the target compounds.
EGYPTIAN JOURNAL OF CHEMISTRY
(2022)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)