Article
Chemistry, Multidisciplinary
Marta Meneghello, Ana Rita Oliveira, Aurore Jacq-Bailly, Ines A. C. Pereira, Christophe Leger, Vincent Fourmond
Summary: Mo/W formate dehydrogenases catalyze the reversible reduction of CO2 to formate, and it has been definitively demonstrated through an electrochemical method that the substrate is indeed CO2, not a hydrated species like HCO3-.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Cristhian Molina-Fernandez, Patricia Luis
Summary: The use of immobilized carbonic anhydrase as a novel approach for CO2 capture presents a promising alternative to address cost and environmental issues. Current research focuses on developing different carriers and immobilization strategies to achieve stability and activity compared to free enzyme in solution.
JOURNAL OF CO2 UTILIZATION
(2021)
Article
Microbiology
Guang Gao, Wei Liu, Xin Zhao, Kunshan Gao
Summary: The diatom Skeletonema costatum responds to UVR, especially UVA, by upregulating its CO2 concentrating mechanisms (CCMs) and enhancing carbon fixation activities. Additionally, UVA promotes active HCO3- uptake and photosynthetic carbon fixation, particularly at lower PAR levels.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Joanna Xiuzhu Xu, Md Siddik Alom, Rahul Yadav, Nicholas C. Fitzkee
Summary: The authors develop a residue-based affinity scale to predict protein orientation on gold nanoparticles. The scale takes into account the steric considerations for hydrophobic residues and the electrostatic interactions for hydrophilic residues. Using this model, the accessibility of active sites on proteins on nanoparticles can be predicted.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Plant Sciences
Justin Findinier, Arthur R. Grossman
Summary: The CO2-concentrating mechanism is an inorganic carbon pump used by eukaryotic algae to promote carbon fixation. It has the potential to be transferred to crop species, enhancing agricultural yields and supporting a growing world population.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Chemistry, Medicinal
Gustavo Provensi, Alessia Costa, Barbara Rani, Maria Vittoria Becagli, Fabio Vaiano, Maria Beatrice Passani, Damiano Tanini, Antonella Capperucci, Simone Carradori, Jacobus P. Petzer, Anel Petzer, Daniela Vullo, Gabriele Costantino, Patrizio Blandina, Andrea Angeli, Claudiu T. Supuran
Summary: This study reported the synthesis of β-arylchalcogeno amines with structural similarity to amphetamine, which showed good activation properties for certain enzymes in the brain. In vivo evaluation demonstrated the procognitive effects of these compounds without causing unwanted side effects. These findings suggest the potential utility of these compounds for improving cognitive decline associated with neurodegenerative and psychiatric diseases.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Polymer Science
Chia-Jung Hsieh, Ju-Chuan Cheng, Chia-Jung Hu, Chi-Yang Yu
Summary: The fusion protein R5-SazCA, formed by combining a silica-condensing peptide with the fastest known carbonic anhydrase, showed high efficiency and stability in CO2 sequestration, making it a promising biocatalyst for this important process.
Article
Green & Sustainable Science & Technology
Shan Chang, Yan He, Yinxi Li, Xuemin Cui
Summary: This study focused on immobilizing carbonic anhydrases on geopolymer microspheres for CO2 capture and sequestration. Optimal conditions included pH 8.0, temperature 30 degrees C, and incubation for 2 hours. The immobilized enzyme showed improved thermal and storage stability compared to the free enzyme.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Franziska Steger, Johanna Reich, Werner Fuchs, Simon K. -M. R. Rittmann, Georg M. Guebitz, Doris Ribitsch, Guenther Bochmann
Summary: Strategies for depleting carbon dioxide (CO2) from flue gases are urgently needed, and carbonic anhydrases (CAs) can contribute to solving this problem. This current study examines four recombinantly produced CAs from different organisms, namely CAs from Acetobacterium woodii (AwCA or CynT), Persephonella marina (PmCA), Methanobacterium thermoautotrophicum (MtaCA or Cab), and Sulphurihydrogenibium yellowstonense (SspCA). The highest expression yields and activities were found for AwCA and PmCA. AwCA showed high stability in a mesophilic temperature range, while PmCA proved to be exceptionally thermostable. These results indicate the potential to utilize CAs from anaerobic microorganisms for CO2 sequestration applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Lian Zhou, Xiaoqin Xiang, Dongpu Ji, Qiulan Chen, Tengfei Ma, Jiuguang Wang, Chaoxian Liu
Summary: The study shows that ZmCA4 plays a critical role in photosynthesis in maize by modulating CO2 signaling regulation through its interaction with ZmPIP2;6. This provides insights into the potential genetic value of ZmCA4 for improving maize yield.
PLANT AND CELL PHYSIOLOGY
(2023)
Article
Environmental Sciences
Liming Qu, Douglas A. Campbell, Kunshan Gao
Summary: The study demonstrates that coastal diatom Thalassiosira weissflogii's physiological responses to ocean acidification vary with different light levels. Under high pCO2 conditions, CO2 concentrating mechanisms are down-regulated, leading to enhanced growth rate only at low light levels.
MARINE POLLUTION BULLETIN
(2021)
Article
Biophysics
Sizhu Ren, Ruixue Chen, Zhangfei Wu, Shan Su, Jiaxi Hou, Yanlin Yuan
Summary: The immobilization of CA is crucial in enhancing enzyme stability and utilization, but the choice of immobilization methods and conditions must be carefully considered to prevent a decrease in CA activity and impact on CO2 conversion. Immobilized CA has promising applications in the environmental sector, particularly in CO2 mineralization and multienzyme cascade catalysis.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Environmental Sciences
Tanvi Sharma, Abhishek Sharma, Chang lei Xia, Su Shiung Lam, Azmat Ali Khan, Sonam Tripathi, Raj Kumar, Vijai Kumar Gupta, Ashok Kumar Nadda
Summary: In this study, a bacterial carbonic anhydrase (CA) was purified and used to convert CO2 into CaCO3. The purified CA showed optimal activity at 35 degrees C and pH 7.5, and exhibited good efficacy in converting CO2 into CaCO3. The study also provided insights into the structure and binding site of the purified CA.
ENVIRONMENTAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Xiaoyin Xu, Sandra E. Kentish, Gregory J. O. Martin
Summary: The study investigated a method of enhancing the productivity of Nannochloropsis salina by cross-linking carbonic anhydrase with glutaraldehyde and encapsulating them into buoyant calcium alginate beads for direct air capture. The CA-GA beads retained high activity even after multiple uses, showing potential for industrial biomass production.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Review
Environmental Sciences
Xing Zhu, Chenxi Du, Bo Gao, Bin He
Summary: High carbon dioxide concentration in the atmosphere calls for eco-friendly mitigation strategies. Carbonic anhydrase (CA) immobilization can enhance its stability and enzyme recycling, but there is limited mass transfer between gaseous CO2 and the active center of immobilized CA. This review focuses on improving the mass transfer process to increase the efficiency of enzymatic CO2 capture for industrial applications.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Agronomy
Liang Zhang, Zhiyu Zhu, Fangfang Chen, Yueqing Zhu, Xiaocan Guo, Minjie Fu, Jiahong Chen, Jianguo Wu, Zhujun Zhu
Summary: In this study, distant hybridization between radish and kohlrabi was successfully achieved using tissue culture and chromosome doubling technology, resulting in the production of xBrassicoraphanus allotetraploids. The allotetraploid hybrids exhibited normal morphology and fertility, providing a basis for the production of new radish germplasm and serving as a bridge for gene transfer between Brassica and Raphanus vegetable species.
NEW ZEALAND JOURNAL OF CROP AND HORTICULTURAL SCIENCE
(2023)
Article
Statistics & Probability
Ruiyu Xu, Jianguo Wu, Xiaowei Yue, Yongxiang Li
Summary: This article proposes an online structural change-point detection method for high-dimensional streaming data through dynamic sparse subspace learning and an efficient Pruned Exact Linear Time algorithm. The effectiveness of the method is demonstrated through simulation studies and a real case study.
Review
Chemistry, Multidisciplinary
Xiao-Fan Chen, Zhi-Cheng Lin, Zenghua Qi, Zongwei Cai, Zhi-Feng Chen
Summary: Exposure to pollutants can cause damage to the eyes of aquatic organisms. Zebrafish is a commonly used model to study ocular toxicity and has shown morphological changes, retinal damage, and abnormalities in visual signal processes. The underlying mechanisms involve thyroid hormone signaling, retinoic acid signaling, and retinal glucose metabolism. This review discusses the phenotypes and signaling pathways associated with ocular toxicity from contaminants, detection methods, and a predictive model for potential ocular toxicity.
ENVIRONMENTAL CHEMISTRY LETTERS
(2023)
Article
Environmental Sciences
Guangmei Wu, Guitao Shi, Chuanjin Li, Ye Hu, Hongmei Ma, Zhenlou Chen
Summary: During the 2015-2016 Chinese Antarctic Research Expedition, a study was conducted on Particulate-bound mercury (PBM) in the boundary layer. The study found a significant latitudinal gradient in PBM, with higher levels over the Northern Hemisphere influenced by both continental and oceanic sources. Over the Southern Ocean, PBM levels were extremely low, while elevated PBM was observed across the Antarctic Ice Sheet, particularly at Dome A. The study also revealed the role of inland Antarctic snow in influencing atmospheric PBM concentrations over the Antarctic coastal seas.
ATMOSPHERIC ENVIRONMENT
(2023)
Article
Geosciences, Multidisciplinary
Yongjie Wang, Guitao Shi, Danhe Wang, Qian Zhao, Su Jiang, Yangjie Li, Dongqi Wang, Chuanjin Li, Zhenlou Chen, Roberto Bargagli
Summary: This study investigated soil mercury levels in different areas of Antarctica and found a close relationship between mercury distribution and organic carbon content. The findings contribute to a better understanding of the biogeochemical cycle of mercury in Antarctic terrestrial ecosystems.
Article
Plant Sciences
Yan Wang, Wei Dong, Qin Zhang, Zhen-Peng Li, Yue-Xing Wang, Xiu-Fen Li, Long-Jiang Huang
Summary: An efficient and scalable process for the synthesis of 19-hydroxyprogesterone was developed, achieving a total yield of 34.5%, which is significantly higher than the previously reported process (11.0% total yield). The plausible ring-opening mechanism of the 6,19-epoxy bridge in compound 7 was proposed, and the structures of intermediates were confirmed by LC-MS analysis.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Environmental Sciences
Wei Huang, Guodong Cao, Chengliang Deng, Yanyan Chen, Tao Wang, Da Chen, Zongwei Cai
Summary: This study investigated the effects of TCS exposure on kidney function in mice. The results showed that TCS caused renal injury, oxidative stress, inflammation, and fibrosis in a dose-dependent manner. Metabolite analysis revealed lipid accumulation and defective fatty acid metabolism in TCS-exposed mouse kidney, which may contribute to renal function impairment.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Huiyan Li, Huilin Zhang, Xiaofang He, Peiran Zhao, Tong Wu, Jinxuan Xiahou, Yelin Wu, Yanyan Liu, Yang Chen, Xingwu Jiang, Guanglei Lv, Zhenwei Yao, Jian Wu, Wenbo Bu
Summary: A communication interception strategy is developed to block spatiotemporal crosstalk between lysosomes and endoplasmic reticulum (ER) using amorphous-core@crystalline-shell Fe@Fe3O4 nanoparticles (ACFeNPs). This strategy induces autophagy and ER stress, leading to a significant therapeutic effect for cancer treatment.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Pengfei Hou, Yumiao Tian, Yu Xie, Fei Du, Gang Chen, Aleksandra Vojvodic, Jianzhong Wu, Xing Meng
Summary: This study develops a neural network potential (NNP) for aqueous MXene systems using deep neural networks and an active learning scheme, providing ab initio precision at low cost. The oxidation behaviors of super large aqueous MXene systems are investigated at nanosecond timescales, revealing the atomic-level process of MXenes oxidation and the inhibitory effects of free protons and oxides on subsequent oxidation reactions. These findings contribute to the development of effective protection strategies for controlling the stability of MXenes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Polymer Science
Alejandro Gallegos, Jianzhong Wu
Summary: In this work, a hierarchical method that incorporates liquid-state theories with the site-binding model is proposed to quantify the charging behavior of weak polyelectrolytes over a broad range of solution conditions.
Article
Engineering, Biomedical
Yuanrong Li, Jianguo Wu, Chuanjiang He, Honghui He, Mingjun Xie, Ke Yao, Jing He, Yan Duan, Liujing Zhaung, Ping Wang, Yong He
Summary: Many mammalian tissues have specific cellular arrangements under stress stimulus, but conventional 3D encapsulation fails to replicate these arrangements accurately, so advanced cellular arrangement approaches are needed. In this study, a novel 3D prestress bioprinting approach is developed, using static sustained tensile stress, molecular chain orientation, and slow crosslinking in bioink to guide tissue construction. The semi-crosslinking state of the bioink provides excellent elasticity for applying stress on cells during the printing process. After printing, the bioink gradually crosslinks and maintains the applied stress force to induce cell-orientated growth. This approach allows for directional arrangement of multiple cell types, with adjustable internal stress in the hydrogel filament, and has potential applications in engineering skeletal muscles, tendons, ligaments, vascular networks, or combinations thereof.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Environmental Sciences
Guanghui Zhao, Taihu Sun, Dongqi Wang, Shu Chen, Yan Ding, Yilan Li, Guitao Shi, Hechen Sun, Shengnan Wu, Yizhe Li, Chenyang Wu, Yufang Li, Zhongjie Yu, Zhenlou Chen
Summary: This study used stable isotopes to investigate the sources and transformation processes of nitrate in Suzhou Creek. The results showed that treated wastewater, soil nitrogen, and nitrogen fertilizer were the main sources of nitrate in the river. Reducing nitrate concentrations in treated wastewater is crucial for addressing nitrogen pollution in urban rivers.
ENVIRONMENTAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Wenjing Mu, Liyan Jia, Musen Zhou, Jianzhong Wu, Yiyang Lin, Stephen Mann, Yan Qiao
Summary: This study develops an interactive binary population of coacervate microdroplets that spontaneously self-sort into chain-like protocell networks. These networks exhibit macromolecular self-sorting, localized enzyme/ribozyme biocatalysis, and interdroplet molecular translocation. The protocell superstructures can be reconfigured and used for biomolecular sorting.
Review
Biochemistry & Molecular Biology
Hui Chen, Cheng Jin, Li Xie, Jian Wu
Summary: Succinate, an intermediate of the TCA cycle, is crucial in mitochondrial metabolism, energy production, and is also considered a signaling molecule in metabolism and hepatic diseases. Its downstream signaling pathway through GPR91 leads to various intracellular responses, including succinylation, ROS production, HIF-1 alpha stabilization, and significant impact in cellular metabolism due to its role in the TCA cycle. Understanding the signaling mechanisms of succinate in hepatic fibrosis, metabolic reprogramming, inflammatory or immune responses, and carcinogenesis is of great interest. This review aims to provide the current understanding of succinate in mediating metabolism, inflammatory and immune responses in liver diseases, with the aim of establishing a molecular basis for therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Mathematics, Applied
Marco Tosato, Xue Zhang, Jianhong Wu
Summary: We investigate the behavior of solutions to a scalar Delay Differential Equation (DDE) with periodic switching between two constant values. This equation naturally arises in structured vector populations involved in the spread of various vector-borne diseases in a periodically changing environment. We examine the influence of two different time lags and the switching time on the existence and patterns of periodic solutions, with a specific focus on multi-cycles within the prime period.
DIFFERENTIAL EQUATIONS AND DYNAMICAL SYSTEMS
(2023)
