Article
Chemistry, Medicinal
Sara Hooshmand, Mohammad Reza Mahdinezhad, Shirin Taraz Jamshidi, Mohammad Soukhtanloo, Farshad Mirzavi, Mehrdad Iranshahi, Maedeh Hasanpour, Ahmad Ghorbani
Summary: This study found that Morus nigra extract exhibits hepatoprotective effects on diethylnitrosamine-induced hepatocellular carcinoma through inhibiting oxidative stress and the Wnt4/beta-catenin pathway, prolonging the survival of rats with HCC.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Lingling Wang, Jiawei Wang, Mengjie Ma, Liping Shen, Tao Huang, Chunyue Huang, An Jia, Xiao Hu
Summary: Six undescribed prenylated flavonoids and four known compounds were isolated from Morus nigra L. Their structures and absolute configurations were determined through analysis of spectroscopic data and computational calculations. The compounds demonstrated insulin sensitizing activities, with one compound showing high binding affinity to PPARγ.
Article
Plant Sciences
Amanda de Assis Carneiro, Simone Batista Pires Sinoti, Marcela Medeiros de Freitas, Luiz Alberto Simeoni, Christopher William Fagg, Perola de Oliveira Magalhaes, Damaris Silveira, Yris Maria Fonseca-Bazzo
Summary: Inhibition of systemic inflammation is beneficial for treating non-communicable diseases, and the hydroethanolic extract of M. nigra leaves can activate PPAR and promote anti-inflammatory effects. The extract contains rutin and isoquercitrin as major compounds and reduces the production of ROS, NO, and TNF-alpha.
Article
Plant Sciences
Erika N. Vega, Adriana K. Molina, Carla Pereira, Maria Ines Dias, Sandrina A. Heleno, Paula Rodrigues, Isabel P. Fernandes, Maria Filomena Barreiro, Dejan Stojkovic, Marina Sokovic, Marcio Carocho, Joao C. M. Barreira, Isabel C. F. R. Ferreira, Lillian Barros
Summary: The importance of color in product acceptance and the growing awareness of health effects have led to a preference for natural additives in food. This study analyzed juices from Morus nigra L. and Rubus fruticosus L., developing stable and safe natural coloring formulations as alternatives to commonly used artificial colorants.
Article
Biochemistry & Molecular Biology
Lu Yang, Jiuyang Zhao, Shaoli Fan, Jinfa Liao, Yicun Chen, Yangdong Wang
Summary: Mulberry leaves collected after frost have superior medicinal properties. This study conducted metabolic profiling analyses on two types of mulberry leaves harvested at different times and identified over 100 compounds. The results showed that frost had different effects on the accumulation of metabolites in Morus nigra L. and Morus alba L., and picking time also influenced the levels of DNJ alkaloids and flavonoids in mulberry leaves.
Article
Plant Sciences
Oluwakemi O. Ariyo, Abayomi M. Ajayi, Benneth Ben-Azu, Adegbuyi O. Aderibigbe
Summary: The ethylacetate fraction of Morus mesozygia leaf extract showed anti-arthritic activity, reducing inflammation and pain, and improving associated behavioral deficits. It demonstrated these effects by inhibiting oxidative stress and inflammation response in arthritis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Milena Polumackanycz, Marek Wesolowski, Agnieszka Viapiana
Summary: By comparing the leaves of white and black mulberry, it was found that black mulberry leaves have higher levels of flavonoids and phenolic acids, while white mulberry leaves contain higher levels of various phenolic compounds in water extracts, with gallic acid being the highest. There is a strong relationship between antioxidant activity and total phenolics and flavonoids, indicating the crucial role of phenolic compounds as antioxidant agents in white and black mulberry leaves.
PLANT FOODS FOR HUMAN NUTRITION
(2021)
Article
Agriculture, Multidisciplinary
Xinxiu Ren, Yu Sun, Qinfeng Guo, Haodong Liu, Hui Jiang, Xiaoshi He, Xia Li, Xuan Shi, Zhilong Xiu, Yuesheng Dong
Summary: This research found that the total flavonoids of Morus nigra L. (TFM) could reduce the progression from prediabetes to type 2 diabetes and improve insulin resistance by regulating suppressor of cytokine signaling and protein tyrosine phosphatase 1B, thus maintaining intestinal homeostasis and restraining inflammatory factors.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Forestry
Jiajun Yang, Yongbo Wu
Summary: This study aimed to observe the internal state of mulberry seedlings under salt stress by proteomic analysis, revealing significant changes in the expressions of proteins related to plant hormones, ion channels, REDOX homeostasis, etc. after salt bursts. This phenotype may be associated with disruption of the apoplast, indirectly increasing ion migration rate into the shoots.
Article
Chemistry, Medicinal
Guilherme Donadel, Mariana Dalmagro, Joao Antonio Berta de Oliveira, Giuliana Zardeto, Mariana Moraes Pinc, Jaqueline Hoscheid, Odair Alberton, Salviano Tramontin Belettini, Ezilda Jacomassi, Arquimedes Gasparotto, Emerson Luiz Botelho Lourenco
Summary: Medicinal plant Eugenia uniflora has been evaluated for its safety in the treatment of vulvovaginitis, and the results show that the vaginal formulations from E. uniflora are safe in this experimental model.
Article
Forestry
Ghulam Ali Bajwa, Muhammad Umair, Yasir Nawab, Zahid Rizwan
Summary: The study revealed significant differences in aboveground biomass and carbon sequestration among different varieties of mulberry, with the Latifolia variety showing the most potential. Allometric equations based on EDBH were found to accurately estimate AGB.
JOURNAL OF FORESTRY RESEARCH
(2021)
Article
Environmental Sciences
Sultan A. M. Saghir, Mahfoudh A. M. Abdulghani, Reem S. Alruhaimi, Ahmad F. Ahmeda, Naif A. Al-Gabri, Saleh A. M. A. Alomaisi, Amirin Sadikun, Vikneswaran Murugaiyah, Ayman M. Mahmoud
Summary: This study evaluated the toxicity of the methanolic extract of A. carambola leaves (MEAC) in rats. The results showed that MEAC was safe up to a dose of 5000 mg/kg and did not have toxic effects on the rats.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Humberto Bonilla Mancilla, Mauro Rodriguez Cerron, Percy Grijalva Aroni, Jesus Eduardo Pomachagua Paucar, Candelaria Tejada Tovar, Manoj Kumar Jindal, Ganesan Gowrisankar
Summary: This study investigated the adsorption efficiency of Sambucus nigra L. leaves for Cr(VI) and analyzed the experimental data of the adsorption process. The results showed that under specific conditions, Sambucus nigra L. leaves exhibited a high removal efficiency for Cr(VI). This study provides a cost-effective approach for reducing heavy metal pollution in industrial wastewater.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Food Science & Technology
Thamer Aljutaily, Sarah M. Almutairi, Hend F. Alharbi
Summary: The study reveals the nephroprotective and antioxidative stress potential of the Brassica nigra sprout extract. The administration of BNS extract at doses of 250 and 500 mg/kg effectively improved weight gain, normalized lipid profile, and protected kidney function in rats with CCl4-induced renal toxicity. Furthermore, BNS extract increased antioxidant enzyme activities and reduced oxidative stress levels. These findings highlight the significance of further clinical studies to confirm the nephroprotective efficacy of B. nigra sprout.
Article
Chemistry, Applied
Salma Hago, Engy A. Mahrous, Mohamed Moawad, Samia Abdel-Wahab, Essam Abdel-Sattar
Summary: Morus nigra and Bauhinia variegata have hypoglycemic effects in Egyptian folk medicine. The extracts of both plants showed significant effects in reducing blood glucose levels in diabetic rats, beyond just hypoglycemic effects, including prevention of liver and kidney tissue damage associated with diabetes.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biology
Robson B. Freitas, Paquita Gonzalez, Nara Maria B. Martins, Edson R. Andrade, Maria Jesus Cesteros Morante, Iban Conies Picos, Serafin Costilla Garcia, Liliane F. Bauermann, Juan Pablo Barrio
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2017)
Article
Plant Sciences
Mariana Piana, Camila Camponogara, Aline Augusti Boligon, Michel Mansur Machado, Thiele Faccim de Brum, Sara Marchesan Oliveira, Liliane de Freitas Bauermann
JOURNAL OF ETHNOPHARMACOLOGY
(2016)
Article
Plant Sciences
Thiele Faccim de Brum, Camila Camponogara, Roberta da Silva Jesus, Bianca Vargas Belke, Mariana Piana, Aline Augusti Boligon, Fernanda Brum Pires, Sara Marchesan Oliveira, Marcelo Barcellos da Rosa, Liliane de Freitas Bauermann
JOURNAL OF ETHNOPHARMACOLOGY
(2016)
Article
Neurosciences
Glauce Regina Pigatto, Igor Santos Coelho, Rosane Schenkel Aquino, Liliane Freitas Bauermann, Adair Roberto Soares Santos
MOLECULAR NEUROBIOLOGY
(2017)
Article
Medicine, Legal
Andreia R. H. da Silva, Fernanda Z. Reginato, Camille G. Guex, Kassia C. Figueredo, Isabel C. da C. Araldi, Robson B. de Freitas, Aline A. Boligon, Margareth L. Athayde, Cinthia Melazzo de Andrade Mazzanti, Gilberti H. Huebscher, Liliane de F. Bauermann
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2016)
Article
Plant Sciences
Juliana Calil Brondani, Fernanda Ziegler Reginato, Evelyne da Silva Brum, Marina de Souza Vencato, Cibele Lima Lhamas, Carine Viana, Maria Izabel Ugalde Marques da Roche, Liliane de Freitas Bauermann, Melaina Palermo Manfron
JOURNAL OF ETHNOPHARMACOLOGY
(2017)
Article
Microbiology
Roberta S. Jesus, Mariana Piana, Robson B. Freitas, Thiele F. Brum, Camilla F. S. Alves, Bianca V. Belke, Natalia Jank Mossmann, Ritiel C. Cruz, Roberto C. V. Santos, Tanise V. Dalmolin, Bianca V. Bianchini, Marli M. A. Campos, Liliane de Freitas Bauermann
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Isabel Cristina da Costa Araldi, Fernando Primitivo Romero Bordin, Francine Carla Cadona, Fernanda Barbisan, Veronica Farina Azzolin, Cibele Ferreira Teixeira, Tadeu Baumhardt, Ivana Beatrice Manica da Cruz, Marta Maria Medeiros Frescura Duarte, Liliane de Freitas Bauermann
CHEMICO-BIOLOGICAL INTERACTIONS
(2018)
Article
Plant Sciences
Rachel de Lima, Camille Gaube Guex, Andreia Regina Haas da Silva, Cibele Lima Lhamas, Karen Luise dos Santos Moreira, Rosana Casoti, Rafaela Castro Dornelles, Maria Izabel Ugalde Marques da Rocha, Marcelo Leite da Veiga, Liliane de Freitas Bauermann, Melania Palermo Manfron
JOURNAL OF ETHNOPHARMACOLOGY
(2018)
Article
Medicine, Legal
Camille Gaube Guex, Fernanda Ziegler Reginato, Kassia Caroline Figueredo, Andreia Regina Haas da da Silva, Fernanda Brum Pires, Roberta da Silva Jesus, Cibele Lima Lhamas, Gilberti Helena Hubscher Lopes, Liliane de Freitas Bauermann
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Andreia Regina Haas da Silva, Leonardo Quintana Soares Lopes, Gabriela Buzatti Cassanego, Patricia Romualdo de Jesus, Kassia Caroline Figueredo, Roberto Christ Vianna Santos, Gilberti Helena Hubscher Lopes, Liliane de Freitas Bauermann
BIOMEDICAL JOURNAL
(2018)
Article
Plant Sciences
Camille Gaube Guex, Fernanda Ziegler Reginato, Patricia Romualdo de Jesus, Juliana Calil Brondani, Gilberti Helena Hubscher Lopes, Liliane de Freitas Bauermann
JOURNAL OF ETHNOPHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Micheli Lamberti Jobim, Veronica Farina Azzolin, Charles Elias Assmann, Vera Maria Melchiors Morsch, Ivana Beatrice Manica da Cruz, Liliane de Freitas Bauermann
MOLECULAR BIOLOGY REPORTS
(2019)
Article
Medicine, Legal
Jocelene Filippin Cossetin, Evelyne da Silva Brum, Rosana Casoti, Camila Camponogara, Rafaela Castro Dornelles, Maiara Maziero, Caren Tatiane de David Antoniazzi, Camille Gaube Guex, Andiara Prattes Ramos, Francielle Guedes Pintos, Ana Martiele Engelmann, Cinthia Melazzo de Andrade, Melania Palermo Manfron, Sara Marchesan Oliveira, Liliane de Freitas Bauermann, Michele Rorato Sagrillo, Alencar Kolinski Machado, Adair Roberto Soares Santos, Gabriela Trevisan
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2019)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)