Production of oncolytic adenovirus and human mesenchymal stem cells in a single-use, Vertical-Wheel bioreactor system: Impact of bioreactor design on performance of microcarrier-based cell culture processes

Human amniocyte-derived cells are a promising cell host for adenoviral vector production under serum-free conditions

(2015) Ana Carina Silva et al.   Biotechnology Journal

Exploring continuous and integrated strategies for the up- and downstream processing of human mesenchymal stem cells

(2015) Bárbara Cunha et al.   JOURNAL OF BIOTECHNOLOGY

Filtration methodologies for the clarification and concentration of human mesenchymal stem cells

(2015) Bárbara Cunha et al.   JOURNAL OF MEMBRANE SCIENCE

Human amniocyte-derived cells are a promising cell host for adenoviral vector production under serum-free conditions

(2015) Ana Carina Silva et al.   Biotechnology Journal

Modulation of mesenchymal stromal cell characteristics by microcarrier culture in bioreactors

(2014) Julia Hupfeld et al.   BIOTECHNOLOGY AND BIOENGINEERING

A xenogeneic-free bioreactor system for the clinical-scale expansion of human mesenchymal stem/stromal cells

(2014) Francisco dos Santos et al.   BIOTECHNOLOGY AND BIOENGINEERING

Growth and functional harvesting of human mesenchymal stromal cells cultured on a microcarrier-based system

(2014) Sâmia R. Caruso et al.   BIOTECHNOLOGY PROGRESS

Assessment of mass transfer and mixing in rigid lab-scale disposable bioreactors at low power input levels

(2014) Gerco van Eikenhorst et al.   BIOTECHNOLOGY PROGRESS

Challenges in Manufacturing Adenoviral Vectors for Global Vaccine Product Deployment

(2014) Jort Vellinga et al.   HUMAN GENE THERAPY

A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods

(2014) Marialaura Madrigal et al.   Journal of Translational Medicine

Long Term Expansion of Bone Marrow-Derived hMSCs on Novel Synthetic Microcarriers in Xeno-Free, Defined Conditions

(2014) Martial Hervy et al.   PLoS One

Combining Hypoxia and Bioreactor Hydrodynamics Boosts Induced Pluripotent Stem Cell Differentiation Towards Cardiomyocytes

(2014) Cláudia Correia et al.   Stem Cell Reviews and Reports

Trial Watch:

(2014) Jonathan Pol et al.   OncoImmunology

Mesenchymal stem cells: a new trend for cell therapy

(2013) Xin Wei et al.   ACTA PHARMACOLOGICA SINICA

FGF2 induces RANKL gene expression as well as IL1β regulated MHC class II in human bone marrow-derived mesenchymal progenitor stromal cells

(2013) Chiara Bocelli-Tyndall et al.   ANNALS OF THE RHEUMATIC DISEASES

Allogeneic cell therapy bioprocess economics and optimization: Single-use cell expansion technologies

(2013) Ana S. Simaria et al.   BIOTECHNOLOGY AND BIOENGINEERING

Pre-Clinical Development of a Recombinant, Replication-Competent Adenovirus Serotype 4 Vector Vaccine Expressing HIV-1 Envelope 1086 Clade C

(2013) Jeff Alexander et al.   PLoS One

Metabolic Regulation in Pluripotent Stem Cells during Reprogramming and Self-Renewal

(2012) Jin Zhang et al.   Cell Stem Cell

Bioprocess development for canine adenovirus type 2 vectors

(2012) P Fernandes et al.   GENE THERAPY

Modulation of mesenchymal stem cell actin organization on conventional microcarriers for proliferation and differentiation in stirred bioreactors

(2012) Sébastien Sart et al.   Journal of Tissue Engineering and Regenerative Medicine

Process engineering of human pluripotent stem cells for clinical application

(2012) Margarida Serra et al.   TRENDS IN BIOTECHNOLOGY

Development of a measles vaccine production process in MRC-5 cells grown on Cytodex1 microcarriers and in a stirred bioreactor

(2011) Khaled Trabelsi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Improving expansion of pluripotent human embryonic stem cells in perfused bioreactors through oxygen control

(2010) Margarida Serra et al.   JOURNAL OF BIOTECHNOLOGY

Adenoviral Producer Cells

(2010) Imre Kovesdi et al.   Viruses-Basel

Physiological responses of CHO cells to repetitive hydrodynamic stress

(2009) Ruben Godoy-Silva et al.   BIOTECHNOLOGY AND BIOENGINEERING

Integrating human stem cell expansion and neuronal differentiation in bioreactors

(2009) Margarida Serra et al.   BMC BIOTECHNOLOGY

Cytoskeletal control of growth and cell fate switching

(2009) Akiko Mammoto et al.   CURRENT OPINION IN CELL BIOLOGY

Expansion of human mesenchymal stromal cells on microcarriers: growth and metabolism

(2009) D. Schop et al.   Journal of Tissue Engineering and Regenerative Medicine

Improving baculovirus production at high cell density through manipulation of energy metabolism

(2009) Nuno Carinhas et al.   METABOLIC ENGINEERING

Evaluation of the effect of chronic hydrodynamical stresses on cultures of suspensed CHO-6E6 cells

(2008) Ruben Godoy-Silva et al.   BIOTECHNOLOGY AND BIOENGINEERING

Scalable culture systems using different cell lines for the production of Peste des Petits ruminants vaccine

(2008) Ana Carina Silva et al.   VACCINE