Article
Multidisciplinary Sciences
Ming Wu, Hongyan Wang, Dece Kong, Jin Shao, Chao Song, Tieyi Yang, Yan Zhang
Summary: This study revealed that miR-452-3p plays a crucial role in osteoblast differentiation by targeting Smad4. Overexpression of miR-452-3p inhibited the expression of osteoblast marker genes and decreased calcium nodules and ALP activity, while knockdown of miR-452-3p had the opposite effect.
Review
Biochemistry & Molecular Biology
Yen-Zung Wu, Hsuan-Ti Huang, Tsung-Lin Cheng, Yen-Mou Lu, Sung-Yen Lin, Cheng-Jung Ho, Tien-Ching Lee, Chia-Hao Hsu, Peng-Ju Huang, Han Hsiang Huang, Jhong-You Li, Yu-De Su, Shih-Chieh Chen, Lin Kang, Chung-Hwan Chen
Summary: miRNAs play crucial roles in osteoporosis, and analyzing human blood samples can help identify miRNAs with diagnostic value and therapeutic potential. Further studies are needed to validate their clinical application value.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Wilson Cheuk Wing Chan, Zhijia Tan, Michael Kai Tsun To, Danny Chan
Summary: Bone is a dynamic tissue that responds to environmental changes such as nutrition and mechanical stress. Bone homeostasis is maintained through bone remodeling in adulthood, which involves a controlled balance between bone-resorbing osteoclasts and bone-forming osteoblasts. During embryonic development, bones can form through intramembraneous or endochondral ossification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Austin P. Hensley, Audrey McAlinden
Summary: miRNAs are important epigenetic factors in regulating bone development, homeostasis, and repair processes by suppressing specific target genes. Studies have shown that alterations in miRNA levels or activity can lead to significant changes in cellular processes. Research has also revealed the potential therapeutic applications of miRNA regulation in various bone conditions.
Article
Biochemistry & Molecular Biology
Gang Wang, Lifu Wan, Lecheng Zhang, Chao Yan, Yuelei Zhang
Summary: This study found that miR-133a plays a role in regulating cell proliferation, osteoblast differentiation, and adipocyte differentiation of BMSCs by targeting FGFR1. BMSC-specific knockdown of miR-133a can attenuate bone loss.
DNA AND CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Selvaraj Vimalraj, Sekaran Saravanan, Raghunandhakumar Subramanian
Summary: The study evaluated the molecular role of Rutin and rutin-Zn(II) complex on osteoblast differentiation and mineralization in human dental pulp cells and zebrafish model, finding them to be non-toxic and enhancing the expression of osteoblast differentiation marker genes and calcium deposition. The results suggest that Rutin-Zn(II) complex may serve as a novel agent for bone tissue engineering applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Review
Biochemistry & Molecular Biology
Dulshara Sachini Amarasekara, Sumi Kim, Jaerang Rho
Summary: Osteoblasts, as bone-forming cells, are regulated by transcription factors and cytokine networks to control osteoblast differentiation, playing pivotal roles in bone modeling and remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Meiyu Piao, Sung Ho Lee, Myeong Ji Kim, Hyung Sik Kim, Kwang Youl Lee
Summary: YY2, a paralog of YY1, regulates osteoblast differentiation by upregulating the promoter activity of the osteogenic transcription factor Osx.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Hui Dong, Ronghan Liu, Ke Zou, Zhengxin Jin, Jianning Kang, Ying Zhang, Xiaodi Zhang, Zhengfang Sun, Guilian Yu, Nana Huang, Morgan Bretches, Shang-You Yang, Bin Ning
Summary: Osteoporosis, a common bone disease, can be treated by higenamine (HG), a small-molecule compound that promotes bone formation through the SMAD2/3 pathway. In vitro experiments showed that HG induced expressions of osteogenic markers in mouse bone marrow stromal cell (BMSCs) and preosteoblastic cell cultures, while in vivo experiments on animal models confirmed enhanced bone formation and prevented bone loss. IQGAP1 was identified as a novel target of HG, and HG exerted its osteogenic effects by binding to the Glu-1019 site of IQGAP1 and promoting SMAD2/3 phosphorylation while inhibiting SMAD4 ubiquitination.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Shivang Shah, Elisha Pendleton, Oliver Couture, Mustafa Broachwalla, Teresa Kusper, Lauren A. C. Alt, Michael J. Fay, Nalini Chandar
Summary: The study investigated the role of p53 tumor suppressor gene in microRNA expression during osteoblast differentiation. Results showed that p53 deficiency led to a reduction in expression of microRNAs during differentiation, while miR-34b and miR-140 were significantly increased during differentiation but decreased in a p53 deficient state. The findings suggest that p53 mediated regulation of osteoblast differentiation can occur through specific microRNAs targeting bone specific genes.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2021)
Article
Pharmacology & Pharmacy
Subhashis Pal, Maninder Singh, Konica Porwal, Sangam Rajak, Nabanita Das, Swati Rajput, Arun K. Trivedi, Rakesh Maurya, Rohit A. Sinha, Mohammad Siddiqi, Sabyasachi Sanyal, Naibedya Chattopadhyay
Summary: Isovitexin selectively induced osteoblast differentiation through AdipoRs and AMP-activated protein kinase, promoting oxidative phosphorylation and ATP synthesis in osteoblasts.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Meiyu Piao, Sung Ho Lee, Yuankuan Li, Joong-Kook Choi, Chang-Yeol Yeo, Kwang Youl Lee
Summary: This study reveals the positive impact of CypE on osteoblast differentiation by enhancing the transcriptional activity of Runx2 through its PPIase activity. The involvement of the Akt signaling pathway in CypE's function in osteoblast differentiation is also identified.
Article
Chemistry, Medicinal
Xiaoqing Zhang, Aiyan Ji, Zhiming Wang, Hongyue Lou, Jiafeng Li, Lingling Zheng, Yujing Zhou, Chunrong Qu, Xingdang Liu, Hao Chen, Zhen Cheng
Summary: The study demonstrated the introduction of azide into a fluorescent dye for NIR-II bone imaging and its impact on in vivo behavior, showing specific bone-targeting ability. This opens up new possibilities for biological applications of azide-containing compounds.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Yang Yang, Xin Fan, Yukai Ren, Kai Wu, Xiangyu Tian, Fengbiao Wen, Donglei Liu, Yuxia Fan, Song Zhao
Summary: This study reveals that SOX2 promotes the proliferation, invasion, and migration of esophageal cancer cells by regulating the miR-30e/USP4/SMAD4/CK2 axis, serving as a potential target for the treatment of EC.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Guoqin Hu, Xian Shi, Xiuxia Qu, Chunqing Han, Anran Hu, Zhongtang Jia, Jiatao Yang, Huanliang Liu, Yu Wu
Summary: Atf7ip regulates osteoblast differentiation by negatively regulating Sp7 expression, and its overexpression impairs osteoblast differentiation while depletion promotes it. Atf7ip contributes to the nucleus localization of Setdb1 and its inhibition may be a potential therapeutic measure for enhancing bone formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)