Article
Clinical Neurology
Song Li, Zhengzhi Wu, Weidong Le
Summary: In Western medicine, dementia affects cognition, mental health, and physical abilities, while Traditional Chinese Medicine explains it from the perspectives of brain dystrophy, Spleen-Kidney weakness, Blood stasis, and Phlegm stagnation. Ancient Chinese physicians believed that dementia manifests not only as cognitive symptoms but also as psychiatric disorders and sleep disturbance, offering various treatment methods.
ALZHEIMERS & DEMENTIA
(2021)
Review
Pharmacology & Pharmacy
Lei Li, Man Wang, Jikuai Chen, Juelin Chen, Yawei Wang, Minghao Zhao, Qing Song, Shuogui Xu
Summary: As global warming continues, heat waves are becoming more frequent and intense, leading to an increase in the incidence of heat stroke. Heat stroke is associated with significant morbidity and mortality, and further research is urgently needed to address this issue. Traditional Chinese medicine offers potential treatment methods, including herbal therapies and external treatments, which may provide clinical benefits and research directions for heat stroke.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Wei Zhuang, Shao-Li Liu, Sheng-Yan Xi, Ying-Nan Feng, Ke Wang, Teliebald Abduwali, Ping Liu, Xiao-Jiang Zhou, Lan Zhang, Xian-Zhe Dong
Summary: This article summarizes the frequently used traditional Chinese medicine decoctions and Chinese patent medicines for treating depression, reviews their clinical therapeutic effects and possible mechanisms, and highlights the importance of traditional Chinese medicine in the management of depression.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Xue Bai, Meng Zhang
Summary: Research has shown that traditional Chinese medicine has a clinical impact on vascular dementia, improving patients' cognitive function and quality of life. The pharmacological mechanisms of TCM for VD treatment include targeting the kidneys, eliminating turbidity, and promoting blood circulation, indicating promising prospects.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Chao Mo, Jie Zhao, Jingyan Liang, Huiling Wang, Yu Chen, Guodong Huang
Summary: Exosomes play a crucial role in intercellular communication, and the interaction between exosomes and traditional Chinese medicine (TCM) has beneficial effects on various diseases. TCM formulas and compounds can modulate exosomes to inhibit cell proliferation, reduce inflammation, and attenuate fibrosis. Additionally, exosomes serve as a natural delivery system for TCM compounds, and they may also be potential biomarkers for TCM syndromes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biology
Qi Zhang, Jianhang Zhou, Bob Zhang
Summary: This study systematically summarizes the development of computational TCM diagnosis, focusing on digital acquisition devices, collected datasets, and computational detection methods. It provides principles, applications, and current progress in computing for computational TCM diagnosis while discussing future development directions and technological trends.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Chien-Yu Ko, Jung Chao, Pei-Yu Chen, Shan-Yu Su, Tomoji Maeda, Chin-Yu Lin, Hung-Che Chiang, Shyh-Shyun Huang
Summary: The study investigated 74 skin whitening prescriptions sold in TCM pharmacies in Taiwan, revealing 90 traditional Chinese medicinal materials mainly sourced from Apiaceae and Leguminosae. Oral prescriptions were mostly warm and sweet, while external prescriptions included cold and bitter medicinal materials, with a focus on tonifying and replenishing effects. Pharmacological analysis indicated potential benefits for wound healing, inflammatory skin diseases, and anti-hyperpigmentation.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Wang Shao-Mei, Ye Li-Fang, Wang Li-Hong
Summary: Heart failure often stems from various cardiovascular diseases, with an energy metabolism disorder of cardiomyocytes serving as a molecular basis. Current drugs like ARNi and SGLT-2 inhibitors target myocardial metabolism to treat HF. Traditional Chinese medicine, including Danshen yin and Fufang Danshen dripping pill, has gained acceptance for HF treatment, potentially serving as a complementary approach for prevention.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Integrative & Complementary Medicine
Jillian L. Capodice, Barbara M. Chubak
Summary: Traditional Chinese Medicine (TCM) is a comprehensive medical system that has been developed over thousands of years and is utilized in the treatment of COVID-19. This paper highlights the use of TCM in treating COVID-19, discussing concepts and challenges of integrating TCM into medical settings.
Review
Pharmacology & Pharmacy
Ming Lyu, Guanwei Fan, Guangxu Xiao, Taiyi Wang, Dong Xu, Jie Gao, Shaoqin Ge, Qingling Li, Yuling Ma, Han Zhang, Jigang Wang, Yuanlu Cui, Junhua Zhang, Yan Zhu, Boli Zhang
Summary: The COVID-19 pandemic poses a significant threat to global public health and safety, with the crucial role and potential mechanisms of Traditional Chinese Medicine (TCM) in combination with Western medicine highlighted and discussed. A comprehensive review of the clinical effects and potential mechanisms of TCM on COVID-19 is presented, aiming to provide reference for healthcare professionals and the public, and facilitate understanding of the true scientific value of TCM.
ACTA PHARMACEUTICA SINICA B
(2021)
Letter
Pharmacology & Pharmacy
Lisha You, Kun Liang, Rui An, Xinhong Wang
Summary: This review provides a brief overview of the global contribution of traditional Chinese medicine (TCM), as well as the underlying obstacles and limitations for its development and modernization. The laborious progression of TCM globalization is illustrated through statistics and corresponding reasons. Innovative strategies and advanced technologies are advised to facilitate and accelerate TCM's expansion into the global markets.
PHARMACOLOGICAL RESEARCH
(2022)
Letter
Pharmacology & Pharmacy
Lisha You, Kun Liang, Rui An, Xinhong Wang
Summary: This review focuses on the global contribution of traditional Chinese medicine and the obstacles faced in its development and modernization. It also presents statistics and reasons to illustrate the challenges of TCM globalization, while offering innovative strategies and advanced technologies to facilitate its expansion into global markets.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Integrative & Complementary Medicine
Chenyang Ai, Yi Zou, Hao Liu, Zheqiong Yang, Jinlei Xi
Summary: The prevalence of allergic disorders has increased, leading to a lower quality of life for patients and a higher demand for drugs to treat these diseases. Traditional Chinese medicine offers distinct benefits in treating allergic illnesses, such as long-term treatment maintenance, prevention of disease recurrence, and fewer adverse reactions. Recent developments in Chinese herbal formula, Chinese patent medicine, and active ingredients of traditional Chinese medicine have been analyzed, discussing their components, efficacy, and mechanisms of action. The importance of improving traditional Chinese herbal formulas and developing safe and effective Chinese patent medicines is emphasized in the field of traditional Chinese medicine research.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Review
Neurosciences
Wei Shen, Ning Jiang, Wenxia Zhou
Summary: Adult neurogenesis is important for cognitive function and mood regulation, but abnormal adult neurogenesis is linked to neurological and psychiatric diseases. Traditional Chinese medicine (TCM) has been shown to have unique advantages in improving adult neurogenesis and treating these diseases through regulating various stages of adult neurogenesis. This review summarizes the progress and key mechanisms through which TCM improves adult neurogenesis, and suggests possible strategies of TCM in the treatment of neuropsychiatric disorders.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Pharmacology & Pharmacy
Zhihua Yang, Shanshan Lin, Yangxi Liu, Qiuan Ren, Zhao Ge, Ci Wang, Yingfei Bi, Xianliang Wang, Jingyuan Mao
Summary: Coronary microvascular disease (CMVD) is common in patients with cardiovascular risk factors and is associated with an increased risk of adverse cardiovascular events. Traditional Chinese medicine (TCM), with its clinical advantages of syndrome differentiation and individualized treatment, shows potential efficacy and action mechanisms for CMVD. However, there are still many scientific issues and gaps in the research of CMVD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yuka Takahashi, Katsuya Narumi, Takanobu Nadai, Hinata Ueda, Taiki Yamamura, Ayako Furugen, Masaki Kobayashi
Summary: Apple polyphenols such as phloretin and phloridzin inhibit the transport of substrate drugs mediated by OATP2B1 in vitro. Specifically, phloretin can decrease the uptake of rosuvastatin in rats, suggesting a potential role in altering drug absorption. However, the systemic exposure of rosuvastatin was not significantly affected by phloretin in rats.
Article
Pharmacology & Pharmacy
Ayako Furugen, Yuki Kanno, Nanami Ohyama, Yuko Kurosawa, Naoko Jinno, Katsuya Narumi, Ken Iseki, Masaki Kobayashi
Summary: Exposure to valproate during pregnancy can increase fetal risks by altering the gene expression of folate carriers and metabolism-related enzymes in the placenta. Maintaining folate levels is crucial for adequate fetal development, with the placenta playing a critical role in this process.
DRUG METABOLISM AND PHARMACOKINETICS
(2021)
Article
Pharmacology & Pharmacy
Keisuke Okamoto, Fumi Kitaichi, Yoshitaka Saito, Hinata Ueda, Katsuya Narumi, Ayako Furugen, Masaki Kobayashi
Summary: Cisplatin is a widely used anticancer drug, but its nephrotoxicity is a significant adverse effect. Studies have shown that multiple doses of Cisplatin can upregulate the expression of renal transporters such as P-gp, and that ascorbic acid may attenuate kidney injury and oxidative stress caused by Cisplatin.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Akira Yamagami, Katsuya Narumi, Yoshitaka Saito, Ayako Furugen, Shungo Imai, Yoshimasa Kitagawa, Yoichi Ohiro, Ryo Takagi, Yoh Takekuma, Mitsuru Sugawara, Masaki Kobayashi
Summary: Third-generation oral cephalosporins, especially cefcapene-pivoxil, have been commonly used in the Japanese dental field for prophylactic antibiotics. However, after the implementation of clinical guidelines, the usage of amoxicillin has increased while the usage of cefcapene-pivoxil has decreased. This antibiotic switch is cost-effective and does not significantly affect the incidence rates of infectious complications.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Mai Koishikawa, Ayako Furugen, Nanami Ohyama, Katsuya Narumi, Shuhei Ishikawa, Masaki Kobayashi
Summary: This study found differences in the uptake of antiepileptic drugs during placental trophoblast differentiation. The differentiated cells showed lower uptake of gabapentin and lamotrigine, with a decreased maximum uptake rate for gabapentin. Furthermore, the transport of gabapentin was trans-stimulated by histidine and methionine.
Article
Pharmacology & Pharmacy
Ayako Mori, Izumi Kato, Hitoshi Kashiwagi, Shungo Imai, Katsuya Narumi, Yuki Sato, Ayako Furugen, Yuma Yamada, Masaki Kobayashi
Summary: This study developed an online role-play-based medical interview training method for pharmacy students and conducted the training sessions using video teleconferencing software. The questionnaire results indicated that students were more tense during online interviews, and they perceived differences between online and face-to-face interviews in terms of eye contact and document presentation.
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2022)
Article
Pharmacology & Pharmacy
Hinata Ueda, Katsuya Narumi, Ayako Furugen, Yoshitaka Saito, Masaki Kobayashi
Summary: This study reveals that the T755I variant of the AOX1 protein, which is found in East Asian populations, negatively affects protein dimer formation and metabolic activity. These findings provide valuable insights into the mechanisms underlying inter-individual differences in the therapeutic efficacy or toxicity of AOX1 substrate drugs.
DRUG METABOLISM AND DISPOSITION
(2022)
Article
Pharmacology & Pharmacy
Yuto Mukai, Atsushi Yamaguchi, Tomoya Sakuma, Takanobu Nadai, Ayako Furugen, Katsuya Narumi, Masaki Kobayashi
Summary: This study evaluated the expression and role of MCT1, MCT2, and MCT4 in l-lactate uptake in hepatocellular carcinoma cells. Results showed that both MCT1 and MCT4 were involved in l-lactate transport in HepG2 and Huh-7 cells at pH 6.0, while MCT2 had no effect.
BIOPHARMACEUTICS & DRUG DISPOSITION
(2022)
Letter
Oncology
Atsushi Yamaguchi, Yoshitaka Saito, Katsuya Narumi, Ayako Furugen, Yoh Takekuma, Naofumi Shinagawa, Yasushi Shimizu, Hirotoshi Dosaka-Akita, Mitsuru Sugawara, Masaki Kobayashi
Summary: Patients treated with immune checkpoint inhibitors (ICIs) may develop immune-related adverse events (irAEs) in various organs of the body, and skin irAEs may serve as a predictive marker for the development of multisystem irAEs. Therefore, patients with skin irAEs should be treated and monitored for other types of irAEs.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Atsushi Yamaguchi, Yuto Mukai, Tomoya Sakuma, Katsuya Narumi, Ayako Furugen, Yuma Yamada, Masaki Kobayashi
Summary: Metabolic reprogramming of cancer cells is a potential target for cancer therapy. This study found that a hypoxic environment can alter the sensitivity of drugs targeting energy metabolism, and that MCT4 is involved in this mechanism.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Takanobu Nadai, Katsuya Narumi, Yuto Mukai, Hinata Ueda, Ayako Furugen, Yoshitaka Saito, Masaki Kobayashi
Summary: This study found that MCT1 expression increased under normal glucose conditions. The MCT4 selective inhibitor, Bindarit, decreased 4-OHT sensitivity, while the MCT1 substrate/inhibitor, 5-oxoproline (5-OP), enhanced 4-OHT-induced cytotoxicity.
ANTICANCER RESEARCH
(2023)
Article
Oncology
Atsushi Yamaguchi, Yuto Mukai, Tomoya Sakuma, Ayako Furugen, Katsuya Narumi, Masaki Kobayashi
Summary: This study found that statins can inhibit the transport activities of hMCT1, hMCT2, and hMCT4, with atorvastatin showing potent isoform-selective inhibition of hMCT2. Docking simulation revealed that atorvastatin could interact with a specific site, potentially leading to the discovery of more potent hMCT2-selective inhibitors. These findings are important for understanding the inhibitory mechanism of statins against hMCT1, hMCT2, and hMCT4, and may contribute to the development of novel anticancer agents.
ANTICANCER RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Genki Yasuda, Atsuhito Kubota, Keisuke Okamoto, Katsuya Narumi, Ayako Furugen, Izumi Kato, Ayako Mori, Yoshitaka Saito, Takashi Satoh, Natsuko Takahashi-Suzuki, Ken Iseki, Masaki Kobayashi
Summary: Alpha-defensin 5 is secreted by Paneth cells in the small intestine and its decrease in level is a risk factor for inflammatory bowel disease (IBD). P-glycoprotein (P-gp), encoded by ABCB1/MDR1 gene, plays a role in protecting the gastrointestinal barrier and may contribute to IBD. This study found that alpha-defensin 5 regulates P-gp expression and function by increasing TNF-alpha expression in Caco-2 cells.
BIOPHARMACEUTICS & DRUG DISPOSITION
(2023)
Article
Dentistry, Oral Surgery & Medicine
Akira Yamagami, Katsuya Narumi, Yoshitaka Saito, Ayako Furugen, Shungo Imai, Yoshimasa Kitagawa, Yoichi Ohiro, Ryo Takagi, Yoh Takekuma, Mitsuru Sugawara, Masaki Kobayashi
Summary: This study developed a model for predicting the risk of surgical site infection after lower third molar surgery. The model showed good predictive metrics and can improve the accuracy of predicting surgical site infection risk.
Article
Pharmacology & Pharmacy
Nanami Ohyama, Ayako Furugen, Riko Sawada, Ryoichi Aoyagi, Ayako Nishimura, Takeshi Umazume, Katsuya Narumi, Masaki Kobayashi
Summary: This study aimed to investigate the effects of clinically relevant concentrations of antiepileptic drugs on syncytialization of trophoblasts. The results showed that exposure to valproic acid (VPA) influenced the expression of syncytialization-associated genes, inhibited cell fusion, and was correlated with neonatal and placental parameters. These findings have important implications for understanding the toxicity mechanisms of antiepileptic drugs and predicting risks to placental and fetal development.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
