Scalable culture of human induced pluripotent cells on microcarriers under xeno-free conditions using single-use vertical-wheel™ bioreactors

Concise Review: Induced Pluripotent Stem Cell Research in the Era of Precision Medicine

(2017) Takashi Hamazaki et al.   STEM CELLS

Microcarriers with Synthetic Hydrogel Surfaces for Stem Cell Expansion

(2017) Andrew D. Dias et al.   Advanced Healthcare Materials

Microcarrier-based platforms for in vitro expansion and differentiation of human pluripotent stem cells in bioreactor culture systems

(2016) Sara M. Badenes et al.   JOURNAL OF BIOTECHNOLOGY

Long-term expansion of human induced pluripotent stem cells in a microcarrier-based dynamic system

(2016) Sara M Badenes et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Induced pluripotent stem cell technology: a decade of progress

(2016) Yanhong Shi et al.   NATURE REVIEWS DRUG DISCOVERY

Pluripotent stem cells in disease modelling and drug discovery

(2016) Yishai Avior et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pluripotent stem cells progressing to the clinic

(2016) Alan Trounson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Impact of Feeding Strategies on the Scalable Expansion of Human Pluripotent Stem Cells in Single-Use Stirred Tank Bioreactors

(2016) Christina Kropp et al.   Stem Cells Translational Medicine

Neural commitment of human pluripotent stem cells under defined conditions recapitulates neural development and generates patient-specific neural cells

(2015) Tiago G. Fernandes et al.   Biotechnology Journal

Production of oncolytic adenovirus and human mesenchymal stem cells in a single-use, Vertical-Wheel bioreactor system: Impact of bioreactor design on performance of microcarrier-based cell culture processes

(2015) Marcos F. Q. Sousa et al.   BIOTECHNOLOGY PROGRESS

Robust Expansion of Human Pluripotent Stem Cells: Integration of Bioprocess Design With Transcriptomic and Metabolomic Characterization

(2015) Marta M. Silva et al.   Stem Cells Translational Medicine

Neural commitment of human pluripotent stem cells under defined conditions recapitulates neural development and generates patient-specific neural cells

(2015) Tiago G. Fernandes et al.   Biotechnology Journal

Human pluripotent stem cell-derived products: Advances towards robust, scalable and cost-effective manufacturing strategies

(2014) Michael J. Jenkins et al.   Biotechnology Journal

Metabolic Profiling and Flux Analysis of MEL-2 Human Embryonic Stem Cells during Exponential Growth at Physiological and Atmospheric Oxygen Concentrations

(2014) Jennifer Turner et al.   PLoS One

Application of human mesenchymal and pluripotent stem cell microcarrier cultures in cellular therapy: Achievements and future direction

(2013) Allen Kuan-Liang Chen et al.   BIOTECHNOLOGY ADVANCES

Stem cell bioprocessing for regenerative medicine

(2013) Tiago G. Fernandes et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Scalable expansion of human induced pluripotent stem cells in the defined xeno-free E8 medium under adherent and suspension culture conditions

(2013) Ying Wang et al.   Stem Cell Research

Passaging and colony expansion of human pluripotent stem cells by enzyme-free dissociation in chemically defined culture conditions

(2012) Jeanette Beers et al.   Nature Protocols

Stem cell cultivation in bioreactors

(2011) Carlos A.V. Rodrigues et al.   BIOTECHNOLOGY ADVANCES

Microcarrier expansion of mouse embryonic stem cell-derived neural stem cells in stirred bioreactors

(2011) Carlos A. V. Rodrigues et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Chemically defined conditions for human iPSC derivation and culture

(2011) Guokai Chen et al.   NATURE METHODS

Improving expansion of pluripotent human embryonic stem cells in perfused bioreactors through oxygen control

(2010) Margarida Serra et al.   JOURNAL OF BIOTECHNOLOGY

Investigations into the Metabolism of Two-Dimensional Colony and Suspended Microcarrier Cultures of Human Embryonic Stem Cells in Serum-Free Media

(2010) Xiaoli Chen et al.   STEM CELLS AND DEVELOPMENT

A Fresh Look at iPS Cells

(2009) Shinya Yamanaka   CELL

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Attachment and growth of human embryonic stem cells on microcarriers

(2008) Blaine Wesley Phillips et al.   JOURNAL OF BIOTECHNOLOGY