Quercetin: A functional dietary flavonoid with potential chemo-preventive properties in colorectal cancer

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

(2017) Felipe de Sousa e Melo et al.   NATURE

Antioxidant polyphenols in cancer treatment: Friend, foe or foil?

(2017) Gian Luigi Russo et al.   SEMINARS IN CANCER BIOLOGY

Effect of Root Extracts of Medicinal Herb Glycyrrhiza glabra on HSP90 Gene Expression and Apoptosis in the HT-29 Colon Cancer Cell Line

(2016) Seyed Manuchehr Nourazarian et al.   Asian Pacific Journal of Cancer Prevention

Novel quercetin derivative TEF induces ER stress and mitochondria-mediated apoptosis in human colon cancer HCT-116 cells

(2016) Imran Khan et al.   BIOMEDICINE & PHARMACOTHERAPY

Peroxisome Proliferator-Activated Receptor Ligands and Their Role in Chronic Myeloid Leukemia: Therapeutic Strategies

(2016) Bahman Yousefi et al.   Chemical Biology & Drug Design

DNA damage response regulation by microRNAs as a therapeutic target in cancer

(2016) Maryam Majidinia et al.   DNA REPAIR

Phenolic composition of orange peels and modulation of redox status and matrix metalloproteinase activities in primary (Caco-2) and metastatic (LoVo and LoVo/ADR) colon cancer cells

(2016) Ayokunle O. Ademosun et al.   EUROPEAN FOOD RESEARCH AND TECHNOLOGY

Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis

(2016) Lin Yang et al.   Molecular Medicine Reports

8-C-(E-phenylethenyl)quercetin from onion/beef soup induces autophagic cell death in colon cancer cells through ERK activation

(2016) Yueliang Zhao et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Indian gooseberry ( Emblica officinalis Gaertn.) suppresses cell proliferation and induces apoptosis in human colon cancer stem cells independent of p53 status via suppression of c-Myc and cyclin D1

(2016) Ramakrishna Vadde et al.   Journal of Functional Foods

Molecular Targets Underlying the Anticancer Effects of Quercetin: An Update

(2016) Fazlullah Khan et al.   Nutrients

Fruit and vegetables and cancer risk: a review of southern European studies

(2015) Federica Turati et al.   BRITISH JOURNAL OF NUTRITION

Colorectal Cancer Heterogeneity and Targeted Therapy: A Case for Molecular Disease Subtypes

(2015) J. F. Linnekamp et al.   CANCER RESEARCH

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

Quercetin in Cancer Treatment, Alone or in Combination with Conventional Therapeutics?

(2015) Ana Brito et al.   CURRENT MEDICINAL CHEMISTRY

Anti Proliferative and Pro Apoptotic Effects of Flavonoid Quercetin Are Mediated by CB1 Receptor in Human Colon Cancer Cell Lines

(2015) Maria Grazia Refolo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Quercetin induces human colon cancer cells apoptosis by inhibiting the nuclear factor-kappa B Pathway

(2015) Xiang-An Zhang et al.   Pharmacognosy Magazine

Guidelines on Genetic Evaluation and Management of Lynch Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer

(2014) Francis M. Giardiello et al.   GASTROENTEROLOGY

Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner

(2014) GUEN TAE KIM et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Low Intake of Vegetables and Fruits and Risk of Colorectal Cancer: The Japan Collaborative Cohort Study

(2014) Norihiro Aoyama et al.   JOURNAL OF EPIDEMIOLOGY

A novel classification of colorectal tumors based on microsatellite instability, the CpG island methylator phenotype and chromosomal instability: implications for prognosis

(2013) C. C. J. M. Simons et al.   ANNALS OF ONCOLOGY

Oncogenic mutations and microsatellite instability phenotype predict specific anatomical subsite in colorectal cancer patients

(2013) Giovanni Corso et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Declining Risk of Colorectal Cancer in Inflammatory Bowel Disease

(2013) Maurice W. M. D. Lutgens et al.   INFLAMMATORY BOWEL DISEASES

Site-Specific Anticancer Effects of Dietary Flavonoid Quercetin

(2013) Katrin Sak   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Quercetin enhances hypoxia-mediated apoptosis via direct inhibition of AMPK activity in HCT116 colon cancer

(2012) Hak-Su Kim et al.   APOPTOSIS

Animal models of colorectal cancer

(2012) Robert L. Johnson et al.   CANCER AND METASTASIS REVIEWS

Biomarkers in Early-Stage Colorectal Cancer: Ready for Prime Time?

(2012) David Church et al.   DIGESTIVE DISEASES

Antitumor activities of quercetin and quercetin-5′,8-disulfonate in human colon and breast cancer cell lines

(2012) Haisheng Zhang et al.   FOOD AND CHEMICAL TOXICOLOGY

Use of multivariate analysis to suggest a new molecular classification of colorectal cancer

(2012) Enric Domingo et al.   JOURNAL OF PATHOLOGY

Association of Dietary Quercetin With Reduced Risk of Proximal Colon Cancer

(2012) Zora Djuric et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Quercetin enhances 5-fluorouracil-induced apoptosis in MSI colorectal cancer cells through p53 modulation

(2011) Cristina P. R. Xavier et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The pro-apoptotic effect of quercetin in cancer cell lines requires ERβ-dependent signals

(2011) Pamela Bulzomi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Quercetin Suppresses Cyclooxygenase-2 Expression and Angiogenesis through Inactivation of P300 Signaling

(2011) Xiangsheng Xiao et al.   PLoS One

Combination of quercetin with radiotherapy enhances tumor radiosensitivity in vitro and in vivo

(2011) Chenghe Lin et al.   RADIOTHERAPY AND ONCOLOGY

Advanced colorectal cancer: ESMO Clinical Practice Guidelines for treatment

(2010) E. Van Cutsem et al.   ANNALS OF ONCOLOGY

Induction of apoptosis by quercetin is mediated through AMPKα1/ASK1/p38 pathway

(2010) Yun-Kyoung Lee et al.   CANCER LETTERS

Preclinical Colorectal Cancer Chemopreventive Efficacy and p53-Modulating Activity of 3',4',5'-Trimethoxyflavonol, a Quercetin Analogue

(2010) L. M. Howells et al.   Cancer Prevention Research

Dietary quercetin combining intratumoral doxorubicin injection synergistically induces rejection of established breast cancer in mice

(2010) Gangjun Du et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Apoptotic Effect of Quercetin on HT-29 Colon Cancer Cells via the AMPK Signaling Pathway

(2010) Hyeong-Jin Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Quercetin: A potential drug to reverse multidrug resistance

(2010) Chen Chen et al.   LIFE SCIENCES

Quercetin enhances TRAIL-induced apoptosis in prostate cancer cells via increased protein stability of death receptor 5

(2010) Young-Hwa Jung et al.   LIFE SCIENCES

Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy

(2010) Mohammad R. Noori-Daloii et al.   MEDICAL ONCOLOGY

Effects of various agents on DNA fragmentation and telomerase enzyme activities in adenocarcinoma cell lines

(2010) Didem Turgut Cosan et al.   MOLECULAR BIOLOGY REPORTS

Quercetin Inhibit Human SW480 Colon Cancer Growth in Association with Inhibition of Cyclin D1and Survivin Expression through Wnt/β-Catenin Signaling Pathway

(2009) Bao-En Shan et al.   CANCER INVESTIGATION

Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells

(2009) Cristina P.R. Xavier et al.   CANCER LETTERS

Resveratrol and quercetin cooperate to induce senescence-like growth arrest in C6 rat glioma cells

(2009) Lauren L. Zamin et al.   CANCER SCIENCE

AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin

(2009) Yun-Kyoung Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells

(2009) Su-Yu Chien et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Akt is a direct target for myricetin to inhibit cell transformation

(2009) Takuma Kumamoto et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The dietary flavonoids myricetin and fisetin act as dual inhibitors of DNA topoisomerases I and II in cells

(2009) Miguel López-Lázaro et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Cytotoxicity of flavones and flavonols to a human esophageal squamous cell carcinoma cell line (KYSE-510) by induction of G2/M arrest and apoptosis

(2009) Qiang Zhang et al.   TOXICOLOGY IN VITRO

Dietary Polyphenols as Topoisomerase II Poisons: B Ring and C Ring Substituents Determine the Mechanism of Enzyme-Mediated DNA Cleavage Enhancement

(2008) Omari J. Bandele et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Quercetin suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1α (HIF-1α) through inhibiting protein synthesis

(2008) Dae-Hee Lee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Effects of low dose quercetin: Cancer cell-specific inhibition of cell cycle progression

(2008) Jae-Hoon Jeong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Quercetin May Suppress Rat Aberrant Crypt Foci Formation by Suppressing Inflammatory Mediators That Influence Proliferation and Apoptosis

(2008) Cynthia A. Warren et al.   JOURNAL OF NUTRITION

Cranberry extract and quercetin modulate the expression of cyclooxygenase-2 (COX-2) and IκBα in human colon cancer cells

(2008) Richard Narayansingh et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Quercetin promotes degradation of survivin and thereby enhances death-receptor–mediated apoptosis in glioma cells

(2008) Markus D. Siegelin et al.   NEURO-ONCOLOGY

Molecular Classification and Correlates in Colorectal Cancer

(2007) Shuji Ogino et al.   JOURNAL OF MOLECULAR DIAGNOSTICS