Article
Biophysics
Jingwen Wang, Jing Wang, Shuilai Qiu, Weijian Chen, Liang Cheng, Wenxiang Du, Jinghao Wang, Longfei Han, Lei Song, Yuan Hu
Summary: A black phosphorus-based biodegradable material with enhanced hydrophilicity, shape recovery, and osteodifferentiation properties was proposed in this study. By integrating amino black phosphorous into PLCL, the composite fibers showed excellent shape recovery and osteogenic capabilities, making them suitable for tissue engineering applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Radha Sachan, Sudhir G. Warkar, Roli Purwar
Summary: The shape memory properties of triblock copolymeric films were studied by synthesizing films with varying poly(epsilon-caprolactone) (PCL) chain length and constant polydimethylsiloxane (PDMS) content. The results showed that increasing the PCL chain length led to changes in the crystal morphology, thermal properties, and shape memory performance of the films. The inclusion of PDMS block affected the crystallization kinetics and shape fixity of the films.
Article
Polymer Science
Kenta Hashimoto, Naruki Kurokawa, Atsushi Hotta
Summary: New biodegradable shape-memory polymers (SMPs) were synthesized by blending PLCL and sc-PLA, showing controllable switching temperatures and shape-recovery ratios. The SMPs can be used as biomaterials for medical devices.
Article
Engineering, Chemical
Seyede Elaheh Ghafouri, Seyed Rasoul Mousavi, Maliheh Khakestani, Shahla Mozaffari, Narges Ajami, Hossein Ali Khonakdar
Summary: This study investigates the release of levetiracetam using poly(lactic acid), poly(epsilon-caprolactone), and their blend electrospun nanofibers as novel systems. Scanning electron microscopy confirms the smooth and beads-free morphology of the samples. With increasing levetiracetam content, the average diameters of the nanofibers also increase. FTIR spectroscopy is used for structural confirmation and observation of functional groups. X-ray diffraction reveals a decrease in crystallinity and different drug release kinetics are evaluated using various models.
POLYMER ENGINEERING AND SCIENCE
(2022)
Article
Polymer Science
Qi Wang, Xuefeng Yan, Ping Liu, Yiyan Xu, Qingbao Guan, Zhengwei You
Summary: A new near-infrared light-triggered shape memory polymer (PDA/EA) is developed by combining photothermal conversion agent polydopamine (PDA) nanoparticles and epoxy acrylate polymer (EA) effectively. The introduction of PDA improves the dynamic mechanical properties and thermal resistance compared to EA, making PDA/EA a promising environmentally friendly and highly efficient photoactive SMP.
Review
Agronomy
Meisam Zargar, Maryam Bayat, Francess Sia Saquee, Simbo Diakite, Nakhaev M. Ramzanovich, Khasukhadzhiev A. S. Akhmadovich
Summary: The number of effective herbicides available to farmers is decreasing due to increasing herbicide resistance. It is important to address weed management challenges by investigating the potential of newly introduced materials, such as biocompatible polymer-based nanoparticles.
Article
Materials Science, Multidisciplinary
Thannaphat Jenvoraphot, Boontharika Thapsukhon, Donraporn Daranarong, Robert Molloy, Chayarop Supanchart, Suttichai Krisanaprakornkit, Paul D. Topham, Brian Tighe, Anisa Mahomed, Winita Punyodom
Summary: In this research, a periodontal membrane with nanoporous structure and tetracycline drug loading was designed and fabricated to improve periodontal regeneration and anti-inflammatory effect.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Zengjie Fan, Yuan Wei, Zhengrong Yin, Haofei Huang, Xiaozhu Liao, Luyi Sun, Bin Liu, Fengzhen Liu
Summary: A microneedle patch loaded with VEGF and NIR-triggered graphene oxide was designed for minimally invasive treatment of myocardial infarction (MI), showing promising application prospects in promoting neovascularization, reducing myocardial fibrosis, and restoring cardiac function.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Multidisciplinary
Nikola Toshikj, Jean-Jacques Robin, Michel Ramonda, Sylvain Catrouillet, Sebastien Blanquer
Summary: Efficient and rapid organocatalyzed ring-opening polymerization was used to synthesize PTMC-b-PCL-b-PTMC block copolymers, with controlled architectures achieved through an additional cross-linking step. The crystalline-driven phase-separated morphology predominated, and the cross-linked thin films exhibited shape-memory properties, while remaining stable with access to thermodynamic phase-separated morphologies below the poly(epsilon-caprolactone) melting point.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Chuangui Sheng, Fangzhi Yu, Youming Feng, Ming Gao, Wei Li, Lele Li, Jian Zhao
Summary: Metal-organic frameworks (MOFs) are used as a promising platform for protein delivery due to their high loading capacity and tunable functionality. However, the controlled release of proteins from MOFs-based nanocarriers is still a challenge. In this study, a MOFs-based protein delivery system that can precisely control protein release using near-infrared (NIR) light is reported. The system involves the encapsulation of proteins and upconversion nanoparticles (UCNPs) within MOFs and the use of NIR light to trigger the release of the proteins.
Article
Polymer Science
Chaobo Hao, Kaibin Wang, Zhuo Wang, Ruixia Duan, Hao Liu, Miaoming Huang, Wentao Liu, Suqin He, Chengshen Zhu
Summary: The study presents a new method for fabricating triple one-way and two-way shape memory polymers using blends of EVA and PCL. The blends show excellent shape memory properties with dual and triple one-way shape memory capabilities, as well as remarkable and recyclable triple two-way shape memory performance. This new preparation method may have potential applications in soft robotics, actuators, and cranes.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Polymer Science
Honggang Mei, Bingjie Zhao, Yuan Gao, Lei Li, Liyue Liu, Sixun Zheng
Summary: This contribution presents a novel synthesis method for block copolymer networks composed of PCL and PE. The materials exhibit phase-separated morphology and shape memory properties. The combination of PCL with PE results in triple shape memory properties, triggered by the melting and crystallization of PCL and PE blocks.
CHINESE JOURNAL OF POLYMER SCIENCE
(2022)
Article
Materials Science, Characterization & Testing
Lidong Feng, Sheng Xiang, Yanlong Liu, Xinchao Bian, Gao Li, Xuesi Chen
Summary: An analytical method using gas chromatography with an internal standard was developed to quantitatively determine residual monomers in PLCL, which showed high precision with RSD less than 5.6% and 4.3% for LA and CL measurements, respectively. The recovery rate of standard addition for LA and CL in PLCL was between 96.5%-101.5% and 98.4%-104.2%, with RSD not exceeding 2.0%, indicating the method was sufficiently accurate.
Article
Nanoscience & Nanotechnology
Karolina Chojnacka-Gorka, Karol Wolski, Szczepan Zapotoczny
Summary: By incorporating a small amount of multiwalled carbon nanotubes arranged in a specific manner, the apparent elastic modulus of microcapsules can be significantly increased, leading to enhanced mechanical stability. Additionally, a light-triggered increase in permeability of the capsule walls can be achieved, demonstrating the potential for durable and conveniently loaded/unloaded microcapsules for practical applications as microcontainers and microreactors.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Polymer Science
C. Greant, B. Van Durme, L. Van Damme, J. Brancart, J. Van Hoorick, S. Van Vlierberghe
Summary: Digital light processing (DLP) is a promising 3D printing technique for tissue engineering, but the lack of 'smart' photoresponsive polymers limits its potential. This study combines biodegradable shape memory polymers with DLP printing to create thermoresponsive porous scaffolds. The developed photosensitive resins exhibit excellent properties and the 3D printed scaffolds are biocompatible and show shape memory behavior, making them suitable for minimally invasive tissue engineering strategies.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Materials Science, Biomaterials
Sevgi Secer, Deniz Ceylan Tuncaboylu
Summary: Mechanically enhanced poloxamer (F127)-based injectable hydrogels in the presence of hyaluronic acid (HA) and three types of cyclodextrin (CD) molecules were prepared in this study. The addition of HA and CD molecules improved the performance of the gels, making them more mucoadhesive.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Rainhard Machatschek, Matthias Heuchel, Andreas Lendlein
Summary: Polyimides and polyetherimides (PEI) exhibit the capability to react with nucleophiles under mild conditions, allowing for surface properties adjustment through post-functionalization targeting phthalimide groups. Investigating surface functionalization using ultra-thin PEI films on a Langmuir trough, it was found that hydrolysis enhances film stability and activates ester formation. The direct amidation of PEI with Lewis acid catalyst resulted in free amine groups, showing a greater impact of hydrolysis on material properties when compared to amidation.
JOURNAL OF MATERIALS RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Yue Liu, Oliver E. C. Gould, Karl Kratz, Andreas Lendlein
Summary: Polymeric devices capable of controlled release of submicron particles on demand have been demonstrated using a temperature-memory polymer sheet as a matrix to embed and release polystyrene subMP based on particle size and temperature. The technology allows for sequential release of subMPs based on their size and temperature-memory effect, showing potential applications in assembly, particle sorting, and release technologies in microtechnology, catalysis, and controlled release.
Article
Materials Science, Multidisciplinary
Hanieh Moradian, Manfred Gossen, Andreas Lendlein
Summary: This study investigates the effects of different payload designs on gene co-expression, and finds that co-delivery of individual monocistronic nucleic acids is more effective than a bicistronic design.
MRS COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Lucile Tartivel, Anna M. Blocki, Steffen Braune, Friedrich Jung, Marc Behl, Andreas Lendlein
Summary: This study presents microporous hydrogels with an inverse shape-memory effect, which can change their shape through heating and cooling. These hydrogels can gently load bioactive components without causing activation, making them potential candidates for tissue regeneration.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Shuo Zhou, Xun Xu, Nan Ma, Friedrich Jung, Andreas Lendlein
Summary: Glycerol-based epoxy networks have great potential for surface functionalization, but the production process may lead to the presence of organochlorides, affecting cytotoxicity.
Article
Materials Science, Multidisciplinary
Shanshan Zhang, Yue Liu, Rainhard Machatschek, Andreas Lendlein
Summary: We report the successful production of cohesive and well-organized type I collagen ultrathin films of about 10 nm thickness using the Langmuir-Blodgett technique. Investigation of molecular behavior at the air-water interface reveals the existence and disappearance of a network structure in the protein nanosheet. Highly aligned and fibrillar structures are observed by atomic force microscopy and optical microscopy.
Article
Energy & Fuels
Natalia A. Tarazona, Rainhard Machatschek, Jennifer Balcucho, Andreas Lendlein, Jinneth Lorena Castro-Mayorga, Juan F. Saldarriaga
Summary: The production and consumption of commodity polymers are crucial for the development of modern society. Polymer-based materials play important roles in various fields such as healthcare, transport, food preservation, construction, electronics, and water management. However, considering the environmental crisis caused by plastic consumption, advanced polymers should incorporate functions that meet application demands and minimize environmental harm. This article discusses strategies to enhance the sustainability of plastics, including measuring and reducing negative impacts, using renewable sources for synthesis, designing biodegradable and recyclable materials, and enzymatic recycling for a circular bioeconomy. International cooperation is also emphasized for achieving the Sustainable Development Goals (SDGs) through leading-edge polymer-based materials.
MRS ENERGY & SUSTAINABILITY
(2022)
Article
Materials Science, Multidisciplinary
Falk Hoffmann, Rainhard Machatschek, Andreas Lendlein
Summary: This study investigates the degradation of polymers using mathematical models, comparing different chain cut mechanisms and analyzing the influence of internal molecular parameters. The results show that the shape of the degradation curve is similar for both chain cut mechanisms, and a characteristic time and maximum length of soluble fragments can be extracted to enhance the description and design of polymers.
JOURNAL OF MATERIALS RESEARCH
(2022)
Article
Medicine, Research & Experimental
Hanieh Moradian, Toralf Roch, Larissa Anthofer, Andreas Lendlein, Manfred Gossen
Summary: In vitro transcribed (IVT)-mRNA is a promising therapeutic modality that can be tailored to modulate innate immune responses of human cells. Uridine modifications were found to be particularly important for IVT-mRNA performance, while 5'-end modifications had modest effects on mRNA expression and immune responses.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Materials Science, Multidisciplinary
Magdalena Mazurek-Budzynska, Marc Behl, Richard Neumann, Andreas Lendlein
Summary: This study presents multifunctional 4D actuators processed by 3D-printing, with actuator functionality integrated into the shaped body. The materials are based on crosslinked poly(carbonate-urea-urethane) networks (PCUU) synthesized in an integrated process, showing reversible deformation when thermomechanically programmed.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Husna Kilic, Deniz Ceylan Tuncaboylu, Aslihan Argun, Dilek Ozturk Civelek
Summary: In this study, biocompatible SM-x networks with self-healing and shape memory properties were prepared. The mechanical properties of the gels can be controlled by the amount of SM introduced. The viability of human skin fibroblast cells on SM-x hydrogels was correlated to the water contact angle of the structures. The wide range of properties of SM-x gel samples may have significant potential in biomedical applications.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Polymer Science
Christian Wischke, Dieter Hofmann
Summary: This study investigates the preparation of ellipsoidal polymer particles through unidirectional stretching at elevated temperatures. The resulting aspect ratios of the particles are often not precisely predictable. An elastic deformation model is used to evaluate the dimensions of the particles and suggests that it may be applicable to predict the conditions needed to prepare ellipsoids of desired aspect ratios.
Article
Polymer Science
Osamah Altabal, Christian Wischke
Summary: A procedure for mechanical analysis of free-standing PACA films using microindentation was explored to determine the effects of different side chain compositions on the material. This method may be relevant for characterizing various coating materials and assist in the design and evaluation of hybrid material devices.
Article
Pharmacology & Pharmacy
Osamah Altabal, Christian Wischke, Andreas Lendlein
Summary: The design of cavities and brittle coating layers enable a pre-defined release of different compounds through stress concentration phenomena. This proof of concept provides insights for further exploration in technology and medicine for deformation-induced on-demand dosage applications.
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
